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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Public Speaking Anxiety Clear all
Recruiting Not applicable Interventional

Reward Processing and Exposure Therapy for Social Anxiety Disorder

NCT06776991
View directory record Official record
Conditions
Social Anxiety Disorder (Social Phobia), Public Speaking Anxiety, Anhedonia, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Phobic Disorders
Interventions
Positive Affect Treatment - Behavioral (PAT-B), Relaxation Treatment, Exposure Therapy
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 60 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Effects of Low-Level Laser Stimulation With and Without Fear Extinction Training

NCT02926352
View directory record Official record
Conditions
Phobias, Claustrophobia, Social Phobia
Interventions
Extinction Training, Low-Level Laser Therapy, Sham Low-Level Laser Therapy
Behavioral · Device
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
112 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Acute Anxiolytic Effects of Riluzole on Subjects With Social Anxiety Disorder

NCT03017508
View directory record Official record
Conditions
Social Anxiety Disorder, Performance Anxiety
Interventions
BHV-0223, Placebo
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
22 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Jun 10, 2026, 3:10 PM EDT
Recruiting Phase 2 Interventional

A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder

NCT06809179
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
Fasedienol Nasal Spray - Placebo Nasal Spray, Fasedienol Nasal Spray - Fasedienol Nasal Spray, Placebo Nasal Spray - Placebo Nasal Spray
Drug
Lead sponsor
VistaGen Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
9
States / cities
Sherman Oaks, California • Walnut Creek, California • Largo, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Not applicable Interventional

Treatment of Social Phobia

NCT00000370
View directory record Official record
Conditions
Phobic Disorders, Social Phobia, Public Speaking Anxiety
Interventions
Cognitive behavior therapy, Performance-based exposure therapy, Psychosocial intervention
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
1998 – 2003
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 17, 2018 · Synced Jun 10, 2026, 3:10 PM EDT
Terminated Phase 4 Interventional Results available

Brief Intervention to Reduce Fear of Public Speaking

NCT02790736
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
propranolol, Placebo
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2023 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality Intervention for Speech Anxiety

NCT06086756
View directory record Official record
Conditions
Public Speaking, Speech Anxiety
Interventions
Exposure intervention plus positive mood induction, Exposure intervention plus negative mood induction
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2023 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Not applicable Interventional Results available

Reward Processes and Rehearsal in Exposure Therapy

NCT06132425
View directory record Official record
Conditions
Anxiety Disorders, Public Speaking Fear
Interventions
Exposure, Rehearsal
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
88 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 12, 2025 · Synced Jun 10, 2026, 3:10 PM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Medication Enhanced Rapid Therapy

NCT02099825
View directory record Official record
Conditions
Anxiety Disorders
Interventions
d-cycloserine and mifepristone
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 55 Years · Male only
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Apr 25, 2023 · Synced Jun 10, 2026, 3:10 PM EDT
Active, not recruiting Phase 3 Interventional

Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-4)

NCT06615557
View directory record Official record
Conditions
Social Anxiety Disorder (SAD)
Interventions
Fasedienol Nasal Spray, Placebo Nasal Spray
Drug
Lead sponsor
VistaGen Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
26
States / cities
Phoenix, Arizona • Little Rock, Arkansas • Bellflower, California + 21 more
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Phase 3 Interventional Results available

PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge

NCT04754802
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
PH94B Nasal Spray, Placebo Nasal Spray
Drug
Lead sponsor
VistaGen Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
224 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
21
States / cities
Los Angeles, California • Orange, California • Riverside, California + 18 more
Source: ClinicalTrials.gov public record
Updated Sep 11, 2025 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Phase 4 Interventional

The Use of Quetiapine (Seroquel) in the Treatment of Social Phobia: Public Speaking Environment

NCT00407199
View directory record Official record
Conditions
Social Phobia
Interventions
quetiapine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 25 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 26, 2011 · Synced Jun 10, 2026, 3:10 PM EDT
Completed No phase listed Observational

Predictors of Exposure Success in Public Speaking Anxiety

NCT02163148
View directory record Official record
Conditions
Performance Anxiety
Interventions
Massed speech exposure session
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jun 10, 2026, 3:10 PM EDT
Recruiting Phase 3 Interventional

Study to Evaluate the Efficacy and Safety of VQW-765 for the On-Demand Treatment of Social Anxiety Disorder

NCT07221578
View directory record Official record
Conditions
Social Anxiety Disorder (SAD)
Interventions
VQW-765, Placebo
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
18 Years to 65 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
30
States / cities
Phoenix, Arizona • Scottsdale, Arizona • Encino, California + 26 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exposure With Acceptance-Based Versus Habituation-Based Rationale for Public Speaking Anxiety

NCT00842946
View directory record Official record
Conditions
Public Speaking, Social Fear
Interventions
Exposure w/ Acceptance-Based Rationale, Exposure w/ Habituation-Based Rationale
Behavioral
Lead sponsor
Drexel University
Other
Eligibility
18 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2014 · Synced Jun 10, 2026, 3:10 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Multisite Virtual Reality Intervention for Speech Anxiety

NCT06593847
View directory record Official record
Conditions
Public Speaking, Speech Anxiety
Interventions
Single-session VR exposure intervention
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 70 Years
Enrollment
1,542 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
6
States / cities
Tucson, Arizona • Carbondale, Illinois • Boston, Massachusetts + 2 more
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Jun 10, 2026, 3:10 PM EDT
Terminated Phase 3 Interventional Results available

PH94B Nasal Spray for Anxiety Induced by a Public Speaking Challenge - 2

NCT05011396
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
PH94B Nasal Spray, Placebo Nasal Spray
Drug
Lead sponsor
VistaGen Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
15
States / cities
Phoenix, Arizona • Garden Grove, California • Oceanside, California + 12 more
Source: ClinicalTrials.gov public record
Updated Nov 23, 2025 · Synced Jun 10, 2026, 3:10 PM EDT
Recruiting Not applicable Interventional

Group Exposure Workshops for Socially Anxious Undergraduates

NCT06673407
View directory record Official record
Conditions
Social Anxiety Disorder, Public Speaking Fear, Public Speaking Anxiety, Social Fear
Interventions
Group Exposure for Social Anxiety, Self-Compassion Enhanced Group Exposure Therapy for Social Anxiety, Peer-Enhanced Group Exposure Therapy for Social Anxiety, Peer and Self-Compassion Enhanced Group Exposure Therapy for Social Anxiety
Behavioral
Lead sponsor
University of Colorado, Boulder
Other
Eligibility
18 Years to 30 Years
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated May 19, 2025 · Synced Jun 10, 2026, 3:10 PM EDT
Active, not recruiting Phase 3 Interventional

Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder (PALISADE-3)

NCT06358651
View directory record Official record
Conditions
Social Anxiety Disorder
Interventions
Fasedienol Nasal Spray, Placebo Nasal Spray
Drug
Lead sponsor
VistaGen Therapeutics, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
238 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
24
States / cities
Phoenix, Arizona • Fayetteville, Arkansas • Little Rock, Arkansas + 21 more
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Jun 10, 2026, 3:10 PM EDT