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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Quadriceps Clear all
Terminated Not applicable Interventional Results available

Effect of Electromyographic Biofeedback on Quadriceps Neuromuscular Function in Patients With Quadriceps Inhibition

NCT02095223
View directory record Official record
Conditions
Knee Injuries
Interventions
Electromyographic Biofeedback, Traditional Exercise
Device · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 40 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Coral Gables, Florida
Source: ClinicalTrials.gov public record
Updated Jan 31, 2017 · Synced Sep 19, 2026, 9:05 AM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Safety and Efficacy of Aceneuramic Acid Extended-Release (Ace-ER) Tablets in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myopathy (HIBM)

NCT02736188
View directory record Official record
Conditions
Hereditary Inclusion Body Myopathy, Distal Myopathy With Rimmed Vacuoles, Distal Myopathy, Nonaka Type, GNE Myopathy, Quadriceps Sparing Myopathy
Interventions
Aceneuramic Acid Extended-Release Tablets
Drug
Lead sponsor
Ultragenyx Pharmaceutical Inc
Industry
Eligibility
18 Years and older
Enrollment
143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
5
States / cities
Los Angeles, California • Orange, California • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Sep 19, 2026, 9:05 AM EDT
Terminated Not applicable Interventional

Total Knee Arthroplasty Utilizing Adductor Canal Block: Effect on Quadriceps Sparing

NCT02081911
View directory record Official record
Conditions
Osteoarthritis (Knee)
Interventions
High Volume Adductor Canal Block, Low Volume Adductor Canal Block, Femoral Nerve Block
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2016 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Rehabilitation Programs for Patellofemoral Pain Syndrome

NCT00445224
View directory record Official record
Conditions
Patellofemoral Pain Syndrome
Interventions
Hip Progressive Resistive Exercise, Quad Progressive Resistive Exercises
Other
Lead sponsor
Timothy Uhl
Other
Eligibility
15 Years to 35 Years · Female only
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 27, 2017 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional Results available

Functional Resistance Training to Improve Knee Function After ACL Reconstruction

NCT03282565
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Functional Resistance Training with Brace, Control, Functional Resistance Training with Elastic Band
Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Assessment of Efficacy of Low Intensity Resistance Training in Women at Risk for Symptomatic Knee Osteoarthritis

NCT01440972
View directory record Official record
Conditions
Knee Osteoarthritis, Symptomatic Knee Osteoarthritis
Interventions
partial blood flow restriction (PBFR), low intensity resistance training
Other
Lead sponsor
University of Iowa
Other
Eligibility
45 Years to 65 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 4, 2016 · Synced Sep 19, 2026, 9:05 AM EDT
Enrolling by invitation Not applicable Interventional

A Study Of Focused Shockwave For Anterior Knee Pain Following Anterior Cruciate Ligament Reconstruction

NCT07580157
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Focused Shockwave, Sham Focused Shockwave
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 6, 2026 · Synced Sep 19, 2026, 9:05 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy

NCT04234282
View directory record Official record
Conditions
Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity, Knee Pain Swelling, Muscle Weakness, Muscle Weakness Condition, Power
Interventions
Manual Physical Therapy
Procedure
Lead sponsor
Jennifer Moreno Clinic
Other
Eligibility
45 Years to 74 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020
U.S. locations
1
States / cities
Fort Sam Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Sep 19, 2026, 9:05 AM EDT
Completed No phase listed Observational

GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM)

NCT01784679
View directory record Official record
Conditions
Hereditary Inclusion Body Myopathy, GNE Myopathy, Nonaka Disease, Quadriceps Sparing Myopathy (QSM), Distal Myopathy With Rimmed Vacuoles (DMRV)
Interventions
Not listed
Lead sponsor
Ultragenyx Pharmaceutical Inc
Industry
Eligibility
Not listed
Enrollment
319 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Irvine, California
Source: ClinicalTrials.gov public record
Updated Apr 26, 2018 · Synced Sep 19, 2026, 9:05 AM EDT
Recruiting Not applicable Interventional

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

NCT05461326
View directory record Official record
Conditions
Orthopedic Disorder, Anterior Cruciate Ligament Injuries
Interventions
Quad tendon, BTB
Procedure
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
14 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2030
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Sep 19, 2026, 9:05 AM EDT
Not listed No phase listed Observational Accepts healthy volunteers

Straight Leg Raise Continuation

NCT05568784
View directory record Official record
Conditions
Quadriceps Muscle Atrophy, Leg Injury
Interventions
Straight Leg Raise exercise
Other
Lead sponsor
Andrews Research & Education Foundation
Other
Eligibility
18 Years to 55 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Gulf Breeze, Florida
Source: ClinicalTrials.gov public record
Updated Feb 20, 2024 · Synced Sep 19, 2026, 9:05 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Tourniquet Pressure in Primary Total Knee Arthroplasty

NCT02830087
View directory record Official record
Conditions
Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
Interventions
Tourniquet Cuff Pressure
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Bermuda Run, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Neuromuscular Consequences of Knee Arthroscopy

NCT01786772
View directory record Official record
Conditions
Tear of Fibrocartilage of Joint
Interventions
Cryotherapy and compression, Cryotherapy
Other
Lead sponsor
Creighton University
Other
Eligibility
15 Years to 65 Years
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2017
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Sep 19, 2026, 9:05 AM EDT
Recruiting No phase listed Observational

Respiratory, Limb Muscle Properties, and Physical Performance in Adult Lung Transplant Recipients

NCT07747337
View directory record Official record
Conditions
Lung Transplantation, End Stage Lung Disease
Interventions
Respiratory and Limb Muscle Assessment
Diagnostic Test
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 4, 2026 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Effects of Whole Body Vibration on Quadriceps Function, Landing Biomechanics, and Performance in Individuals With ACL Reconstruction

NCT07681193
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, ACL Injury, ACL Tear, Biomechanical Phenomena
Interventions
Whole body vibration (WBV), Sham Whole body vibration
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 35 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 1, 2026 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Electrical Stimulation to Strengthen Muscles in the Lower Legs in Patients Requiring Prolonged Mechanical Ventilation

NCT01825135
View directory record Official record
Conditions
Muscle Weakness
Interventions
Neuromuscular electrical stimulation, sham stimulation
Device
Lead sponsor
RML Specialty Hospital
Other
Eligibility
18 Years and older
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Hinsdale, Illinois
Source: ClinicalTrials.gov public record
Updated May 2, 2017 · Synced Sep 19, 2026, 9:05 AM EDT
Withdrawn Not applicable Interventional

Does Supplementing of Quadriceps Strength With Exoskeleton After Total Knee Arthroplasty in High Risk Population Reduce Transfer to Extended Care Facility (ECF)

NCT03762603
View directory record Official record
Conditions
Primary Knee Replacement Surgery
Interventions
Robotic exoskeleton device
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 99 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 10, 2025 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients

NCT03440593
View directory record Official record
Conditions
Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders, Calorie Deficiency, Diaphragm Injury, Quadriceps Muscle Atrophy
Interventions
Caloric delivery will target results of IC measurement.
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 21, 2020 · Synced Sep 19, 2026, 9:05 AM EDT
Terminated Not applicable Interventional

Treatment of Muscle Weakness in Critically Ill Patients

NCT02247895
View directory record Official record
Conditions
Critical Illness, Respiratory Failure, Myopathy, Weakness
Interventions
Sham Treatment, Electrical stimulation
Device
Lead sponsor
Gerald Supinski
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 21, 2020 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NM Balance Regulation With ULLS and Loss of Sleep

NCT05956964
View directory record Official record
Conditions
Muscle Weakness, Quadriceps Muscle Atrophy, Sleep Disturbance
Interventions
Sleep Restriction, Sleep Adequate
Behavioral
Lead sponsor
Lance Bollinger
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Sep 19, 2026, 9:05 AM EDT
Completed Not applicable Interventional

Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT03209531
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Operant Conditioning, Control, Single Pulse Transcranial Magnetic Stimulation
Behavioral · Device
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2025
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 19, 2026, 9:05 AM EDT
Recruiting Not applicable Interventional

The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial

NCT05754632
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries, Knee Injuries, Quadriceps Muscle Atrophy
Interventions
Blood Flow Restriction using Delfi Personalized Tourniquet System
Device
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
12 Years to 18 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
1
States / cities
Farmington, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 6, 2026 · Synced Sep 19, 2026, 9:05 AM EDT
Not listed No phase listed Observational

Knee Arthroplasty Registry

NCT01132365
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
any knee joint arthroplasty device
Device
Lead sponsor
Heekin Orthopedic Research Institute
Other
Eligibility
21 Years to 93 Years
Enrollment
7,793 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 25, 2016 · Synced Sep 19, 2026, 9:05 AM EDT
Completed No phase listed Observational

Quantifying Quadriceps Atrophy Following Tibial Plateau Fracture

NCT02781623
View directory record Official record
Conditions
Atrophy
Interventions
MRI
Procedure
Lead sponsor
NYU Langone Health
Other
Eligibility
18 Years to 65 Years
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2022
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Nov 15, 2022 · Synced Sep 19, 2026, 9:05 AM EDT