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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Respiratory Failure, ICU Clear all
Completed Phase 1Phase 2 Interventional Results available

Testing the Feasibility of Patient Controlled Sedation for Ventilated ICU Patients

NCT01606852
View directory record Official record
Conditions
Acute Respiratory Failure, Anxiety
Interventions
Dexmedetomidine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 12, 2018 · Synced Jul 21, 2026, 9:31 PM EDT
Withdrawn No phase listed Observational

Integrated Pulmonary Index (IPI) as a Determinate of Weaning Success and/or Failure in the Pediatric Population

NCT01795196
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
Rush University Medical Center
Other
Eligibility
1 Year to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Dec 27, 2022 · Synced Jul 21, 2026, 9:31 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

A Study of Communication Between Clinicians, Patients, and Families in the Intensive Care Unit (ICU)

NCT06042621
View directory record Official record
Conditions
Acute Respiratory Failure, Mechanical Ventilation, Life-Supporting Treatments, Communication, Decision Making, Critical Care, Palliative Care
Interventions
Not listed
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
7,818 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
5
States / cities
Chicago, Illinois • Philadelphia, Pennsylvania • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Feb 4, 2026 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

RCT of Mesh Versus Jet Nebulizers on Clinical Outcomes During Mechanical Ventilation in the Intensive Care Unit

NCT02056119
View directory record Official record
Conditions
Respiratory Insufficiency
Interventions
Vibrating Mesh Nebulizer Arm, Jet Nebulizer Arm
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
1 Year and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Jul 21, 2026, 9:31 PM EDT
Not yet recruiting Phase 1Phase 2 Interventional

Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial

NCT07293078
View directory record Official record
Conditions
Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure, Acute Kidney Injury, Delirium Confusional State, Shock
Interventions
Point-of-care large language model decision support (ChatGPT-5)
Other
Lead sponsor
MetroWest Artificial Intelligence Research Workgroup
Other
Eligibility
18 Years and older
Enrollment
1,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Framingham, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Post-ICU Palliative Care Intervention (PIPCI) Trial

NCT03456323
View directory record Official record
Conditions
Critical Illness, Frailty, Palliative Care
Interventions
Palliative Care Consultation, Usual Care
Behavioral · Other
Lead sponsor
Columbia University
Other
Eligibility
50 Years and older
Enrollment
66 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 15, 2024 · Synced Jul 21, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

NCT06446453
View directory record Official record
Conditions
Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal
Interventions
Echography-guided Surfactant THERapy (ESTHER)
Diagnostic Test
Lead sponsor
Connecticut Children's Medical Center
Other
Eligibility
0 Hours to 2 Hours
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Jul 21, 2026, 9:31 PM EDT
Terminated No phase listed Observational

Effects of Obesity on Care and Outcomes in Mechanically Ventilated Individuals in the Intensive Care Unit

NCT00296088
View directory record Official record
Conditions
Obesity, Respiratory Insufficiency
Interventions
Not listed
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older
Enrollment
582 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2013 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 3 Interventional

Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients

NCT05456542
View directory record Official record
Conditions
Respiratory Failure
Interventions
Cuff Leak Test, Dexamethasone 4mg
Diagnostic Test · Drug
Lead sponsor
St. Joseph's Healthcare Hamilton
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 9, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU

NCT03642002
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Interventions
Toning, Ocean drum & SOK melody, SOK, Process, Holding Harmonic Container
Other · Behavioral
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
178 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2028
U.S. locations
3
States / cities
New York, New York • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 8, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 2 Interventional Results available

Vitamin D in Ventilated ICU Patients

NCT01372995
View directory record Official record
Conditions
Respiratory Failure
Interventions
Enteral Vitamin D3 50,000 IU, Enteral Vitamin D3 100,000IU, Inactive substance
Drug · Other
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 8, 2017 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Improving Psychological Distress Among Critical Illness Survivors and Their Caregivers

NCT01983254
View directory record Official record
Conditions
Intensive Care Unit Survivors, Informal Caregivers (Family and Friends)
Interventions
coping skills training, education program
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
417 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
4
States / cities
Chapel Hill, North Carolina • Durham, North Carolina • Pittsburgh, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Jan 20, 2020 · Synced Jul 21, 2026, 9:31 PM EDT
Terminated Phase 3 Interventional Results available

Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)

NCT01206166
View directory record Official record
Conditions
Critical Illness, Acute Respiratory Failure
Interventions
Olimel (5.7%E / N9E)
Drug
Lead sponsor
Clinical Evaluation Research Unit at Kingston General Hospital
Other
Eligibility
18 Years and older
Enrollment
125 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
7
States / cities
Boulder, Colorado • St Louis, Missouri • Cleveland, Ohio + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 15, 2021 · Synced Jul 21, 2026, 9:31 PM EDT
Completed No phase listed Observational

Effects Of Invasive And Noninvasive Mechanical Ventilation On Sleep In The Intensive Care Unit (ICU)

NCT00638339
View directory record Official record
Conditions
Respiratory Insufficiency, Respiration, Artificial, Sleep Deprivation
Interventions
Not listed
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2017
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 5, 2019 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU

NCT02003053
View directory record Official record
Conditions
Critically Ill, Respiratory Failure
Interventions
Inspiratory Muscle Trainer
Device
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 90 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 6, 2018 · Synced Jul 21, 2026, 9:31 PM EDT
Not yet recruiting Not applicable Interventional

Personalized Ventilator Settings for Patients on ECMO

NCT07673250
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU, Ventilator Induced Lung Injury
Interventions
Personalized Positive End-Expiratory Pressure (PEEP)
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2031
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jun 28, 2026 · Synced Jul 21, 2026, 9:31 PM EDT
Recruiting Not applicable Interventional

COMPARE-VENT Feasibility Pilot Study

NCT07656259
View directory record Official record
Conditions
Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness, Mechanical Ventilation, Cardiogenic Shock, Cardiopulmonary
Interventions
Volume Controlled Mode, Pressure Controlled Mode
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 8, 2026 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional Results available

Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study

NCT02051816
View directory record Official record
Conditions
Respiratory Failure
Interventions
Video Laryngoscopy, Apneic Oxygenation, Direct Laryngoscopy, No Apneic Oxygenation
Device
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2015
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated May 23, 2017 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Not applicable Interventional

Rounding Summaries for Families of Critically Ill Patients

NCT03969810
View directory record Official record
Conditions
Acute Respiratory Failure, Intensive Care Unit Syndrome, Communication
Interventions
Rounding Summary
Behavioral
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
252 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 8, 2021 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 1 Interventional Results available

Novel Arm Restraint in the Intensive Care Unit

NCT03621475
View directory record Official record
Conditions
Acute Respiratory Failure
Interventions
Novel restraint
Device
Lead sponsor
University of Vermont
Other
Eligibility
65 Years and older
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated May 28, 2025 · Synced Jul 21, 2026, 9:31 PM EDT
Active, not recruiting Not applicable Interventional

Critical Illness Myopathy as a Cause of Debilitating ICU-Acquired Weakness

NCT00937001
View directory record Official record
Conditions
Myopathy, Cognitive Impairment
Interventions
Biopsy/Ultrasound
Procedure
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years to 99 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 1, 2026 · Synced Jul 21, 2026, 9:31 PM EDT
Not listed Not applicable Interventional

A Randomized Controlled Trial of a Video Decision Aid in the ICU

NCT01776333
View directory record Official record
Conditions
Respiratory Failure, Cardiac Event
Interventions
video decision aid
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
21 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
3
States / cities
Los Angeles, California • Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Early Phase 1 Interventional

Reduction of Bacterial Resistance With Inhaled Antibiotics in the Intensive Care Unit

NCT01878643
View directory record Official record
Conditions
Respiratory Infection, Bacterial Resistance, Respiratory Failure
Interventions
vancomycin or gentamicin, Placebo
Drug
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2002
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Jun 16, 2013 · Synced Jul 21, 2026, 9:31 PM EDT
Completed Phase 4 Interventional Results available

Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit

NCT00872027
View directory record Official record
Conditions
Depression
Interventions
Escitalopram, Placebo
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
25 Years and older
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 18, 2017 · Synced Jul 21, 2026, 9:31 PM EDT