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Showing 1–24 of 49 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sciatic Nerve Clear all
Recruiting Phase 3 Interventional

Efficacy of EXPAREL vs. Bupivacaine

NCT07212114
View directory record Official record
Conditions
Total Ankle Arthroplasty, Postsurgical Analgesia
Interventions
EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml
Drug
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
104 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Feb 22, 2026 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Phase 4 Interventional Results available

Analgesic Benefits of Perineural Versus Intravenous Dexamethasone in Patients Receiving Sciatic Nerve Block

NCT01616173
View directory record Official record
Conditions
Fracture of Ankle
Interventions
Dexamethasone, Saline
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 70 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)

NCT02223364
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Peripheral nerve blocks with Bupivacaine, Intra articular injection with Ropivacaine, Intra articular injection with liposomal bupivacaine
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
165 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 30, 2017 · Synced Sep 4, 2026, 7:08 PM EDT
Withdrawn Not applicable Interventional

Trial Comparing Duration of Analgesia After Popliteal Fossa Sciatiac Nerve Block With Ropivacaine 0.5% When Combined With Placebo, Dexamethasone 4mg or Dexamethasone 8 mg

NCT01641419
View directory record Official record
Conditions
Pain, Sciatic Block
Interventions
Placebo, Dexamethasone 4 mg, Dexamethasone 8 mg
Drug
Lead sponsor
Baylor College of Medicine
Other
Eligibility
18 Years to 64 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Sep 4, 2026, 7:08 PM EDT
Recruiting Not applicable Interventional

Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care

NCT07397117
View directory record Official record
Conditions
Sciatica Acute
Interventions
nerve block with ropivacaine, Standard medical treatment
Procedure · Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Sep 4, 2026, 7:08 PM EDT
Terminated Phase 4 Interventional

Ultrasound-Guided Continuous Sciatic Nerve Blocks: Popliteal Versus Subgluteal Catheters

NCT01325012
View directory record Official record
Conditions
Foot Surgery
Interventions
Subgluteal Sciatic Nerve Block, Popliteal Sciatic Nerve Block
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
La Jolla, California • San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 28, 2013 · Synced Sep 4, 2026, 7:08 PM EDT
Completed No phase listed Observational

Effectiveness Study of Physical Therapy as an Adjunct to a Lumbar Therapeutic Selective Nerve Root Block

NCT00934284
View directory record Official record
Conditions
Sciatic Neuropathy, Radiculopathy, Intervertebral Disk Displacement
Interventions
Lumbar injection, Rehabilitation following lumbar injection
Other
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 60 Years
Enrollment
44 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 4, 2026, 7:08 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

A Comparison of Two Injection Locations in Obese Patients Having Lower Leg/Foot Surgery

NCT01550094
View directory record Official record
Conditions
Strain of Muscle and/or Tendon of Lower Leg, Fracture of Lower Leg, Crushing Injury of Lower Leg, Fracture Malunion - Ankle and/ or Foot, Complete Tear, Ankle and/or Foot Ligament, Pathological Fracture - Ankle and/or Foot, Loose Body in Joint of Ankle and/or Foot
Interventions
Not listed
Lead sponsor
Jose Soberon, MD
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2015
U.S. locations
1
States / cities
New Orleans, Louisiana
Source: ClinicalTrials.gov public record
Updated Oct 13, 2015 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Not applicable Interventional

Prospective Femoral Versus Femoral and Sciatic Nerve Block for Anterior Cruciate Ligament (ACL) Reconstruction

NCT01447277
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
Sciatic Block, Femoral Block only
Procedure
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Feb 20, 2020 · Synced Sep 4, 2026, 7:08 PM EDT
Active, not recruiting Phase 1Phase 2 Interventional Accepts healthy volunteers

Efficacy of Non-weight Based, Low Dose Dex-Dex Adjuncts in Prolonging Peripheral Nerve Blocks

NCT07099222
View directory record Official record
Conditions
Postoperative Pain, Nausea and Vomiting, Postoperative, Dizziness, Constipation, Duration of Response, Narcotics Consumption, Pain After Surgery
Interventions
Low, non-weight based dose of Dexamethasone and Dexmedetomidine in peripheral nerve blocks, Ropivacaine with low, non weight based Dexamethasone additive
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 75 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 4, 2026, 7:08 PM EDT
Completed No phase listed Observational

Cost Effectiveness of OMT for Chronic Low Back Pain

NCT03532230
View directory record Official record
Conditions
Lumbar Radiculopathy, Lesion of Sciatic Nerve, Left Lower Limb, Lesion of Sciatic Nerve, Right Lower Limb, Lumbar Spinal Stenosis, Lumbar Spondylosis, Lumbago With Sciatica, Left Side, Lumbago With Sciatica, Right Side
Interventions
Osteopathic Manipulative Treatment (OMT)
Procedure
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 84 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
3
States / cities
East Lansing, Michigan • Stratford, New Jersey • Voorhees Township, New Jersey
Source: ClinicalTrials.gov public record
Updated May 3, 2020 · Synced Sep 4, 2026, 7:08 PM EDT
Terminated Not applicable Interventional Results available

