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ClinicalTrials.gov public records Last synced Oct 18, 2026, 11:59 PM EDT

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Showing 73–96 of 142 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Quadriplegia/Tetraplegia Clear all
Active, not recruiting No phase listed Observational

Nerve Transfer After Spinal Cord Injury- Multi-center

NCT04023591
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
Interventions
Surgery/Occupational Therapy
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 65 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2030
U.S. locations
7
States / cities
Stanford, California • Miami, Florida • Ann Arbor, Michigan + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2026 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia

NCT00507546
View directory record Official record
Conditions
Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated May 22, 2014 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Biofeedback for Wheelchair Users

NCT02700178
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Biofeedback
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Feb 18, 2020 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis

NCT01393444
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injury, Brachial Plexus Injury, Muscular Dystrophy, ALS, Brainstem Stroke
Interventions
Implantation of ECoG sensors on the brain surface
Device
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years to 70 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 12, 2016 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Dose Escalation Study of AST-OPC1 in Spinal Cord Injury

NCT02302157
View directory record Official record
Conditions
Cervical Spinal Cord Injury, Spine Injury, Spinal Cord Trauma
Interventions
AST-OPC1
Biological
Lead sponsor
Lineage Cell Therapeutics, Inc.
Industry
Eligibility
18 Years to 69 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
9
States / cities
La Jolla, California • Los Angeles, California • San Jose, California + 6 more
Source: ClinicalTrials.gov public record
Updated Jul 14, 2021 · Synced Oct 18, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury

NCT05553457
View directory record Official record
Conditions
Spinal Cord Injuries, Tetraplegia
Interventions
Testing of MyHand-SCI Device
Device
Lead sponsor
Columbia University
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 5, 2026 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

Electrical Activation of The Diaphragm for Ventilatory Assist

NCT00010374
View directory record Official record
Conditions
Spinal Cord Injury, Quadriplegia
Interventions
NeuRx DPS
Device
Lead sponsor
Synapse Biomedical
Industry
Eligibility
18 Years and older
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2000 – 2008
U.S. locations
4
States / cities
Englewood, Colorado • Atlanta, Georgia • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 18, 2020 · Synced Oct 18, 2026, 11:59 PM EDT
Not yet recruiting Not applicable Interventional

iBCI Optimization for Veterans With Paralysis

NCT05470478
View directory record Official record
Conditions
Spinal Cord Injury, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome, Muscular Dystrophy
Interventions
Mobile neural decoding platform (mobile iBCI)
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 80 Years
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jul 27, 2026 · Synced Oct 18, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

NCT07521930
View directory record Official record
Conditions
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke, Spinal Cord Injuries (SCI), Muscular Dystrophies, Muscular Atrophy, Progressive, Pontine Hemorrhage, Pontine Infarction
Interventions
INTENT Neural Interface System
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 80 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Oct 9, 2026 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Upper Extremity Surgery in Spinal Cord Injury

NCT01899664
View directory record Official record
Conditions
Quadriplegia, Spinal Cord Diseases, Spinal Cord Injuries
Interventions
Nerve Transfer Surgery
Procedure
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Nov 3, 2021 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI

NCT04624607
View directory record Official record
Conditions
Spinal Cord Injuries, Paraplegia, Spinal, Tetraplegia/Tetraparesis
Interventions
Transspinal-transcortical paired-associative stimiulation combined with robotic gait training, Transcortical-transspinal paired-associative stimiulation combined with robotic gait training
Device
Lead sponsor
College of Staten Island, the City University of New York
Other
Eligibility
18 Years to 70 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Staten Island, New York
Source: ClinicalTrials.gov public record
Updated Nov 13, 2020 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Phase 2 Interventional

24hr Effects of Tiotropium Bromide in Tetraplegia

NCT02586649
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Tiotropium Bromide, Placebo
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 16, 2020 · Synced Oct 18, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

Cortical Recording and Stimulating Array Brain-Machine Interface

NCT01894802
View directory record Official record
Conditions
Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury, Above Elbow Amputation
Interventions
Implantation of CRS Arrays
Device
Lead sponsor
Michael Boninger
Other
Eligibility
22 Years to 70 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2029
U.S. locations
2
States / cities
Chicago, Illinois • Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 20, 2026 · Synced Oct 18, 2026, 11:59 PM EDT
Withdrawn Not applicable Interventional

