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Showing 1–24 of 48 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sevoflurane Clear all
Completed Phase 4 Interventional Results available

Using the SEDLine for the Titration of Sevoflurane in Elderly Patients Recovery Using the SEDLine TM for the Titration of Sevoflurane in Elderly Patients Undergoing Non-Cardiac Surgery After Beta-Adrenergic Blockade

NCT00938782
View directory record Official record
Conditions
Anesthesia, General
Interventions
Sedline
Device
Lead sponsor
Stanford University
Other
Eligibility
65 Years and older
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2012
U.S. locations
2
States / cities
Stanford, California • Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 18, 2015 · Synced Jul 22, 2026, 6:44 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effects of Sevoflurane and Propofol on Light Flash Evoked Pupillometry

NCT00695890
View directory record Official record
Conditions
Measurement of Pupil Diameter
Interventions
Not listed
Lead sponsor
University of Medicine and Dentistry of New Jersey
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females

NCT01310582
View directory record Official record
Conditions
Ureteral Stent Occlusion, Exposure Laser, Ureterostomy; Functional Disturbance, Vaginal Diseases, Injury of Bladder, Excessive Repair, Calculi
Interventions
Desflurane, Sevoflurane
Drug
Lead sponsor
Hahnemann University Hospital
Other
Eligibility
60 Years to 85 Years · Female only
Enrollment
57 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 23, 2013 · Synced Jul 22, 2026, 6:44 PM EDT
Not listed Phase 4 Interventional

Sevoflurane Versus Propofol on Optic Nerve Sheath Diameter During Anesthesia in Steep Trendelenburg Position

NCT04289090
View directory record Official record
Conditions
Percentage of Change in ONSD During Anesthesia With Sevoflurane Versus Propofol in Two Groups of Patients
Interventions
Sevoflurane Inhalant Product, Propofol 10 MG/ML
Drug
Lead sponsor
State University of New York - Downstate Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
1
States / cities
Brooklyn, New York
Source: ClinicalTrials.gov public record
Updated Feb 27, 2020 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

ANI Versus Standard Care in Surgical Patients Receiving Balanced Sevoflurane-Fentanyl Anesthesia

NCT03684590
View directory record Official record
Conditions
Acute Pain
Interventions
ANI-guided opioid administration, Standard opioid administration
Device · Other
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 75 Years
Enrollment
102 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Apr 29, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional

Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14

NCT00000262
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
30% Nitrous oxide, 0.4% Sevoflurane, 0.2% sevoflurane, Placebo
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
Not listed
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1996 – 1999
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Sevoflurane's Effect on Neurocognition Study

NCT06044740
View directory record Official record
Conditions
Anesthesia, Pain, Amnesia
Interventions
Sevoflurane, Peripheral Nerve Stimulation
Drug · Device
Lead sponsor
Keith M Vogt
Other
Eligibility
18 Years to 59 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?

NCT01737593
View directory record Official record
Conditions
Emergence Agitation, Pain
Interventions
Acetaminophen
Drug
Lead sponsor
University of California, Los Angeles
Other
Eligibility
6 Months to 6 Years
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Oct 20, 2016 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 4 Interventional Results available

Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block

NCT01199237
View directory record Official record
Conditions
Airway Reflexes, Protective, Recovery After Neuromuscular Block, Anesthetic Recovery
Interventions
Sevoflurane, Desflurane, Rocuronium, Neostigmine, Glycopyrrolate
Drug
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 65 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 15, 2014 · Synced Jul 22, 2026, 6:44 PM EDT
Completed No phase listed Observational

Effects of Sevoflurane and Propofol on Light Flashed Evoked Pupillometry

NCT01219569
View directory record Official record
Conditions
Blindness
Interventions
propofol, Sevoflurane
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 70 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Apr 23, 2015 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery

NCT03062488
View directory record Official record
Conditions
Emergence Agitation, Pain
Interventions
IV acetaminophen, Fentanyl, PO acetaminophen
Drug
Lead sponsor
Nemours Children's Clinic
Other
Eligibility
24 Months to 7 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 17, 2020 · Synced Jul 22, 2026, 6:44 PM EDT
Completed No phase listed Observational

Effect of Duration of Exposure of Anesthesia With Sevoflurane on Emergence Delirium

