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ClinicalTrials.gov public records Last synced Oct 8, 2026, 8:42 PM EDT

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Showing 73–96 of 183 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Severe Neurologic Injury Clear all
Completed No phase listed Observational

Objective Brain Function Assessment of mTBI/Concussion in College Athletes

NCT02477943
View directory record Official record
Conditions
Brain Injuries, Traumatic, Concussion, Mild, Concussion, Brain, Concussion, Intermediate, Concussion, Severe
Interventions
BrainScope Ahead 200iD, Advanced MRI Neuroimaging
Device
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
18 Years to 25 Years
Enrollment
520 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
11
States / cities
Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 8, 2026, 8:42 PM EDT
Not listed Not applicable Interventional

Improving Bowel Function and Quality of Life After Spinal Cord Injury

NCT03949660
View directory record Official record
Conditions
Neurogenic Bowel
Interventions
Stimulation for blood pressure without stand, Stimulation for blood pressure with stand, Stimulation for trunk and core without stand, Stimulation for trunk or core with stand
Device
Lead sponsor
University of Louisville
Other
Eligibility
18 Years to 75 Years
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
2
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 8, 2026, 8:42 PM EDT
Withdrawn Early Phase 1 Interventional

Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries

NCT02959294
View directory record Official record
Conditions
Traumatic Encephalopathies, Chronic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe, Concussion, Brain
Interventions
Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline IV deployment AD-cSVF
Procedure · Device
Lead sponsor
Robert W. Alexander, MD, FICS
Industry
Eligibility
16 Years to 70 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2024
U.S. locations
1
States / cities
Stevensville, Montana
Source: ClinicalTrials.gov public record
Updated Feb 16, 2021 · Synced Oct 8, 2026, 8:42 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury

NCT02732288
View directory record Official record
Conditions
Disorders of Consciousness
Interventions
melatonin
Dietary Supplement
Lead sponsor
Rockefeller University
Other
Eligibility
18 Years to 65 Years
Enrollment
1 participant
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 30, 2023 · Synced Oct 8, 2026, 8:42 PM EDT
Active, not recruiting Not applicable Interventional

Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation

NCT04123847
View directory record Official record
Conditions
Spinal Cord Injuries
Interventions
Standing and Stepping, Standing, Stepping and Voluntary Movement with spinal cord Epidural Stimulation
Other · Device
Lead sponsor
Susan Harkema PhD
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2025
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Dec 17, 2024 · Synced Oct 8, 2026, 8:42 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

MRI Markers of Feedback Timing During Learning in Individuals with TBI with and Without Clinical Depression

NCT05009511
View directory record Official record
Conditions
Traumatic Brain Injury, Major Depressive Disorder
Interventions
Learning through feedback
Behavioral
Lead sponsor
Kessler Foundation
Other
Eligibility
18 Years to 65 Years
Enrollment
180 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
West Orange, New Jersey
Source: ClinicalTrials.gov public record
Updated Oct 9, 2024 · Synced Oct 8, 2026, 8:42 PM EDT
Completed Phase 1Phase 2 Interventional

Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells

NCT01575470
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
autologous bone marrow mononuclear cells
Biological
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
18 Years to 55 Years
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2015
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 13, 2016 · Synced Oct 8, 2026, 8:42 PM EDT
Completed No phase listed Observational

Validation of Brain Function Assessment Algorithm for mTBI/Concussion in College Athletes

NCT02957461
View directory record Official record
Conditions
Brain Injuries, Traumatic, Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate
Interventions
BrainScope Ahead 200iD
Device
Lead sponsor
BrainScope Company, Inc.
Industry
Eligibility
18 Years to 25 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
8
States / cities
Fayetteville, Arkansas • Storrs, Connecticut • Tampa, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated May 23, 2019 · Synced Oct 8, 2026, 8:42 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Trifecta Research Study

NCT07717866
View directory record Official record
Conditions
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Injury, Depression - Major Depressive Disorder, Suicidal Ideation
Interventions
Magnetic e-Resonance Therapy (MeRT), Ibogaine Hydrochloride with Magnesium Sulfate, 5-methoxy-N,N-dimethyltryptamine, Physiological Supplementation
Device · Drug
Lead sponsor
Axial Therapeutic Research
Industry
Eligibility
18 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Northridge, California
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Oct 8, 2026, 8:42 PM EDT
Completed Phase 2 Interventional

