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Showing 1–24 of 34 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Second Trimester Abortions Clear all
Completed Not applicable Interventional Results available

Pre-Operative Effects of Mifepristone on Dilation and Evacuation Services

NCT01862991
View directory record Official record
Conditions
Legally Induced Abortion Without Mention of Complication
Interventions
Hygroscopic cervical dilators, Misoprostol, Intra-amniotic digoxin, Mifepristone
Other · Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
2
States / cities
San Jose, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 13, 2024 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Phase 4 Interventional Results available

Overnight Pain Treatment Investigating Opioids vs. Nonopioids

NCT03545893
View directory record Official record
Conditions
Abortion Second Trimester
Interventions
Ibuprofen 600 mg, OxyCODONE 5 Mg Oral Tablet
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older · Female only
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 24, 2020 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation

NCT02033083
View directory record Official record
Conditions
Second Trimester Abortion
Interventions
Laminaria, Dilapan-S
Device
Lead sponsor
Planned Parenthood of Greater New York
Other
Eligibility
18 Years and older · Female only
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 11, 2021 · Synced Sep 15, 2026, 10:03 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Pharmacological Inhibition of Lactation After 16 to 20 Week Abortion

NCT06123026
View directory record Official record
Conditions
Lactation Suppressed, Second Trimester Abortion
Interventions
Cabergoline, Placebo
Drug
Lead sponsor
Northwestern University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 28, 2024 · Synced Sep 15, 2026, 10:03 PM EDT
Recruiting Phase 2 Interventional

Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement

NCT07487246
View directory record Official record
Conditions
Pain Management, Abortion, Second Trimester Abortion, Dilation and Evacuation
Interventions
Ketorolac, oral ibuprofen, Placebo, Lidocaine HCl 1%, Saline
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Immediate vs. Delayed Insertion of Copper T 380A IUD After Termination of Pregnancy Over 12-weeks Gestation

NCT00540046
View directory record Official record
Conditions
Contraception Behavior
Interventions
Copper T 380A IUD
Device
Lead sponsor
NYU Langone Health
Other
Eligibility
16 Years and older · Female only
Enrollment
215 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
2
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 8, 2015 · Synced Sep 15, 2026, 10:03 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Same-day Dilapan-S With Adjunctive Misoprostol

NCT01818414
View directory record Official record
Conditions
Therapeutic Abortion
Interventions
Misoprostol, Folic Acid
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older · Female only
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 27, 2017 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mifepristone and Mid-Trimester Termination of Pregnancy

NCT00382538
View directory record Official record
Conditions
Abortion, Induced, Abortion, Second Trimester
Interventions
Addition of mifepristone 200 mg 24 hours before induction
Drug
Lead sponsor
Boston University
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2006
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2008 · Synced Sep 15, 2026, 10:03 PM EDT
Terminated Phase 3 Interventional Results available

Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion

NCT01436266
View directory record Official record
Conditions
Abortion, Blood Loss
Interventions
Misoprostol, Folic acid
Drug · Other
Lead sponsor
Boston University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mifepristone Versus Laminaria for Cervical Ripening in Midtrimester Induction

NCT00383032
View directory record Official record
Conditions
Abortion, Induced
Interventions
mifepristone
Drug
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
16 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2006
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Oct 23, 2023 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study of Priming Before Induction Termination of Pregnancy

NCT00495560
View directory record Official record
Conditions
Abortion, Induced, Abortion, Second Trimester
Interventions
Addition of misoprostol 25 mcg 12 hours before induction
Drug
Lead sponsor
Boston University
Other
Eligibility
18 Years to 45 Years · Female only
Enrollment
25 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2008 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E

NCT03134183
View directory record Official record
Conditions
Abortion, Second Trimester
Interventions
Vaginal Misoprostol, Buccal Misoprostol
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
70 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 17, 2018 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Phase 2 Interventional Results available

Cabergoline for Lactation Inhibition After Early Second-Trimester Abortion or Pregnancy Loss

