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ClinicalTrials.gov public records Last synced Nov 5, 2026, 6:06 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 437 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Severe Trauma Clear all

Conditions: Critical Illness, Acute Kidney Injury
Interventions: 0.9% Saline, Physiologically-balanced isotonic crystalloid; Other
Lead sponsor: Vanderbilt University; Other
Eligibility: 18 Years and older
Enrollment: 5,381 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Burns, Trauma
Interventions: micro-imaging; Other
Lead sponsor: University of South Alabama; Other
Eligibility: 19 Years to 80 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Mobile, Alabama

Conditions: Concussion, Mild, Concussion, Brain, Concussion, Severe, Concussion, Intermediate, Concussion; Syndrome, Concussion Injury of Cerebrum, Concussion with Brief Loss of Consciousness, Alexithymia
Interventions: Treatment; Behavioral
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2025
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression, Post Traumatic Stress Disorder
Interventions: Get Moving and Get Well, Health and Humor Class; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 27 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2015
U.S. locations: 1
States / cities: North Little Rock, Arkansas

Conditions: Bipolar Affective Disorders, Cyclothymic Disorder, Schizoaffective Disorder, Major Depressive Disorder, Dysthymic Disorder, Obsessive-Compulsive Disorder, Panic Disorder, Posttraumatic Stress Disorder, Premenstrual Dysphoric Disorder, Social Anxiety Disorder
Interventions: Not listed
Lead sponsor: Weill Medical College of Cornell University; Other
Eligibility: 18 Years to 40 Years · Female only
Enrollment: 29 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Diorder, Early Life Trauma
Interventions: Lumateperone 42 mg, Placebo; Drug · Other
Lead sponsor: University of Texas at Austin; Other
Eligibility: 21 Years to 70 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Traumatic Brain Injury, Depression
Interventions: In-person Cognitive Behavioral Therapy, Telephone Cognitive Behavioral Therapy; Behavioral
Lead sponsor: University of Washington; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2013
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Bronchopulmonary Dysplasia
Interventions: transpyloric feeding, gastric feeding; Other
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 4 Weeks to 24 Weeks
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Interventions: Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only; Combination Product
Lead sponsor: Anthony P King; Other
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Post-Traumatic Stress Disorder
Interventions: Cognitive behavioral therapy (CBT), Brief PTSD treatment; Behavioral
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2008
U.S. locations: 5
States / cities: Monmouth Junction, New Jersey • New Brunswick, New Jersey • Newark, New Jersey

Conditions: Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery, Acute Kidney Injury (AKI), Myocardial Injury After Noncardiac Surgery (MINS), Vasopressor
Interventions: Norepinephrine, Phenylephrine; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 18,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 9
States / cities: San Francisco, California • College Park, Maryland • Ann Arbor, Michigan + 6 more

Conditions: Traumatic Brain Injury
Interventions: Autologous HB-adMSCs, Normal Saline; Biological · Drug
Lead sponsor: Hope Biosciences LLC; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 51 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 2
States / cities: Houston, Texas • San Antonio, Texas

Conditions: Injury of Kidney, Acute Renal Failure
Interventions: I5NP (a small interfering RNA), placebo; Drug
Lead sponsor: Quark Pharmaceuticals; Industry
Eligibility: 21 Years to 85 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2010
U.S. locations: 6
States / cities: Washington D.C., District of Columbia • Boston, Massachusetts • Cleveland, Ohio + 3 more

Conditions: Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State, Unresponsive Wakefulness Syndrome, Brain Injury, TBI Traumatic Brain Injury
Interventions: Functional Near-Infrared Spectroscopy Monitoring; Other
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years and older
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Subarachnoid Hemorrhage, Severe Traumatic Brain Injury
Interventions: Stepwise normothermia protocol, Ibuprofen, Acetominophen; Other · Drug
Lead sponsor: University of Washington; Other
Eligibility: 18 Years to 85 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
Interventions: Familiar Auditory Sensory Training, Sham Auditory Sensory Training; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2012
U.S. locations: 3
States / cities: Chicago, Illinois • Hines, Illinois • Richmond, Virginia

