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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Rheumatic Arthritis Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SKI-O-703 in Healthy Volunteers

NCT03315494
View directory record Official record
Conditions
Arthritis, Rheumatoid
Interventions
SKI-O-703 capsule, Placebo capsule
Drug
Lead sponsor
Oscotec Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Oct 19, 2017 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional Results available

The Cherokee Study: Cherokee Health for Elderly Residents With Osteoarthritis of the Knee

NCT04946344
View directory record Official record
Conditions
Osteoarthritis
Interventions
Diet & Exercise, Attention Control
Behavioral
Lead sponsor
Wake Forest University
Other
Eligibility
50 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
2
States / cities
Cherokee, North Carolina • Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2024 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional

Validity of AI in Treatment of the Musculoskeletal Conditions by Vifive

NCT05290272
View directory record Official record
Conditions
Shoulder Adhesive Capsulitis, Knee Osteoarthritis
Interventions
ViFIVE Digital Care Progrma
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Nov 21, 2024 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Phase 4 Interventional Results available

Pre vs Post Block in Total Knee Arthroplasty (TKA)

NCT05974501
View directory record Official record
Conditions
Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
Interventions
Dexamethasone, Acetaminophen, Lyrica, Celebrex, Meloxicam, Oxycodone, Ropivacaine
Drug
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
84 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Feb 11, 2025 · Synced Jun 26, 2026, 1:03 AM EDT
Terminated Phase 1 Interventional

Curcuma Longa L in Rheumatoid Arthritis

NCT02543931
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Meriva, placebo
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Nov 29, 2016 · Synced Jun 26, 2026, 1:03 AM EDT
Recruiting No phase listed Observational

Exactech Shoulder Post Market Clinical Follow-up Study

NCT05603728
View directory record Official record
Conditions
Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
Interventions
Not listed
Lead sponsor
Exactech
Industry
Eligibility
21 Years and older
Enrollment
20,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2031
U.S. locations
24
States / cities
Laguna Woods, California • Redwood City, California • Stockton, California + 19 more
Source: ClinicalTrials.gov public record
Updated Dec 14, 2025 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

6-Month Phase I/II Open Label PRTX-100 in Previous Rheumatoid Arthritis Study Participants and Sera Collection

NCT02330445
View directory record Official record
Conditions
Arthritis, Rheumatoid
Interventions
PRTX-100
Drug
Lead sponsor
Protalex, Inc.
Industry
Eligibility
18 Years and older
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2016
U.S. locations
1
States / cities
Coeur d'Alene, Idaho
Source: ClinicalTrials.gov public record
Updated Oct 15, 2018 · Synced Jun 26, 2026, 1:03 AM EDT
Not listed Not applicable Interventional

On-Table Versus Off-Table Total Hip Arthroplasty

NCT04831372
View directory record Official record
Conditions
Arthroplasty, Replacement, Hip, Osteoarthritis, Hip
Interventions
Off Table Group, On Table Group
Procedure
Lead sponsor
Carilion Clinic
Other
Eligibility
18 Years and older
Enrollment
93 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Roanoke, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 15, 2024 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Phase 2 Interventional Results available

A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA)

NCT00520572
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
AZD9056, Etanercept, Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years and older
Enrollment
385 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
8
States / cities
Aventura, Florida • Orlando, Florida • Sarasota, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 3, 2013 · Synced Jun 26, 2026, 1:03 AM EDT
Recruiting Not applicable Interventional

Ischemic Preconditioning in Osteoarthritis and Back Pain

NCT07003113
View directory record Official record
Conditions
Low Back Pain, Knee Osteoarthritis
Interventions
Ischemic Preconditioning, Sham Intervention
Device
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
50 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 16, 2025 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional

Virtual Reality and Older Adult Knee OA

NCT04951661
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Virtual Reality
Device
Lead sponsor
Tufts University
Other
Eligibility
60 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Chestnut Hill, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 13, 2022 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Phase 3 Interventional

Study to Assess Efficacy of Tacrolimus + Methotrexate Versus Placebo + Methotrexate in Treatment of Rheumatoid Arthritis

NCT00036153
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Tacrolimus (Prograf®), Methotrexate
Drug
Lead sponsor
Astellas Pharma Inc
Industry
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2004
U.S. locations
42
States / cities
Birmingham, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 36 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2012 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional Results available