NCT06029673
View directory record Official record
Conditions
Lactation Suppressed
Interventions
Cabergoline 1 MG, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
2
States / cities
San Jose, California • Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Sep 15, 2026, 10:03 PM EDT
Terminated Not applicable Interventional Results available

Pilot Study of the Addition of Osmotic Dilators to Preparation Prior to Labor Induction Abortion

NCT00855842
View directory record Official record
Conditions
Abortion, Induced
Interventions
osmotic dilator insertion
Device
Lead sponsor
Boston University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 7, 2011 · Synced Sep 15, 2026, 10:03 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Cervical Preparation for Same-Day Dilation & Evacuation

NCT06799052
View directory record Official record
Conditions
Abortion, Second Trimester, Procedural Pain, Procedural Complication
Interventions
Transcervical single-balloon catheter, Synthetic osmotic dilators
Device
Lead sponsor
Boston Medical Center
Other
Eligibility
16 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 29, 2026 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Nitrous Oxide Versus Intravenous Sedation for Anesthesia

NCT02755090
View directory record Official record
Conditions
Pregnancy Termination in Second Trimester
Interventions
Nitrous Oxide, IV Saline
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older · Female only
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
2
States / cities
Denver, Colorado • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Transcervical Balloon Compared to Osmotic Dilators Prior to Surgical Abortion

NCT05099991
View directory record Official record
Conditions
Abortion, Second Trimester
Interventions
Single Foley Balloon, Dilapan-S
Device
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2023
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Apr 17, 2024 · Synced Sep 15, 2026, 10:03 PM EDT
Terminated Phase 3 Interventional Results available

MisOpRostol Effect on Second Trimester Abortion Blood Loss

NCT06078501
View directory record Official record
Conditions
Blood Loss, Surgical, Second Trimester Abortion
Interventions
Misoprostol 400mcg buccal, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
7 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 23, 2025 · Synced Sep 15, 2026, 10:03 PM EDT
Withdrawn Phase 2Phase 3 Interventional

Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation

NCT07537894
View directory record Official record
Conditions
Abortion, Stillbirth, PTSD (Childbirth-Related), Grief (Traumatic Grief and Existential Grief)
Interventions
Dexmedetomidine (IV) 0.5 mcg/kg, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Misoprostol Alone to Dilapan With Misoprostol and Comparing Buccal to Vaginal Misoprostol

NCT02363556
View directory record Official record
Conditions
Second Trimester Abortions
Interventions
Misoprostol administered vaginally, Misoprostol administered buccally, Misoprostol administered vaginally with Dilapan, Misoprostol administered buccally with Dilapan
Procedure
Lead sponsor
Medstar Health Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
160 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Silver Spring, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 29, 2017 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional

TENS Unit To Decrease Pain After Laminaria Insertion

NCT06529003
View directory record Official record
Conditions
Second Trimester Abortion
Interventions
Transcutaneous Electrical Nerve Stimulation (TENS) unit, Placebo
Device
Lead sponsor
Queen's Medical Center
Other
Eligibility
18 Years and older · Female only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2025
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 15, 2026, 10:03 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes

NCT06820177
View directory record Official record
Conditions
Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use, Blood Loss
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older · Female only
Enrollment
276 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
3
States / cities
San Diego, California • Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Jun 14, 2026 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

OPIOID Study - Pain With Osmotic Dilators

NCT03710239
View directory record Official record
Conditions
Abortion in Second Trimester
Interventions
Dilapan-S, Laminaria
Device
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older · Female only
Enrollment
68 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Albany, New York
Source: ClinicalTrials.gov public record
Updated Mar 15, 2020 · Synced Sep 15, 2026, 10:03 PM EDT
Completed Phase 2 Interventional Results available

Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss

NCT04701333
View directory record Official record
Conditions
Lactation Suppressed
Interventions
Cabergoline 1 MG, Placebo
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older · Female only
Enrollment
73 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2024 · Synced Sep 15, 2026, 10:03 PM EDT