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ClinicalTrials.gov public records Last synced Jun 26, 2026, 1:18 PM EDT

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Showing 1–24 of 726 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Respiration Failure Clear all
Completed No phase listed Observational

Parental Perception of COVID-19 Vaccine in Technology Dependent Patients

NCT05084976
View directory record Official record
Conditions
Chronic Respiratory Failure, Tracheostomy Complication, Mechanical Ventilation Complication
Interventions
COVID 19 vaccine counseling
Behavioral
Lead sponsor
Northwell Health
Other
Eligibility
Up to 21 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Lake Success, New York
Source: ClinicalTrials.gov public record
Updated Jul 17, 2022 · Synced Jun 26, 2026, 1:18 PM EDT
Active, not recruiting Not applicable Interventional

Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.

NCT06737432
View directory record Official record
Conditions
Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation, Ventilator-induced Lung Injury (VILI), Quality Improvement, Ventilator Associated Events
Interventions
RKP Monitoring Software
Other
Lead sponsor
The University of Texas Medical Branch, Galveston
Other
Eligibility
Up to 100 Years
Enrollment
875 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Galveston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Withdrawn No phase listed Observational

Clinical Pediatric Pneumonia Score in Critically Ill Children

NCT02139384
View directory record Official record
Conditions
Community Acquired Pneumonia
Interventions
Not listed
Lead sponsor
Loma Linda University
Other
Eligibility
1 Day to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 24, 2017 · Synced Jun 26, 2026, 1:18 PM EDT
Not yet recruiting Not applicable Interventional

Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients

NCT07452406
View directory record Official record
Conditions
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Interventions
Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 9, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Terminated Not applicable Interventional Results available

King Video Laryngoscope Versus Direct Laryngoscopy for Prehospital Intubation: A Randomized Controlled Trial

NCT02208349
View directory record Official record
Conditions
Respiratory Failure
Interventions
King Video Laryngoscope, traditional direct laryngoscopy (DL)
Device
Lead sponsor
Saint Vincent Hospital, Pennsylvania
Other
Eligibility
18 Years to 120 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Erie, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 5, 2018 · Synced Jun 26, 2026, 1:18 PM EDT
Recruiting Phase 2 Interventional

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

NCT06977581
View directory record Official record
Conditions
Asthma
Interventions
PF-07275315, Placebo
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 70 Years
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
36
States / cities
Mobile, Alabama • Chandler, Arizona • Lancaster, California + 29 more
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Completed No phase listed Observational

Development of a Tracheal Sound Sensor

NCT05506267
View directory record Official record
Conditions
Respiratory Insufficiency, Opioid Overdose, Hypoventilation
Interventions
Trachea Sound Sensor (TSS)
Device
Lead sponsor
Thomas Jefferson University
Other
Eligibility
18 Years to 80 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 17, 2022 · Synced Jun 26, 2026, 1:18 PM EDT
Terminated Not applicable Interventional

Feasibility of the AveCure Microwave Ablation Technology for the Bronchoscopic Treatment of Malignant Central Airway Obstructions

NCT06105606
View directory record Official record
Conditions
Airway Obstruction, Central Airway Obstruction
Interventions
AveCure Flexible Microwave Ablation Probe
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Not applicable Interventional Results available

HVNI Ambulation Feasibility Study

NCT03885726
View directory record Official record
Conditions
Respiratory Insufficiency, Dyspnea
Interventions
Precision Flow Plus, Treatment as Usual
Device
Lead sponsor
Vapotherm, Inc.
Industry
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
3
States / cities
Saint Charles, Missouri • Mount Vernon, Ohio • Newport News, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 18, 2020 · Synced Jun 26, 2026, 1:18 PM EDT
Terminated Phase 3 Interventional Results available

Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis

NCT04706507
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
IV Ganciclovir, Normal saline
Drug
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years to 85 Years
Enrollment
205 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
20
States / cities
Denver, Colorado • Baltimore, Maryland • Boston, Massachusetts + 16 more
Source: ClinicalTrials.gov public record
Updated Dec 11, 2025 · Synced Jun 26, 2026, 1:18 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures

NCT06533904
View directory record Official record
Conditions
Trauma, Rib Fractures, Chest Wall Disorder, Respiratory Insufficiency, Pain, Chest, Rib Trauma, Rib Fracture Multiple, Respiratory Failure, Respiratory Distress Syndrome
Interventions
Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen
Procedure · Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Not applicable Interventional Results available

Assessing Ventilator Safety in Patients on Pressure-Support Ventilation

NCT05125952
View directory record Official record
Conditions
Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
Interventions
Viasys Avea Ventilator, Philips Respironics NM3 device, Servo U ventilator, Vyaire SmartCath adult nasogastric tube with Esophageal balloon
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Jun 26, 2026, 1:18 PM EDT
Not listed Not applicable Interventional

Walking and Blood Pressure in Older Adults With Respiratory Impairment.

