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ClinicalTrials.gov public records Last synced Nov 14, 2026, 6:15 PM EST

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Showing 1–24 of 455 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Respiratory Distress Syndrome, Adult Clear all

Conditions: Critical Illness, Sleep, Acute Lung Injury, Acute Respiratory Distress Syndrome
Interventions: Dexmedetomidine, Midazolam and Fentanyl; Drug
Lead sponsor: University of Arizona; Other
Eligibility: 18 Years to 85 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2019
U.S. locations: 2
States / cities: Tucson, Arizona

Conditions: ARDS, Human, Lung, Wet, Thyroid, Pulmonary Edema, Lung Inflammation
Interventions: Liothyronine Sodium (T3+0.9% sodium chloride) modified formulation specifically for airway instillation., Non-intervention; Drug · Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 2
States / cities: Edina, Minnesota • Minneapolis, Minnesota

Conditions: Sepsis, Delirium, Impaired Cognition
Interventions: Dexmedetomidine, Propofol; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 438 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 11
States / cities: San Francisco, California • Baton Rouge, Louisiana • Boston, Massachusetts + 7 more

Conditions: Acute Respiratory Distress Syndrome
Interventions: CUROSURF® (poractant alfa); Drug
Lead sponsor: Chiesi Farmaceutici S.p.A.; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Covid-19, ARDS, Human, Acute Lung Injury
Interventions: Heparin, 0.9% Sodium-chloride; Drug
Lead sponsor: Frederick Health; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Frederick, Maryland

Conditions: Acute Respiratory Distress Syndrome, Diaphragm Injury, Neuromuscular Blockade
Interventions: Not listed
Lead sponsor: University Health Network, Toronto; Other
Eligibility: 19 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2018
U.S. locations: 6
States / cities: Boston, Massachusetts • Springfield, Massachusetts • Cleveland, Ohio + 3 more

Conditions: Respiratory Distress Syndrome, Newborn
Interventions: Neer Infrared Spectroscopy; Device
Lead sponsor: Keck School of Medicine of USC; Other
Eligibility: 1 Hour to 24 Hours
Enrollment: 50 participants
Timeline: 2023 – 2024
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Acute Respiratory Distress Syndrome
Interventions: Not listed
Lead sponsor: Nationwide Children's Hospital; Other
Eligibility: 0 Years to 18 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2005
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Respiratory Distress Syndrome
Interventions: Lucinactant delivered via investigational delivery device, nCPAP; Drug
Lead sponsor: Windtree Therapeutics; Industry
Eligibility: 26 Weeks to 32 Weeks
Enrollment: 221 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 22
States / cities: Birmingham, Alabama • Little Rock, Arkansas • Loma Linda, California + 18 more

Conditions: Infant Respiratory Distress Syndrome, Respiratory Insufficiency, Apnea of Prematurity
Interventions: Nasal high frequency ventilation; Other
Lead sponsor: Tarah T Colaizy; Other
Eligibility: 7 Days to 3 Months
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Neonatal Respiratory Distress Syndrome
Interventions: Not listed
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 2
States / cities: Indianapolis, Indiana

Conditions: Acute Respiratory Distress Syndrome in Children
Interventions: Either supine or prone positioning and either CMV or HFOV; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 2 Weeks to 20 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 28
States / cities: Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 24 more

Conditions: Respiratory Distress Syndrome in Premature Infants, Very Low Birth Weight Baby
Interventions: iNO, Nitrogen; Drug · Other
Lead sponsor: University of Oklahoma; Other
Eligibility: 1 Minute to 2 Minutes
Enrollment: 33 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2017
U.S. locations: 2
States / cities: Oklahoma City, Oklahoma

Conditions: Covid19
Interventions: Aviptadil, Aviptadil Placebo, Corticosteroid; Biological · Drug
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years and older
Enrollment: 471 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 40
States / cities: Tucson, Arizona • Fresno, California • Loma Linda, California + 28 more

