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Showing 1–24 of 60 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pulmonary Vein Ablation Clear all
Recruiting Not applicable Interventional

Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

NCT06099730
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulsed Field Ablation (PFA)
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
442 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
6
States / cities
Jonesboro, Arkansas • Boston, Massachusetts • New York, New York + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 7, 2026 · Synced Jul 24, 2026, 7:10 PM EDT
Not listed Not applicable Interventional

Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation

NCT01672138
View directory record Official record
Conditions
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Interventions
Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years to 80 Years
Enrollment
186 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Nov 15, 2018 · Synced Jul 24, 2026, 7:10 PM EDT
Not listed Not applicable Interventional

Ibutilide Administration During Pulmonary Vein Ablation

NCT00589992
View directory record Official record
Conditions
Atrial Fibrillation, Pulmonary Vein Ablation
Interventions
Ibutilide fumarate
Drug
Lead sponsor
Ball Memorial Hospital
Other
Eligibility
18 Years to 80 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2016
U.S. locations
1
States / cities
Muncie, Indiana
Source: ClinicalTrials.gov public record
Updated Jan 30, 2012 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Not applicable Interventional

Pulmonary Vein Isolation in Athletes

NCT03226847
View directory record Official record
Conditions
Athletes, Atrial Fibrillation, Catheter Ablation
Interventions
Pulmonary Vein Isolation
Procedure
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 12, 2021 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Not applicable Interventional Results available

Assessing Arrhythmias After Ablation Using Implantable Recorders

NCT01176617
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Reveal XT implantable loop recorder
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 4, 2018 · Synced Jul 24, 2026, 7:10 PM EDT
Recruiting Not applicable Interventional

Low Voltage-Directed Catheter Ablation for Atrial Fibrillation

NCT03355456
View directory record Official record
Conditions
Atrial Fibrillation - Symptomatic
Interventions
Radiofrequency ablation
Procedure
Lead sponsor
Ohad Ziv
Other
Eligibility
18 Years to 85 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 9, 2024 · Synced Jul 24, 2026, 7:10 PM EDT
Withdrawn No phase listed Observational

Catheter Ablation for Atrial Fibrillation and Heart Failure

NCT01082601
View directory record Official record
Conditions
Congestive Heart Failure, Atrial Fibrillation, Arrhythmia
Interventions
Pulmonary Vein Isolation (PVI)
Procedure
Lead sponsor
St. Luke's-Roosevelt Hospital Center
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
2
States / cities
Ridgewood, New Jersey • New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 16, 2012 · Synced Jul 24, 2026, 7:10 PM EDT
Recruiting Not applicable Interventional

A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

NCT07187115
View directory record Official record
Conditions
Atrial Fibrillation (AF), Persistant Atrial Fibrillation
Interventions
FARAPOINT Pulsed Field Ablation System, OptiMap System (non-ablative), FARAPULSE Pulsed Field Ablation (PFA) System and Opal HDx Mapping System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
699 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2030
U.S. locations
33
States / cities
Birmingham, Alabama • Gilbert, Arizona • Phoenix, Arizona + 27 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 24, 2026, 7:10 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Pulmonary Vein Isolation To Reduce Future Risk Of Atrial Fibrillation In Patients Undergoing Typical Flutter

NCT01710150
View directory record Official record
Conditions
Typical Atrial Flutter, Risk Factors With Future Development of Atrial Flutter
Interventions
CTI ablation alone, CTI ablation and Pulmonary vein isolation (PVI)
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Jul 24, 2026, 7:10 PM EDT
Terminated Not applicable Interventional

Posterior Wall Substrate Modification Using Irreversible Electroporation for Paroxysmal Atrial Fibrillation

NCT06364215
View directory record Official record
Conditions
Atrial Fibrillation Paroxysmal
Interventions
Farapulse PFA, Pulmonary Vein Isolation alone, Farapulse PFA, Pulmonary Vein Isolation and Left atrial Posterior Wall Isolation
Device
Lead sponsor
Jorge Romero
Other
Eligibility
21 Years to 90 Years
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
18
States / cities
Birmingham, Alabama • Washington D.C., District of Columbia • Jacksonville, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated May 14, 2026 · Synced Jul 24, 2026, 7:10 PM EDT
Active, not recruiting Not applicable Interventional

RESOLVE-AF: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy.

