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Showing 1–24 of 45 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Separation Anxiety Disorder Clear all
Active, not recruiting Not applicable Interventional

Comparative Effectiveness of Internet-based Versus Parent-Coached Cognitive-Behavioral Therapy For Children and Adolescents With Anxiety and OCD

NCT07024758
View directory record Official record
Conditions
Obsessive Compulsive Disorder (OCD), Anxiety Disorder of Childhood or Adolescence, Social Anxiety Disorder of Childhood, Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder, Panic Disorder, Panic Attacks, Panic Disorder (With or Without Agoraphobia), Phobia, Specific
Interventions
Parent Coached Exposure Therapy, Family Based, Internet-Based Cognitive Behavioral Therapy
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
7 Years to 17 Years
Enrollment
174 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 29, 2026 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional

Explanatory Clinical Trial of a Novel Parent Intervention for Childhood Anxiety (SPACE)

NCT02310152
View directory record Official record
Conditions
Anxiety Disorders, Anxiety, Separation, Phobic Disorders
Interventions
Parent-Based Treatment of Child and Adolescent Anxiety Disorders, CBT
Behavioral
Lead sponsor
Yale University
Other
Eligibility
7 Years to 14 Years
Enrollment
124 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 8, 2020 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Child and Adolescent Anxiety Disorders (CAMS)

NCT00052078
View directory record Official record
Conditions
Anxiety Disorders, Social Phobia, Generalized Anxiety Disorder
Interventions
Sertraline (SRT), Cognitive Behavioral Therapy (CBT), Placebo
Drug · Behavioral
Lead sponsor
Johns Hopkins University
Other
Eligibility
7 Years to 17 Years
Enrollment
488 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2008
U.S. locations
6
States / cities
Los Angeles, California • Baltimore, Maryland • New York, New York + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 18, 2017 · Synced Sep 5, 2026, 2:42 AM EDT
Active, not recruiting Not applicable Interventional

Evaluation of Family-Based Behavioral Treatments for Youth With Anxiety and Obsessive-Compulsive Disorder

NCT05967468
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Conditions
Obsessive-Compulsive Disorder in Children, Anxiety Disorder of Childhood, Social Anxiety Disorder of Childhood, Obsessive-Compulsive Disorder in Adolescence, Generalized Anxiety Disorder, Separation Anxiety, Panic Disorder, Panic Disorder With Agoraphobia, Panic Attacks
Interventions
Family Based, Internet-Based Cognitive Behavioral Therapy, Bibliotherapy, low therapist contact SPACE, Relaxation and Mentorship
Behavioral · Other
Lead sponsor
Baylor College of Medicine
Other
Eligibility
7 Years to 13 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Sep 1, 2026 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders

NCT03585010
View directory record Official record
Conditions
Anxiety Disorder of Childhood, Separation Anxiety Disorder of Childhood, Social Anxiety Disorder of Childhood, Generalized Anxiety Disorder
Interventions
Supportive Parenting for Anxious Childhood Emotions, Parent Educational Support, Cognitive-Behavioral Therapy
Behavioral
Lead sponsor
Yale University
Other
Eligibility
6 Years to 12 Years
Enrollment
214 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 21, 2026 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Virtual Reality System to Increase Access to Exposure Therapy for Anxiety and OCD

NCT02713516
View directory record Official record
Conditions
Anxiety, Obsessive Compulsive Disorder
Interventions
Virtual Reality
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
7 Years to 12 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 12, 2018 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional

Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment

NCT02305537
View directory record Official record
Conditions
Social Anxiety Disorder, Specific Phobia, Separation Anxiety Disorder, Panic Disorder, Agoraphobia, Obsessive-Compulsive Disorder
Interventions
McLean Anxiety Mastery Program
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
6 Years to 19 Years
Enrollment
559 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 19, 2025 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety

NCT02810171
View directory record Official record
Conditions
Anxiety Disorders, Social Anxiety Disorder, Social Phobia, Generalized Anxiety Disorder, Separation Anxiety Disorder, Specific Phobia, Phobia, Agoraphobia, Panic Disorder, Panic Attack, Anxiety
Interventions
Cognitive Behavioral Therapy, Relaxation Therapy
Behavioral
Lead sponsor
University of Michigan
Other
Eligibility
7 Years to 17 Years
Enrollment
207 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 19, 2021 · Synced Sep 5, 2026, 2:42 AM EDT
Active, not recruiting Phase 3 Interventional Accepts healthy volunteers

Partners in Caring for Anxious Youth

NCT04598230
View directory record Official record
Conditions
Anxiety, Separation, Anxiety, Generalized, Anxiety, Social
Interventions
Cognitive Behavioral Therapy (CBT), Combination therapy (COMB)
Behavioral · Drug
Lead sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Other
Eligibility
7 Years to 17 Years
Enrollment
468 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
3
States / cities
Los Angeles, California • Chicago, Illinois • Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 30, 2026 · Synced Sep 5, 2026, 2:42 AM EDT
Terminated Not applicable Interventional

Attention Bias Modification Treatment for Anxious Youth

NCT01979263
View directory record Official record
Conditions
Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Phobia, Specific Phobia, Obsessive-Compulsive Disorder
Interventions
Attention Bias Modification Computer Task, Placebo Computer Task
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
7 Years to 17 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
2
States / cities
New York, New York • White Plains, New York
Source: ClinicalTrials.gov public record
Updated Jul 29, 2019 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Computerized Cognitive Behavioral Therapy for Childhood Anxiety in Community Health Centers

