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Showing 1–24 of 174 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Sleep Circadian Rhythms Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sleep Length and Circadian Regulation in Humans

NCT00843843
View directory record Official record
Conditions
Sleep Disorders
Interventions
Bright light box
Device
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years to 45 Years
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2014
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Mar 7, 2016 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers

NCT00490945
View directory record Official record
Conditions
Circadian Rhythm Sleep Disorders
Interventions
VEC-162
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
18 Years to 50 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2005
U.S. locations
2
States / cities
Boston, Massachusetts • Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 25, 2014 · Synced Sep 8, 2026, 5:56 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Couples Health Aging, Rhythms and Sleep Study

NCT05952284
View directory record Official record
Conditions
Aging, Memory Loss
Interventions
Not listed
Lead sponsor
University of Utah
Other
Eligibility
50 Years and older
Enrollment
340 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Feb 12, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Effects of Sleep, Fatigue, and Timing of Post-dates Inductions Among Nulliparas

NCT01542151
View directory record Official record
Conditions
Pregnancy, Prolonged
Interventions
Time of labor induction
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
14 Years and older · Female only
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
1
States / cities
Fresno, California
Source: ClinicalTrials.gov public record
Updated Mar 25, 2015 · Synced Sep 8, 2026, 5:56 PM EDT
Terminated No phase listed Observational Accepts healthy volunteers

Cardiometabolic Risk of Shiftwork

NCT01264913
View directory record Official record
Conditions
Sleep Deprivation, Circadian Dysregulation, Shift-Work Sleep Disorder
Interventions
sleep extension & circadian alignment
Behavioral
Lead sponsor
University of Chicago
Other
Eligibility
18 Years to 50 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 2, 2016 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Self-Care for Dementia Caregivers

NCT05309577
View directory record Official record
Conditions
Aging, Mental Disorder, Eating, Healthy, Physical Inactivity, Prodromal Symptoms, Sleep, Alzheimer Disease, Dementia, Circadian Rhythm Disorders
Interventions
Behavioral Self-Monitoring + Motivational Interviewing
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
50 Years to 99 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2025
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 22, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Melatonin Treatment for Induced Transient Insomnia

NCT00950885
View directory record Official record
Conditions
Delayed Sleep Phase Disorder, Jet-lag, Shift-work Disorder
Interventions
Low Dose Melatonin, Placebo, High Dose Melatonin
Biological
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 30 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 7, 2017 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients

NCT01284140
View directory record Official record
Conditions
Critical Illness, Sleep Deprivation, Respiratory Failure, Sleep Disorders, Circadian Rhythm
Interventions
Sleep and circadian rhythm promotion, Usual care
Behavioral
Lead sponsor
Brian Gehlbach
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2016
U.S. locations
2
States / cities
Chicago, Illinois • Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated May 6, 2018 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance

NCT00438438
View directory record Official record
Conditions
Healthy
Interventions
forced desynchrony protocol with sleep restriction
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 35 Years
Enrollment
9 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 1, 2011 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms

NCT03826563
View directory record Official record
Conditions
Psychosis, Sleep
Interventions
oral melatonin tablets (NatureMade brand), Placebo
Drug · Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
11 Years to 30 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2023
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2023 · Synced Sep 8, 2026, 5:56 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders

NCT00387179
View directory record Official record
Conditions
Sleep Disorders, Circadian Rhythm
Interventions
Melatonin, Methylxanthine, Light Therapy
Drug · Procedure
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Eligibility
18 Years to 40 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Boulder, Colorado
Source: ClinicalTrials.gov public record
Updated Aug 24, 2009 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

The Influence of Sleep on Cardiovascular Outcomes

NCT06535178
View directory record Official record
Conditions
Circadian Rhythm, Cardiometabolic Health, Vascular Health, Pain
Interventions
Sleep Regularity Group
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
18 Years to 50 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2026
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Nov 9, 2025 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Zolpidem CR and Hospitalized Patients With Dementia

NCT00814502
View directory record Official record
Conditions
Dementia, Alzheimer Disease, Dementia, Vascular, Sleep Disorders, Circadian Dysregulation
Interventions
Zolpidem CR, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
60 Years to 99 Years
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 21, 2017 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

