- Conditions
- Restless Legs Syndrome
- Interventions
- Not listed
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- NIH
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 90 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2003 – 2007
- U.S. locations
- 1
- States / cities
- Bethesda, Maryland
Search Results
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Search by query text, NCT ID, condition, intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, or age. Results are retrieved from ClinicalTrials.gov and synchronized into the directory. Search pages remain noindex by default.
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Showing 1–24
of 109
matching trials from the live ClinicalTrials.gov search.
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- Conditions
- Restless Legs Syndrome (RLS)
- Interventions
- L-Tyrosine
- Dietary Supplement
- Lead sponsor
- Seton Healthcare Family
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 5 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2012
- U.S. locations
- 1
- States / cities
- Austin, Texas
- Conditions
- RLS
- Interventions
- HORIZANT 600 mg
- Drug
- Lead sponsor
- XenoPort, Inc.
- Industry
- Eligibility
- 13 Years to 17 Years
- Enrollment
- 144 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2016 – 2024
- U.S. locations
- 11
- States / cities
- Redwood City, California • San Diego, California • Gulf Breeze, Florida + 8 more
- Conditions
- Restless Legs Syndrome
- Interventions
- Noninvasive Peripheral Nerve Stimulation (NPNS)
- Device
- Lead sponsor
- Noctrix Health, Inc.
- Industry
- Eligibility
- 18 Years to 89 Years
- Enrollment
- 21 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2023
- U.S. locations
- 2
- States / cities
- Downey, California • Dublin, Ohio
- Conditions
- Restless Legs Syndrome (RLS)
- Interventions
- Injectafer, Placebo
- Drug · Other
- Lead sponsor
- American Regent, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 209 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2018
- U.S. locations
- 19
- States / cities
- Mobile, Alabama • National City, California • Rancho Mirage, California + 15 more
- Conditions
- Restless Legs Syndrome
- Interventions
- ropinirole
- Drug
- Lead sponsor
- GlaxoSmithKline
- Industry
- Eligibility
- 18 Years to 79 Years
- Enrollment
- 140 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005
- U.S. locations
- 37
- States / cities
- Alabaster, Alabama • Jasper, Alabama • Peoria, Arizona + 33 more
- Conditions
- Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
- Interventions
- H-Reflex, Somatosensory evoked potential (SSEP), Vibratory Electrophysiological Response Potential (ERP), Transcranial Magnetic Stimulation (TMS), Spinal Cord Stimulator (SCS) manipulation
- Other
- Lead sponsor
- University of Alabama at Birmingham
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 50 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2025 – 2028
- U.S. locations
- 1
- States / cities
- Birmingham, Alabama
- Conditions
- Restless Legs Syndrome (RLS), Restless Legs Syndrome
- Interventions
- Ropinirole
- Drug
- Lead sponsor
- GlaxoSmithKline
- Industry
- Eligibility
- 18 Years to 79 Years
- Enrollment
- 360 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2004
- U.S. locations
- 49
- States / cities
- Alabaster, Alabama • Birmingham, Alabama • Jasper, Alabama + 44 more
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa, Vision Disorders, Acute Coronary Syndrome, Implantable Defibrillator User, Congestive Heart Failure, Hypertrophic Obstructive Cardiomyopathy, Orthostatic Hypotension, Syncope, Presyncope, Narcolepsy, Dementia, Multiple Sclerosis, Parkinson Disease, Brain Injuries, Spinal Cord Injuries, Stroke, Vertigo, Dizziness, Seizures, Substance Use, Insulin Dependent Diabetes Mellitus, Arthritis, Foot--Abnormalities, Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea, End Stage Renal Disease, Sleep Apnea, Insomnia, Restless Legs Syndrome
- Interventions
- Driving Decision Aid, Older Drivers Website
- Behavioral
- Lead sponsor
- University of Colorado, Denver
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 529 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2023
- U.S. locations
- 3
- States / cities
- La Jolla, California • Aurora, Colorado • Indianapolis, Indiana
- Conditions
- Restless Legs Syndrome
- Interventions
- rasagiline, placebo (sugar pill)
- Drug
- Lead sponsor
- University of Virginia
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 52 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2010 – 2012
- U.S. locations
- 8
- States / cities
- Pinellas Park, Florida • Augusta, Georgia • Chicago, Illinois + 5 more
- Conditions
- Restless Legs Syndrome
- Interventions
- morphine Placebo, GEn 600 mg, Morphine, GEn Placebo
- Drug
- Lead sponsor
- XenoPort, Inc.
