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ClinicalTrials.gov public records Last synced Sep 30, 2026, 8:13 PM EDT

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Showing 25–48 of 107 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Pulmonary Nodule Clear all
Not listed No phase listed Observational

nCLE For Diagnosis Of Peripheral Lung Nodules By Robotic Navigational Bronchoscopy

NCT04441749
View directory record Official record
Conditions
Diagnosis of Peripheral Lung Nodules
Interventions
Images acquired by needle-based Confocal Laser Endomicroscopy (nCLE)
Device
Lead sponsor
Fox Chase Cancer Center
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 8, 2023 · Synced Sep 30, 2026, 8:13 PM EDT
Active, not recruiting No phase listed Observational

Nodify XL2 Classifier Clinical Utility Study in Low to Moderate Risk Lung Nodules

NCT04171492
View directory record Official record
Conditions
Nodule Solitary Pulmonary, Non-small Cell Carcinoma
Interventions
Not listed
Lead sponsor
Biodesix, Inc.
Industry
Eligibility
40 Years and older
Enrollment
2,000 participants
Timeline
2020 – 2026
U.S. locations
23
States / cities
Aurora, Colorado • Boston, Connecticut • Washington D.C., District of Columbia + 17 more
Source: ClinicalTrials.gov public record
Updated Sep 19, 2025 · Synced Sep 30, 2026, 8:13 PM EDT
Completed No phase listed Observational

Thin and Ultrathin Bronchoscopy With Transbronchial Needle Aspiration and Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions

NCT04331587
View directory record Official record
Conditions
Peripheral Pulmonary Nodules
Interventions
BF-P190 4 mm thin bronchoscope, BF-MP190F 3 mm ultrathin bronchoscope, Radial ultrasound probe (UM S20-17S), PeriView FLEX 21G Single Use Aspiration Needle
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 19, 2024 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Not applicable Interventional

CBCT in Guiding Bronchoscopy in Patients With Lung Lesions

NCT02978170
View directory record Official record
Conditions
Pulmonary Mass
Interventions
Cone-Beam Computed Tomography
Procedure
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 4, 2019 · Synced Sep 30, 2026, 8:13 PM EDT
Recruiting Not applicable Interventional

Avecure Flexible Microwave Ablation Probe For Lung Nodules

NCT05281237
View directory record Official record
Conditions
Stage I - II Primary Lung Cancer, Stage I Lung Cancer, Stage II Lung Cancer, Lung Cancer Stage I, Lung Cancer Stage II, Lung Cancer
Interventions
AveCure 16 Gauge Flexible Microwave Ablation Probe
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
22 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Not applicable Interventional Results available

Pilot Study of Navigational Bronchoscopy and Transthoracic Needle Biopsy

NCT02109458
View directory record Official record
Conditions
Peripheral Pulmonary Nodules
Interventions
Navigation guided bronchoscopy
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 99 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Sep 30, 2026, 8:13 PM EDT
Completed No phase listed Observational Results available

A Multi-Center Trial of the ProLung Test™

NCT01566682
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
Fresh Medical Laboratories
Industry
Eligibility
18 Years and older
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2019
U.S. locations
15
States / cities
Los Angeles, California • San Diego, California • Stanford, California + 12 more
Source: ClinicalTrials.gov public record
Updated Sep 4, 2019 · Synced Sep 30, 2026, 8:13 PM EDT
Not yet recruiting Not applicable Interventional

Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions

NCT07411989
View directory record Official record
Conditions
Peripheral Pulmonary Lesions (PPLs), Lung Nodules
Interventions
Bronchoscopy for peripheral pulmonary lesion biopsy
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
346 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Chicago, Illinois • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Not applicable Interventional Results available

Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules

NCT02075320
View directory record Official record
Conditions
Signs and Symptoms
Interventions
Stationary Digital Chest Tomosynthesis
Device
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Phase 1 Interventional

Pilot and Feasibility Study of the Imaging Potential of EC17: Intraoperative Folate-fluorescein Conjugate (EC17) Lung Cancer (CA)

NCT01778920
View directory record Official record
Conditions
Lung and Pleural Malignancies, Neoplasms, Nodules, Adenocarcinoma
Interventions
EC17 imaging contrast agent
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Phase 1 Interventional

Amino Acid Tracer (FACBC) Positron Emission Tomography for Lung Nodule

NCT01502670
View directory record Official record
Conditions
Lung Cancer
Interventions
18F-FACBC Radiotracer
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Nov 19, 2013 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Not applicable Interventional

Confocal Laser Endomicroscopy Nodule Localization by Robotic Bronchoscopy

NCT05231278
View directory record Official record
Conditions
Lung Neoplasms
Interventions
nCLE aided RANB biospy
Device
Lead sponsor
Johnson & Johnson Enterprise Innovation Inc.
Industry
Eligibility
22 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
4
States / cities
Concord, California • Altoona, Pennsylvania • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 13, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The SEQUENCE Trial

