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ClinicalTrials.gov public records Last synced Oct 20, 2026, 6:01 AM EDT

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Showing 145–168 of 184 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Psychological Distress Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

COVID-19 and the Healthy Minds Program for Educators

NCT04426318
View directory record Official record
Conditions
Anxiety, Depression, Psychological Stress, Psychological Distress, Well-being
Interventions
Healthy Minds Program Foundations Training
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
698 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Results available

Mobile Coping Skills Training to Improve Cardiorespiratory Failure Survivors' Psychological Distress

NCT04329702
View directory record Official record
Conditions
Cardiorespiratory Failure
Interventions
Coping skills training mobile app with call from CST therapist, Coping skills training mobile app only
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 3, 2023 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional

Utilizing Novel Information Technology to Promote Exercise and Well-Being in Adolescents and Young Adults With Cancer

NCT03778658
View directory record Official record
Conditions
Adolescent, Young Adult, Cancer, Physical Activity, Psychological Distress, Social Isolation
Interventions
Physical Activity Intervention
Behavioral
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
15 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2024 · Synced Oct 20, 2026, 6:01 AM EDT
Recruiting Not applicable Interventional

Flourish in Schools Pilot Study

NCT07506525
View directory record Official record
Conditions
Psychological Distress, Suicidal Ideation
Interventions
Flourish
Device
Lead sponsor
Candice Biernesser
Other
Eligibility
11 Years to 21 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Bay Village, Ohio • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking

NCT03488927
View directory record Official record
Conditions
Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression, Alcohol Abuse, Drinking, College, Alcohol Drinking, Alcohol; Harmful Use, Social Stigma, Social Norms, Social Responsibility, Social Behavior, Empathy, Coping Skills, Coping Behavior
Interventions
Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
Behavioral
Lead sponsor
University of New Hampshire
Other
Eligibility
18 Years to 24 Years
Enrollment
1,268 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
Durham, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 20, 2026, 6:01 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Project VALOR: Veteran Stress and Wellbeing

NCT06095817
View directory record Official record
Conditions
Alcohol Use Disorder, Depression
Interventions
Internet Delivered Brief Intervention (IDBI)
Behavioral
Lead sponsor
Cornell University
Other
Eligibility
18 Years to 62 Years
Enrollment
140 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Results available

The Care After Life-threatening Medical Events Study

NCT04589559
View directory record Official record
Conditions
Cardiac Arrest, Fear
Interventions
Heart Rate Variability Biofeedback Training
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Aug 19, 2022 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional

Guided Eight-week Online Acceptance and Commitment Therapy for Distressed Family Caregivers of People With Dementia

NCT04847986
View directory record Official record
Conditions
Psychological Distress
Interventions
acceptance and commitment therapy (ACT), Control group
Behavioral
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 28, 2022 · Synced Oct 20, 2026, 6:01 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

General Psychological Distress, PTSD, and Co-Morbidities in Healthcare Workers Consequent to Occupational Trauma

NCT04626050
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Moral Injury
Interventions
Medical Music, Narrative Writing, Prolonged Exposure Therapy, Interpersonal Psychotherapy
Behavioral
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 20, 2026, 6:01 AM EDT
Not listed Phase 3 Interventional Accepts healthy volunteers

Stress Free UC Merced: The Effect of 8 Weeks of Mindfulness App Headspace on Stress in a Sample of University Employees

NCT03652168
View directory record Official record
Conditions
Stress, Psychological Distress
Interventions
Meditation
Behavioral
Lead sponsor
University of California, Merced
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Merced, California
Source: ClinicalTrials.gov public record
Updated Aug 29, 2018 · Synced Oct 20, 2026, 6:01 AM EDT
Not listed Not applicable Interventional

Peer Intervention to Improve Access Among Rural Women Veterans With Psychological Distress and Unmet Social Needs

NCT05477706
View directory record Official record
Conditions
Psychological Distress, Depression, PTSD, Anxiety
Interventions
Personalized Support for Progress (PSP), Tailored Referral (TR)
Other
Lead sponsor
Syracuse VA Medical Center
Federal
Eligibility
18 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
2
States / cities
Syracuse, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 28, 2022 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Thriving Together: Supporting Resilience in the Healthcare Workforce