Conditions: COPD, Congestive Heart Failure, Asthma, Respiratory Distress Syndrome, Adult, Pneumonia
Interventions: Not listed
Lead sponsor: Tufts Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2003 – 2009
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Respiratory Distress Syndrome, Adult
Interventions: Not listed
Lead sponsor: National Jewish Health; Other
Eligibility: 18 Years and older
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2012
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute, Myocarditis Due to Drug, Myocarditis Viral, Pericardial Diseases, Valvular Heart Diseases, Hypertension, Sepsis, Acute Kidney Injury, Pulmonary Edema - Acute, Pulmonary Edema With Heart Failure, Pulmonary Edemas, Acute Respiratory Distress Syndrome, Pulmonary Embolism Acute, Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute Massive, Pulmonary Embolism Subacute Massive, Venous Thrombosis Pulmonary, Venous Thrombosis (Disorder), Venous Thrombosis, Deep, Peripheral Arterial Disease, Peripheral Arterial Disease (PAD), Aortic Diseases, Muskuloskeletal Diseases, Brain Aging, Brain Aneurysm, Brain Aging Related Conditions, Ultrasound, Ultrasound Exams, Ultrasound Guidance
Interventions: OMNIPHYS Multimodal Ultrasound Imaging System; Device
Lead sponsor: Truway Health, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 25,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2046
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
Interventions: Nitric Oxide; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 80 Years
Enrollment: 70 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Ventilator-Induced Lung Injury, Sepsis Syndrome, Mechanical Ventilation Complication
Interventions: PEEP (positive end-expiratory pressure) - maximum, PEEP (positive end-expiratory pressure) - standard; Procedure
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 18 Years and older
Enrollment: 7 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Acute Lung Injury, Sepsis
Interventions: Ascorbic Acid, Placebo: 5% Dextrose in water; Drug
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 18 Years and older
Enrollment: 170 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 5
States / cities: Atlanta, Georgia • Lexington, Kentucky • Cleveland, Ohio + 2 more

Conditions: Premature Neonate
Interventions: Higher permissive hypercapnia, Lower Permissive Hypercapnia; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 7 Days to 14 Days
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
Interventions: Pressure Targeted High Flow, CPAP; Procedure
Lead sponsor: University of Texas at Austin; Other
Eligibility: 7 Days to 40 Weeks
Enrollment: 78 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 2
States / cities: San Diego, California • Austin, Texas

Conditions: Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia
Interventions: Non-Bronchoscopic Mini Bronchoalveolar Lavage; Other
Lead sponsor: William Janssen, MD; Other
Eligibility: 18 Years to 99 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn, Ventilation Perfusion Mismatch
Interventions: Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP; Other
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 7 Days to 30 Days
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Search by objective public record fields.

Sleep Intervention During Acute Lung Injury

Treatment of ARDS With Instilled T3

The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure

Poractant Alfa (Curosurf®)) -- Effect in Adult Patients Diagnosed With 2019 Novel Coronavirus (SARS-COV-19; (Covid-19)) Acute Respiratory Distress Syndrome (ARDS)

Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury

Re-Evaluation of Systemic Early Neuromuscular Blockade and Transthoracic Ultrasound Assessment of the Diaphragm

Application of Lung Near-Infrared Spectroscopy (NIRS) in Preterm Infants

Short Term Outcomes of Children With Acute Respiratory Distress Syndrome

The Safety and Efficacy of Lucinactant for Inhalation in Premature Neonates 26 to 32 Weeks Gestational Age

Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study

The Use of Maternal Serum Unconjugated Estriol for Monitoring the Prevention of Neonatal Respiratory Distress Syndrome

PROSpect: Prone and Oscillation Pediatric Clinical Trial

Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation

Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)

Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care

Viral-Related Neutrophil Response and Condition Severity in People With ARDS

Multimodal Physiologic State Intelligence Study

Vascular ARDS Recruitment After Inhaled Nitric Oxide

CT for Personalized Mechanical Ventilation

Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury

Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants

Pressure Targeting During High Flow Therapy in Premature Infants

Macrophage Programing in Acute Lung Injury: MiniBAL

Ventilator Pressure and Optimization of Compliance and Hemodynamics