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ClinicalTrials.gov public records Last synced Oct 30, 2026, 10:36 AM EDT

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Showing 121–144 of 191 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Propofol Clear all
Completed Not applicable Interventional Results available

A Pilot Study to Assess the Amnesic Properties of Propofol in Pediatric Patients

NCT02278003
View directory record Official record
Conditions
Pediatric Pateints, Amnesic Properties of Propofol
Interventions
memory test, Propofol
Other · Drug
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
4 Years to 14 Years
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 10, 2018 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Results available

Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction

NCT05509192
View directory record Official record
Conditions
Anesthesia
Interventions
MTPI, Classic Induction
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years and older
Enrollment
154 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Results available

Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management

NCT01368809
View directory record Official record
Conditions
Ambulatory Surgery, Coughing
Interventions
Saline, Fentanyl
Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 5, 2016 · Synced Oct 30, 2026, 10:36 AM EDT
Terminated Phase 2Phase 3 Interventional Results available

Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain

NCT04356352
View directory record Official record
Conditions
Injection Site Irritation, Pain
Interventions
Lidocaine, Esmolol, Placebo
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 60 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 30, 2026, 10:36 AM EDT
Terminated Not applicable Interventional Results available

Decreasing Propofol Injection Pain by Pre-Treatment With Lidocaine in Pediatric Procedural Sedation

NCT02512783
View directory record Official record
Conditions
Pain
Interventions
Lidocaine, Normal Saline, Propofol
Drug
Lead sponsor
Children's Hospitals and Clinics of Minnesota
Other
Eligibility
2 Months to 17 Years
Enrollment
171 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 21, 2016 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Results available

Preventing Propofol-associated Injection Pain

NCT00864682
View directory record Official record
Conditions
Pain
Interventions
Saline, Lidocaine / propofol admixture, lidocaine pretreatment
Drug
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years to 80 Years
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 27, 2021 · Synced Oct 30, 2026, 10:36 AM EDT
Terminated Phase 1 Interventional

How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units

NCT00826553
View directory record Official record
Conditions
Delirium, Respiratory Failure
Interventions
Dexmedetomidine, GABA agonist
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 5, 2017 · Synced Oct 30, 2026, 10:36 AM EDT
Enrolling by invitation Phase 1 Interventional Accepts healthy volunteers

Induction of Dreaming With EEG and Anesthesia in Healthy Adults

NCT07198711
View directory record Official record
Conditions
Healthy Volunteers
Interventions
Propofol - Emergence-from-LOR Protocol, Propofol - Light Sedation Protocol
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Not applicable Interventional

The Utility of Pretracheal Stethoscope in Detecting Respiratory Abnormalities in Sedated Children

NCT01957566
View directory record Official record
Conditions
Sedation
Interventions
APS
Procedure
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
2 Years to 18 Years
Enrollment
105 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 26, 2018 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 3 Interventional

THRIVE Feasibility Trial

NCT05346588
View directory record Official record
Conditions
Surgery--Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia Emergence Delirium, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Nausea, Postoperative, Anesthesia Morbidity, Depression, Sleep Disorders, Circadian Rhythm
Interventions
Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
4
States / cities
Stanford, California • Ann Arbor, Michigan • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 24, 2023 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Results available

Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block

NCT02469961
View directory record Official record
Conditions
Shoulder Pain
Interventions
Dexmedetomidine, Propofol, Interscalene block
Drug · Other
Lead sponsor
Maimonides Medical Center
Other
Eligibility
21 Years to 100 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2024 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Results available

Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

NCT00997321
View directory record Official record
Conditions
Sedation
Interventions
propofol, Ketamine
Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Apr 2, 2012 · Synced Oct 30, 2026, 10:36 AM EDT
Active, not recruiting Phase 4 Interventional

Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression

NCT06317636
View directory record Official record
Conditions
Chronic Pain, Depression
Interventions
Ketamine, Normal saline
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 30, 2026, 10:36 AM EDT
Terminated Phase 2 Interventional Results available

Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial

NCT05378113
View directory record Official record
Conditions
Injection Site Irritation
Interventions
Ondansetron, Lidocaine
Drug
Lead sponsor
Emory University
Other
Eligibility
2 Years to 17 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Apr 24, 2026 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia

NCT03820388
View directory record Official record
Conditions
Surgery
Interventions
Propofol 2mg/kg, Etomidate 0.3 mg/kg, Propofol 1 mg/kg, Etomidate 0.15 mg/kg
Drug
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Feb 23, 2021 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 4 Interventional Results available

Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department

NCT02404610
View directory record Official record
Conditions
Pain
Interventions
Moderate Procedural Sedation with a sedative medication., Deep Procedural Sedation with a sedative medication., propofol
Procedure · Drug
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 30, 2021 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Bispectral Index and Levels of Sedation With Propofol With/Without Remifentanil in Healthy Volunteers (SONORA)

NCT04466384
View directory record Official record
Conditions
Anesthesia
Interventions
BIS
Device
Lead sponsor
Medtronic - MITG
Industry
Eligibility
18 Years to 60 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 19, 2022 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 2Phase 3 Interventional

Neural and Antidepressant Effects of Propofol

NCT03684447
View directory record Official record
Conditions
Treatment Resistant Depression
Interventions
Propofol
Drug
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Sep 9, 2026 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Not applicable Interventional Results available

A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters

NCT01065350
View directory record Official record
Conditions
Blood Pressure
Interventions
Propofol, Ketamine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 60 Years
Enrollment
85 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated May 3, 2013 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs

NCT02624050
View directory record Official record
Conditions
Hypotension, Anesthesia
Interventions
Methohexital, Propofol
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years and older
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 28, 2025 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 3 Interventional Results available

Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)

NCT05312385
View directory record Official record
Conditions
Sedation
Interventions
Isoflurane, Propofol, Isoflurane (run-ins)
Drug
Lead sponsor
Sedana Medical
Industry
Eligibility
18 Years and older
Enrollment
277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
14
States / cities
Aurora, Colorado • Atlanta, Georgia • Chicago, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Oct 30, 2026, 10:36 AM EDT
Completed No phase listed Observational

Propofol Sedation Study

NCT00597740
View directory record Official record
Conditions
Anesthesia
Interventions
Not listed
Lead sponsor
Scottsdale Healthcare
Other
Eligibility
18 Years to 80 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Scottsdale, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 3, 2013 · Synced Oct 30, 2026, 10:36 AM EDT
Withdrawn Phase 1Phase 2 Interventional Accepts healthy volunteers

EEG Study of IV Methylphenidate-Induced Emergence From Propofol Sedation

NCT03610282
View directory record Official record
Conditions
Anesthesia
Interventions
IV Methylphenidate, Propofol
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 21, 2020 · Synced Oct 30, 2026, 10:36 AM EDT
Completed Phase 1 Interventional Results available

Susceptibility of Motor-Evoked Potentials to Varying Targeted Blood Levels of Dexmedetomidine

NCT00671931
View directory record Official record
Conditions
Scoliosis
Interventions
low dexmedetomidine, low propofol, high dexmedetomidine, low propofol, Dexmedetomidine, Dexmedetomidin
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 25 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 23, 2013 · Synced Oct 30, 2026, 10:36 AM EDT