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Showing 1–19 of 19 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Pulpitis Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Clinical Comparison of Vital Pulp Capping Restorative Protocols

NCT02635867
View directory record Official record
Conditions
Deep Dental Caries
Interventions
Indirect Pulp capping-Resin-modified calcium silicate - TheraCal, Indirect Pulp capping-Calcium hydroxide - Dycal, Indirect Pulp capping-Resin-based dentin bonding agent, Direct Pulp capping-Resin-modified calcium silicate - TheraCal, Direct Pulp capping-Calcium hydroxide - Dycal
Procedure
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 64 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2019
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 11, 2023 · Synced Jul 22, 2026, 2:38 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Combination of Buffered Anesthetic to Treat Mandibular Molars

NCT06047366
View directory record Official record
Conditions
Symptomatic Irreversible Pulpitis
Interventions
Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi, Mepivacaine plain
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 12, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment

NCT05338671
View directory record Official record
Conditions
Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
Interventions
Local anesthetic
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
35 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Phase 2 Interventional

Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment

NCT06655454
View directory record Official record
Conditions
Pain Assessment, Quality of Life (QOL), Analgesic Use
Interventions
Supplemental Postoperative Bupivacaine, Placebo Injection
Drug
Lead sponsor
New York University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

A Clinical Trial Comparing FS With ZOE and Non-eugenol Based Materials in Primary Teeth Pulpotomies

NCT05557812
View directory record Official record
Conditions
Pulpitis
Interventions
non-eugenol based ZOE base material with Ferric Sulfate in primary molar pulpotomies, eugenol based zinc oxide and Ferric Sulfate
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
3 Years to 7 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 25, 2025 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Results available

Effect of Buffered Numbing Solution on Patients With Toothaches

NCT01868776
View directory record Official record
Conditions
Irreversible Pulpitis (Toothache)
Interventions
buffered lidocaine, nonbuffered lidocaine
Drug
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 5, 2020 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator

NCT04552132
View directory record Official record
Conditions
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Interventions
Multisonic vs Sonic activation of irrigants
Device
Lead sponsor
St. Louis University
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jun 14, 2023 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Pain Measured by NRS and EEG in Acute Pulpitis

NCT06526572
View directory record Official record
Conditions
Acute Pulpitis
Interventions
Brain wave analysis using electroencephalography (EEG)., Numerical rate Scale (NRS)
Diagnostic Test
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 30, 2024 · Synced Jul 22, 2026, 2:38 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Comparative Effectiveness in the Management of Irreversible Pulpitis

NCT04922229
View directory record Official record
Conditions
Irreversible Pulpitis
Interventions
RCT, Pulpotomy
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
12 Years to 99 Years
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2031
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jul 22, 2026, 2:38 PM EDT
Withdrawn Not applicable Interventional

Endodontic-Restorative Pre-Radiation Therapy of Head and Neck Cancer Patients

NCT04996641
View directory record Official record
Conditions
Pulpitis - Irreversible, Caries, Head and Neck Cancer
Interventions
Root canal treatment and crown
Procedure
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 26, 2023 · Synced Jul 22, 2026, 2:38 PM EDT
Not listed Phase 4 Interventional Accepts healthy volunteers

Success and Color Stability of MTA Pulpotomized Primary Molars: an RCT

NCT02702505
View directory record Official record
Conditions
Reversible Pulpitis, Dental Pulp Diseases
Interventions
NeoMTA, ProRoot MTA
Biological · Other
Lead sponsor
Texas A & M University Baylor College Of Dentistry
Other
Eligibility
2 Years to 8 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Jul 22, 2026, 2:38 PM EDT
Terminated Not applicable Interventional

Electrical and Formocresol Pulpotomy in Primary Molars

NCT01622153
View directory record Official record
Conditions
Reversible Pulpitis, Caries
Interventions
Formocresol application after pulpotomy preparation, GENTLEray 980 Soft Tissue diode laser
Procedure
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
3 Years to 8 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated May 9, 2017 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars

NCT01496846
View directory record Official record
Conditions
Irreversible Pulpitis
Interventions
IANB Articaine, SUP Articaine, SUP Lidocaine
Drug
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 30, 2017 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis

NCT05227300
View directory record Official record
Conditions
Symptomatic Irreversible Pulpitis
Interventions
Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution, 2% lidocaine with 1:100,000 epinephrine
Drug
Lead sponsor
Indiana University
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated May 13, 2024 · Synced Jul 22, 2026, 2:38 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Evaluation of Methylprednisolone or Ibuprofen on Efficacy of Nerve Blocks With Symptomatic Irreversible Pulpitis

NCT04157036
View directory record Official record
Conditions
Irreversible Pulpitis
Interventions
Ibuprofen, Methylprednisolone
Drug
Lead sponsor
Walter Reed National Military Medical Center
Federal
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 28, 2022 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Occurrence of Post-op Pain Following Gentlewave

NCT03635515
View directory record Official record
Conditions
Root Canal Infection, Endodontic Disease, Endodontic Inflammation, Post-Operative Pain
Interventions
Gentlewave, Standard Endodontic Protocol
Device · Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 14, 2023 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Postoperative Pain After Activation of Irrigant

NCT06528574
View directory record Official record
Conditions
Pain
Interventions
Conventional root canal treatment, Ultrasonic, Apical negative pressure, Combined Ultrasonic and negative pressure
Device
Lead sponsor
Cleveland Dental Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2024 · Synced Jul 22, 2026, 2:38 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Intentional Pulpotomy to Preserve Hopeless Molars

NCT04385693
View directory record Official record
Conditions
Pulpitis, Dental Pulp Diseases, Tooth Diseases
Interventions
Pulpotomy, Extraction and placement of space maintainer
Procedure
Lead sponsor
University of Florida
Other
Eligibility
5 Years to 10 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jun 5, 2023 · Synced Jul 22, 2026, 2:38 PM EDT
Recruiting No phase listed Observational

Bite Force Measurements

NCT06843525
View directory record Official record
Conditions
Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
Interventions
Not listed
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 89 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 23, 2025 · Synced Jul 22, 2026, 2:38 PM EDT