Conditions: Schizophrenia, Major Depression, Bipolar Disorder, PTSD
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: Up to 120 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2019
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Corneal Persistent Epithelial Defect
Interventions: Nexagon® (lufepirsen) High Dose Concentration, Nexagon® (lufepirsen) Low Dose Concentration, Vehicle, Open-label Nexagon® (lufepirsen); Drug
Lead sponsor: Glaukos Corporation; Industry
Eligibility: Not listed
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Post-Traumatic Stress Disorder, Depression
Interventions: Group Intervention for Interpersonal Trauma, Information only; Behavioral · Other
Lead sponsor: Georgetown University; Other
Eligibility: 18 Years to 70 Years · Female only
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Washington D.C., District of Columbia

Conditions: Stress, Psychological, Post-Traumatic Stress Disorder, Major Injury
Interventions: DEF-only, DEF + COPE; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: Up to 5 Years
Enrollment: 57 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Traumatic Brain Injury
Interventions: autologous bone marrow mononuclear cells; Biological
Lead sponsor: The University of Texas Health Science Center, Houston; Other
Eligibility: 18 Years to 55 Years
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2015
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Chronic Condition, Chronic Pain, Chronic Disease, Major Depressive Disorder, Post Traumatic Stress Disorder, Anxiety Disorders
Interventions: Ketamine; Drug
Lead sponsor: RIVER Foundation; Other
Eligibility: 18 Years and older
Enrollment: 50,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2029
U.S. locations: 2
States / cities: Bigfork, Montana • Helena, Montana

Conditions: Peripheral Nerve Injury(Ies)
Interventions: Not listed
Lead sponsor: Major Extremity Trauma Research Consortium; Other
Eligibility: 18 Years to 65 Years
Enrollment: 242 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2024
U.S. locations: 17
States / cities: Denver, Colorado • Miami, Florida • Bloomington, Indiana + 13 more

Conditions: Cardiac Surgery
Interventions: teprasiran, Placebo; Drug
Lead sponsor: Quark Pharmaceuticals; Industry
Eligibility: 18 Years and older
Enrollment: 1,043 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2021
U.S. locations: 36
States / cities: Birmingham, Alabama • Los Angeles, California • New Haven, Connecticut + 28 more

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Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit

Microcirculatory Assessment in Patients With Trauma and Severe Burns

Building Emotional Self-Awareness Teletherapy (BEST)

Get Moving and Get Well - Pilot Study

The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels

Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse

Life Improvement Following Traumatic Brain Injury

Transpyloric Feeding in Severe Bronchopulmonary Dysplasia

Mindfulness-based Psilocybin Therapy for PTSD

Cognitive Behavioral Treatment for Post-Traumatic Stress Disorder in People With Additional Serious Mental Illnesses

The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

A Dose Escalation and Safety Study of I5NP in Patients Undergoing Major Cardiovascular Surgery

fNIRS for Disorders of Consciousness

Outcomes Associated With Application of a Normothermia Protocol in Patients With Severe Neurological Insult and Fever

The Efficacy of Familiar Voice Stimulation During Coma Recovery

Procedures for Sample Acquisition and Distribution for The Human Brain Collection Core

NEXAGON for the Treatment of Corneal Persistent Epithelial Defects Following Severe Ocular Injuries

Group Intervention for Interpersonal Trauma

Intervention to Reduce Stress in 0-5 Year Olds With Burns

Treatment of Severe Adult Traumatic Brain Injury Using Bone Marrow Mononuclear Cells

RIVER At Home Ketamine Protocols

Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma

QPI-1002 Phase 3 for Prevention of Major Adverse Kidney Events (MAKE) in Subjects at High Risk for AKI Following Cardiac Surgery