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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Serious Mental Illness Symptoms Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial

NCT02696109
View directory record Official record
Conditions
Depression, Stress Disorders, Post-traumatic, Bipolar Disorder
Interventions
Treatment As Usual, Cornerstone
Behavioral
Lead sponsor
New York University
Other
Eligibility
17 Years to 18 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 31, 2022 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional

Health Promotion and Fitness for Younger and Older Adults With SMI

NCT02090335
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
Interventions
In SHAPE, Fitness Club Membership
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
21 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 17, 2014 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial 2)

NCT04283994
View directory record Official record
Conditions
Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasms, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Lung Diseases, Interstitial, Peripheral Vascular Disease, Diabetes With End Organ Injury
Interventions
Survey-based Patient/Clinician Jumpstart, EHR-based Clinician Jumpstart
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
756 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jun 23, 2025 · Synced Jun 10, 2026, 5:59 PM EDT
Recruiting Not applicable Interventional

Enhancing Rehabilitation for Veterans With Serious Mental Illness

NCT06586164
View directory record Official record
Conditions
Schizophrenia, Psychosis, Serious Mental Illness, PTSD, Schizoaffective Disorder, Bipolar Disorder
Interventions
Targeted Cognitive Training
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years to 83 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

NCT04723602
View directory record Official record
Conditions
Ebola Virus Disease, Marburg Virus Disease
Interventions
cAd3-Marburg, cAd3-EBO-S
Biological
Lead sponsor
Albert B. Sabin Vaccine Institute
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Aug 2, 2022 · Synced Jun 10, 2026, 5:59 PM EDT
Recruiting Not applicable Interventional

Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital

NCT07359157
View directory record Official record
Conditions
Serious Mental Illness, Psychotic Disorder, Depression, Bipolar
Interventions
Changing Lives and Changing Outcomes-9
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
1
States / cities
Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Reducing Cardiovascular Risk in Adults With Serious Mental Illness

NCT02451670
View directory record Official record
Conditions
Chronic Disease, Mental Disorder, Health Behavior, Bipolar Disorder, Schizophrenia
Interventions
Prioritized Clinical Decision Support
Behavioral
Lead sponsor
HealthPartners Institute
Other
Eligibility
18 Years to 75 Years
Enrollment
10,347 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
3
States / cities
Duluth, Minnesota • Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 4, 2019 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional

Medication Adherence in Older Adults With Serious Mental Illness

NCT00224380
View directory record Official record
Conditions
Schizophrenia, Bipolar Disorder, Depression
Interventions
Using Medications Effectively
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
50 Years and older
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
1
States / cities
Nashua, New Hampshire
Source: ClinicalTrials.gov public record
Updated Sep 22, 2009 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional

Self-Management Training and Automated Telehealth to Improve SMI Health Outcomes

NCT02188732
View directory record Official record
Conditions
Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Depression
Interventions
CBHH+AT, CBHH+SMT, CBHH
Behavioral
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
301 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Cambridge, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional

Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness

NCT03695289
View directory record Official record
Conditions
Obesity, Mentally Ill Persons
Interventions
iOTA SMI, Health Education Control
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 15, 2020 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Improving Outcomes for Individuals With Serious Mental Illness and Diabetes

NCT01410357
View directory record Official record
Conditions
Diabetes Mellitus, Bipolar Disorder, Depression, Psychotic Disorders, Schizophrenia
Interventions
Targeted Training in Illness Management (TTIM)
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 3, 2017 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Augmenting Hospitalization for Serious Mental Illness: Cognitive Bias Modification

NCT03509181
View directory record Official record
Conditions
Depression, Bipolar Disorder, Anxiety Disorders, Psychiatric Disorder
Interventions
I-Change, Symptom Tracking
Behavioral
Lead sponsor
Mclean Hospital
Other
Eligibility
18 Years and older
Enrollment
68 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Belmont, Massachusetts
Source: ClinicalTrials.gov public record
Updated Feb 6, 2024 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Lift Mobile Mindfulness for COVID-19 Distress Symptoms

NCT04581200
View directory record Official record
Conditions
COVID-19, Cardiorespiratory Failure
Interventions
Lift
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
4
States / cities
Aurora, Colorado • Ann Arbor, Michigan • Durham, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Nov 6, 2023 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Phase 3 Interventional Results available

Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD)

NCT00337571
View directory record Official record
Conditions
Behavioral Symptoms, Autistic Disorder
Interventions
Aripiprazole, Placebo
Drug
Lead sponsor
Otsuka Pharmaceutical Development & Commercialization, Inc.
Industry
Eligibility
6 Years to 17 Years
Enrollment
218 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
31
States / cities
Birmingham, Alabama • Dothan, Alabama • Phoenix, Arizona + 28 more
Source: ClinicalTrials.gov public record
Updated May 12, 2026 · Synced Jun 10, 2026, 5:59 PM EDT
Withdrawn Phase 1Phase 2 Interventional

Primary Care iSBIRT to Reduce Serious Teen Health Risks

NCT00891631
View directory record Official record
Conditions
Substance-related Disorders, Depression, High-risk Sex
Interventions
iSBIRT, iSBIRT/TE
Behavioral
Lead sponsor
Boston Children's Hospital
Other
Eligibility
12 Years to 21 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 6, 2016 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Interactive Obesity Treatment Approach for Obesity Prevention in Adults With Early Serious Mental Illness: iOTA-SMI

NCT03980743
View directory record Official record
Conditions
Obesity, Overweight, Severe Mental Disorder
Interventions
iOTA text messaging intervention, Health Education text messaging intervention
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
2
States / cities
Miami, Florida • St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Oct 25, 2024 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Coach to Fit Weight Loss Intervention for Individuals With Serious Mental Illness

NCT04560335
View directory record Official record
Conditions
Serious Mental Illness
Interventions
Coach to FIt, Treatment as Usual
Behavioral
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
257 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 8, 2026 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Project to Improve Communication About Serious Illness - Pilot Study

NCT03746392
View directory record Official record
Conditions
Malignant Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Disease Chronic, Congestive Heart Failure, Liver Failures, Chronic, Renal Insufficiency, Chronic, Dementia, Diabetes Complications, Peripheral Vascular Disease, Frail Elderly
Interventions
Jumpstart Intervention
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
2
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 21, 2025 · Synced Jun 10, 2026, 5:59 PM EDT
Recruiting No phase listed Observational

AIMS Medical Outcomes Study

NCT04512755
View directory record Official record
Conditions
Mental Health Issue, PTSD, Pain, Chronic Pain, Chronic Disease
Interventions
Not listed
Lead sponsor
Advanced Integrative Medical Science Institute
Other
Eligibility
Not listed
Enrollment
500 participants
Timeline
2020 – 2030
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Jan 31, 2023 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Randomized Trial Of Achieving Healthy Lifestyles In Psych Rehabilitation

NCT00902694
View directory record Official record
Conditions
Overweight and Obesity
Interventions
ACHIEVE Intervention, Control
Behavioral · Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
291 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 29, 2025 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)

NCT04281784
View directory record Official record
Conditions
Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive, Heart Failure，Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Lung Diseases, Interstitial, Peripheral Vascular Disease, Diabetes With End Organ Injury
Interventions
EHR-based Clinician Jumpstart
Behavioral
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
2,512 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
3
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Phase 2 Interventional

Reducing Weight and Diabetes Risk in an Underserved Population (STRIDE)

NCT00790517
View directory record Official record
Conditions
Weight Loss, Diabetes Mellitus, Type 2, Psychotic Disorders
Interventions
Premier Lifestyle Intervention with DASH Diet
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2014
U.S. locations
3
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 16, 2015 · Synced Jun 10, 2026, 5:59 PM EDT
Not listed Not applicable Interventional

Multi-component Intervention for Diabetes in Adults With Serious Mental Illness

NCT03627377
View directory record Official record
Conditions
Schizophrenia, Obesity, Diabetes, Lifestyle Risk Reduction, Serious Mental Illness
Interventions
Multi-component Intervention for Diabetes in Adults with Serious Mental Illness
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 65 Years
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2021 · Synced Jun 10, 2026, 5:59 PM EDT
Completed Not applicable Interventional Results available

Project Bridge: Peer Health Navigator Intervention

NCT02022462
View directory record Official record
Conditions
Schizophrenia, Depression, Medical Disorders, Serious Mental Illness
Interventions
Health Navigation
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 65 Years
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Santa Fe Springs, California
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Jun 10, 2026, 5:59 PM EDT