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ClinicalTrials.gov public records Last synced Jun 11, 2026, 2:32 AM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Replacement Clear all
Active, not recruiting No phase listed Observational

JOURNEY II XR Safety and Effectiveness PMCF

NCT03136887
View directory record Official record
Conditions
Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint, Failed Osteotomies, Failed Unicompartmental Replacement
Interventions
JOURNEY II XR Total Knee System
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
22 Years to 75 Years
Enrollment
176 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2029
U.S. locations
14
States / cities
Loma Linda, California • Fort Lauderdale, Florida • Aurora, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Aug 11, 2024 · Synced Jun 11, 2026, 2:32 AM EDT
Recruiting Not applicable Interventional

Cold and Compression Post TKA

NCT07023185
View directory record Official record
Conditions
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
Interventions
Cold and Compression, SOC (Standard of care)
Device · Other
Lead sponsor
Ochsner Health System
Other
Eligibility
50 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 1, 2026 · Synced Jun 11, 2026, 2:32 AM EDT
Terminated Phase 3 Interventional

Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer

NCT00002976
View directory record Official record
Conditions
Endometrial Cancer
Interventions
conjugated estrogens
Drug
Lead sponsor
Gynecologic Oncology Group
Network
Eligibility
Female only
Enrollment
2,108 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 1997
U.S. locations
149
States / cities
Birmingham, Alabama • Mobile, Alabama • Phoenix, Arizona + 99 more
Source: ClinicalTrials.gov public record
Updated Apr 10, 2013 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparing Surgical and Economical Parameters of Total Knee Replacement.

NCT03427047
View directory record Official record
Conditions
Osteo Arthritis Knee, Total Knee Arthroplasty
Interventions
MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
Device
Lead sponsor
Medacta USA
Industry
Eligibility
16 Years to 75 Years
Enrollment
82 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Jun 12, 2023 · Synced Jun 11, 2026, 2:32 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Navio Robotic Versus Conventional Total Knee Arthroplasty

NCT03519269
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Navio™ Robotics-assisted Surgical System
Device
Lead sponsor
Columbia University
Other
Eligibility
40 Years to 85 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 7, 2025 · Synced Jun 11, 2026, 2:32 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Healthy Living After Knee Replacement

NCT05190666
View directory record Official record
Conditions
Arthroplasty, Overweight and Obesity
Interventions
PACE Weight Loss program, Chronic Disease Self-Management
Behavioral
Lead sponsor
University of South Carolina
Other
Eligibility
Not listed
Enrollment
182 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Columbia, South Carolina
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

Raltegravir Therapy for Women With HIV and Fat Accumulation

NCT00656175
View directory record Official record
Conditions
HIV Infections, Lipodystrophy
Interventions
raltegravir
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
4
States / cities
Los Angeles, California • Boston, Massachusetts • Cleveland, Ohio + 1 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2012 · Synced Jun 11, 2026, 2:32 AM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation

NCT02697227
View directory record Official record
Conditions
Cigarette Smoker, Tobacco Use Disorder
Interventions
Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Smoking Cessation Intervention
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 75 Years
Enrollment
85 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Phase 2 Interventional Results available

Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery

NCT00484354
View directory record Official record
Conditions
Kidney Failure, Acute, Renal Replacement Therapy
Interventions
Sodium bicarbonate, Normal saline, Bicarbonate, Placebo
Drug · Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years and older
Enrollment
123 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Jun 11, 2026, 2:32 AM EDT
Not listed No phase listed Observational

Post-Implant Performance of the EC-3 IOL

NCT01333345
View directory record Official record
Conditions
Cataract
Interventions
Not listed
Lead sponsor
Aaren Scientific Inc.
Industry
Eligibility
Not listed
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011
U.S. locations
2
States / cities
Venice, Florida • Dover, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 11, 2011 · Synced Jun 11, 2026, 2:32 AM EDT
Not listed No phase listed Observational

Validation of Consumer Activity Monitors in Postoperative Total Arthroplasty Patients

NCT03958370
View directory record Official record
Conditions
Arthropathy of Knee, Arthritis Knee, Arthritis, Degenerative
Interventions
Fitbit
Other
Lead sponsor
Benaroya Research Institute
Other
Eligibility
18 Years to 100 Years
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 21, 2019 · Synced Jun 11, 2026, 2:32 AM EDT
Completed No phase listed Observational

A Single-Center, Epidemiological Study of the Survivorship of the DePuy Sigma HP Unicompartmental Knee Prosthesis

NCT01656694
View directory record Official record
Conditions
Osteoarthritis, Unicompartmental Knee Arthroscopy
Interventions
DePuy Sigma HP Partial Knee
Device
Lead sponsor
Mississippi Sports Medicine and Orthopaedic Center
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Mar 21, 2018 · Synced Jun 11, 2026, 2:32 AM EDT
Not listed No phase listed Observational

