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Showing 1–24 of 114 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sleep Apnea, Central Clear all
Completed Phase 2 Interventional

Continuous Positive Airway Pressure for the Treatment of Stroke

NCT00368628
View directory record Official record
Conditions
Acute Ischemic Stroke, Sleep Apnea
Interventions
continuous positive airway pressure
Procedure
Lead sponsor
Yale University
Other
Eligibility
50 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 2, 2009 · Synced Jul 22, 2026, 3:27 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Sparkle Respiratory Effort Validation

NCT04630639
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Sleep Apnea, Central
Interventions
Sparkle
Device
Lead sponsor
Philips Clinical & Medical Affairs Global
Industry
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jun 22, 2021 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Phase 3 Interventional Results available

"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"

NCT02348606
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
JZP-110, Placebo oral tablet
Drug
Lead sponsor
Jazz Pharmaceuticals
Industry
Eligibility
18 Years to 75 Years
Enrollment
476 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
45
States / cities
Glendale, Arizona • Scottsdale, Arizona • Little Rock, Arkansas + 38 more
Source: ClinicalTrials.gov public record
Updated Jul 22, 2019 · Synced Jul 22, 2026, 3:27 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment

NCT04118387
View directory record Official record
Conditions
Sleep Disordered Breathing, Able Bodied
Interventions
Acetazolamide + supplemental oxygen + PAP therapy, Zolpidem + PAP therapy, Buspirone + PAP therapy
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional

Sleep Disordered Breathing and Its Impact on Neuro-cognitive Performance and Quality of Life in Parkinson Disease

NCT02034357
View directory record Official record
Conditions
Parkinson's Disease, Sleep Disordered Breathing, Sleep Obstructive Apnea
Interventions
Neurocognitive function, Sleep evaluations
Other
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
89 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Mar 23, 2016 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Phase 1 Interventional Results available

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

NCT05094271
View directory record Official record
Conditions
OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease
Interventions
Supplemental Oxygen, Continuous Positive Airway Pressure Machine, Room Air
Other · Device
Lead sponsor
University of California, San Diego
Other
Eligibility
65 Years to 85 Years
Enrollment
182 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2025
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated May 10, 2026 · Synced Jul 22, 2026, 3:27 AM EDT
Terminated Phase 3 Interventional Results available

Buspirone as a Potential Treatment for Recurrent Central Apnea

NCT00746954
View directory record Official record
Conditions
Central Apnea, Heart Failure
Interventions
Acetazolamide, Buspirone
Drug
Lead sponsor
VA Office of Research and Development
Federal
Eligibility
40 Years to 75 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2011
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 13, 2016 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders

NCT01626989
View directory record Official record
Conditions
Sleep Disordered Breathing, Sleep Apnea, Central
Interventions
BiPAP auto Advanced, BiPAP auto SV4
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
3
States / cities
Little Rock, Arkansas • Portage, Michigan • Mason, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 24, 2019 · Synced Jul 22, 2026, 3:27 AM EDT
Enrolling by invitation Not applicable Interventional

Long-term Evaluation of Nasopharyngeal Airway in Hypotonia

NCT06614582
View directory record Official record
Conditions
Hypotonia, Muscle, Obstructive Sleep Apnea, Nasal Airway Obstruction
Interventions
Self-Supporting Nasopharyngeal Airway (ssNPA)
Device
Lead sponsor
University of Michigan
Other
Eligibility
3 Years to 23 Years
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2026
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Dec 1, 2025 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Respicardia, Inc. Pivotal Trial of the remedē System

NCT01816776
View directory record Official record
Conditions
Sleep Apnea, Central, Sleep Disordered Breathing, Heart Failure
Interventions
Treatment Group (transvenous stimulation of the phrenic nerve), Control Group (Optimal Medical Therapy)
Device
Lead sponsor
Respicardia, Inc.
Industry
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
23
States / cities
Los Angeles, California • Jacksonville, Florida • Downers Grove, Illinois + 19 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2018 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure

NCT01446913
View directory record Official record
Conditions
Transient Ischemic Attack, Stroke
Interventions
Standard CPAP Intervention, Enhanced CPAP Intervention
Device · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
New Haven, Connecticut • Indianapolis, Indiana
Source: ClinicalTrials.gov public record
Updated Nov 17, 2020 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Phase 2Phase 3 Interventional

Enabling Sleep Apnea Patient-Centered Care Via an Internet Intervention

NCT00662623
View directory record Official record
Conditions
Sleep Apnea Syndromes
Interventions
i-PAP, Usual Care (Standard Care)
Behavioral
Lead sponsor
Veterans Medical Research Foundation
Other
Eligibility
18 Years and older
Enrollment
200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 12, 2016 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluation of Software Enhancements to the Respironics BiPAP Auto Servo Ventilation (AutoSV) Device

NCT00720213
View directory record Official record
Conditions
Sleep Disordered Breathing, Sleep Apnea, Central
Interventions
Respironics BiPAP autoSV2, Respironics BiPAP autoSV3
Device
Lead sponsor
Philips Respironics
Industry
Eligibility
21 Years to 80 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
5
States / cities
Tucson, Arizona • Little Rock, Arkansas • Portage, Michigan + 2 more
Source: ClinicalTrials.gov public record
Updated Jan 28, 2019 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