NCT06676956
View directory record Official record
Conditions
Pulmonary Nodules
Interventions
Linear EBUS first, Robotic-assisted bronchoscopy first
Diagnostic Test
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older
Enrollment
320 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
5
States / cities
Sacramento, California • Chicago, Illinois • Baltimore, Maryland + 2 more
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Active, not recruiting Not applicable Interventional

Teachable Moment to Opt-out of Tobacco: Interactive Voice Response Quit Line for Veteran Active Smokers With Lung Nodules

NCT04574518
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Tobacco Use
Interventions
TeaM OUT Intervention, Enhanced Usual Care
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
223 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Minneapolis, Minnesota • Portland, Oregon • Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 4, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Not yet recruiting No phase listed Observational

Multiparametric Lung MRI With Diffusion-Weighted Imaging in Lung-RADS 4 Lesion Characterization

NCT07768046
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Lung Neoplasms, Lung Cancer Screening
Interventions
Multiparametric chest MRI with diffusion-weighted imaging
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
50 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2032
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 19, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Completed No phase listed Observational

Diagnostic Study for Lung Cancer Detection Test

NCT01700452
View directory record Official record
Conditions
Lung Cancer
Interventions
Not listed
Lead sponsor
Bioview, Inc.
Industry
Eligibility
18 Years and older
Enrollment
173 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
3
States / cities
Los Angeles, California • Frederick, Maryland • Bethlehem, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 19, 2016 · Synced Sep 30, 2026, 8:13 PM EDT
Completed No phase listed Observational

3-D Reconstruction of CT Scan Images in the Evaluation of Non-Specific Pulmonary Nodules

NCT00613041
View directory record Official record
Conditions
Undiagnosed Pulmonary Nodules, Lung Nodules
Interventions
CT Scan
Procedure
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Sep 30, 2026, 8:13 PM EDT
Active, not recruiting No phase listed Observational

A Multicenter, Retrospective, Chart Review Study Evaluating the Impact and Utility of the Blood-Based Proteomic Integrated Classifier and Auto-Antibody Tests in the Real-World

NCT06728319
View directory record Official record
Conditions
Lung Nodules
Interventions
Not listed
Lead sponsor
Biodesix, Inc.
Industry
Eligibility
40 Years and older
Enrollment
4,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
5
States / cities
Brandon, Florida • Fort Walton Beach, Florida • Somerset, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2025 · Synced Sep 30, 2026, 8:13 PM EDT
Active, not recruiting No phase listed Observational

A Combined Biomarker Model for Risk Stratification of Indeterminate Pulmonary Nodules

NCT06074133
View directory record Official record
Conditions
Pulmonary Nodule
Interventions
Blood collection, Chest Computed Tomography
Procedure
Lead sponsor
Vanderbilt-Ingram Cancer Center
Other
Eligibility
21 Years and older
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
4
States / cities
Aurora, Colorado • Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 4, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Completed Phase 1 Interventional

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors

NCT00413322
View directory record Official record
Conditions
Tumor
Interventions
belinostat, 5-Fluorouracil (5-FU)
Drug
Lead sponsor
Valerio Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
3
States / cities
Scottsdale, Arizona • Omaha, Nebraska • Portsmouth, New Hampshire
Source: ClinicalTrials.gov public record
Updated Jul 8, 2015 · Synced Sep 30, 2026, 8:13 PM EDT
Active, not recruiting No phase listed Observational

Using e-Nose Technology to Identify Early Lung Cancer

NCT04734145
View directory record Official record
Conditions
Lung; Node, Lung Cancer
Interventions
Breathprinting test
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
21 Years to 85 Years
Enrollment
119 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Completed No phase listed Observational

Cios Mobile 3D Spin for Robotic Bronchoscopy

NCT04740047
View directory record Official record
Conditions
Pulmonary Nodule, Solitary, Pulmonary Cancer, Lung Cancer, Lung Cancer, Nonsmall Cell, Lung Adenocarcinoma
Interventions
Ion Endoluminal System
Diagnostic Test
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 27, 2024 · Synced Sep 30, 2026, 8:13 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

CBCT-Guided Navigational Bronchoscopy For Lung Nodules

NCT04758403
View directory record Official record
Conditions
Peripheral Pulmonary Nodules, Lung; Node, Cone Beam Computed Tomography, Guided Navigation Bronchoscopy
Interventions
Navigation Bronchoscopy, Cone beam computed tomography (CBCT)
Radiation
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 22, 2026 · Synced Sep 30, 2026, 8:13 PM EDT
Completed No phase listed Observational

Evaluate the Utility of the ProLung Test as Adjunctive to CT Scan in the Diagnosis of Lung Cancer

NCT01958931
View directory record Official record
Conditions
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
Interventions
Not listed
Lead sponsor
Fresh Medical Laboratories
Industry
Eligibility
18 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 9, 2013 · Synced Sep 30, 2026, 8:13 PM EDT