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ClinicalTrials.gov public records Last synced Oct 21, 2026, 12:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 176 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Septic Shock Clear all

Conditions: Sepsis, Septic Shock
Interventions: Vitamin C, Vitamin B1; Drug
Lead sponsor: Trinity Health Of New England; Other
Eligibility: 18 Years to 90 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Hartford, Connecticut

Conditions: Acute Renal Failure
Interventions: Renal tubule assist device; Device
Lead sponsor: RenaMed Biologics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2007
U.S. locations: 13
States / cities: Birmingham, Alabama • Augusta, Georgia • Chicago, Illinois + 10 more

Conditions: Sepsis Severe, Septic Shock
Interventions: Sepsis Bundle; Other
Lead sponsor: Rhode Island Hospital; Other
Eligibility: 18 Years and older
Enrollment: 10,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Septic Shock
Interventions: Not listed
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Shock, Septic
Interventions: Lactated Ringer, Normal Saline, Plasma-lyte; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 2 Months to 17 Years
Enrollment: 9,041 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2026
U.S. locations: 22
States / cities: Davis, California • Los Angeles, California • San Francisco, California + 19 more

Conditions: Severe Sepsis, Severe Sepsis Without Septic Shock
Interventions: Not listed
Lead sponsor: Beckman Coulter, Inc.; Industry
Eligibility: 18 Years to 89 Years
Enrollment: 40,000 participants
Timeline: 2021 – 2026
U.S. locations: 10
States / cities: Irvine, California • Augusta, Georgia • Indianapolis, Indiana + 6 more

Conditions: Sepsis, Infection
Interventions: Up-front individualized dosing algorithm, Usual Care; Other
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Multiple Organ Failure, Septic Shock, Severe Sepsis
Interventions: Best Practice, early metabolic resuscitation; Other · Dietary Supplement
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 2 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Septic Shock
Interventions: L-Carnitine, Normal Saline; Drug
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2012
U.S. locations: 2
States / cities: Jackson, Mississippi • Charlotte, North Carolina

Conditions: Sepsis, Septic Shock
Interventions: Not listed
Lead sponsor: Bluejay Diagnostics, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 450 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026
U.S. locations: 5
States / cities: Gainesville, Florida • Boston, Massachusetts • Winston-Salem, North Carolina + 2 more

Conditions: Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic, Community Acquired Pneumonia
Interventions: Not listed
Lead sponsor: National Center for Genome Resources; Other
Eligibility: 6 Years and older
Enrollment: 1,200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2010
U.S. locations: 3
States / cities: Detroit, Michigan • Durham, North Carolina

Conditions: Glucose, Metabolism, Isotope Labeling, Immune System and Related Disorders, Critical Illness, Intensive Care Unit (ICU), Sepsis
Interventions: 13C6-Glucose; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Severe Sepsis, Septic Shock, Sepsis
Interventions: Not listed
Lead sponsor: University of Florida; Other
Eligibility: 18 Years and older
Enrollment: 110 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Sepsis, Sepsis, Severe, Septic Shock
Interventions: Sepsis care bundle; Other
Lead sponsor: HealthPartners Institute; Other
Eligibility: 18 Years to 100 Years
Enrollment: 215 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Stillwater, Minnesota

Conditions: Septic Shock
Interventions: Esmolol; Drug
Lead sponsor: Samuel Brown; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Murray, Utah

Conditions: Burns
Interventions: Rosuvastatin, Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2011
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Sepsis, Septic Shock
Interventions: Not listed
Lead sponsor: Bluejay Diagnostics, Inc.; Industry
Eligibility: 22 Years and older
Enrollment: 143 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024
U.S. locations: 7
States / cities: Boston, Massachusetts • St Louis, Missouri • Brooklyn, New York + 4 more

Conditions: Sepsis, Shock, Septic
Interventions: Not listed
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 58 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Jacksonville, Florida

Conditions: Septic Shock
Interventions: D5W, Thiamine; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 88 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2014
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Septic Shock, Weight, Body
Interventions: Not listed
Lead sponsor: Methodist Health System; Other
Eligibility: 18 Years and older
Enrollment: 945 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Septic Shock
Interventions: Acetyl-L-Carnitine; Drug
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 13 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2009
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Sepsis, Septic Shock
Interventions: vasopressin - early initiation, vasopressin - standard initiation; Drug
Lead sponsor: The Cleveland Clinic; Other
Eligibility: 18 Years and older
Enrollment: 300 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Septic Shock
Interventions: Methylene Blue, Phenylephrine; Drug
Lead sponsor: Carilion Clinic; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Roanoke, Virginia

Conditions: Septic Shock
Interventions: Not listed
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2017
U.S. locations: 1
States / cities: Chicago, Illinois

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Vitamin C & Thiamine to Treat Sepsis and Septic Shock

Open-Label Study To Evaluate the Safety and Efficacy of the Renal Assist Device In Patients With Acute Renal Failure

Assessment for Implementation Methods in Sepsis

Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock

Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol

BLOOM: Pragmatic Feasibility Trial

Early Metabolic Resuscitation for Septic Shock

L-Carnitine Administration in Early Sepsis

Multicenter Symphony™ IL-6 Monitoring Sepsis ED Pilot Study

Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests

Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit

The Role of Dysfunctional HDL in Severe Sepsis

EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock

Esmolol to Control Adrenergic Storm in Septic Shock- ROLL-IN 2

Pilot Trial of Statin Use in Burn Patients

Multicenter Symphony IL-6 Monitoring Sepsis ICU Study

Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis

Thiamine as a Metabolic Resuscitator in Septic Shock

Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock

Acetyl-L-Carnitine in the Treatment of Septic Shock

Early Versus Late Adjunctive Vasopressin in Septic Shock

Methylene Blue as a Third-line Vasopressor in Septic Shock

Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock