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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Shoulder Osteoarthritis Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Occupation-Based Intervention Compared With Therapeutic Exercise for Older Adults With Shoulder OA.

NCT04641546
View directory record Official record
Conditions
Osteoarthritis Shoulder
Interventions
Therapeutic Exercise, Occupation-Based Intervention
Procedure
Lead sponsor
Bay Path University
Other
Eligibility
65 Years and older
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Nov 23, 2020 · Synced Jun 10, 2026, 6:19 AM EDT
Completed Not applicable Interventional

Comparing the Outcome of Cemented All-Polyethylene Pegged vs. Keeled Components Through a Subscapularis Tenotomy or a Subscapularis Peel

NCT03735173
View directory record Official record
Conditions
Arthropathy Shoulder, Shoulder Pain, Shoulder Osteoarthritis, Shoulder Arthritis, Shoulder Arthropathy Associated With Other Conditions, Necrosis of Bone, Arthritis, Inflammatory Arthritis
Interventions
ReUnion TSA, pegged design, ReUnion TSA, keeled design
Procedure
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
4 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2021
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 11, 2021 · Synced Jun 10, 2026, 6:19 AM EDT
Active, not recruiting Not applicable Interventional

Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder Arthroplasty

NCT03726554
View directory record Official record
Conditions
Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects, Post-Traumatic Arthritis
Interventions
Comprehensive Reverse Porous Augmented Glenoid, Comprehensive Mini Humeral Tray
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2030
U.S. locations
6
States / cities
Gulf Breeze, Florida • Louisville, Kentucky • Royal Oak, Michigan + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 28, 2025 · Synced Jun 10, 2026, 6:19 AM EDT
Completed Not applicable Interventional Results available

Comprehensive Shoulder System Nano IDE

NCT01936259
View directory record Official record
Conditions
Joint Disease
Interventions
Mini Stem, Nano
Device
Lead sponsor
Zimmer Biomet
Industry
Eligibility
21 Years to 90 Years
Enrollment
258 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2019
U.S. locations
12
States / cities
Scottsdale, Arizona • Fort Lauderdale, Florida • Fort Wayne, Indiana + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 12, 2020 · Synced Jun 10, 2026, 6:19 AM EDT
Recruiting Phase 1 Interventional

The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis

NCT04929951
View directory record Official record
Conditions
Osteoarthritis Shoulder, Shoulder Pain
Interventions
Micro Fragmented Adipose Tissue, Corticosteroid injection
Biological
Lead sponsor
Stanford University
Other
Eligibility
25 Years to 75 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2027
U.S. locations
1
States / cities
Stanford, California
Source: ClinicalTrials.gov public record
Updated Oct 29, 2025 · Synced Jun 10, 2026, 6:19 AM EDT
Not listed Not applicable Interventional

Fixed Inclination Humeral Cut

NCT03922763
View directory record Official record
Conditions
Shoulder Osteoarthritis
Interventions
Anatomical cut, Cutting guide
Procedure
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 21, 2019 · Synced Jun 10, 2026, 6:19 AM EDT
Withdrawn Not applicable Interventional

Anatomic Versus Reverse Shoulder Arthroplasty for Primary Glenohumeral Osteoarthritis

NCT06513559
View directory record Official record
Conditions
Glenohumeral Osteoarthritis
Interventions
Anatomic total shoulder replacement, Reverse total shoulder replacement
Device
Lead sponsor
University of Utah
Other
Eligibility
60 Years to 85 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 27, 2025 · Synced Jun 10, 2026, 6:19 AM EDT
Not listed Not applicable Interventional

Comparison Of A Novel Sling With A Traditional Abduction Sling After Shoulder Surgery

NCT05274737
View directory record Official record
Conditions
Rotator Cuff Tears, Osteo Arthritis Shoulders
Interventions
Novel sling, Traditional abduction sling
Device
Lead sponsor
Orthopedic Institute, Sioux Falls, SD
Other
Eligibility
Not listed
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Jun 15, 2022 · Synced Jun 10, 2026, 6:19 AM EDT
Not listed Not applicable Interventional

SMR Stemless Reverse Vs SMR Reverse Shoulder System

NCT04697004
View directory record Official record
Conditions
Arthroplasty, Replacement
Interventions
Investigational Arm: SMR Stemless Reverse, Control Arm: SMR Reverse Shoulder System
Device
Lead sponsor
Limacorporate S.p.a
Industry
Eligibility
22 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
11
States / cities
Los Angeles, California • Denver, Colorado • Boca Raton, Florida + 7 more
Source: ClinicalTrials.gov public record
Updated Oct 1, 2024 · Synced Jun 10, 2026, 6:19 AM EDT
Recruiting No phase listed Observational

Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

NCT05700682
View directory record Official record
Conditions
Osteoarthritis, Knee, Osteoarthritis, Hip, Osteo Arthritis Shoulders, Synovitis of Knee, Synovitis/Tenosynovitis - Hip, Synovitis, Pain, Chronic
Interventions
Shoulder/Hip/Knee Embolization with Embozene Microspheres
Device
Lead sponsor
Palo Alto Veterans Institute for Research
Other
Eligibility
25 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Aug 6, 2025 · Synced Jun 10, 2026, 6:19 AM EDT
Withdrawn Not applicable Interventional

Amnion-Based Injections in the Shoulder

NCT03770546
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Adhesive Capsulitis
Interventions
Amnion Injection, Betamethasone injection
Biological · Drug
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
18 Years to 100 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Nov 25, 2021 · Synced Jun 10, 2026, 6:19 AM EDT
Completed Not applicable Interventional Results available

Three Injections of EUFLEXXA (Sodium Hyaluronate) for Treatment of Chronic Shoulder Pain Associated With Osteoarthritis (OA)

NCT00969501
View directory record Official record
Conditions
Osteoarthritis
Interventions
EUFLEXXA
Drug
Lead sponsor
Georgia Institute for Clinical Research, LLC
Other
Eligibility
30 Years to 79 Years
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Marietta, Georgia
Source: ClinicalTrials.gov public record
Updated May 6, 2013 · Synced Jun 10, 2026, 6:19 AM EDT
Active, not recruiting Phase 3 Interventional

ZILRETTA in Subjects With Shoulder Osteoarthritis

NCT06269705
View directory record Official record
Conditions
Glenohumeral Osteoarthritis
Interventions
ZILRETTA, Placebo
Drug · Other
Lead sponsor
Pacira Pharmaceuticals, Inc
Industry
Eligibility
50 Years to 80 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
32
States / cities
Vestavia Hills, Alabama • Surprise, Arizona • Tucson, Arizona + 29 more
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Easytech Reversed Shoulder System Clinical Study

NCT03806842
View directory record Official record
Conditions
Osteo Arthritis Shoulders, Avascular Necrosis of the Head of Humerus, Rotator Cuff Tear
Interventions
Easytech group
Device
Lead sponsor
FX Shoulder Solutions
Industry
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
6
States / cities
Sun City West, Arizona • Menlo Park, California • Philadelphia, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Sep 27, 2023 · Synced Jun 10, 2026, 6:19 AM EDT
Enrolling by invitation No phase listed Observational

Subscapularis-Sparing Total Shoulder Arthroplasty

NCT07410650
View directory record Official record
Conditions
Total Shoulder Arthroplasty
Interventions
Subscapularis-Sparing Total Shoulder Arthroplasty
Procedure
Lead sponsor
University of Utah
Other
Eligibility
18 Years to 90 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Enrolling by invitation Not applicable Interventional

Pyrocarbon Hemiarthroplasty Versus Total Shoulder Arthroplasty for the Treatment of Glenohumeral Osteoarthritis

