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Showing 1–24 of 57 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Reducing Post Traumatic Stress Clear all
Active, not recruiting Not applicable Interventional

The Feasibility and Examination of the Effects of Floatation-based REST on a Community Sample With PTSD

NCT04368689
View directory record Official record
Conditions
Post-Traumatic Stress Disorders
Interventions
Floatation-based reduced environmental stimulation therapy
Other
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 20, 2026 · Synced Jun 26, 2026, 10:36 PM EDT
Recruiting Phase 2 Interventional

Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms

NCT07316088
View directory record Official record
Conditions
PTSD, Post Traumatic Stress Disorder
Interventions
OTX-601 Digital Therapeutic, OTX-003 Comparator app
Device
Lead sponsor
Oui Therapeutics, Inc.
Industry
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Tallahassee, Florida
Source: ClinicalTrials.gov public record
Updated Jan 4, 2026 · Synced Jun 26, 2026, 10:36 PM EDT
Withdrawn Not applicable Interventional

Warrior CARE: Naturalistic Observation and Harm Reduction

NCT05386862
View directory record Official record
Conditions
Post Traumatic Stress Disorder, Cannabis Use, Suicide
Interventions
Reduce THC Use
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
19 Years to 69 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional

Suicide and Trauma Reduction Initiative Among VEterans

NCT03933059
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Psychotherapy
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2022
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 3, 2025 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional

Risk Reduction for Drug Use and Sexual Revictimization

NCT00998153
View directory record Official record
Conditions
Risk Reduction Through Family Therapy, Usual Care
Interventions
Risk Reduction through Family Therapy
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
12 Years to 17 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2018 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Program for Alleviating and Resolving Trauma and Stress 2

NCT05095428
View directory record Official record
Conditions
Post-traumatic Stress Disorder
Interventions
PARTS Program, NBSR-T Program
Behavioral
Lead sponsor
Cambridge Health Alliance
Other
Eligibility
18 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Somerville, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 2, 2025 · Synced Jun 26, 2026, 10:36 PM EDT
Recruiting Phase 4 Interventional

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

NCT06903819
View directory record Official record
Conditions
Orthopedic Trauma Surgery Patients, Postoperative Pain, Opioid Use, Depression, Post-traumatic Stress Disorder (PTSD)
Interventions
Ketamine, standard general anesthesia
Drug
Lead sponsor
Texas Tech University Health Sciences Center
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
2
States / cities
Lubbock, Texas
Source: ClinicalTrials.gov public record
Updated Mar 23, 2026 · Synced Jun 26, 2026, 10:36 PM EDT
Terminated Not applicable Interventional Results available

Effectiveness of Cognitive Processing Therapy in Pregnant Women With a History of Pregnancy Loss/Complication

NCT01277354
View directory record Official record
Conditions
Post-traumatic Stress Disorder, Stress Disorders, Anxiety, Depression
Interventions
Cognitive Processing Therapy, Waitlist Placebo
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 49 Years · Female only
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jun 26, 2026, 10:36 PM EDT
Not listed Not applicable Interventional

Stress-Reducing Interventions in HIV+ Patients: Pilot

NCT00599599
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic, HIV Infections
Interventions
Prolonged Exposure Therapy
Behavioral
Lead sponsor
Kent State University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
2
States / cities
Akron, Ohio • Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 4, 2009 · Synced Jun 26, 2026, 10:36 PM EDT
Recruiting Not applicable Interventional

Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

NCT06296589
View directory record Official record
Conditions
Stress Disorders, Post-Traumatic
Interventions
Trauma Informed Guilt Reduction Therapy, Prolonged Exposure Therapy
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
3
States / cities
Little Rock, Arkansas • New Orleans, Louisiana • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 21, 2025 · Synced Jun 26, 2026, 10:36 PM EDT
Recruiting Not applicable Interventional

Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

NCT05751473
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Prolonged Exposure for Primary Care (PE-PC), EAP Treatment as Usual (TAU)
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
18 Years and older
Enrollment
410 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
12
States / cities
San Diego, California • Carrollton, Georgia • Ann Arbor, Michigan + 7 more
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Jun 26, 2026, 10:36 PM EDT
Recruiting Not applicable Interventional

Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

NCT06957067
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
CPT Skills, Cognitive Processing Therapy, Present Centered Therapy, Shared Decision Making, Measurement Based Care
Behavioral
Lead sponsor
United States Department of Defense
Federal
Eligibility
18 Years and older
Enrollment
280 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
4
States / cities
Phoenix, Arizona • New Orleans, Louisiana • Charleston, South Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 13, 2025 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effects of Reduced Environmental Stimulation on Anxiety

