- Conditions
- Prosthetic Joint Infection
- Interventions
- vancomycin hydrochloride and tobramycin sulfate
- Combination Product
- Lead sponsor
- Osteal Therapeutics, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2020
- U.S. locations
- 4
- States / cities
- Saginaw, Michigan • Charlotte, North Carolina • Oklahoma City, Oklahoma + 1 more
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Showing 25–48
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- Conditions
- Prosthetic-joint Infection
- Interventions
- Semi-quantitative electrochemical leukocyte esterse test strip, Roche Chemstrip
- Diagnostic Test
- Lead sponsor
- Center for Innovation and Research Organization
- Network
- Eligibility
- 18 Years and older
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 8
- States / cities
- Denver, Colorado • Weston, Florida • Louisville, Kentucky + 5 more
- Conditions
- Prosthetic-joint Infection, Arthroplasty Complications
- Interventions
- Treatment of Chronic TKA PJI
- Procedure
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 18 Years and older
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2026 – 2029
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
- Conditions
- Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA, Chronic Kidney Diseases, Diabetes, Autoimmune Diseases, Inflammatory Disease, Tobacco Use
- Interventions
- Cephalexin, Doxycycline, Cefadroxil
- Drug
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years to 99 Years
- Enrollment
- 4,618 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2026
- U.S. locations
- 2
- States / cities
- Iowa City, Iowa • Rochester, Minnesota
- Conditions
- Prosthetic Joint Infection of the Knee
- Interventions
- Static Antibiotic Spacer Surgical Implant, Articulating Antibiotic Spacer Surgical Implant
- Device
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 4 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2017
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota
- Conditions
- Prosthetic-joint Infection
- Interventions
- VT-X7 Treatment System, Two-stage exchange arthroplasty, SOC Antibiotics, Experimental Antibiotics
- Combination Product · Procedure · Drug
- Lead sponsor
- Osteal Therapeutics, Inc.
- Industry
- Eligibility
- 22 Years to 84 Years
- Enrollment
- 76 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2024
- U.S. locations
- 19
- States / cities
- Phoenix, Arizona • Los Angeles, California • Sarasota, Florida + 15 more
- Conditions
- Prosthetic-joint Infection
- Interventions
- PLG0206, Placebo
- Drug
- Lead sponsor
- Peptilogics
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 240 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 9
- States / cities
- Sarasota, Florida • Tamarac, Florida • Baltimore, Maryland + 6 more
- Conditions
- Prosthetic Joint Infection
- Interventions
- No intervention: sample collection study
- Other
- Lead sponsor
- Rothman Institute Orthopaedics
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 120 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2017 – 2018
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Joint Arthroplasty, Shoulder, Cutibacterium Acnes, Prosthetic Joint Infection
- Interventions
- Prontosan Wound Gel
- Device
- Lead sponsor
- St. Louis University
- Other
- Eligibility
- 18 Years and older · Male only
- Enrollment
- 60 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026
- U.S. locations
- 1
- States / cities
- St Louis, Missouri
- Conditions
- Joint Infection
- Interventions
- Intraoperative Intraosseous Vancomycin
- Drug
- Lead sponsor
- OrthoCarolina Research Institute, Inc.
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 100 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2020 – 2027
- U.S. locations
- 10
- States / cities
- San Francisco, California • Gainesville, Florida • Weston, Florida + 5 more
- Conditions
- Osteoarthritis, Hip Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation, Complications; Arthroplasty
- Interventions
- Implantation of a static, non-articulating cement spacer., Implantation of an articulating spacer.
- Procedure
- Lead sponsor
- Rush University Medical Center
- Other
- Eligibility
- 18 Years to 100 Years
- Enrollment
- 80 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2020
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated, Tibial Component Revision
- Interventions
- Constrained Condylar bearing, posterior stabilized bearing
- Device
- Lead sponsor
- Rush University Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 170 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2038
- U.S. locations
- 1
- States / cities
- Chicago, Illinois
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Infected Spacers
- Interventions
- CEM-102, IV or Oral standard of care antibiotics, Rifampin
- Drug
- Lead sponsor
- Arrevus Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2014
- U.S. locations
- 13
- States / cities
- Sarasota, Florida • Tamarac, Florida • Savannah, Georgia + 8 more
- Conditions
- Prosthetic Joint Infection
- Interventions
- TNP-2092
- Drug
- Lead sponsor
- TenNor Therapeutics Limited
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 13 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2022
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Prosthetic Joint Infections
- Interventions
- [124I]FIAU
- Radiation
- Lead sponsor
- BioMed Valley Discoveries, Inc
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 23 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2012 – 2013
- U.S. locations
- 10
- States / cities
- Mobile, Alabama • Tucson, Arizona • Little Rock, Arkansas + 7 more
- Conditions
- Prosthetic Joint Infection
- Interventions
- leukocyte esterase electrochemical assay
- Diagnostic Test
- Lead sponsor
- Rothman Institute Orthopaedics
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 230 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2020 – 2021
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Staphylococcal Infection, Staphylococcus Aureus Prosthetic Joint Infection
- Interventions
- Not listed
- Lead sponsor
- Mayo Clinic
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2007
- U.S. locations
- 1
- States / cities
- Rochester, Minnesota
- Conditions
- Prosthetic Joint Infection
- Interventions
- TRL1068, a human monoclonal antibody
- Drug
- Lead sponsor
- Trellis Bioscience LLC
- Industry
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2024
- U.S. locations
- 9
- States / cities
- Birmingham, Alabama • Los Angeles, California • Santa Monica, California + 6 more
- Conditions
- Prosthetic-joint Infection
- Interventions
- Culturelle Digestive Daily Probiotic Capsule
- Dietary Supplement
- Lead sponsor
- NYU Langone Health
- Other
- Eligibility
- 18 Years to 90 Years
- Enrollment
- 152 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2027
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Prosthetic Joint Infection
- Interventions
- Bacteriophage, Placebo
- Drug
- Lead sponsor
- Adaptive Phage Therapeutics, Inc.
- Industry
- Eligibility
- 18 Years and older
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2027
- U.S. locations
- 10
- States / cities
- San Diego, California • Hartford, Connecticut • Idaho Falls, Idaho + 5 more
- Conditions
- Prosthetic Joint Infection, Surgical Skin Infection
- Interventions
- Integuseal
- Device
- Lead sponsor
- Rothman Institute Orthopaedics
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 160 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2008 – 2009
- U.S. locations
- 1
- States / cities
- Philadelphia, Pennsylvania
- Conditions
- Surgical Site Infection
- Interventions
- Not listed
- Lead sponsor
- University of Nebraska
- Other
- Eligibility
- 19 Years and older
- Enrollment
- 234 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012 – 2015
- U.S. locations
- 1
- States / cities
- Omaha, Nebraska
- Conditions
- Prosthesis Related Infections
- Interventions
- [124I]FIAU
- Radiation
- Lead sponsor
- BioMed Valley Discoveries, Inc
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 12 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2010 – 2013
- U.S. locations
- 3
- States / cities
- Little Rock, Arkansas • Baltimore, Maryland • Lake Success, New York
- Conditions
- Bone Infection, Osteomyelitis, Septic Arthritis, Joint Infection, Prosthetic Joint Infection
- Interventions
- Dalbavancin, Vancomycin
- Drug
- Lead sponsor
- Infectious Diseases Physicians, Inc.
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 41 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2018 – 2022
- U.S. locations
- 1
- States / cities
- Annandale, Virginia