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Showing 1–24 of 33 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pulmonary Nodule, Solitary Clear all
Recruiting No phase listed Observational

Biomarkers for Risk Stratification in Lung Cancer

NCT03774758
View directory record Official record
Conditions
Nodule Solitary Pulmonary, Non-small Cell Lung Cancer
Interventions
Guardant Health ct-DNA LUNAR assay
Diagnostic Test
Lead sponsor
University of California, San Francisco
Other
Eligibility
40 Years and older
Enrollment
590 participants
Timeline
2017 – 2030
U.S. locations
3
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Retrospective Clinical Trial Comparing Radiologists' Diagnosis Accuracy in Lung Cancer Screening Population With and Without the Help of an AI/ML Tech-based SaMD

NCT06751576
View directory record Official record
Conditions
High Risk Cancer, Lung Cancer
Interventions
Median LCS
Device
Lead sponsor
Median Technologies
Industry
Eligibility
50 Years to 80 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
3
States / cities
Philadelphia, Pennsylvania • Memphis, Tennessee • Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 5, 2025 · Synced Jul 22, 2026, 6:00 AM EDT
Not listed No phase listed Observational

LungLB in Subjects Presenting With Indeterminate Pulmonary Nodules

NCT05171491
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
LungLife AI
Industry
Eligibility
40 Years and older
Enrollment
425 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
12
States / cities
Los Angeles, California • Bay Pines, Florida • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jun 12, 2024 · Synced Jul 22, 2026, 6:00 AM EDT
Recruiting No phase listed Observational

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

NCT06426628
View directory record Official record
Conditions
Pulmonary Nodule, Solitary, Lung Cancer
Interventions
Not listed
Lead sponsor
Veracyte, Inc.
Industry
Eligibility
29 Years to 85 Years
Enrollment
2,400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
22
States / cities
Hartford, Connecticut • Stamford, Connecticut • Bay Pines, Florida + 19 more
Source: ClinicalTrials.gov public record
Updated Nov 12, 2024 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Phase 2 Interventional Results available

18F-FSPG PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules

NCT02448225
View directory record Official record
Conditions
Lung Carcinoma, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
Interventions
Computed Tomography, fluorodeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392, Laboratory Biomarker Analysis, Positron Emission Tomography, Positron Emission Tomography (PET)
Procedure · Radiation · Drug + 1 more
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
40 Years to 80 Years
Enrollment
46 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
2
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 18, 2022 · Synced Jul 22, 2026, 6:00 AM EDT
Terminated No phase listed Observational

Liquid Biopsy With PET/CT Versus PET/CT Alone in Diagnosis of Small Lung Nodules

NCT05066776
View directory record Official record
Conditions
Lung Cancer, Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 7, 2023 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study

NCT03634241
View directory record Official record
Conditions
Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8, Stage IA1 Lung Cancer AJCC v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8, Stage IB Lung Cancer AJCC v8, Stage II Lung Cancer AJCC v8, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8
Interventions
Pembrolizumab, Quality-of-Life Assessment, Computed Tomography, Biospecimen Collection
Biological · Other · Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
2
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Early Phase 1 Interventional

Near Infrared Fluorescence Imaging With Indocyanine Green

NCT02851368
View directory record Official record
Conditions
Solitary Pulmonary Nodules
Interventions
near infrared fluorescence imaging (NIFI), Indocyanine Green
Device · Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Nov 20, 2017 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Not applicable Interventional

The Watch the Spot Trial

NCT02623712
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Coin Lesion, Pulmonary, Lung Neoplasms, Carcinoma, Non-small-cell Lung
Interventions
More Frequent Surveillance Strategy, Less Frequent Surveillance Strategy
Other
Lead sponsor
Kaiser Permanente
Other
Eligibility
35 Years and older
Enrollment
34,686 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2024
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2025 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational

Non-Invasive Biomarkers For Early Detection Of Lung Cancers

NCT01580332
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
Douglas W. Johnson MD, FACR
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 22, 2014 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational

Cios Mobile 3D Spin for Robotic Bronchoscopy

NCT04740047
View directory record Official record
Conditions
Pulmonary Nodule, Solitary, Pulmonary Cancer, Lung Cancer, Lung Cancer, Nonsmall Cell, Lung Adenocarcinoma
Interventions
Ion Endoluminal System
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 26, 2024 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

GE Healthcare VolumeRAD Lung Nodule Detection Study

NCT00963651
View directory record Official record
Conditions
Pulmonary Nodule, Solitary, Multiple Pulmonary Nodules
Interventions
Chest tomosynthesis and X-ray
Device
Lead sponsor
American College of Radiology - Image Metrix
Industry
Eligibility
18 Years and older
Enrollment
187 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
3
States / cities
Ann Arbor, Michigan • Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jul 23, 2013 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational

A Registry to Evaluate the Performance of the BDX-XL2 Test

NCT03766958
View directory record Official record
Conditions
Nodule Solitary Pulmonary, NSCLC
Interventions
Not listed
Lead sponsor
Biodesix, Inc.
Industry
Eligibility
40 Years and older
Enrollment
842 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
15
States / cities
Sun City, Arizona • Northridge, California • Pueblo, Colorado + 12 more
Source: ClinicalTrials.gov public record
Updated May 23, 2024 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational

Percutaneous Localization: Open-label Registry of Thoracic Surgery

NCT04066699
View directory record Official record
Conditions
Lung Lesion(s) Requiring Evaluation, Pulmonary Metastasis, Pulmonary Nodule, Solitary, Peripheral Lung Lesions
Interventions
Percutaneous localization of suspicious lung lesion(s) using electromagnetic navigation and tools.
Procedure
Lead sponsor
Veran Medical Technologies
Industry
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
5
States / cities
Lone Tree, Colorado • Bangor, Maine • Poughkeepsie, New York + 2 more
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Jul 22, 2026, 6:00 AM EDT
Active, not recruiting Not applicable Interventional

Robotic Versus Electromagnetic Bronchoscopy for Pulmonary LesIon AssessmeNT Using Integrated Intraprocedural Imaging

NCT06654271
View directory record Official record
Conditions
Peripheral Pulmonary Lesion, Lung Nodule, Solitary
Interventions
Robotic assisted bronchoscopy (RAB), Electromagnetic navigation bronchoscopy (ENB)
Device
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
440 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
4
States / cities
Chicago, Illinois • Baltimore, Maryland • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational

Evaluate the Utility of the ProLung Test as Adjunctive to CT Scan in the Diagnosis of Lung Cancer

NCT01958931
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
Fresh Medical Laboratories
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 8, 2013 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational

Prospective Post-market Data Collection for Ion Endoluminal System to Understand CT to Body Divergence

NCT04735341
View directory record Official record
Conditions
Lung Cancer, Pulmonary Nodule, Solitary
Interventions
Ion Endoluminal System
Device
Lead sponsor
Intuitive Surgical
Industry
Eligibility
18 Years and older
Enrollment
30 participants
Timeline
2020 – 2022
U.S. locations
1
States / cities
Pinehurst, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 8, 2022 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Not applicable Interventional Results available

Clinical Evaluation of Primary Sampling Scatter Correction for Chest Tomosynthesis

NCT04076696
View directory record Official record
Conditions
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Interventions
Scatter corrected s-DCT
Device
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2022 · Synced Jul 22, 2026, 6:00 AM EDT
Completed No phase listed Observational Results available

A Multi-Center Trial of the ProLung Test™

NCT01566682
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
Fresh Medical Laboratories
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Stanford, California + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Phase 3 Interventional Results available

ELUCIDATE: Enabling Lung Cancer Identification Using Folate Receptor Targeting

NCT04241315
View directory record Official record
Conditions
Lung Neoplasms, Lung Cancer
Interventions
OTL38 for Injection, Near infrared camera imaging system
Drug · Device
Lead sponsor
On Target Laboratories, LLC
Industry
Eligibility
18 Years and older
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
12
States / cities
Stamford, Connecticut • Iowa City, Iowa • Boston, Massachusetts + 8 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Jul 22, 2026, 6:00 AM EDT
Terminated No phase listed Observational

Utility of CAML as Diagnostic for Early Stage Lung Cancer

NCT03992183
View directory record Official record
Conditions
Pulmonary Nodule, Multiple, Pulmonary Nodule, Solitary
Interventions
Not listed
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Jul 22, 2026, 6:00 AM EDT
Terminated Not applicable Interventional

Cryobiopsy Versus Forceps Biopsy for Pulmonary Lesions

NCT02983903
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
transbronchial biopsy
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Jul 22, 2026, 6:00 AM EDT
Completed Phase 1 Interventional

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors

NCT00413322
View directory record Official record
Conditions
Tumor
Interventions
belinostat, 5-Fluorouracil (5-FU)
Drug
Lead sponsor
Valerio Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
3
States / cities
Scottsdale, Arizona • Omaha, Nebraska • Portsmouth, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 7, 2015 · Synced Jul 22, 2026, 6:00 AM EDT
Recruiting Not applicable Interventional

Assessment of a Radiomics-based Computer-Aided Diagnosis Tool for Pulmonary nodulES

NCT05968898
View directory record Official record
Conditions
Lung Cancer, Pulmonary Nodule, Solitary
Interventions
Optellum Virtual Nodule Clinic
Device
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
35 Years to 89 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2030
U.S. locations
3
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Jul 22, 2026, 6:00 AM EDT