NCT03051074
View directory record Official record
Conditions
Generalized Anxiety Disorder, Agoraphobia, Panic Disorder, PostTraumatic Stress Disorder, Social Anxiety Disorder, Major Depressive Disorder
Interventions
Floating, Comparison
Behavioral
Lead sponsor
Laureate Institute for Brain Research, Inc.
Other
Eligibility
18 Years to 55 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Tulsa, Oklahoma
Source: ClinicalTrials.gov public record
Updated Oct 5, 2023 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Family Communication and Support in the Pediatric Intensive Care Unit

NCT02144779
View directory record Official record
Conditions
Reducing Post Traumatic Stress
Interventions
Assigned to palliative care team, Usual Care
Behavioral
Lead sponsor
Ross Hays
Other
Eligibility
18 Years to 90 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Nov 19, 2015 · Synced Jun 26, 2026, 10:36 PM EDT
Active, not recruiting Not applicable Interventional

The Group Risk Reduction Intervention Therapy (GRRIT) Project

NCT05401838
View directory record Official record
Conditions
Suicidal Ideation, Suicide, Attempted, Coping Skills, Depression, Anxiety, PTSD
Interventions
Group Brief Cognitive-Behavioral Therapy (G-BCBT), Dialectical Behavior Therapy (DBT) Skills Group
Behavioral
Lead sponsor
University of North Carolina, Charlotte
Other
Eligibility
18 Years to 99 Years
Enrollment
141 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 27, 2026 · Synced Jun 26, 2026, 10:36 PM EDT
Recruiting Phase 2 Interventional

BXCL501 After Stress to Increase Recovery Success

NCT06943404
View directory record Official record
Conditions
Acute Stress Reaction, Acute Stress Disorder, Post-traumatic Stress Disorder
Interventions
BXCL501 (dexmedetomidine HCl), Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 65 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
3
States / cities
Jacksonville, Florida • St Louis, Missouri • Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Phase 2 Interventional

Stress Reduction in Middle Eastern Refugees

NCT01288690
View directory record Official record
Conditions
Post Traumatic Stress Disorder
Interventions
Narrative Exposure Therapy
Behavioral
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
63 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 16, 2013 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional Results available

Using Emotion Regulation to Decrease Aggression in Veterans With PTSD

NCT02724787
View directory record Official record
Conditions
Chronic Post-Traumatic Stress Disorder
Interventions
Manage Emotions to Reduce Aggression (MERA)
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 65 Years · Male only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Sep 16, 2019 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)

NCT01641146
View directory record Official record
Conditions
HIV, Depression, Posttraumatic Stress Disorder
Interventions
Enhanced Sexual Health Intervention for Men (ES-HIM), Health Promotion (HP) Comparison Arm
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Male only
Enrollment
118 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2011
U.S. locations
4
States / cities
Inglewood, California • Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Nov 27, 2016 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional

Integrative Risk Reduction and Treatment for Teen Substance Use Problems and PTSD

NCT01751035
View directory record Official record
Conditions
PTSD, Alcohol Use Disorders, Substance Use Disorders
Interventions
Risk Reduction through Family Therapy, Treatment as Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
13 Years to 18 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 2, 2018 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Phase 4 Interventional

Reducing Cannabis Overuse With Prazosin

NCT04721353
View directory record Official record
Conditions
Cannabis Dependence, Posttraumatic Stress Disorder, Cannabis Use Disorder
Interventions
Prazosin Hydrochloride
Drug
Lead sponsor
VA Puget Sound Health Care System
Federal
Eligibility
18 Years to 80 Years
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 14, 2025 · Synced Jun 26, 2026, 10:36 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Project BrEAtHe: A Culturally Tailored MBSR Intervention for Young Adult Black Men

NCT07009977
View directory record Official record
Conditions
Alcohol Abuse, Substance Abuse, Post Traumatic Stress Disorder
Interventions
self-guided mHealth app only, self-guided mHealth app + 'real-time' feedback
Behavioral
Lead sponsor
UConn Health
Other
Eligibility
18 Years to 29 Years · Male only
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 25, 2026 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional Results available

Reducing Alcohol Use & Post-traumatic Stress Disorder (PTSD) With Cognitive Restructuring & Experiential Acceptance

NCT00760994
View directory record Official record
Conditions
Alcoholism, Stress Disorders, Post-Traumatic
Interventions
Experiential acceptance, Cognitive restructuring, No-intervention control: Nutrition information
Behavioral · Other
Lead sponsor
Seattle Institute for Biomedical and Clinical Research
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 9, 2020 · Synced Jun 26, 2026, 10:36 PM EDT
Completed Not applicable Interventional Results available

Mobile Mindfulness to Improve Psychological Distress After Critical Illness

NCT02701361
View directory record Official record
Conditions
Psychological Distress, Depression, Anxiety, Post-traumatic Stress Disorder, Informal Caregivers, Family Members
Interventions
mobile mindfulness, standard mindfulness, education
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
2
States / cities
Durham, North Carolina • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 6, 2018 · Synced Jun 26, 2026, 10:36 PM EDT