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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Quadriceps Muscle Clear all
Completed Not applicable Interventional

To Determine if a Lower Extremity Strengthening Program Improve Quadriceps Muscle Strength

NCT01080703
View directory record Official record
Conditions
Pulmonary Disease
Interventions
Exercise
Other
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 75 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 3, 2014 · Synced Jul 23, 2026, 3:02 PM EDT
Enrolling by invitation Not applicable Interventional

A Study Of Focused Shockwave For Anterior Knee Pain Following Anterior Cruciate Ligament Reconstruction

NCT07580157
View directory record Official record
Conditions
Anterior Cruciate Ligament Injuries
Interventions
Focused Shockwave, Sham Focused Shockwave
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jul 23, 2026, 3:02 PM EDT
Terminated Not applicable Interventional Results available

Effect of All-Stim 2 Quadriceps Treatments on Limb Muscle Strength In Mechanically Ventilated Patients

NCT02332187
View directory record Official record
Conditions
Weakness
Interventions
Active electrical stimulation using an All Stim stimulator, Sham electrical stimulation using an All Stim stimulator
Device
Lead sponsor
Gerald Supinski
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 1, 2022 · Synced Jul 23, 2026, 3:02 PM EDT
Withdrawn Not applicable Interventional

BFR Therapy After ACL Reconstruction

NCT03794570
View directory record Official record
Conditions
ACL Injury, Quadriceps Muscle Atrophy
Interventions
Blood flow restriction therapy - with Delfi Personalized Tourniquet System, Sham blood flow restriction therapy - with Delfi Personalized Tourniquet System
Device
Lead sponsor
Steadman Philippon Research Institute
Other
Eligibility
14 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Vail, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 3, 2019 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Multi-Ingredient Preworkout Supplement on Peak Torque and Muscle Activation During Fatigue

NCT07217210
View directory record Official record
Conditions
Healthy Adult Male
Interventions
Multi-ingredient preworkout supplement
Dietary Supplement
Lead sponsor
Northern Illinois University
Other
Eligibility
19 Years to 29 Years · Male only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
DeKalb, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional

The Effect of Transcutaneous Electrical Nerve Stimulation on Quadriceps Central Activation and Gait

NCT00976079
View directory record Official record
Conditions
Tibial Femoral Knee Osteoarthritis, Osteoarthritis
Interventions
Transcutaneous electrical nerve stimulation (TENS), Placebo TENS
Device
Lead sponsor
University of Virginia
Other
Eligibility
18 Years to 80 Years
Enrollment
49 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Sep 13, 2009 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Photomedicine Project 14: PBMT for Performance Enhancement in SOF

NCT06380179
View directory record Official record
Conditions
Photobiomodulation Therapy, Photomedicine, Low-Level Laser Therapy, Performance Enhancement, Quadriceps, Special Operations Readiness
Interventions
THOR3 training + Photobiomodulation Therapy (PBMT), THOR3 training + sham PBMT
Device
Lead sponsor
Musculoskeletal Injury Rehabilitation Research for Operational Readiness
Federal
Eligibility
18 Years to 45 Years · Male only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Joint Base Lewis McChord, Washington
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Jul 23, 2026, 3:02 PM EDT
Recruiting Not applicable Interventional

Quadriceps Strengthening ACL Reconstruction

NCT07015541
View directory record Official record
Conditions
ACL Tear
Interventions
NMES and BFR, Standard physical therapy
Other
Lead sponsor
Stanford University
Other
Eligibility
13 Years to 17 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Sunnyvale, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Results available

Functional Resistance Training to Improve Knee Function After ACL Reconstruction

NCT03282565
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Functional Resistance Training with Brace, Control, Functional Resistance Training with Elastic Band
Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 40 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jan 17, 2022 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Phase 1 Interventional

Non-invasive Brain Stimulation to Improve Quadriceps Muscle Function After Anterior Cruciate Ligament Reconstruction

NCT04504344
View directory record Official record
Conditions
Anterior Cruciate Ligament Reconstruction, Quadriceps Muscle Weakness, Transcranial Direct Current Stimulation
Interventions
Anodal transcranial direct current stimulation (tDCS) - Soterix Medical Inc, 1x1 tDCS (conventional)
Device
Lead sponsor
Arcadia University
Other
Eligibility
18 Years to 35 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Glenside, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 8, 2023 · Synced Jul 23, 2026, 3:02 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Tourniquet Pressure in Primary Total Knee Arthroplasty

NCT02830087
View directory record Official record
Conditions
Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
Interventions
Tourniquet Cuff Pressure
Procedure
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 80 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
2
States / cities
Bermuda Run, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 18, 2018 · Synced Jul 23, 2026, 3:02 PM EDT
Recruiting Not applicable Interventional

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

NCT04875052
View directory record Official record
Conditions
Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
Interventions
Experimental: Whole Body Vibration, Experimental: Local Muscle Vibration, Standard ACL Rehabilitation
Device · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
16 Years to 35 Years
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
2
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Effects of β-Hydroxy-β-methylbutyrate Free Acid and High-Intensity Interval Training