Virtual Reality and Spinal Stimulation to Improve Arm Function

NCT05065437
View directory record Official record
Conditions
Tetraplegia
Interventions
Active (Virtual reality and spinal stimulation)
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2022 · Synced Oct 18, 2026, 11:59 PM EDT
Not listed Not applicable Interventional

EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis

NCT06169696
View directory record Official record
Conditions
Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis, Spinal Cord Injuries, Cervical Spinal Cord Injury, Tetraplegic; Paralysis, Quadriplegia/Tetraplegia
Interventions
Intervention/Treatment
Device
Lead sponsor
Synaptrix Labs Inc.
Industry
Eligibility
21 Years to 75 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 18, 2024 · Synced Oct 18, 2026, 11:59 PM EDT
Recruiting Not applicable Interventional

Virtual Peer Coaching in Manual Wheelchair Skills

NCT06295146
View directory record Official record
Conditions
Wheelchair, Paraplegia, Spinal Cord Injury, Tetraplegia/Tetraparesis, Spinal Cord Injuries (SCI)
Interventions
Intervention A: 1-on-1 wheelchair skills training by a peer coach, Intervention B: Training via educational videos
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Random Noise Stimulation to Enhance Cortical Drive & Improve Hand Function

NCT04777149
View directory record Official record
Conditions
Spinal Cord Injuries, Tetraplegia, Cervical Spinal Cord Injury
Interventions
transcranial Random Noise Stimulation (tRNS), transcranial Direct Current Stimulation (tDCS), sham-stimulation
Other
Lead sponsor
Shepherd Center, Atlanta GA
Other
Eligibility
18 Years to 75 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Oct 26, 2022 · Synced Oct 18, 2026, 11:59 PM EDT
Not listed Phase 1 Interventional

Effects of Anticholinergic or Long-Acting Beta 2 Agonist on FeNO and Pulmonary Function in SCI

NCT01355991
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Tiotropium, Salmeterol
Drug
Lead sponsor
James J. Peters Veterans Affairs Medical Center
Federal
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
West Orange, New Jersey • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Oct 23, 2015 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury

NCT01537978
View directory record Official record
Conditions
Paraplegia and Tetraplegia
Interventions
Video gaming for enhanced function after spinal cord injury.
Other
Lead sponsor
VA Palo Alto Health Care System
Federal
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 10, 2014 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)

NCT00385918
View directory record Official record
Conditions
Paraplegia, Quadriplegia, Spinal Cord Injury, Tetraplegia
Interventions
Lokomat Training, Home stretching then Lokomat training
Device · Other
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
18 Years to 80 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2011
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 14, 2014 · Synced Oct 18, 2026, 11:59 PM EDT
Withdrawn No phase listed Observational

Nerve Transfers to Restore Hand Function in Spinal Cord Injury

NCT02861612
View directory record Official record
Conditions
Quadriplegia, Spinal Cord Diseases, Spinal Cord Injuries
Interventions
Nerve Transfer Surgery
Procedure
Lead sponsor
Ottawa Hospital Research Institute
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Mar 21, 2019 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional

Mindfulness Meditation for Subjects With Severe Speech and Physical Impairments

NCT01964664
View directory record Official record
Conditions
Physical Impairments, Cerebral Palsy, Cerebral Ataxia, locked-in Syndrome
Interventions
Mindfulness Meditation Training, Audio Group
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Portland Metropolitan Area, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 13, 2017 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Not applicable Interventional Results available

Hand Function for Tetraplegia

NCT00890916
View directory record Official record
Conditions
Spinal Cord Injury, Tetraplegia
Interventions
FIRSTHAND System
Device
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 18, 2026, 11:59 PM EDT
Completed Phase 2Phase 3 Interventional Results available

Fenofibrate Treatment in SCI

NCT02455336
View directory record Official record
Conditions
Spinal Cord Injury, Dyslipidemia
Interventions
Fenofibrate, No intervention
Drug · Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
21 Years to 69 Years
Enrollment
23 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2018
U.S. locations
2
States / cities
West Orange, New Jersey • The Bronx, New York
Source: ClinicalTrials.gov public record
Updated Jun 26, 2019 · Synced Oct 18, 2026, 11:59 PM EDT