The Effects of Dexamethasone on the Duration of Sciatic Nerve Blocks

NCT00616603
View directory record Official record
Conditions
Total Knee Arthroplasty
Interventions
Ropivacaine, Dexamethasone, Normal Saline
Drug
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 80 Years
Enrollment
43 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2011
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Jun 10, 2014 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Not applicable Interventional Results available

A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)

NCT00580294
View directory record Official record
Conditions
Pain
Interventions
Oxymorphone
Drug
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 2, 2016 · Synced Sep 4, 2026, 7:08 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Pre-post Spinal Popliteal Block

NCT05354791
View directory record Official record
Conditions
Foot Surgery, Ankle Surgery
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
Not listed
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2024 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Phase 3 Interventional Results available

Phase 3, Sciatic Nerve Block With EXPAREL for Subjects Undergoing Bunionectomy

NCT05157841
View directory record Official record
Conditions
Bunionectomy, Hallux Valgus
Interventions
Bupivacaine liposome injectable suspension 266 mg, Bupivacaine HCl, Bupivacaine liposome injectable suspension 133 mg
Drug
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
18 Years and older
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
7
States / cities
North Little Rock, Arkansas • Pasadena, California • Dayton, Ohio + 4 more
Source: ClinicalTrials.gov public record
Updated Jun 25, 2025 · Synced Sep 4, 2026, 7:08 PM EDT
Terminated Not applicable Interventional Results available

Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement

NCT02161484
View directory record Official record
Conditions
Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty, Peripheral Nerve Block, Lumbar Plexus Nerve Block, Parasacaral (Sciatic) Nerve Block
Interventions
Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%, Bupivacaine 0.0625%
Procedure · Drug
Lead sponsor
Rita Merman
Other
Eligibility
18 Years to 75 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 28, 2018 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sciatic Technique Comparison of Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents

NCT02947633
View directory record Official record
Conditions
Anterior Cruciate Ligament (ACL) Tear
Interventions
Single-injection sciatic PNB, Continuous sciatic PNB
Drug
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
10 Years to 18 Years
Enrollment
141 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2024
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Not applicable Interventional

Obturator Nerve Block With Femoral and Sciatic Block

NCT01409460
View directory record Official record
Conditions
Nerve Block; Pain Medication
Interventions
Oburator Nerve block, Sham Injection in pectineus muscle.
Procedure
Lead sponsor
Trinity Health Of New England
Other
Eligibility
18 Years to 85 Years
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
Hartford, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 3, 2011 · Synced Sep 4, 2026, 7:08 PM EDT
Terminated Phase 4 Interventional Results available

A Study Comparing Continuous Sciatic Nerve Block to Single Shot Sciatic Nerve Block

NCT01615939
View directory record Official record
Conditions
Fracture of Foot
Interventions
Bupivacaine, Ropivacaine
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 80 Years
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 31, 2016 · Synced Sep 4, 2026, 7:08 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Strain-Counterstrain Treatment of Piriformis Pain

NCT05023005
View directory record Official record
Conditions
Low Back Pain, Mechanical, Piriformis Syndrome, Somatic Dysfunction of Sacral Region (Finding)
Interventions
Strain-Counterstrain treatment of piriformis muscle
Other
Lead sponsor
Loma Linda University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Apr 23, 2026 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Phase 4 Interventional

Ultrasound Guidance Versus Electrical Stimulation for Continuous Popliteal-Sciatic Nerve Blocks

NCT00876681
View directory record Official record
Conditions
Postoperative Pain, Foot Numbness
Interventions
Popliteal catheter placed via ultrasound or electrical stimulation
Procedure
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Oct 7, 2009 · Synced Sep 4, 2026, 7:08 PM EDT
Terminated Phase 3 Interventional Results available

IPACK Versus Popliteal Sciatic Nerve Block in ACL Reconstruction

NCT03983941
View directory record Official record
Conditions
Anterior Cruciate Ligament Tear
Interventions
Ropivacaine injection
Drug
Lead sponsor
Sujana Dontukurthy
Other
Eligibility
Up to 21 Years
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 15, 2021 · Synced Sep 4, 2026, 7:08 PM EDT
Withdrawn No phase listed Observational

Comparing the Ultrasound Appearance of the Sciatic Nerve With Its Appearance Under a Microscope

NCT02384447
View directory record Official record
Conditions
Diabetes
Interventions
Not listed
Lead sponsor
University of Toledo Health Science Campus
Other
Eligibility
18 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
Toledo, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 9, 2015 · Synced Sep 4, 2026, 7:08 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks

NCT01898689
View directory record Official record
Conditions
Relatively Healthy Volunteers
Interventions
Ropivacaine 0.1%, Ropivacaine 0.4%
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 18, 2021 · Synced Sep 4, 2026, 7:08 PM EDT