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Showing 1–24 of 53 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Seminal Fluid Clear all
Recruiting Phase 2 Interventional Accepts healthy volunteers

Effects of NLS-133, a Potential Non-Hormonal "On-Demand" Male Contraceptive

NCT07393334
View directory record Official record
Conditions
Male Contraception, Semen Volume, Sperm Motility
Interventions
NLS-133, Placebo, Active Comparator #1
Drug
Lead sponsor
Next Life Sciences
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Study of the Consumer Use of a New Home Test to Measure Sperm Concentration

NCT02475395
View directory record Official record
Conditions
Fertility, Male, Sub-Fertility, Male
Interventions
TRAK device
Device
Lead sponsor
Sandstone Diagnostics
Industry
Eligibility
20 Years to 50 Years
Enrollment
272 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
3
States / cities
Encino, California • Tarzana, California • Great Neck, New York
Source: ClinicalTrials.gov public record
Updated Oct 17, 2017 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

The Biology of HIV Transmission

NCT00001092
View directory record Official record
Conditions
HIV Infections
Interventions
Not listed
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2008
U.S. locations
3
States / cities
Los Angeles, California • San Diego, California • San Francisco, California
Source: ClinicalTrials.gov public record
Updated Oct 21, 2015 · Synced Sep 9, 2026, 1:03 AM EDT
Terminated No phase listed Observational

Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor Stem Cell Transplant

NCT01077440
View directory record Official record
Conditions
Cancer Survivor, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms, Neuroblastoma, Testicular Germ Cell Tumor
Interventions
DNA analysis, polymerase chain reaction, flow cytometry, laboratory biomarker analysis
Genetic · Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older · Male only
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational

A Study of the Pre- and Post-operative Semen Analyses and Reproductive Hormone Levels of Men Undergoing Weight-reduction Surgery

NCT00596739
View directory record Official record
Conditions
Male Infertility
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 16, 2016 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational

Determination of HIV-1 Production by the Prostate

NCT00001584
View directory record Official record
Conditions
HIV Infections
Interventions
Not listed
Lead sponsor
National Cancer Institute (NCI)
NIH
Eligibility
Male only
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2001
U.S. locations
1
States / cities
Bethesda, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 3, 2008 · Synced Sep 9, 2026, 1:03 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Male Fertility Program

NCT01467869
View directory record Official record
Conditions
Spinal Cord Injury
Interventions
Not listed
Lead sponsor
University of Miami
Other
Eligibility
18 Years to 50 Years · Male only
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1991 – 2040
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 16, 2026 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg

NCT00382135
View directory record Official record
Conditions
Erectile Dysfunction
Interventions
tadalafil, placebo
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
45 Years and older · Male only
Enrollment
282 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Oct 24, 2007 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Environment and Reproductive Health; Human Exposure to Bisphenol A, Phthalates and Fertility and Pregnancy Outcomes

NCT00011713
View directory record Official record
Conditions
Infertility
Interventions
Completion questionnaires/providing biological samples
Other
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
18 Years to 55 Years
Enrollment
1,474 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2020
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 10, 2020 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational

Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors

NCT00499798
View directory record Official record
Conditions
Brain and Central Nervous System Tumors, Chemotherapeutic Agent Toxicity, Infertility
Interventions
Not listed
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
18 Years to 60 Years · Male only
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2014
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated May 29, 2017 · Synced Sep 9, 2026, 1:03 AM EDT
Withdrawn No phase listed Observational Accepts healthy volunteers

A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0

NCT02839447
View directory record Official record
Conditions
Male Infertility
Interventions
Diagnostic
Diagnostic Test
Lead sponsor
Aytu BioPharma, Inc.
Industry
Eligibility
21 Years to 45 Years · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
6
States / cities
Miami, Florida • New Orleans, Louisiana • Rochester, Minnesota + 3 more
Source: ClinicalTrials.gov public record
Updated Mar 7, 2024 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Not applicable Interventional

The Effects of Thymopentin on HIV Infectivity of Blood Cells and Semen in HIV-Infected Patients

NCT00002289
View directory record Official record
Conditions
HIV Infections
Interventions
Thymopentin
Drug
Lead sponsor
Immunobiology Research Institute
Industry
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
U.S. locations
1
States / cities
Annandale, New Jersey
Source: ClinicalTrials.gov public record
Updated Jun 23, 2005 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Residence Time of Biomarkers of Semen Exposure

NCT00984555
View directory record Official record
Conditions
Semen Exposure
Interventions
Not listed
Lead sponsor
CONRAD
Other
Eligibility
18 Years to 55 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
2
States / cities
Baltimore, Maryland • Norfolk, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 21, 2010 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effect of Udenafil on Spermatogenesis