- Industry
- Eligibility
- 18 Years to 65 Years · Male only
- Enrollment
- 18 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2011
- U.S. locations
- 1
- States / cities
- Austin, Texas
- Conditions
- Sleep Disorders, Sleep Apnea, Obstructive, Restless Legs Syndrome, Sleep Disorders, Circadian Rhythm, Sleep Initiation and Maintenance Disorders
- Interventions
- Sleep Hygiene Education, Expert-Led Sleep Disorders Screening and Treatment, Online Sleep Disorders Screening
- Behavioral · Other
- Lead sponsor
- Brigham and Women's Hospital
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 683 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2005 – 2010
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Restless Legs Syndrome
- Interventions
- Rotigotine
- Drug
- Lead sponsor
- UCB BIOSCIENCES, Inc.
- Industry
- Eligibility
- 13 Years and older
- Enrollment
- 14 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2011 – 2015
- U.S. locations
- 5
- States / cities
- Los Angeles, California • Orange, California • Spring Hill, Florida + 2 more
- Conditions
- Restless Legs Syndrome
- Interventions
- Rotigotine
- Drug
- Lead sponsor
- UCB Pharma
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 279 participants
- Timeline
- 2005 – 2007
- U.S. locations
- 1
- States / cities
- RTP, North Carolina
- Conditions
- Restless Legs Syndrome
- Interventions
- Ropinirole Extended Release (XR)
- Drug
- Lead sponsor
- GlaxoSmithKline
- Industry
- Eligibility
- 18 Years to 79 Years
- Enrollment
- 380 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2005 – 2006
- U.S. locations
- 60
- States / cities
- Alabaster, Alabama • Jasper, Alabama • Mesa, Arizona + 55 more
- Conditions
- Restless Legs Syndrome
- Interventions
- NTX100
- Device
- Lead sponsor
- Noctrix Health, Inc.
- Industry
- Eligibility
- 21 Years and older
- Enrollment
- 325 participants
- Timeline
- 2023 – 2027
- U.S. locations
- 7
- States / cities
- Downey, California • San Ramon, California • Newton, Massachusetts + 4 more
- Conditions
- Restless Legs Syndrome
- Interventions
- buprenorphine transdermal delivery system (BTDS), Placebo for BTDS patch
- Drug
- Lead sponsor
- Massachusetts General Hospital
- Other
- Eligibility
- 25 Years to 75 Years
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2014 – 2016
- U.S. locations
- 1
- States / cities
- Boston, Massachusetts
- Conditions
- Restless Legs Syndrome
- Interventions
- XP13512, Diphenhydramine, Placebo
- Drug
- Lead sponsor
- XenoPort, Inc.
- Industry
- Eligibility
- 21 Years to 65 Years
- Enrollment
- 130 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007
- U.S. locations
- 1
- States / cities
- Albuquerque, New Mexico
- Conditions
- Restless Legs Syndrome
- Interventions
- Levetiracetam (Keppra)
- Drug
- Lead sponsor
- Sleep Health Centers
- Other
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 20 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2003 – 2005
- U.S. locations
- 1
- States / cities
- Newton, Massachusetts
- Conditions
- Restless Legs Syndrome
- Interventions
- NTX100 Neuromodulation System - Active, NTX100 Neuromodulation System - Sham, NTX100 Neuromodulation System - Open-Label
- Device
- Lead sponsor
- Noctrix Health, Inc.
- Industry
- Eligibility
- 22 Years to 79 Years
- Enrollment
- 133 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2021 – 2022
- U.S. locations
- 7
- States / cities
- San Leandro, California • Colorado Springs, Colorado • Atlanta, Georgia + 4 more
- Conditions
- Restless Legs Syndrome, Neuropathic Pain
- Interventions
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement, Continuous Blood Pressure, Partial pressure of oxygen, Microneurography, Anthropometric Measurements, John Hopkins Restless Legs Severity Scale, Continuous Blood Pressure Diary
- Diagnostic Test · Other · Behavioral
- Lead sponsor
- Marshall Holland
- Other
- Eligibility
- 18 Years to 85 Years
- Enrollment
- 15 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2020
- U.S. locations
- 1
- States / cities
- Iowa City, Iowa
- Conditions
- Restless Leg Disorder, Restless Leg Syndrome (RLS), Pregnancy, Sleep Disorder (Disorder)
- Interventions
- Peroneal Nerve Stimulation (PNS) Device
- Device
- Lead sponsor
- Rhode Island Hospital
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 15 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Providence, Rhode Island
- Conditions
- Restless Legs Syndrome
- Interventions
- GEn (XP13512/GSK1838262), Placebo
- Drug
- Lead sponsor
- XenoPort, Inc.
- Industry
- Eligibility
- 18 Years and older
- Enrollment
- 217 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2007 – 2008
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Obstructive Sleep Apnea, Restless Leg Syndrome, Insomnia
- Interventions
- Not listed
- Lead sponsor
- Washington University School of Medicine
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 635 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2009 – 2014
- U.S. locations
- 1
- States / cities
- St Louis, Missouri