Randomized Fixed Bearing vs Mobile Bearing Cruciate Retaining TKA

NCT00289094
View directory record Official record
Conditions
Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Rheumatoid Arthritis, Avascular Necrosis of Bone
Interventions
Total knee replacement
Device
Lead sponsor
DePuy Orthopaedics
Industry
Eligibility
18 Years to 75 Years
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2007
U.S. locations
2
States / cities
Billings, Montana • Vancouver, Washington
Source: ClinicalTrials.gov public record
Updated Sep 12, 2022 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional

Rheumatoid Arthritis Coping Enhancement

NCT04246827
View directory record Official record
Conditions
Rheumatoid Arthritis, Obesity, Pain
Interventions
Enhanced Lifestyle Weight Management
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 28, 2020 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional Results available

Implementing Group Physical Therapy (PT) for Veterans With Knee Osteoarthritis (Group PT): Function QUERI 2.0

NCT05282927
View directory record Official record
Conditions
Knee Osteoarthritis
Interventions
Implementation Strategy: Foundational REP, Implementation Strategy: Enhanced REP (enREP)
Other
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
Not listed
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 9, 2025 · Synced Jun 26, 2026, 1:03 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals

NCT06701461
View directory record Official record
Conditions
Osteo Arthritis Knee
Interventions
Electrodermal Activity signal
Device
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years to 80 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional

Rheumatoid Arthritis Shared Decision Making

NCT05530694
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Clinician communication training, Patient activation, RA Medication summary guide and RA Choice
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
900 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
4
States / cities
San Francisco, California • Wilmington, Delaware • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Phase 2 Interventional Results available

A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease

NCT04391894
View directory record Official record
Conditions
Dry Eye
Interventions
ECF843, ECF843 vehicle
Drug · Other
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
718 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
52
States / cities
Chandler, Arizona • Mesa, Arizona • Phoenix, Arizona + 46 more
Source: ClinicalTrials.gov public record
Updated Jan 27, 2025 · Synced Jun 26, 2026, 1:03 AM EDT
Completed No phase listed Observational

Clinically Important Changes in Rheumatoid Arthritis

NCT00056602
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Not listed
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
18 Years to 100 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2019
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 5, 2020 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Self-Management of Osteoarthritis

NCT00288912
View directory record Official record
Conditions
Osteoarthritis
Interventions
Health Education, Osteoarthritis Self-Management
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
523 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Jun 26, 2026, 1:03 AM EDT
Not listed Phase 1 Interventional Accepts healthy volunteers

Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

NCT02854683
View directory record Official record
Conditions
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID), Postural Tachycardia Syndrome (POTS), Neurally Mediated Syncope (NMS)
Interventions
Normal Saline, Oral Rehydration Solution
Drug · Dietary Supplement
Lead sponsor
New York Medical College
Other
Eligibility
15 Years to 29 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Hawthorne, New York
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Jun 26, 2026, 1:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis

NCT01156155
View directory record Official record
Conditions
Rheumatoid Arthritis, Osteoarthritis, Periodontal Disease
Interventions
Digital xray of jaw and teeth, Blood draw, questionnaires, Periodontal Examination, Bilateral digital xray of hands
Radiation · Procedure · Other
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
617 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2018
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Nov 1, 2023 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Not applicable Interventional Results available

Gel-One Treatment in Knee Osteoarthritis

NCT01934218
View directory record Official record
Conditions
Osteoarthritis Knee
Interventions
Gel-One, PBS
Device
Lead sponsor
Seikagaku Corporation
Industry
Eligibility
40 Years to 80 Years
Enrollment
814 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
41
States / cities
Birmingham, Alabama • Sheffield, Alabama • Phoenix, Arizona + 38 more
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Jun 26, 2026, 1:03 AM EDT
Completed Phase 2 Interventional Results available

Psoriatic Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to NSAIDs or Non-biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) Therapy

NCT01490450
View directory record Official record
Conditions
Arthritis, Psoriatic
Interventions
Placebo matching BMS-945429, BMS-945429
Biological
Lead sponsor
CSL Behring
Industry
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
8
States / cities
San Diego, California • Denver, Colorado • Trumbull, Connecticut + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 4, 2021 · Synced Jun 26, 2026, 1:03 AM EDT