NCT06033417
View directory record Official record
Conditions
Respiratory Impairment, Elevated Blood Pressure, Physical Inactivity
Interventions
Increased lifestyle walking (intervention), Health education only (control)
Other
Lead sponsor
Iowa State University
Other
Eligibility
65 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Ames, Iowa
Source: ClinicalTrials.gov public record
Updated Sep 12, 2023 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age

NCT05391555
View directory record Official record
Conditions
Opioid Toxicity, Pupillary Miosis, Respiratory Depression
Interventions
Remifentanil Hydrochloride, Pupillometry measurement
Drug · Device
Lead sponsor
University of California, San Francisco
Other
Eligibility
40 Years to 60 Years
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 1, 2025 · Synced Jun 26, 2026, 1:18 PM EDT
Terminated Not applicable Interventional

Randomized Study of the pdSTIM™ System in Failure to Wean Mechanically Ventilated Patients

NCT05998018
View directory record Official record
Conditions
Neuromodulation, Phrenic Nerve Stimulation, Ventilator Induced Diaphragm Dysfunction, Mechanical Ventilation Weaning
Interventions
pdSTIM System Therapy, Conventional Medical Management
Device · Other
Lead sponsor
Stimdia Medical Inc.
Industry
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
21
States / cities
Mobile, Alabama • Chandler, Arizona • Goodyear, Arizona + 18 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Terminated No phase listed Observational

Nanowear Heart Failure Management Multi-sensor Algorithm

NCT03719079
View directory record Official record
Conditions
Heart Failure
Interventions
SimpleSENSE
Device
Lead sponsor
Nanowear Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2024
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 8, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Recruiting Phase 2 Interventional

A Clinical Trial to Evaluate agenT-797 Plus Standard of Care in Participants With Severe Pneumonia With Moderate to Severe Acute Hypoxemic Respiratory Failure

NCT07615010
View directory record Official record
Conditions
Pneumonia
Interventions
agenT-797, Placebo, Standard of Care (SOC)
Drug
Lead sponsor
MiNK Therapeutics
Industry
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
3
States / cities
San Francisco, California • Houston, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 25, 2026 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Not applicable Interventional

Safety and Effectiveness of Sonu for Pediatric Nasal Congestion

NCT06773013
View directory record Official record
Conditions
Nasal Congestion and Inflammations
Interventions
Acoustic Resonance (Sound) Therapy
Device
Lead sponsor
Third Wave Therapeutics
Industry
Eligibility
12 Years to 21 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Portola Valley, California
Source: ClinicalTrials.gov public record
Updated Sep 9, 2025 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Not applicable Interventional

Anesthetic Optimization in Scoliosis Surgery

NCT02481570
View directory record Official record
Conditions
Adolescent Idiopathic Scoliosis, Respiratory Depression, Postoperative Pain
Interventions
pharmacokinetic simulation
Other
Lead sponsor
University of Florida
Other
Eligibility
10 Years to 18 Years
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Aug 11, 2019 · Synced Jun 26, 2026, 1:18 PM EDT
Terminated Not applicable Interventional

Treatment of Muscle Weakness in Critically Ill Patients

NCT02247895
View directory record Official record
Conditions
Critical Illness, Respiratory Failure, Myopathy, Weakness
Interventions
Sham Treatment, Electrical stimulation
Device
Lead sponsor
Gerald Supinski
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Jun 21, 2020 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Not applicable Interventional Results available

Bougie Use in Emergency Airway Management

NCT02902146
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Bougie, Endotracheal tube
Device
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
18 Years and older
Enrollment
757 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 10, 2019 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Phase 3 Interventional Results available

Targeting Acute Congestion With Tolvaptan in Congestive Heart Failure

NCT01644331
View directory record Official record
Conditions
Heart Failure, Dyspnea
Interventions
Tolvaptan, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
18
States / cities
Aurora, Colorado • Atlanta, Georgia • Gainesville, Georgia + 14 more
Source: ClinicalTrials.gov public record
Updated Apr 26, 2017 · Synced Jun 26, 2026, 1:18 PM EDT
Completed Not applicable Interventional

Nasal Saline Irrigation After Radiation Therapy for Oropharyngeal Cancer

NCT02338102
View directory record Official record
Conditions
Nasal Obstruction, Rhinitis, Vasomotor, Epistaxis
Interventions
Saline mixture
Other
Lead sponsor
Lisa Shnayder
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Nov 3, 2015 · Synced Jun 26, 2026, 1:18 PM EDT
Recruiting Not applicable Interventional

The Efficacy of Distal Pharyngeal Airway for Oxygenation During TEE

NCT05974488
View directory record Official record
Conditions
Airway Obstruction
Interventions
McMurray Enhanced Airway, Nasal Cannula
Device
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Oct 5, 2025 · Synced Jun 26, 2026, 1:18 PM EDT