NCT01230541
View directory record Official record
Conditions
Spermatogenesis, Erectile Dysfunction
Interventions
Placebo, Udenafil
Drug
Lead sponsor
Warner Chilcott
Industry
Eligibility
25 Years to 64 Years · Male only
Enrollment
239 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
23
States / cities
Huntsville, Alabama • Anaheim, California • San Diego, California + 19 more
Source: ClinicalTrials.gov public record
Updated Nov 29, 2011 · Synced Sep 9, 2026, 1:03 AM EDT
Not listed No phase listed Observational

Relationship of the Microenvironment and Male Fertility

NCT04704141
View directory record Official record
Conditions
Male Infertility, Male Hypogonadism
Interventions
Hormone replacement therapy
Drug
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years and older · Male only
Enrollment
150 participants
Timeline
2023 – 2026
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

GSK1349572 Exposure in Blood, Seminal Fluid, and Rectal Fluid and Tissue in Healthy Male Subjects

NCT01459315
View directory record Official record
Conditions
Healthy
Interventions
dolutegravir
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 49 Years · Male only
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 3, 2013 · Synced Sep 9, 2026, 1:03 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Assessing the Effect of Abstinence Period on Semen Parameters

NCT05701163
View directory record Official record
Conditions
Infertility, Male
Interventions
Abstinence followed by semen sample collection.
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
20 Years to 45 Years · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 26, 2025 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers

NCT01595308
View directory record Official record
Conditions
Male Infertility
Interventions
Pomegranate juice
Dietary Supplement
Lead sponsor
POM Wonderful LLC
Industry
Eligibility
18 Years to 40 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated May 13, 2012 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

The Impact of Prednisone on Semen Parameters and Pregnancy Rates Post Vasectomy Reversal

NCT04788823
View directory record Official record
Conditions
Vasectomy Reversal
Interventions
Prednisone
Drug
Lead sponsor
Charitable Union for the Research and Education of Peyronie's Disease
Other
Eligibility
18 Years to 65 Years · Male only
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Orem, Utah
Source: ClinicalTrials.gov public record
Updated Aug 25, 2026 · Synced Sep 9, 2026, 1:03 AM EDT
Terminated Phase 2 Interventional Results available

A Trial to Compare Efficacy and Safety of Follitropin Delta Versus Placebo (Inactive Treatment) in the Treatment of Men With Idiopathic Infertility (Unexplained Reduction of Semen Quality) (ADAM)

NCT05403476
View directory record Official record
Conditions
Male Idiopathic Infertility
Interventions
FE 999049, Placebo
Drug
Lead sponsor
Ferring Pharmaceuticals
Industry
Eligibility
18 Years to 50 Years · Male only
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
13
States / cities
Tempe, Arizona • San Jose, California • Centennial, Colorado + 10 more
Source: ClinicalTrials.gov public record
Updated Aug 27, 2026 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Not applicable Interventional Results available

Home Semen Testing in Men Beginning Attempts to Conceive

NCT05503862
View directory record Official record
Conditions
Male Infertility
Interventions
YoSperm
Device
Lead sponsor
Northwestern University
Other
Eligibility
18 Years and older · Male only
Enrollment
106 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2025
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 2, 2026 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Folic Acid and Zinc Supplementation Trial (FAZST)

NCT01857310
View directory record Official record
Conditions
Pregnancy, Live Birth, Spontaneous Abortion
Interventions
5 mg folic acid and 30 mg elemental zinc, Placebo Comparator: Placebo
Dietary Supplement · Drug
Lead sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Eligibility
18 Years to 45 Years
Enrollment
2,370 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2019
U.S. locations
4
States / cities
Chicago, Illinois • Iowa City, Iowa • Minneapolis, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 18, 2020 · Synced Sep 9, 2026, 1:03 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue

NCT00855088
View directory record Official record
Conditions
HIV/AIDS, HIV Infections
Interventions
darunavir, Ritonavir, Etravirine
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 49 Years · Male only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated May 12, 2011 · Synced Sep 9, 2026, 1:03 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Evaluation of New Semen Collection & Transportation Kit

NCT04536545
View directory record Official record
Conditions
Sperm Parameters in Fertile and Infertile Men
Interventions
Not listed
Lead sponsor
Turtle Health, Inc.
Industry
Eligibility
Male only
Enrollment
66 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2021
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 5, 2021 · Synced Sep 9, 2026, 1:03 AM EDT