DeVilbiss AutoAdjust With SmartFlex Comparative Study

NCT01203956
View directory record Official record
Conditions
Obstructive Sleep Apnea
Interventions
SmartFlex, Standard
Device
Lead sponsor
DeVilbiss Healthcare LLC
Industry
Eligibility
18 Years and older
Enrollment
28 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2011
U.S. locations
2
States / cities
Dallas, Texas • San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Apr 27, 2015 · Synced Jul 22, 2026, 3:27 AM EDT
Completed No phase listed Observational

Incidence and Nature of Respiratory Impairment in Consecutive Patients Undergoing Bronchoscopy Under Conscious Sedation: A Pilot Study

NCT03886454
View directory record Official record
Conditions
Conscious Sedation, Bronchoscopy
Interventions
Not listed
Lead sponsor
Tufts Medical Center
Other
Eligibility
18 Years and older
Enrollment
33 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2019
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 27, 2019 · Synced Jul 22, 2026, 3:27 AM EDT
Terminated Not applicable Interventional

A Trial to Evaluate a Device for the Treatment of OSA and Snoring

NCT01772017
View directory record Official record
Conditions
Obstructive Sleep Apnea, Snoring
Interventions
Tongue Advancement Retainer Device
Device
Lead sponsor
Sleepy, Inc
Industry
Eligibility
18 Years to 65 Years
Enrollment
15 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
2
States / cities
San Diego, California • Visalia, California
Source: ClinicalTrials.gov public record
Updated Nov 23, 2015 · Synced Jul 22, 2026, 3:27 AM EDT
Completed No phase listed Observational Results available

Post Approval Study of the remedē System

NCT03425188
View directory record Official record
Conditions
Central Sleep Apnea
Interventions
Not listed
Lead sponsor
Respicardia, Inc.
Industry
Eligibility
21 Years and older
Enrollment
53 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2020
U.S. locations
16
States / cities
Los Angeles, California • Jacksonville, Florida • Downers Grove, Illinois + 13 more
Source: ClinicalTrials.gov public record
Updated Apr 21, 2021 · Synced Jul 22, 2026, 3:27 AM EDT
Not yet recruiting Not applicable Interventional

Serene Sleep Palatal Implant System Clinical Confirmatory Trial in Participants Who Snore or Are Diagnosed With Mild-to-moderate Obstructive Sleep Apnea (OSA).

NCT07613281
View directory record Official record
Conditions
Snoring, OSA - Obstructive Sleep Apnea
Interventions
Palatal Implant System
Device
Lead sponsor
Serene Sleep, Inc.
Industry
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026
U.S. locations
2
States / cities
San Francisco, California • Evans, Georgia
Source: ClinicalTrials.gov public record
Updated May 31, 2026 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effect of Treating Sleep Apnea on Cognition in Patients With Dementia

NCT00477828
View directory record Official record
Conditions
Dementia, Sleep Apnea
Interventions
Continuous positive airway pressure
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
50 Years to 85 Years
Enrollment
61 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2006
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated May 23, 2007 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Stroke and CPAP Outcome Study 2

NCT02809430
View directory record Official record
Conditions
Sleep Apnea, Obstructive, Stroke, Patient Adherence
Interventions
Continuous Positive Airway Pressure
Device
Lead sponsor
University of Washington
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Dec 22, 2020 · Synced Jul 22, 2026, 3:27 AM EDT
Not listed Phase 2 Interventional

Reversal of the Neurological Deficit in Acute Stroke With the Signal of Efficacy Trial of Auto BPAP to Limit Damage From Suspected Sleep Apnea

NCT01812993
View directory record Official record
Conditions
Ischemic Stroke
Interventions
Non-invasive ventilatory treatment with auto-BPAP
Device
Lead sponsor
Technische Universität Dresden
Other
Eligibility
18 Years to 80 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2013
U.S. locations
1
States / cities
Memphis, Tennessee
Source: ClinicalTrials.gov public record
Updated Feb 11, 2015 · Synced Jul 22, 2026, 3:27 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

World Trade Center Kidney-Link

NCT03234530
View directory record Official record
Conditions
Chronic Kidney Diseases, Obstructive Sleep Apnea
Interventions
Not listed
Lead sponsor
Icahn School of Medicine at Mount Sinai
Other
Eligibility
18 Years to 75 Years
Enrollment
555 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 8, 2021 · Synced Jul 22, 2026, 3:27 AM EDT
Active, not recruiting Phase 2 Interventional

Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea

NCT06776432
View directory record Official record
Conditions
Sleep Apnea
Interventions
Sivopixant, Placebo, Acetazolamide, SASS-001
Drug
Lead sponsor
Shionogi
Industry
Eligibility
18 Years to 85 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
9
States / cities
La Jolla, California • Brandon, Florida • Miami, Florida + 6 more
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Jul 22, 2026, 3:27 AM EDT
Completed Not applicable Interventional Results available

Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use

NCT01462084
View directory record Official record
Conditions
Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis), Chronic Opioid Use
Interventions
Adaptive servo-ventilation (ASV), Bi-Level PAP
Device
Lead sponsor
ResMed
Industry
Eligibility
18 Years and older
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2012
U.S. locations
1
States / cities
Redwood City, California
Source: ClinicalTrials.gov public record
Updated Apr 16, 2017 · Synced Jul 22, 2026, 3:27 AM EDT