NCT01941368
View directory record Official record
Conditions
Exercise
Interventions
Placebo, HMB-FA, High Intensity Interval Training
Dietary Supplement · Procedure
Lead sponsor
Metabolic Technologies Inc.
Industry
Eligibility
18 Years to 35 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Orlando, Florida
Source: ClinicalTrials.gov public record
Updated Mar 16, 2014 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Performance Output With Haptics - Evaluating Athlete Response and Unrealized Potential

NCT06430879
View directory record Official record
Conditions
Muscle Strength, Muscle Weakness
Interventions
VICTORY PATCH, Sham Patch without VTT
Device
Lead sponsor
SuperPatch Limited LLC
Industry
Eligibility
18 Years to 30 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jul 23, 2026, 3:02 PM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

NCT04977804
View directory record Official record
Conditions
Blood Flow Restriction
Interventions
Exercise, Eccentric plus blood-flow restriction
Other
Lead sponsor
Utah State University
Other
Eligibility
18 Years to 30 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Logan, Utah
Source: ClinicalTrials.gov public record
Updated Dec 6, 2023 · Synced Jul 23, 2026, 3:02 PM EDT
Terminated Phase 3 Interventional Results available

Study to Evaluate the Safety and Efficacy of Aceneuramic Acid Extended-Release (Ace-ER) Tablets in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myopathy (HIBM)

NCT02736188
View directory record Official record
Conditions
Hereditary Inclusion Body Myopathy, Distal Myopathy With Rimmed Vacuoles, Distal Myopathy, Nonaka Type, GNE Myopathy, Quadriceps Sparing Myopathy
Interventions
Aceneuramic Acid Extended-Release Tablets
Drug
Lead sponsor
Ultragenyx Pharmaceutical Inc
Industry
Eligibility
18 Years and older
Enrollment
143 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
5
States / cities
Los Angeles, California • Orange, California • St Louis, Missouri + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 23, 2023 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Results available

Novel Intervention to Influence Muscle Plasticity in Veterans

NCT01093014
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Low-force muscle stimulation, High-force muscle stimulation, Sequential low-force and high-force muscle stimulation
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 75 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Mar 9, 2016 · Synced Jul 23, 2026, 3:02 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps

NCT07381920
View directory record Official record
Conditions
Healthy
Interventions
Cryotherapy
Procedure
Lead sponsor
Wake Forest University
Other
Eligibility
18 Years to 35 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 26, 2026 · Synced Jul 23, 2026, 3:02 PM EDT
Recruiting Not applicable Interventional

Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?

NCT03096366
View directory record Official record
Conditions
Quadriceps Atrophy, ACL Reconstruction
Interventions
Blood flow restriction, Physical therapy
Device · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
14 Years to 55 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2022
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2022 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional

Changes in Quadriceps Function Following Local or Distant Interventions in Individuals With Patellofemoral Pain

NCT01434966
View directory record Official record
Conditions
Patellofemoral Pain Syndrome, Chondromalacia Patellae, Anterior Knee Pain Syndrome
Interventions
Lumbopelvic Manipulation, TENS- Spine, TENS- Knee
Other
Lead sponsor
Creighton University
Other
Eligibility
15 Years to 50 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Dec 13, 2015 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

NM Balance Regulation With ULLS and Loss of Sleep

NCT05956964
View directory record Official record
Conditions
Muscle Weakness, Quadriceps Muscle Atrophy, Sleep Disturbance
Interventions
Sleep Restriction, Sleep Adequate
Behavioral
Lead sponsor
Lance Bollinger
Other
Eligibility
18 Years to 50 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Jul 23, 2026, 3:02 PM EDT
Completed Not applicable Interventional Results available

Electrical Stimulation and Eccentric Exercise for Anterior Cruciate Ligament (ACL) Injury

NCT01555567
View directory record Official record
Conditions
Anterior Cruciate Ligament Injury
Interventions
Electrical Stimulation, Eccentric Exercise
Device · Other
Lead sponsor
University of Michigan
Other
Eligibility
14 Years to 35 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 7, 2015 · Synced Jul 23, 2026, 3:02 PM EDT
Terminated Not applicable Interventional

Total Knee Arthroplasty Utilizing Adductor Canal Block: Effect on Quadriceps Sparing

NCT02081911
View directory record Official record
Conditions
Osteoarthritis (Knee)
Interventions
High Volume Adductor Canal Block, Low Volume Adductor Canal Block, Femoral Nerve Block
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 1, 2016 · Synced Jul 23, 2026, 3:02 PM EDT
Withdrawn Not applicable Interventional

BFRT vs Standard PT After Total Knee Arthroplasty

NCT04366336
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Blood Flow Restriction Training, Standard Physical Therapy
Procedure
Lead sponsor
Norton Healthcare
Other
Eligibility
50 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Mar 6, 2022 · Synced Jul 23, 2026, 3:02 PM EDT