Pediatric Autologous Bone Marrow Mononuclear Cells for Severe Traumatic Brain Injury

NCT01851083
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
autologous bone marrow mononuclear cells, Placebo Infusion
Biological · Other
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
5 Years to 17 Years
Enrollment
47 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2020
U.S. locations
2
States / cities
Phoenix, Arizona • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 20, 2020 · Synced Oct 8, 2026, 8:42 PM EDT
Completed No phase listed Observational

Observational Endothelin and Markers of Cellular Apoptosis In CSF Head Injury

NCT00498498
View directory record Official record
Conditions
Cerebrovascular Trauma, Neurohormones, Cellular Apoptosis, Endothelin System
Interventions
Not listed
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 70 Years
Enrollment
51 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
8
States / cities
Sacramento, California • Torrance, California • Miami, Florida + 5 more
Source: ClinicalTrials.gov public record
Updated Nov 16, 2011 · Synced Oct 8, 2026, 8:42 PM EDT
Terminated Phase 3 Interventional

Safety and Efficacy of Lidoderm (Lidocaine Patch 5%) in Treating Moderate to Severe Pain Associated With Carpal Tunnel Syndrome

NCT00266214
View directory record Official record
Conditions
Carpal Tunnel Syndrome
Interventions
lidocaine patch 5%
Drug
Lead sponsor
Endo USA Inc., a Keenova Therapeutics Company
Industry
Eligibility
18 Years and older
Enrollment
210 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2007
U.S. locations
1
States / cities
Austin, Texas
Source: ClinicalTrials.gov public record
Updated Jun 14, 2011 · Synced Oct 8, 2026, 8:42 PM EDT
Enrolling by invitation No phase listed Observational

Platelet Transfusion and Repeat TEG-PM in Patients With Severe TBI on Antiplatelet Therapy (Repeat TEG-PM)

NCT06433622
View directory record Official record
Conditions
Traumatic Intracranial Hemorrhage
Interventions
Repeat Thromboelastography with Platelet Mapping
Diagnostic Test
Lead sponsor
Lancaster General Hospital
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Lancaster, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Oct 8, 2026, 8:42 PM EDT
Active, not recruiting Phase 2 Interventional

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

NCT02713269
View directory record Official record
Conditions
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine, Metastatic Malignant Neoplasm of Unknown Primary, Metastatic Melanoma, Prostate Carcinoma Metastatic in the Bone, Sarcoma, Solid Neoplasm, Spinal Cord Compression, Stage IV Breast Cancer AJCC v6 and v7, Stage IV Lung Non-Small Cell Cancer AJCC v7, Thyroid Gland Carcinoma
Interventions
Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Radiosurgery, Thermal Ablation Therapy
Procedure · Other · Radiation
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 8, 2026, 8:42 PM EDT
Not listed Phase 1Phase 2 Interventional

Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2

NCT04846010
View directory record Official record
Conditions
Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder), Post-Infectious Arthritis, Post-Infectious Polyneuritis, Post-Infectious Parkinsonism, Post-Infectious Hypothyroidism, Post Infectious Osteoarthritis, Anxiety Disorders, Depression, Depression, Anxiety, Depression, Bipolar, Insomnia, GERD, Gastro Esophageal Reflux, Hepatitis, Glomerulonephritis
Interventions
PurWet, FurFat, PurApo, PurPhl, PurClo, PurInf, Smoliv
Combination Product
Lead sponsor
All Natural Medicine Clinic, LLC
Other
Eligibility
Not listed
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Rockville, Maryland
Source: ClinicalTrials.gov public record
Updated May 26, 2021 · Synced Oct 8, 2026, 8:42 PM EDT
Completed Phase 1Phase 2 Interventional Results available

Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI)

NCT01058395
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Minocycline
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years to 75 Years · Male only
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
2
States / cities
Dearborn, Michigan • Trenton, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 17, 2018 · Synced Oct 8, 2026, 8:42 PM EDT
Withdrawn No phase listed Observational

Noninvasive Monitoring of Cerebral Blood Flow Autoregulation in Patients With Traumatic Brain Injury (TBI)

