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Conditions: Risk Factor
Interventions: Experimental Intervention (MI-PrEP), Enhanced Treatment as Usual (E-TAU); Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 18 Years and older · Female only
Enrollment: 50 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Sexually Transmitted Infections
Interventions: 60 Minute HIV/STI risk reduction counseling.Single 60 min Social Cognitive Theory-based counseling., 20-Min education session; Behavioral
Lead sponsor: University of Connecticut; Other
Eligibility: 18 Years and older
Enrollment: 1,050 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Storrs, Connecticut

Conditions: Depression, Substance-Related Disorders, HIV Infections
Interventions: Antidepressant Medication; Drug
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years to 75 Years
Enrollment: 265 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2004
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: HIV
Interventions: Truvada qd, Maraviroc 300 qd; Drug
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 44 Years · Female only
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 2
States / cities: Atlanta, Georgia

Conditions: Hiv, Adolescent Behavior, Sex, Safe
Interventions: Queer Sex Ed, Keep It Up, Keep It Up-Control, Young Men's Health Project; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 13 Years to 18 Years · Male only
Enrollment: 1,306 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: HIV, STDs
Interventions: Understanding Reproductive Health for Ladeez (GURHL) Code; Behavioral
Lead sponsor: City University of New York, School of Public Health; Other
Eligibility: 18 Years to 25 Years · Female only
Enrollment: 110 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2016
U.S. locations: 1
States / cities: New York, New York

Conditions: HIV Counseling and Testing, HIV Risk Behavior, HIV Prevention
Interventions: Healthcare counseling service; Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 49 Years · Male only
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 2
States / cities: Baltimore, Maryland

Conditions: HIV Infections, Sexually Transmitted Diseases
Interventions: HEART, Growing Minds; Behavioral
Lead sponsor: North Carolina State University; Other
Eligibility: 14 Years to 18 Years
Enrollment: 226 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2019
U.S. locations: 1
States / cities: Raleigh, North Carolina

Conditions: HIV/AIDS, Adherence, Medication
Interventions: Healthy Divas; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older · Male only
Enrollment: 278 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016 – 2020
U.S. locations: 2
States / cities: Los Angeles, California • San Francisco, California

Conditions: HIV
Interventions: strengths-based case management; Behavioral
Lead sponsor: Nova Southeastern University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 562 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2011
U.S. locations: 1
States / cities: Miami, Florida

Conditions: Opioid-use Disorder, HIV Prevention Program
Interventions: Contingency Management with stepped care to PrEP adherence and support services (CoMPASS); Behavioral
Lead sponsor: Yale University; Other
Eligibility: 18 Years and older
Enrollment: 526 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 6
States / cities: Bridgeport, Connecticut • Danbury, Connecticut • New Haven, Connecticut + 1 more

Conditions: HIV Prevention, HIV Risk, Sexual and Reproductive Health
Interventions: Interactive Digital PrEP Toolkit; Behavioral
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years and older · Female only
Enrollment: 125 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2027
U.S. locations: 4
States / cities: Birmingham, Alabama • Montgomery, Alabama • Tuscaloosa, Alabama + 1 more

Conditions: Cardiovascular Diseases, Heart Diseases, HIV Infections, Hyperlipidemia, Hypertriglyceridemia, Insulin Resistance, Atherosclerosis
Interventions: Diet, Exercise, Niacin, Fenofibrate, Placebos; Behavioral · Drug · Other
Lead sponsor: Baylor College of Medicine; Other
Eligibility: 18 Years to 65 Years
Enrollment: 221 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2012
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Behavior, Risk
Interventions: HIV, General health; Behavioral
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 25 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Substance Abuse, HIV Risk, Shame, Guilt, Empathy, Criminogenic Thinking
Interventions: Impact of Crime Modules, TAU; Behavioral
Lead sponsor: George Mason University; Other
Eligibility: 18 Years and older · Male only
Healthy volunteers: Accepts healthy volunteers
Timeline: 2016
U.S. locations: 1
States / cities: Fairfax, Virginia

Conditions: Sexual Behavior
Interventions: Abuse-focused intervention, Sexual behavior-focused intervention; Behavioral
Lead sponsor: The Miriam Hospital; Other
Eligibility: 18 Years and older · Female only
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Rochester, New York