Retrospective Chart Analysis in the Effective Use of FloSeal in Post-Operative Joint Replacements

NCT00958945
View directory record Official record
Conditions
Total Knee Arthroplasty, Arthroplasty, Replacement, Hip
Interventions
Not listed
Lead sponsor
Desert Orthopedic Center Medical Research Foundation
Other
Eligibility
18 Years to 95 Years
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2009
U.S. locations
1
States / cities
Rancho Mirage, California
Source: ClinicalTrials.gov public record
Updated Aug 13, 2009 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Partial Heart Transplantation for Severe Pediatric Semilunar Valve Dysfunction

NCT05372757
View directory record Official record
Conditions
Semilunar Heart Valve Replacement
Interventions
Partial Heart Transplantation
Procedure
Lead sponsor
Medical University of South Carolina
Other
Eligibility
1 Day to 2 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Sep 18, 2024 · Synced Jun 11, 2026, 2:32 AM EDT
Recruiting Not applicable Interventional

A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery

NCT07356323
View directory record Official record
Conditions
Arthroplasty Replacement, Knee, Arthroplasty Total Hip Replacement
Interventions
3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
Device
Lead sponsor
Solventum US LLC
Industry
Eligibility
22 Years and older
Enrollment
179 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
Fishers, Indiana • Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Thigh Pain After Total Knee Arthroplasty (TKA)

NCT02262988
View directory record Official record
Conditions
Osteoarthritis, Knee
Interventions
Total knee replacement
Procedure
Lead sponsor
Fondren Orthopedic Group L.L.P.
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2021
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Not applicable Interventional Results available

Triathlon Total Stabilizer (TS) Outcomes Study

NCT00958789
View directory record Official record
Conditions
Arthroplasty, Replacement, Knee
Interventions
Triathlon TS Knee System
Device
Lead sponsor
Stryker Orthopaedics
Industry
Eligibility
18 Years and older
Enrollment
180 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
12
States / cities
Phoenix, Arizona • Jacksonville, Florida • Chicago, Illinois + 9 more
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Jun 11, 2026, 2:32 AM EDT
Terminated Not applicable Interventional Results available

Wearable Bioimpedance Analyzer for Tracking Body Composition Changes

NCT05986617
View directory record Official record
Conditions
Obesity, Knee Osteoarthritis
Interventions
InBody Band 2
Device
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 99 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 16, 2024 · Synced Jun 11, 2026, 2:32 AM EDT
Active, not recruiting Phase 4 Interventional

An Open-label, Multicenter Study to Assess the Pharmacokinetics (PK), Safety, and Tolerability of Subcutaneous IgPro20 in Immunoglobulin (IG) Treatment-naïve Participants With Primary Immunodeficiency (PID)

NCT07076446
View directory record Official record
Conditions
Primary Immunodeficiency
Interventions
IgPro
Biological
Lead sponsor
CSL Behring
Industry
Eligibility
18 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
8
States / cities
Litchfield Park, Arizona • Scottsdale, Arizona • Centennial, Colorado + 5 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Jun 11, 2026, 2:32 AM EDT
Active, not recruiting Not applicable Interventional

14022 ATTUNE Cementless RP Clinical Performance Evaluation

NCT02839850
View directory record Official record
Conditions
Osteoarthritis
Interventions
Cementless Total Knee Arthroplasty
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
22 Years to 80 Years
Enrollment
540 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
10
States / cities
Denver, Colorado • DeLand, Florida • Lebanon, New Hampshire + 7 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment

NCT02055118
View directory record Official record
Conditions
Hunter Syndrome
Interventions
idursulfase-IT, No IT treatment
Biological · Other
Lead sponsor
Shire
Industry
Eligibility
Up to 18 Years · Male only
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
3
States / cities
Oakland, California • Chicago, Illinois • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 10, 2021 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Not applicable Interventional

Pain Neuroscience Education in Total Knee Arthroplasty

NCT03231566
View directory record Official record
Conditions
Total Knee Replacement
Interventions
Pain Neuroscience Education
Behavioral
Lead sponsor
University of Nevada, Las Vegas
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Las Vegas, Nevada
Source: ClinicalTrials.gov public record
Updated Jul 26, 2017 · Synced Jun 11, 2026, 2:32 AM EDT
Completed Not applicable Interventional Results available

Acupuncture for Low-Dose Opioid for TKA Replacement

NCT04084288
View directory record Official record
Conditions
Knee Osteoarthritis, Pain, Postoperative, Acupuncture
Interventions
Acupuncture, Peripheral Nerve Stimulator
Other · Device
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 70 Years
Enrollment
41 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Dec 26, 2024 · Synced Jun 11, 2026, 2:32 AM EDT