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Showing 1–24 of 138 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Quadraplegia Clear all
Completed Not applicable Interventional

Conditioning Neural Circuits to Improve Upper Extremity Function

NCT02611375
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia
Interventions
transcranial direct current stimulation, peripheral nerve somatosensory stimulation, sham transcranial direct current stimulation
Other
Lead sponsor
Shepherd Center, Atlanta GA
Other
Eligibility
18 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jul 28, 2020 · Synced Jul 22, 2026, 5:13 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional

Spinal Cord Neuromodulation for Spinal Cord Injury

NCT02313194
View directory record Official record
Conditions
Cervical Spinal Cord Injury, Tetraparesis, Tetraplegia
Interventions
Epidural Stimulation, Buspirone
Device · Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Withdrawn Not applicable Interventional

Brain-Computer Interface Implant for Severe Communication Disability

NCT04576650
View directory record Official record
Conditions
Locked-in Syndrome
Interventions
Summit System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
22 Years to 75 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 6, 2022 · Synced Jul 22, 2026, 5:13 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Self-balancing Personal Exoskeleton for SCI

NCT06777576
View directory record Official record
Conditions
Spinal Cord Injuries (SCI), Paraplegia and Tetraplegia
Interventions
Hands-free exoskeleton
Device
Lead sponsor
Wandercraft
Industry
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Results available

Exercise to Reduce Obesity in Spinal Cord Injury

NCT00270855
View directory record Official record
Conditions
Diabetes Mellitus, Obesity, Paraplegia, Quadriplegia, Spinal Cord Injury
Interventions
Arm Crank Ergometry, FES Cycle Ergometer
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years
Enrollment
29 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Nov 16, 2017 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effect of Heat Exposure on Cognition in Persons With Tetraplegia

NCT02488824
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Warm Temperature
Procedure
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 68 Years
Enrollment
41 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Nov 17, 2019 · Synced Jul 22, 2026, 5:13 PM EDT
Terminated Not applicable Interventional Results available

Microelectrode Brain-Machine Interface for Individuals With Tetraplegia

NCT01364480
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injury
Interventions
Implantation of NeuroPort Arrays in the motor cortex
Device
Lead sponsor
Michael Boninger
Other
Eligibility
18 Years to 70 Years
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2022
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 8, 2024 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional

Testing the Decision Aid: Supporting Patient Decisions About Upper Extremity Surgery in Cervical SCI

NCT04995796
View directory record Official record
Conditions
Cervical Spinal Cord Injury, Tetraplegia
Interventions
Surveys for Research Purposes
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 80 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Aug 23, 2022 · Synced Jul 22, 2026, 5:13 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

NCT05157282
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
TESS, Training, Motor Task, sham-TESS
Device · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 70 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
2
States / cities
Chicago, Illinois • Hines, Illinois
Source: ClinicalTrials.gov public record
Updated Jan 15, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury

NCT01537978
View directory record Official record
Conditions
Paraplegia and Tetraplegia
Interventions
Video gaming for enhanced function after spinal cord injury.
Other
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Body Temperature in Persons With Tetraplegia When Exposed to Cold

NCT01822535
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Midodrine hydrochloride
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 68 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 3, 2016 · Synced Jul 22, 2026, 5:13 PM EDT
Recruiting Not applicable Interventional

Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia

NCT05423600
View directory record Official record
Conditions
Tetraplegia/Tetraparesis
Interventions
BES + TS, Experimental: BES+sham TS
Procedure
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 70 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
3
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional

Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury

NCT05432999
View directory record Official record
Conditions
Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia, Spastic Tetraplegia, Paraplegia, Tetraplegia
Interventions
Extracorporeal Shockwave Therapy
Device
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years and older
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 24, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit

NCT04468919
View directory record Official record
Conditions
Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism, Multiple System Atrophy, Brain Tumor Adult, Spinal Cord Injuries, Locked-in Syndrome
Interventions
BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying, BCI-FIT language modeling
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 89 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated May 15, 2025 · Synced Jul 22, 2026, 5:13 PM EDT
Recruiting Not applicable Interventional

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

NCT07521930
View directory record Official record
Conditions
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke, Spinal Cord Injuries (SCI), Muscular Dystrophies, Muscular Atrophy, Progressive, Pontine Hemorrhage, Pontine Infarction
Interventions
INTENT Neural Interface System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia

NCT02379156
View directory record Official record
Conditions
Tetraplegia, Hypothermia, Mild Cognitive Impairment
Interventions
Midodrine Hydrochloride, Cool Temperature
Drug · Other
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 68 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2022
U.S. locations
1
States / cities
The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Mar 20, 2025 · Synced Jul 22, 2026, 5:13 PM EDT
Recruiting Not applicable Interventional

Cortical Recording and Stimulating Array Brain-Machine Interface

NCT01894802
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury, Above Elbow Amputation
Interventions
Implantation of CRS Arrays
Device
Lead sponsor
Michael Boninger
Other
Eligibility
22 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2029
U.S. locations
2
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Recruiting Not applicable Interventional

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

NCT06094205
View directory record Official record
Conditions
Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome, Muscular Dystrophies
Interventions
BrainGate Neural Interface System
Device
Lead sponsor
Leigh R. Hochberg, MD, PhD.
Other
Eligibility
18 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Nov 30, 2025 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional Results available

High Definition Neuromuscular Stimulation in Tetraplegia

NCT04075812
View directory record Official record
Conditions
Spinal Cord Injury at C4-C6 Level
Interventions
Neuromuscular Stimulator
Device
Lead sponsor
Ohio State University
Other
Eligibility
21 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 8, 2021 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional

Enhancing Corticospinal Excitability to Improve Functional Recovery

NCT03237091
View directory record Official record
Conditions
Spinal Cord Injuries, Tetraplegia
Interventions
bihemispheric transcranial pulsed current stimulation (tPCS), unihemispheric transcranial pulsed current stimulation (tPCS), bihemispheric transcranial direct current stimulation (tDCS), unihemispheric transcranial direct current stimulation (tDCS), sham-control
Other
Lead sponsor
Shepherd Center, Atlanta GA
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 7, 2019 · Synced Jul 22, 2026, 5:13 PM EDT
Active, not recruiting Not applicable Interventional Results available

Implanted Myoelectric Control for Restoration of Hand Function in Spinal Cord Injury

NCT00583804
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia
Interventions
IST-12
Device
Lead sponsor
MetroHealth Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1989 – 2027
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Jul 22, 2026, 5:13 PM EDT
Enrolling by invitation Not applicable Interventional

mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness

NCT06426602
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
mindBEAGLE daily device use
Device
Lead sponsor
Amy Wagner
Other
Eligibility
16 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 3, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Active, not recruiting No phase listed Observational

Nerve Transfer After Spinal Cord Injury- Multi-center

NCT04023591
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
Interventions
Surgery/Occupational Therapy
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
7
States / cities
Stanford, California • Miami, Florida • Ann Arbor, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 22, 2026, 5:13 PM EDT
Completed Not applicable Interventional

Effects of Exercise in People With Tetraplegia

NCT01202019
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia
Interventions
Circuit Resistance Training (CRT)
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 55 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2014 · Synced Jul 22, 2026, 5:13 PM EDT