Conditions: HIV Infection
Interventions: Maraviroc, Emtricitabine, Tenofovir disoproxil fumarate, Maraviroc placebo, Emtricitabine placebo, Tenofovir disoproxil fumarate placebo; Drug · Other
Lead sponsor: National Institute of Allergy and Infectious Diseases (NIAID); NIH
Eligibility: 18 Years and older
Enrollment: 594 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2015
U.S. locations: 12
States / cities: Los Angeles, California • San Francisco, California • Washington D.C., District of Columbia + 9 more

Conditions: HIV Prevention, PrEP
Interventions: Using PrEP, Doing it for Ourselves (UPDOs), Standard of Care; Behavioral · Other
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 1,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Substance Use, Delinquency, Risk for HIV Infection
Interventions: Multidimensional Family Therapy Cross-Systems, Enhanced Services as Usual; Behavioral
Lead sponsor: University of Miami; Other
Eligibility: 13 Years to 17 Years
Enrollment: 154 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2011
U.S. locations: 5
States / cities: Clearwater, Florida • Largo, Florida • Miami, Florida

Conditions: Alcohol Consumption, Unsafe Sex
Interventions: Brief Motivational Intervention (BMI), Brief Advice; Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 3
States / cities: Pawtucket, Rhode Island • Providence, Rhode Island • Warwick, Rhode Island

Conditions: Bisexually-active Men, at Risk for HIV
Interventions: RISE life coaching intervention, HIV Counseling; Behavioral
Lead sponsor: Public Health Management Corporation; Other
Eligibility: 18 Years and older · Male only
Enrollment: 169 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2012
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Coronavirus Disease 2019 (COVID-19), Immunocompromised, Hospitalization, Child, Hospitalized
Interventions: Nirmatrelvir, Ritonavir, Placebo for nirmatrelvir; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 12 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 2
States / cities: Cooperstown, New York • New York, New York

Conditions: Unsafe Sex, Physical Violence, Sexual Assault, Sexual Abuse
Interventions: Nutrition Program (NP), Women's Prison CoOp (WPC); Behavioral
Lead sponsor: Brown University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2014
U.S. locations: 3
States / cities: Framingham, Massachusetts • Cranston, Rhode Island

Conditions: HIV, Risk Reduction Behavior
Interventions: InvestiDate, Non-Health Related Video Game; Behavioral · Other
Lead sponsor: Yale University; Other
Eligibility: 14 Years to 18 Years · Female only
Enrollment: 117 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

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Motivational Interviewing to Increase PrEP Uptake (MI-PrEP)

Brief HIV Prevention Counseling for STI Patients in South Africa

Antidepressant Medication for Reducing HIV Risk Behavior in Depressed Intravenous Drug Users

Characterization and Modulation of Mucosal Immunity for HIV Prevention in Women

A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM

Culturally Congruent HIV Risk Reduction App for Young Women, an Acceptability & Pilot Evaluation

Safe Spaces 4 Sexual Health

Reducing HIV Risk Among Adolescents: Evaluating HEART for Teens

Improving Engagement in HIV Care for High-risk Women

Case Management Alternatives for African American Women at High Risk for HIV

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

Evaluating an Interactive Digital Toolkit for Women's PrEP Implementation

Diet, Exercise, Niacin, and Fenofibrate to Reduce Heart Disease Risk Factors in Individuals With HIV Lipodystrophy or Dyslipidemia

Development and Piloting of a Just-in-Time, Personalized HIV Prevention Intervention for Youth Experiencing Homelessness and Unstable Housing

Victim Impact Modules for Jail Inmates

Development of a Novel HIV Risk Reduction Intervention for Abused Women

Evaluating the Safety and Tolerability of Antiretroviral Drug Regimens Used as Pre-Exposure Prophylaxis to Prevent HIV Infection in At-Risk Men Who Have Sex With Men and in At-Risk Women

Using PrEP, Doing It for Ourselves

Juvenile Detention to Community Life

Brief Interventions in the Emergency Department for Alcohol and HIV/Sexual Risk

Evaluation of a New HIV Prevention Intervention for Black Bisexually-active Men

A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19

HIV/STI Risk Reduction for Incarcerated Women With Interpersonal Violence

A Digital Intervention for HIV Prevention in Black Adolescent Girls