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Showing 1–24 of 183 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Shoulder Arthroplasty Clear all
Completed Not applicable Interventional Results available

Hydrogen Peroxide to the Wound Following Surgical Incision Affecting Cultures in Primary Shoulder Arthroplast

NCT04609306
View directory record Official record
Conditions
Primary Anatomic or Reverse Total Shoulder Arthroplasty
Interventions
H2O2 application to incision
Other
Lead sponsor
University of Florida
Other
Eligibility
40 Years to 90 Years · Male only
Enrollment
36 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 21, 2024 · Synced Jul 22, 2026, 5:04 AM EDT
Enrolling by invitation No phase listed Observational

Comprehensive Reverse Shoulder Data Collection

NCT03404778
View directory record Official record
Conditions
Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects, Post-Traumatic Arthitis
Interventions
Biomet Comprehensive Reverse Shoulder
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
175 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2036
U.S. locations
4
States / cities
Towson, Maryland • Royal Oak, Michigan • Edina, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Phase 4 Interventional Results available

Exparel for Total Shoulder Arthroplasty

NCT04364867
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Exparel, Pain Pump
Drug
Lead sponsor
Norton Healthcare
Other
Eligibility
18 Years to 70 Years
Enrollment
102 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
1
States / cities
Louisville, Kentucky
Source: ClinicalTrials.gov public record
Updated Nov 25, 2024 · Synced Jul 22, 2026, 5:04 AM EDT
Recruiting Not applicable Interventional

Cryoneurolysis of the Suprascapular Nerve for Perioperative Pain Control After Receiving a Reverse Total Shoulder Arthroplasty (RTSA)

NCT07125833
View directory record Official record
Conditions
Degenerative Joint Disease of Shoulder
Interventions
Cryoneurolysis, No cryoneurolysis
Device · Other
Lead sponsor
North Texas Medical Research Institute, PLLC
Other
Eligibility
30 Years to 85 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Rockwall, Texas
Source: ClinicalTrials.gov public record
Updated Aug 14, 2025 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Phase 2Phase 3 Interventional Results available

Tranexamic Acid in Reverse Total Shoulder Arthroplasty

NCT02043132
View directory record Official record
Conditions
Shoulder Joint Disease, Complications; Arthroplasty, Intraoperative Complications, Blood Loss, Surgical
Interventions
Tranexamic Acid, Placebo
Drug
Lead sponsor
Corewell Health East
Other
Eligibility
18 Years and older
Enrollment
116 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2016
U.S. locations
1
States / cities
Royal Oak, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 18, 2017 · Synced Jul 22, 2026, 5:04 AM EDT
Recruiting Phase 4 Interventional

Addition of a Pectoserratus Block to Interscalene Block in Patients Undergoing Total Shoulder Replacement

NCT06143306
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
bupivacaine., Saline
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 16, 2026 · Synced Jul 22, 2026, 5:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Easytech Reversed Shoulder System Clinical Study

NCT03806842
View directory record Official record
Conditions
Osteo Arthritis Shoulders, Avascular Necrosis of the Head of Humerus, Rotator Cuff Tear
Interventions
Easytech group
Device
Lead sponsor
FX Shoulder Solutions
Industry
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
6
States / cities
Sun City West, Arizona • Menlo Park, California • Philadelphia, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jul 22, 2026, 5:04 AM EDT
Terminated Not applicable Interventional

Ascension® Humeral Resurfacing Arthroplasty Follow-Up Study

NCT02029469
View directory record Official record
Conditions
Shoulder Arthritis Osteoarthritis, Rheumatoid Arthritis Shoulder, Acquired Deformity of Head, Post-traumatic Arthrosis of Other Joints, Shoulder Region
Interventions
Ascension HRA device
Device
Lead sponsor
Ascension Orthopedics, Inc.
Industry
Eligibility
18 Years to 75 Years
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2014
U.S. locations
1
States / cities
Bay Pines, Florida
Source: ClinicalTrials.gov public record
Updated Aug 17, 2014 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Not applicable Interventional

Reverse Shoulder Replacement: Formal vs. Home Physiotherapy

NCT03430167
View directory record Official record
Conditions
Shoulder Arthropathy Associated With Other Conditions
Interventions
home therapy, formal therapy
Other
Lead sponsor
Washington University School of Medicine
Other
Eligibility
61 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Mar 22, 2023 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Not applicable Interventional

Clinical Research Study of the Benefits of BREG Polar Care Wave to Reduce Opioid Use by Patients Having Undergone Arthroscopic Rotator Cuff Repair Shoulder Surgery

NCT07455474
View directory record Official record
Conditions
Rotator Cuff Tear
Interventions
Breg Polar Care Wave Cold Compression Device
Device
Lead sponsor
University of Nevada, Reno
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
2
States / cities
Mammoth Lakes, California • Taos, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Not applicable Interventional