NCT05883631
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Fibrillation, Persistent, Atrial Fibrillation Paroxysmal, Arrhythmia, Arrhythmias, Cardiac, Atrial Flutter, Atrial Fibrillation, Paroxysmal or Persistent, Atrial Arrhythmia, Atrial Tachycardia
Interventions
Electrographic Flow (EGF) mapping and ablation of EGF-identified sources of Atrial Fibrillation, Electrographic Flow (EGF) mapping (no ablation)
Device
Lead sponsor
Cortex
Industry
Eligibility
18 Years to 80 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
15
States / cities
Birmingham, Alabama • Phoenix, Arizona • Redwood City, California + 11 more
Source: ClinicalTrials.gov public record
Updated Apr 12, 2025 · Synced Jul 24, 2026, 7:10 PM EDT
Withdrawn Not applicable Interventional

Comparison of Hybrid Ablation and Pulmonary Vein Isolation Alone vs Hybrid Ablation With PVI Plus Catheter Ablation

NCT02344394
View directory record Official record
Conditions
Persistent Atrial Fibrillation
Interventions
Medtronic Cryoballoon, Thermocool Catheter, nContact
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Jul 24, 2026, 7:10 PM EDT
Enrolling by invitation Not applicable Interventional

Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation

NCT06988202
View directory record Official record
Conditions
Atrial Fibrillation (AF)
Interventions
Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI), Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Mar 22, 2026 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Not applicable Interventional Results available

Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial

NCT00578617
View directory record Official record
Conditions
Atrial Fibrillation, Arrhythmia
Interventions
Rate Control, Ablation Therapy, Rhythm control
Drug · Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
10
States / cities
Birminham, Alabama • Los Angeles, California • Maywood, Illinois + 7 more
Source: ClinicalTrials.gov public record
Updated Jan 3, 2013 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Phase 4 Interventional Results available

Uninterrupted Dabigatran Etexilate in Comparison to Uninterrupted Warfarin in Pulmonary Vein Ablation (RE-CIRCUIT)

NCT02348723
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Warfarin, Dabigatran Etexilate 150mg
Drug
Lead sponsor
Boehringer Ingelheim
Industry
Eligibility
18 Years and older
Enrollment
678 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
21
States / cities
Little Rock, Arkansas • Fremont, California • Sacramento, California + 17 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2018 · Synced Jul 24, 2026, 7:10 PM EDT
Not listed Not applicable Interventional

Substrate Versus Trigger Ablation for Paroxysmal Atrial Fibrillation

NCT02169037
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
FIRM Ablation, Conventional AF ablation with PVI
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
21 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
2
States / cities
Palo Alto, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Not applicable Interventional

Efficacy of Different Ablation Strategies for Controlling Atrial Fibrillation

NCT00379301
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Radiofrequency ablation
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
166 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 13, 2012 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Not applicable Interventional

Outcome of Atrial Fibrillation Ablation After Permanent Pulmonary Vein Antrum Isolation With or Without Proven Left Atrial Posterior Wall Isolation

NCT01660100
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Pulmonary vein antrum isolation (PVAI), PVAI plus left atrial posterior wall (LAPW) isolation
Procedure
Lead sponsor
Texas Cardiac Arrhythmia Research Foundation
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 18, 2017 · Synced Jul 24, 2026, 7:10 PM EDT
Completed No phase listed Observational

Studying Heart Ablation After Left Atrial Closure in High-Bleeding-Risk Atrial Fibrillation Patients

NCT07580937
View directory record Official record
Conditions
Atrial Fibrillation, Atrial Arrhythmia
Interventions
Data collection
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
198 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
10
States / cities
Chicago, Illinois • Evanston, Illinois • Boston, Massachusetts + 4 more
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 24, 2026, 7:10 PM EDT
Active, not recruiting No phase listed Observational

ADVENT Post Approval Study

NCT06431815
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
FARAPULSE™ Pulsed Field Ablation System
Device
Lead sponsor
Boston Scientific Corporation
Industry
Eligibility
18 Years and older
Enrollment
228 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2029
U.S. locations
25
States / cities
Mobile, Alabama • Scottsdale, Arizona • Oakland, California + 20 more
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Jul 24, 2026, 7:10 PM EDT
Completed Not applicable Interventional Results available

TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation

NCT01278953
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation
Interventions
Catheter ablation to treat paroxysmal atrial fibrillation
Device
Lead sponsor
Abbott Medical Devices
Industry
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 20, 2019 · Synced Jul 24, 2026, 7:10 PM EDT
Completed No phase listed Observational

Safety Monitoring of Patients Having Pulmonary Vein Ablation

NCT00590668
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
Transesophageal Echocardiography
Diagnostic Test
Lead sponsor
The Cleveland Clinic
Other
Eligibility
18 Years and older
Enrollment
42 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2013
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 2, 2017 · Synced Jul 24, 2026, 7:10 PM EDT
Terminated Not applicable Interventional

Comparison of PVI Plus Catheter Ablation or PVI Alone for the Treatment of AFib for Patients With Paroxysmal Atrial Fibrillation

NCT03115554
View directory record Official record
Conditions
Atrial Fibrillation
Interventions
PVI Plus Catheter Ablation, PVI Alone
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 2, 2024 · Synced Jul 24, 2026, 7:10 PM EDT
Withdrawn No phase listed Observational

PVI Using Cryoablation Alone in Paroxysmal AF Patients Converted From Persistent AF With Dofetilide

NCT01877486
View directory record Official record
Conditions
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Interventions
Ablation
Procedure
Lead sponsor
University of Rochester
Other
Eligibility
18 Years to 80 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Ridgewood, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 3, 2016 · Synced Jul 24, 2026, 7:10 PM EDT