NCT02509221
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Not listed
Lead sponsor
State University of New York - Upstate Medical University
Other
Eligibility
1 Year to 6 Years
Enrollment
112 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Aug 27, 2023 · Synced Jul 22, 2026, 6:44 PM EDT
Terminated Not applicable Interventional Results available

Anesthesia in Patients With Mitochondrial Disease

NCT02053766
View directory record Official record
Conditions
Mitochondrial Diseases
Interventions
Sevoflurane, Dexmedetomidine, Propofol
Drug
Lead sponsor
The University of Texas Health Science Center, Houston
Other
Eligibility
1 Day to 17 Years
Enrollment
19 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2020
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Aug 27, 2024 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops

NCT01925391
View directory record Official record
Conditions
Glaucoma, Intraocular Pressure, Anesthesia
Interventions
Tono-pen XL Applanation tonometer + Ocu-film +
Drug
Lead sponsor
University of Miami
Other
Eligibility
1 Year to 18 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
2
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Jun 15, 2014 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional Results available

Addition of Nitrous Oxide and Its Effects on Depth of Anesthesia

NCT00717574
View directory record Official record
Conditions
Deep Sedation, Anesthesia, General
Interventions
Sevoflurane group, Propofol group
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 30, 2017 · Synced Jul 22, 2026, 6:44 PM EDT
Terminated Phase 4 Interventional Results available

Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI

NCT02111447
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Propofol, Sevoflurane, Isoflurane
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
2 Years to 12 Years
Enrollment
6 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 2 Interventional

Effects of Alcohol History on Effects of Sevoflurane and Nitrous Oxide - 13

NCT00000261
View directory record Official record
Conditions
Alcohol-Related Disorders, Opioid-Related Disorders, Substance-Related Disorders
Interventions
30% Nitrous oxide, Placebo, 0.2% sevoflurane, 0.4% sevoflurane, 0.6% sevoflurane
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
Not listed
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 1998
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 26, 2015 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

The Effects of General Anesthetics on Upper Airway Collapsibility in Healthy Subjects

NCT01557920
View directory record Official record
Conditions
Airway Complication of Anaesthesia, Healthy
Interventions
Propofol, Sevoflurane
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 45 Years
Enrollment
18 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 12, 2016 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Phase 3 Interventional

Sevoflurane/Dexmedetomidine vs. Isoflurane for Pediatric Emergence Delirium

NCT06624592
View directory record Official record
Conditions
Delirium on Emergence
Interventions
Sevoflurane, Isoflurane
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
2 Years to 7 Years
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting Not applicable Interventional

Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke

NCT07001267
View directory record Official record
Conditions
Acute Ischemic Stroke Patients
Interventions
Anesthesia drugs during the surgery
Procedure
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Mar 11, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Completed No phase listed Observational Results available

Sevoflurane Concentrations in Children

NCT06510803
View directory record Official record
Conditions
Anesthetic, Sevoflurane, Age
Interventions
The washin of sevoflurane in the GE Ohmeda workstation
Drug
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
2 Years to 7 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 6:44 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Sevoflurane vs Nitrous Oxide Inhalation at Subanesthetic Concentrations - 11

NCT00000259
View directory record Official record
Conditions
Opioid-Related Disorders, Substance-Related Disorders
Interventions
15 % Nitrous oxide, 0.3 % Sevoflurane, 30% Nitrous oxide, 0.6% Sevoflurane, Placebo
Drug · Other
Lead sponsor
University of Chicago
Other
Eligibility
21 Years to 39 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1996 – 1997
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 27, 2015 · Synced Jul 22, 2026, 6:44 PM EDT
Recruiting No phase listed Observational

Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

NCT05837936
View directory record Official record
Conditions
Extubation
Interventions
Total intravenous anesthesia (TIVA), Sevoflurane initiated intravenous anesthesia (SIIVA)
Other
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
Up to 9 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Jul 22, 2026, 6:44 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Comparative Effects of Two Anesthetic Techniques on Auditory Brain Response in Children

NCT02830815
View directory record Official record
Conditions
Auditory Brainstem Response
Interventions
Not listed
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Up to 18 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 1, 2021 · Synced Jul 22, 2026, 6:44 PM EDT