NCT01416805
View directory record Official record
Conditions
Generalized Anxiety Disorder, Social Phobia, Separation Anxiety Disorder
Interventions
Computerized Cognitive Behavioral Therapy, Treatment as usual
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
7 Years to 13 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
4
States / cities
Clearwater, Florida • Fort Lauderdale, Florida • Pensacola, Florida + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Sep 5, 2026, 2:42 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Acoustic Neuromodulation (ANM) for Youth With Anxiety Disorders

NCT02572973
View directory record Official record
Conditions
Separation Anxiety Disorder, Generalized Anxiety Disorder, Social Phobia
Interventions
Acoustic Neuromodulation (ANM)
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
7 Years to 17 Years
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 13, 2019 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional

Comparison of Virtual Reality to Tablet-based Distraction in Children

NCT04414501
View directory record Official record
Conditions
Anxiety, Separation
Interventions
Separation Anxiety
Behavioral
Lead sponsor
Loma Linda University
Other
Eligibility
4 Years to 10 Years
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Loma Linda, California
Source: ClinicalTrials.gov public record
Updated Mar 14, 2021 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders

NCT01565629
View directory record Official record
Conditions
Autism, Asperger's Syndrome, Generalized Anxiety Disorder, Social Phobia, Separation Anxiety Disorder, Obsessive-compulsive Disorder
Interventions
Computer assisted cognitive behavioral therapy.
Behavioral
Lead sponsor
University of South Florida
Other
Eligibility
7 Years to 12 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Oct 25, 2017 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Virtual Reality System for Anxiety and OCD

NCT03636022
View directory record Official record
Conditions
Anxiety, Obsessive-Compulsive Disorder
Interventions
VR System, Control
Other
Lead sponsor
Minnesota HealthSolutions
Industry
Eligibility
7 Years to 17 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 14, 2024 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Results available

Threat Interpretation Bias as Cognitive Marker and Treatment Target in Pediatric Anxiety

NCT04245501
View directory record Official record
Conditions
Anxiety Disorders
Interventions
Cognitive Bias Modification for Interpretations (CBM-I), Interpretation Control Condition (ICC)
Other
Lead sponsor
University of Denver
Other
Eligibility
10 Years to 17 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety

NCT01919970
View directory record Official record
Conditions
Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder, Social Phobia, Separation Anxiety Disorder, Obsessive-compulsive Disorder, Specific Phobia
Interventions
Cognitive Behavioral Therapy, Treatment as usual
Other
Lead sponsor
University of South Florida
Other
Eligibility
6 Years to 12 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2017
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Jun 13, 2019 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Pediatric Anxiety Intervention With an Entertaining Video Game: Feasibility Study

NCT02713425
View directory record Official record
Conditions
Anxiety
Interventions
Entertaining Video Game
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
7 Years to 17 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2017
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 3, 2019 · Synced Sep 5, 2026, 2:42 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Treatment of Pediatric Anxiety Disorders by Predicting Treatment Response Through Biocellular Markers and Sleep

NCT02189213
View directory record Official record
Conditions
Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Phobia
Interventions
Sertraline
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
8 Years to 25 Years
Enrollment
14 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 10, 2021 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism

NCT01563003
View directory record Official record
Conditions
Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder, Social Phobia, Separation Anxiety Disorder, Obsessive-compulsive Disorder
Interventions
Cognitive Behavioral Therapy, Treatment as usual
Other
Lead sponsor
University of South Florida
Other
Eligibility
11 Years to 16 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Apr 16, 2015 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Phase 1Phase 2 Interventional

Brief Behavioral Treatment for Anxiety in Young Children

NCT02051192
View directory record Official record
Conditions
Obsessive-compulsive Disorder, Social Phobia, Generalized Anxiety Disorder, Specific Phobia, Separation Anxiety Disorder, Selective Mutism, Anxiety Disorder, Not Otherwise Specified
Interventions
Parent-Led Exposure Therapy, Treatment As Usual
Behavioral · Other
Lead sponsor
University of South Florida
Other
Eligibility
3 Years to 7 Years
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2016
U.S. locations
1
States / cities
St. Petersburg, Florida
Source: ClinicalTrials.gov public record
Updated Oct 5, 2016 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional

Factorial Optimization Trial to Test Effects of Coping Intervention Components

NCT05822687
View directory record Official record
Conditions
Anxiety, Depression, Coping Skills, Emotional Problem
Interventions
Education, Reappraisal Coping, Distraction Coping, Relaxation Coping
Behavioral
Lead sponsor
Arizona State University
Other
Eligibility
9 Years to 12 Years
Enrollment
148 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Tempe, Arizona
Source: ClinicalTrials.gov public record
Updated Apr 28, 2026 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Not applicable Interventional

Sleep, Mood, and Behavior Study

NCT00787397
View directory record Official record
Conditions
Sleep Difficulties in Pediatric Anxiety Disorder, Generalized Anxiety Disorder, Separation Anxiety Disorder, Social Phobia
Interventions
Cognitive Behavioral Therapy-Sleep
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
9 Years to 14 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 7, 2016 · Synced Sep 5, 2026, 2:42 AM EDT
Completed Phase 2 Interventional Results available

SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP)

NCT01470469
View directory record Official record
Conditions
Generalized Anxiety Disorder (GAD), Anxiety, Separation, Phobia, Social
Interventions
SPD503 (extended-release Guanfacine hydrochloride), Placebo
Drug
Lead sponsor
Shire
Industry
Eligibility
6 Years to 17 Years
Enrollment
83 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
33
States / cities
Birmingham, Alabama • Carson, California • Imperial, California + 29 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Sep 5, 2026, 2:42 AM EDT