NCT05321381
View directory record Official record
Conditions
Emotional Distress, Burn Out, Anxiety
Interventions
Resilience In Stressful Events (RISE) peer support team
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
1,362 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
2
States / cities
Baltimore, Maryland • Chestertown, Maryland
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Results available

Lift Mobile Mindfulness for COVID-19 Distress Symptoms

NCT04581200
View directory record Official record
Conditions
COVID-19, Cardiorespiratory Failure
Interventions
Lift
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
4
States / cities
Aurora, Colorado • Ann Arbor, Michigan • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 7, 2023 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

SoCal Savvy: Testing Savvy Caregiver in a Racially and Ethnically Diverse Sample in Southern California

NCT04421729
View directory record Official record
Conditions
Caregiver Burnout, Psychological Distress
Interventions
Group sessions over 3 weeks, Group sessions over 6 weeks
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
121 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2024 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional

Reducing Distress and Depressive-symptoms in Rural Women

NCT03465813
View directory record Official record
Conditions
Breast Cancer, Psychological Adjustment
Interventions
CaringGuidance After Breast Cancer Diagnosis
Behavioral
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years to 85 Years · Female only
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 25, 2023 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional

A Randomized Controlled Trial of an Online Support Group for Sexual Distress Due to Gynecologic Cancer

NCT01654458
View directory record Official record
Conditions
Sexual Dysfunctions, Psychological, Uterine Cervical Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Genital Neoplasms, Female
Interventions
GyneGals Support Group
Behavioral
Lead sponsor
Women's College Hospital
Other
Eligibility
18 Years and older · Female only
Enrollment
398 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Conscious Pregnancy: Supporting Maternal Cardiometabolic Health With Mindfulness

NCT06898658
View directory record Official record
Conditions
Maternal Cardiometabolic Health, Molecular Impact of Psychological Stress and Socioeconomic Adversity, Maternal Inflammatory Markers, Maternal Diabetes, Maternal Behavior, Maternal Distress
Interventions
Mindfulness Intervention
Behavioral
Lead sponsor
University of California, Irvine
Other
Eligibility
18 Years and older · Female only
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Santa Ana, California
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Caregiver Self-Management of Stress

NCT04337021
View directory record Official record
Conditions
Caregiver Distress, Job Stress
Interventions
Caregiver SOS
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
199 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2024
U.S. locations
2
States / cities
Buffalo, New York • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 18, 2025 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Results available

Improving Psychological Distress Among Critical Illness Survivors and Their Caregivers

NCT01983254
View directory record Official record
Conditions
Intensive Care Unit Survivors, Informal Caregivers (Family and Friends)
Interventions
coping skills training, education program
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 21, 2020 · Synced Oct 20, 2026, 6:01 AM EDT
Recruiting Phase 2 Interventional

Duloxetine in Inflammatory Bowel Diseases

NCT07431606
View directory record Official record
Conditions
Inflammatory Bowel Diseases
Interventions
Duloxetine
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
24 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Phase 1 Interventional Results available

Healthy Minds Program App Dosage

NCT05229406
View directory record Official record
Conditions
Depression, Anxiety, Psychological Distress
Interventions
HMP app
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
92 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Aug 1, 2023 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Enhancing Occupational Therapy Graduate Student Well-Being

NCT07846085
View directory record Official record
Conditions
Occupational Therapy Students
Interventions
Mindful Self Care Survey (MSCS), Placebo
Behavioral · Other
Lead sponsor
Lauren Newhouse
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Carson, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2026 · Synced Oct 20, 2026, 6:01 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Progesterone in Gender Affirming Hormone Therapy Study

NCT06807580
View directory record Official record
Conditions
Transgender Women
Interventions
Placebo, Progesterone
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 20, 2026, 6:01 AM EDT
Completed Not applicable Interventional Results available

Mobile Mindfulness to Improve Psychological Distress After Critical Illness

NCT02701361
View directory record Official record
Conditions
Psychological Distress, Depression, Anxiety, Post-traumatic Stress Disorder, Informal Caregivers, Family Members
Interventions
mobile mindfulness, standard mindfulness, education
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Oct 20, 2026, 6:01 AM EDT