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ClinicalTrials.gov public records Last synced Sep 8, 2026, 5:56 PM EDT

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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Shock Clear all
Recruiting Not applicable Interventional

Effect of CPAP on 6-Minute Walk Test Outcomes in Patients With ECAC

NCT04217603
View directory record Official record
Conditions
Tracheobronchomalacia, Excessive Dynamic Airway Collapse
Interventions
Continuous positive airway pressure (CPAP) device, Sham-continuous positive airway pressure (CPAP) device
Device
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Apr 12, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Active, not recruiting Not applicable Interventional

Analysis of Varus Collapse in Obese Patients With Stem and Non-Stem Tibial Components Following Primary Total Knee Arthroplasty

NCT06019832
View directory record Official record
Conditions
Obesity, Aseptic Loosening, Varus Collapse
Interventions
Total Knee Arthroplasty (TKA), Stemmed Tibial Implant, Non-stemmed tibial implant
Procedure · Device
Lead sponsor
Jacob M. Elkins
Other
Eligibility
40 Years to 99 Years · Female only
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2032
U.S. locations
1
States / cities
North Liberty, Iowa
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Active, not recruiting Not applicable Interventional

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study

NCT03901807
View directory record Official record
Conditions
Septic Shock, Endotoxemia
Interventions
Toraymyxin PMX 20R Extracorporeal Hemoperfusion Cartridge
Device
Lead sponsor
Spectral Diagnostics (US) Inc.
Industry
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2026
U.S. locations
20
States / cities
Birmingham, Alabama • Little Rock, Arkansas • San Francisco, California + 16 more
Source: ClinicalTrials.gov public record
Updated Apr 2, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting No phase listed Observational

Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR

NCT07309029
View directory record Official record
Conditions
Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation
Interventions
Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
Device
Lead sponsor
Atlantic Health System
Other
Eligibility
18 Years to 100 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
2
States / cities
Detroit, Michigan • Morristown, New Jersey
Source: ClinicalTrials.gov public record
Updated Dec 29, 2025 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting Phase 3 Interventional

Prehospital Analgesia INtervention Trial (PAIN)

NCT05437575
View directory record Official record
Conditions
Traumatic Injury
Interventions
Ketamine Hydrochloride, Fentanyl Citrate
Drug
Lead sponsor
Jason Sperry
Other
Eligibility
18 Years and older
Enrollment
994 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2029
U.S. locations
11
States / cities
San Diego, California • San Francisco, California • Camden, New Jersey + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 8, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Terminated Phase 2 Interventional

Efficacy and Safety of Using MPC-5971 in Subjects Undergoing Shock Wave Lithotripsy

NCT00860093
View directory record Official record
Conditions
Nephrolithiasis
Interventions
placebo, MPC-5971
Other · Drug
Lead sponsor
Mission Pharmacal
Industry
Eligibility
18 Years to 70 Years
Enrollment
135 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
3
States / cities
Meridian, Idaho • Columbus, Ohio • Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Mar 6, 2019 · Synced Sep 8, 2026, 5:56 PM EDT
Terminated Phase 3 Interventional Results available

Pragmatic Prehospital Group O Whole Blood Early Resuscitation Trial

NCT03477006
View directory record Official record
Conditions
Hemorrhagic Shock
Interventions
Whole blood
Biological
Lead sponsor
Jason Sperry
Other
Eligibility
18 Years to 89 Years
Enrollment
86 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 5, 2021 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Protective Brace to Prevent Hand and Arm Injuries

NCT00074893
View directory record Official record
Conditions
Cumulative Trauma Disorders, Carpal Tunnel Syndrome
Interventions
piezoelectric wrist brace
Device
Lead sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2004
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 7, 2006 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Phase 3 Interventional Results available

Study of Efficacy and Safety of Canakinumab Treatment for CRS in Participants With COVID-19-induced Pneumonia

NCT04362813
View directory record Official record
Conditions
Cytokine Release Syndrome (CRS) in Patients With COVID-19-induced Pneumonia
Interventions
Canakinumab, Placebo
Drug
Lead sponsor
Novartis Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
454 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
15
States / cities
Birmingham, Alabama • Glendale, California • San Francisco, California + 10 more
Source: ClinicalTrials.gov public record
Updated Jan 23, 2022 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A New Treatment for Mechanical Nasal Obstruction

NCT03456115
View directory record Official record
Conditions
Nasal Obstruction
Interventions
Mechanical nasal dilator
Device
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 17, 2023 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Role of Transposable Elements in Septic Immune Aging

NCT06809868
View directory record Official record
Conditions
Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction, Sepsis, Severe, Sepsis at Intensive Care Unit, Sepsis, Severe Sepsis and Septic Shock, Sepsis, Septic Shock
Interventions
RNA and DNA Sequencing
Genetic
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jan 29, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional

UNITE Study (UMN-GE) for COVID-19

NCT04701489
View directory record Official record
Conditions
Covid19, Cytokine Storm, Inflammation
Interventions
Splenic ultrasound
Device
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Saint Paul, Minnesota
Source: ClinicalTrials.gov public record
Updated May 2, 2024 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Phase 2 Interventional

Effects of Shock Absorbing Insoles on Knee Pain and Walking in Persons With Knee Osteoarthritis

NCT02018380
View directory record Official record
Conditions
Osteoarthritis
Interventions
Shock Absorbing Insole (SofSole Athletes Plus)
Other
Lead sponsor
Winston Salem State University
Other
Eligibility
50 Years and older
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 22, 2013 · Synced Sep 8, 2026, 5:56 PM EDT
Withdrawn Phase 4 Interventional

Angiotensin II vs. Vasopressin in Septic Shock

NCT05193370
View directory record Official record
Conditions
Septic Shock
Interventions
Angiotensin II, Vasopressin
Drug
Lead sponsor
University of New Mexico
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 14, 2024 · Synced Sep 8, 2026, 5:56 PM EDT
Terminated Not applicable Interventional

The Effects of High Energy Acoustic Shock Wave Therapy on Local Skin Perfusion and DFUs

NCT03640988
View directory record Official record
Conditions
Diabetic Foot Ulcer
Interventions
dermaPACE
Device
Lead sponsor
SANUWAVE, Inc.
Industry
Eligibility
22 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Newark, New Jersey
Source: ClinicalTrials.gov public record
Updated Nov 7, 2021 · Synced Sep 8, 2026, 5:56 PM EDT
Withdrawn Not applicable Interventional

Study of Low Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock

NCT03343041
View directory record Official record
Conditions
Bacterial Sepsis
Interventions
low-carbohydrate nutrition, Standard enteral nutrition
Dietary Supplement
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Nov 25, 2021 · Synced Sep 8, 2026, 5:56 PM EDT
Not listed Not applicable Interventional

Peer Support for Post Intensive Care Syndrome Self-Management

NCT03788096
View directory record Official record
Conditions
Critical Illness, Sepsis, Shock, Septic, Shock, Respiratory Failure, Respiratory Distress Syndrome, Adult, Shock, Hypovolemic, Chronic Disease
Interventions
Peer Support with Motivational Interviewing, Usual Care Group
Behavioral
Lead sponsor
University of Texas at Austin
Other
Eligibility
18 Years to 65 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Temple, Texas
Source: ClinicalTrials.gov public record
Updated Nov 1, 2020 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Restrictive Intravenous Fluids Trial in Sepsis

NCT03137446
View directory record Official record
Conditions
Septic Shock, Severe Sepsis
Interventions
Intravenous Fluid Cap
Other
Lead sponsor
Rhode Island Hospital
Other
Eligibility
18 Years and older
Enrollment
113 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Aug 30, 2018 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Using Biomarkers to Optimize Antibiotic Strategies in Sepsis

NCT02207114
View directory record Official record
Conditions
Sepsis
Interventions
Biomarker Algorithm Intervention
Other
Lead sponsor
University of Pennsylvania
Other
Eligibility
Not listed
Enrollment
145 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 4, 2024 · Synced Sep 8, 2026, 5:56 PM EDT
Terminated Not applicable Interventional Results available

Early Insertion of Axillary Impella® With VA ECMO

NCT04084015
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Axillary Impella®
Device
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jun 28, 2021 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Phase I STEBVax in Healthy Adults

NCT00974935
View directory record Official record
Conditions
Toxic Shock Syndrome Staphylococcal
Interventions
Aluminum hydroxide, STEBVax vaccine
Drug · Biological
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Eligibility
18 Years to 40 Years
Enrollment
29 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 18, 2015 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional

Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial

NCT07779720
View directory record Official record
Conditions
Sepsis, Septic Shock
Interventions
Non-Invasive Cardiac Output Monitoring (NICOM)
Other
Lead sponsor
Intermountain Health Care, Inc.
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Murray, Utah
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Withdrawn Not applicable Interventional

Awake Axillary Impella 5.5 Placement - A Feasibility Trial

NCT05782491
View directory record Official record
Conditions
Cardiogenic Shock
Interventions
Interscalene Block, PECS II Block, Superficial Cervical Plexus Block
Procedure
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 18, 2024 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Evaluate the Safety and Tolerability of Valproic Acid in Healthy Volunteers (Part 1)

NCT01951560
View directory record Official record
Conditions
Shock,Hemorrhagic
Interventions
Valproic Acid, Isotonic saline solution
Drug
Lead sponsor
Dr. Hasan Alam
Other
Eligibility
18 Years to 65 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 18, 2016 · Synced Sep 8, 2026, 5:56 PM EDT