SCREENS: Sleep, Circadian Rhythms, and Electronics in the EveNing Study

NCT06192745
View directory record Official record
Conditions
Sleep, Circadian Rhythm, Executive Function, Emotion Regulation
Interventions
no screen control with dim light and calming activities, unfiltered Bright tablet screen, Filtered dim tablet screen, Exciting content, Calming Content
Behavioral
Lead sponsor
Baylor College of Medicine
Other
Eligibility
8 Years to 11 Years
Enrollment
220 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 2, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sleepiness and Brain Function: The Effect of Armodafinil in Shift Work Sleep Disorder

NCT00688142
View directory record Official record
Conditions
Shift Work Sleep Disorder
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 30, 2010 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Results available

Feasibility of Bright Light Therapy on Fatigue, Sleep and Circadian Activity Rhythms in Lung Cancer Survivors

NCT02954809
View directory record Official record
Conditions
Fatigue, Sleep Disturbance, Circadian Dysregulation
Interventions
Morning bright light therapy, Dim light
Device
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
18 Years and older
Enrollment
14 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Apr 30, 2025 · Synced Sep 8, 2026, 5:56 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Yo-Yo Sleep on Cardiometabolic Health

NCT05880758
View directory record Official record
Conditions
Cardiometabolic Syndrome, Obesity
Interventions
Intermittent Short Sleep (ISS), Social Jetlag (SJL), Sustained Adequate Sleep (SAS)
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
18 Years to 49 Years
Enrollment
72 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2028
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 17, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Sleep and Circadian Mechanisms of Non-dipping Blood Pressure

NCT03558893
View directory record Official record
Conditions
Hypertension, Cardiovascular Risk Factor
Interventions
Forced Desynchrony
Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
30 Years to 60 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2024
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 19, 2026 · Synced Sep 8, 2026, 5:56 PM EDT
Withdrawn Not applicable Interventional

Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon

NCT00907595
View directory record Official record
Conditions
Huntington's Disease, Parkinson's Disease, Dementia With Lewy Bodies, Sleep Disorders, Circadian Dysregulation
Interventions
Ramelteon, Placebo
Drug
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
20 Years to 90 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 5, 2012 · Synced Sep 8, 2026, 5:56 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Circadian Rhythm of Melatonin in Burns

NCT01596101
View directory record Official record
Conditions
Sleep, Burns
Interventions
Not listed
Lead sponsor
Shriners Hospitals for Children
Other
Eligibility
5 Years to 18 Years
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2014
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 11, 2014 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional

Investigating Circadian Rhythms in Youth With Persistent Tic Disorders

NCT03508245
View directory record Official record
Conditions
Tourette's Disorder
Interventions
Wearable short wavelength light therapy
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
13 Years to 17 Years
Enrollment
35 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2023 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 3: Sustainment

NCT05956678
View directory record Official record
Conditions
Sleep Wake Disorders, Circadian Rhythm Disorders
Interventions
Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
Behavioral
Lead sponsor
University of California, Berkeley
Other
Eligibility
18 Years and older
Enrollment
130 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
10
States / cities
Concord, California • Fairfield, California • Goleta, California + 7 more
Source: ClinicalTrials.gov public record
Updated May 9, 2024 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Phase 1 Interventional

Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents

NCT02776215
View directory record Official record
Conditions
Circadian Rhythm Sleep Disorders, Non-24 Hour Sleep-Wake Disorder, Autism Spectrum Disorder, Smith-Magenis Syndrome
Interventions
tasimelteon
Drug
Lead sponsor
Vanda Pharmaceuticals
Industry
Eligibility
3 Years to 17 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Mar 20, 2024 · Synced Sep 8, 2026, 5:56 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens

NCT04792697
View directory record Official record
Conditions
Delayed Sleep Phase Syndrome
Interventions
Increase morning bright light, Decrease evening blue light, Sleep Scheduling, Monitor sleep, mood, and substance use
Other · Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
13 Years to 15 Years
Enrollment
115 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 7, 2026 · Synced Sep 8, 2026, 5:56 PM EDT