NCT01605838
View directory record Official record
Conditions
Traumatic Brain Injury (TBI)
Interventions
Not listed
Lead sponsor
Advanced Brain Monitoring, Inc.
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 14, 2015 · Synced Oct 8, 2026, 8:42 PM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Outcomes Mandate National Integration With Cannabis as Medicine

NCT03944447
View directory record Official record
Conditions
Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma, Fibromyalgia, Seizures, Hepatitis C, Cancer, Crohn Disease, HIV/AIDS, Multiple Sclerosis, Traumatic Brain Injury, Sickle Cell Disease, Post Traumatic Stress Disorder, Tourette Syndrome, Ulcerative Colitis, Glaucoma, Epilepsy, Inflammatory Bowel Diseases, Parkinson Disease, Amyotrophic Lateral Sclerosis, Chronic Traumatic Encephalopathy, Anxiety, Depression, Insomnia, Autism, Opioid-use Disorder, Bipolar Disorder, Covid19, SARS-CoV Infection, COVID-19, Corona Virus Infection, Coronavirus
Interventions
Cannabis, Medical, RYAH-Medtech Inhaler
Drug · Device
Lead sponsor
OMNI Medical Services, LLC
Network
Eligibility
7 Years and older
Enrollment
200,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2025
U.S. locations
17
States / cities
Boca Raton, Florida • Bradenton, Florida • Fort Lauderdale, Florida + 13 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2022 · Synced Oct 8, 2026, 8:42 PM EDT
Completed Not applicable Interventional

Screening and Brief Intervention for Substance Misuse Following Traumatic Brain Injury

NCT02129361
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Adapted Screening and Brief Intervention (Adapted SBI), Screening & Education Attention Control
Behavioral
Lead sponsor
Jennifer Bogner, PhD, ABPP
Other
Eligibility
18 Years and older
Enrollment
139 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 21, 2021 · Synced Oct 8, 2026, 8:42 PM EDT
Recruiting No phase listed Observational

Effect of the Stellate Ganglion Block on the Retinal Microcirculation

NCT06797752
View directory record Official record
Conditions
OCTA, Severe Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
Interventions
OCTA Scan
Device
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years and older
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Nov 19, 2025 · Synced Oct 8, 2026, 8:42 PM EDT
Completed Phase 4 Interventional Results available

Project to Improve Symptoms and Mood in People With Spinal Cord Injury

NCT00592384
View directory record Official record
Conditions
Major Depressive Disorder, Dysthymia, Spinal Cord Injuries
Interventions
venlafaxine XR, placebo
Drug
Lead sponsor
University of Washington
Other
Eligibility
18 Years to 64 Years
Enrollment
133 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2012
U.S. locations
6
States / cities
Birmingham, Alabama • Miami, Florida • Chicago, Illinois + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 1, 2015 · Synced Oct 8, 2026, 8:42 PM EDT
Completed Phase 2 Interventional

Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury

NCT00170352
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
Procedure
Lead sponsor
Hennepin Healthcare Research Institute
Other
Eligibility
16 Years to 65 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2008
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 28, 2015 · Synced Oct 8, 2026, 8:42 PM EDT
Active, not recruiting Not applicable Interventional

Multichannel Vestibular Implant Early Feasibility Study

NCT02725463
View directory record Official record
Conditions
Other Disorders of Vestibular Function, Bilateral, Bilateral Vestibular Deficiency (BVD), Gentamicin Ototoxicity, Labyrinth Diseases, Vestibular Diseases, Sensation Disorders
Interventions
Labyrinth Devices MVI™ Multichannel Vestibular Implant
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
22 Years to 90 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2028
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 8, 2026, 8:42 PM EDT
Terminated Phase 2 Interventional

A Phase 2a Dose Escalation Study With SLV334 in Patients With Traumatic Brain Injury.

NCT00735085
View directory record Official record
Conditions
Traumatic Brain Injury
Interventions
SLV334, Placebo
Drug
Lead sponsor
Abbott Products
Industry
Eligibility
16 Years to 65 Years
Enrollment
57 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
5
States / cities
Baltimore, Maryland • Dayton, Ohio • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2011 · Synced Oct 8, 2026, 8:42 PM EDT