NCT07226388
View directory record Official record
Conditions
Glenohumeral Osteoarthritis
Interventions
Hemiarthroplasty with pyrocarbon, Anatomic total shoulder arthroplasty
Device
Lead sponsor
Washington University School of Medicine
Other
Eligibility
40 Years to 65 Years
Enrollment
74 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2040
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Feb 18, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Recruiting Not applicable Interventional

Efficacy of Intra-articular Injections for the Treatment of Primary Glenohumeral Osteoarthritis(GHOA)

NCT04949087
View directory record Official record
Conditions
Arthritis Shoulder
Interventions
Glenohumeral Injection
Procedure
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2028
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Feb 16, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Recruiting Not applicable Interventional

Evaluation of Structural and Functional Integrity of the Rotator Cuff After Total Shoulder Arthroplasty

NCT03921944
View directory record Official record
Conditions
Osteoarthritis of Shoulder
Interventions
CT scan of the shoulders
Diagnostic Test
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
45 Years and older
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 4, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Active, not recruiting No phase listed Observational

Pyrocarbon Clinical Follow-up Study

NCT05049993
View directory record Official record
Conditions
Osteoarthritis of the Shoulder, Avascular Necrosis, Traumatic Arthritis
Interventions
Aequalis Pyrocarbon Humeral Head
Device
Lead sponsor
Stryker Trauma and Extremities
Industry
Eligibility
22 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2027
U.S. locations
8
States / cities
Denver, Colorado • Fort Lauderdale, Florida • New Orleans, Louisiana + 5 more
Source: ClinicalTrials.gov public record
Updated Feb 9, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Recruiting Phase 2 Interventional Accepts healthy volunteers

Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder

NCT02844738
View directory record Official record
Conditions
Osteoarthritis
Interventions
[StroMed + platelet rich plasma (PRP)]
Biological
Lead sponsor
VivaTech International, Inc.
Industry
Eligibility
18 Years to 90 Years
Enrollment
4,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2026
U.S. locations
1
States / cities
Grove City, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 13, 2025 · Synced Jun 10, 2026, 6:19 AM EDT
Terminated No phase listed Observational

A Disease-based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-derived Regenerative Cells

NCT04405297
View directory record Official record
Conditions
Knee Osteoarthritis, Hip Osteoarthritis, Ankle Osteoarthritis, Shoulder Osteoarthritis, Wrist Osteoarthritis
Interventions
Adipose-derived regenerative cells
Device
Lead sponsor
Sanford Health
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
1
States / cities
Sioux Falls, South Dakota
Source: ClinicalTrials.gov public record
Updated Oct 21, 2025 · Synced Jun 10, 2026, 6:19 AM EDT
Withdrawn Not applicable Interventional

Effectiveness of Manual Therapy and Exercise in Shoulder OA

NCT02587559
View directory record Official record
Conditions
Osteoarthritis
Interventions
physical therapy
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
50 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2020
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Sep 12, 2019 · Synced Jun 10, 2026, 6:19 AM EDT
Terminated Phase 1 Interventional

CAM Procedure With BMAC for Shoulder OA

NCT04826224
View directory record Official record
Conditions
Shoulder Osteoarthritis
Interventions
Concentrated bone marrow aspirate administration after Comprehensive Arthroscopic Management (CAM) surgical procedure.
Biological
Lead sponsor
Shane A. Shapiro
Other
Eligibility
50 Years and older
Enrollment
2 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
Jacksonville, Florida
Source: ClinicalTrials.gov public record
Updated Jan 19, 2026 · Synced Jun 10, 2026, 6:19 AM EDT
Withdrawn Phase 4 Interventional

Effective Pain Management During Shoulder Replacement Surgery With EXPAREL

NCT03474510
View directory record Official record
Conditions
Pain, Postoperative, Shoulder Osteoarthritis
Interventions
local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block
Drug · Other
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 28, 2021 · Synced Jun 10, 2026, 6:19 AM EDT