Prospective RCT Comparing Perioperative Pain

NCT03253198
View directory record Official record
Conditions
Arthroplasty Shoulder
Interventions
Saline, Bupivacaine liposome
Drug
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
156 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Jul 22, 2026, 5:04 AM EDT
Recruiting No phase listed Observational

Hospital for Special Surgery Shoulder Arthroplasty Cohort

NCT00527839
View directory record Official record
Conditions
Shoulder Arthroplasty
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2027
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 11, 2026 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Phase 4 Interventional Results available

Analgesia After Total Shoulder Arthroplasty

NCT01782872
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Interscalene Block (ISB) - 0.375% Ropivacaine + additives, Interscalene Block (ISB) - 0.2% Ropivacaine + additives, Interscalene Block (ISB) - 0.1% Ropivacaine + additives, Interscalene Block (ISB) - Systemic Control
Procedure
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 80 Years
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2016 · Synced Jul 22, 2026, 5:04 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

TSA Versus RSA in Patients >75

NCT04827277
View directory record Official record
Conditions
Total Shoulder Arthoplasty
Interventions
Reverse Total Shoulder Replacement, Anatomic Total Shoulder Replacement
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
75 Years and older
Enrollment
108 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 31, 2021 · Synced Jul 22, 2026, 5:04 AM EDT
Completed No phase listed Observational Results available

Safety of Treatment of Shoulder Repair

NCT04552119
View directory record Official record
Conditions
Rotator Cuff
Interventions
HEALICOIL Knotless PEEK, HEALICOIL Knotless REGENESORB
Device
Lead sponsor
Smith & Nephew, Inc.
Industry
Eligibility
18 Years and older
Enrollment
138 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
5
States / cities
Redwood City, California • Colorado Springs, Colorado • Denver, Colorado + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 15, 2026 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

NCT06042608
View directory record Official record
Conditions
Postoperative Pain, Acute, Shoulder Pain
Interventions
intercostobrachial nerve block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Phase 4 Interventional Results available

Exparel for Postoperative Pain Management in Shoulder Surgery

NCT02472314
View directory record Official record
Conditions
Fracture of Shoulder and Upper Arm
Interventions
1.3% Liposomal Bupivacaine, 0.125% Bupivacaine
Drug
Lead sponsor
Wayne State University
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Dearborn, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 28, 2023 · Synced Jul 22, 2026, 5:04 AM EDT
Not listed Not applicable Interventional

Fixed Inclination Humeral Cut

NCT03922763
View directory record Official record
Conditions
Shoulder Osteoarthritis
Interventions
Anatomical cut, Cutting guide
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2019 · Synced Jul 22, 2026, 5:04 AM EDT
Completed No phase listed Observational

Reverse Shoulder Replacement: Age 60 or Younger Outcomes

NCT03148184
View directory record Official record
Conditions
Shoulder Arthritis
Interventions
shoulder x-ray
Diagnostic Test
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 60 Years
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Jul 16, 2019 · Synced Jul 22, 2026, 5:04 AM EDT
Recruiting No phase listed Observational

Return to Golf After Orthopaedic Surgery

NCT05675618
View directory record Official record
Conditions
Hip Osteoarthritis, Knee Osteoarthritis, Shoulder Osteoarthritis
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years and older
Enrollment
432 participants
Timeline
2023 – 2026
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Not applicable Interventional

Subscapularis Indocyanine Green Perfusion Pilot Study

NCT05179941
View directory record Official record
Conditions
Shoulder Pain, Shoulder Arthritis, Shoulder Arthroplasty
Interventions
Perfusion with Indocyanine green
Procedure
Lead sponsor
Dartmouth-Hitchcock Medical Center
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Aug 3, 2023 · Synced Jul 22, 2026, 5:04 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Liposome Bupivacaine Interscalene Total Shoulder

NCT03587636
View directory record Official record
Conditions
Acute Pain
Interventions
liposome bupivacaine, Bupivacaine
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
77 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated May 1, 2022 · Synced Jul 22, 2026, 5:04 AM EDT
Enrolling by invitation No phase listed Observational

Reverse Shoulder Arthroplasty vs Rotator Cuff Repair for 60+

NCT06848023
View directory record Official record
Conditions
Shoulder Injuries, Shoulder Pain
Interventions
Reverse Total Shoulder Arthroplasty, Rotator Cuff Repair
Procedure
Lead sponsor
Campbell Clinic
Other
Eligibility
60 Years to 95 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Germantown, Tennessee
Source: ClinicalTrials.gov public record
Updated Jul 27, 2025 · Synced Jul 22, 2026, 5:04 AM EDT
Completed No phase listed Observational Results available

Post- Surgery Recovery: Nerve Blocks w/ Sedation vs. Nerve Block w/ Either Sedation/Gen. Anesthesia

NCT02602080
View directory record Official record
Conditions
Nausea, Emesis
Interventions
Not listed
Lead sponsor
Hospital for Special Surgery, New York
Other
Eligibility
18 Years to 99 Years
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 1, 2019 · Synced Jul 22, 2026, 5:04 AM EDT