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ClinicalTrials.gov public records Last synced Oct 19, 2026, 6:37 PM EDT

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Showing 1–24 of 54 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Sleep Disorder, Shift-Work Clear all
Recruiting Not applicable Interventional

Shift Worker Intervention for Sleep Health

NCT06384742
View directory record Official record
Conditions
Shift Work Type Circadian Rhythm Sleep Disorder, Insomnia, Psychophysiological
Interventions
Shift Worker Intervention for Sleep Health
Behavioral
Lead sponsor
Oregon State University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated May 2, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Improving Metabolic & Mental Health in Female Healthcare Shift Workers

NCT06158204
View directory record Official record
Conditions
Sleep, Inadequate, Overweight and Obesity, Work Related Stress, Healthy Lifestyle
Interventions
Lifestyle Intervention
Behavioral
Lead sponsor
Auburn University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Auburn, Alabama
Source: ClinicalTrials.gov public record
Updated Jan 8, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Shift Work, Heredity, Insulin, and Food Timing Study

NCT02997319
View directory record Official record
Conditions
Shift Work Type Circadian Rhythm Sleep Disorder, Diabetes Mellitus, Type 2, Circadian Rhythm Sleep Disorder, Shift Work Type, Insulin Resistance
Interventions
Not listed
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 60 Years
Enrollment
365 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 19, 2021 · Synced Oct 19, 2026, 6:37 PM EDT
Terminated Not applicable Interventional Results available

Transcranial Direct Current Stimulation Therapy for Sleepiness Related to Shift Work Disorder (tDCS-SWORD)

NCT03879044
View directory record Official record
Conditions
Shift-Work Sleep Disorder
Interventions
Transcranial Direct Current Stimulation
Device
Lead sponsor
Ohio State University
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Oct 25, 2021 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Phase 1 Interventional

Sleep Enhancement Training Study for Novice Shiftworkers

NCT00786266
View directory record Official record
Conditions
Shift-Work Sleep Disorder
Interventions
Sleep Enhancement Training System, NIOSH shiftwork booklet
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
20 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Oct 19, 2026, 6:37 PM EDT
Terminated Not applicable Interventional

Effect and Utilization of Protected Time Among Interns on Extended Duty-Hour Call Shifts

NCT00983008
View directory record Official record
Conditions
Fatigue, Sleep Deprivation, Depression
Interventions
Protected time and Dedicated time
Behavioral
Lead sponsor
Providence Health & Services
Other
Eligibility
Not listed
Enrollment
11 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 26, 2019 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Skeletal Response to Simulated Night Shift

NCT05074277
View directory record Official record
Conditions
Osteoporosis, Circadian Rhythm Sleep Disorder, Shift Work Type
Interventions
Simulated short term night shift work schedule
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
20 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Aurora, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 22, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Active, not recruiting No phase listed Observational Accepts healthy volunteers

Objective Assessment of the Effects of Shift Work on Drowsiness and Driving Impairment in Hospital Staff

NCT01672489
View directory record Official record
Conditions
Impaired Driving, Sleep Driving
Interventions
Not listed
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2026
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 14, 2024 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Phase 3 Interventional Results available

Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepiness

NCT00228553
View directory record Official record
Conditions
Excessive Daytime Sleepiness, Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, Chronic Shift Work Sleep Disorder
Interventions
Armodafinil 100 to 250 mg/day
Drug
Lead sponsor
Cephalon
Industry
Eligibility
18 Years to 65 Years
Enrollment
743 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
74
States / cities
Birmingham, Alabama • Phoenix, Arizona • Hot Springs, Arkansas + 64 more
Source: ClinicalTrials.gov public record
Updated Jul 19, 2013 · Synced Oct 19, 2026, 6:37 PM EDT
Terminated Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder

NCT04788953
View directory record Official record
Conditions
Excessive Sleepiness, Shift-work Disorder
Interventions
Solriamfetol Oral Tablet, Placebo
Drug
Lead sponsor
Charles A. Czeisler, PhD, MD
Other
Eligibility
18 Years to 64 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Sep 24, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Sleepiness and Brain Function: The Effect of Armodafinil in Shift Work Sleep Disorder

NCT00688142
View directory record Official record
Conditions
Shift Work Sleep Disorder
Interventions
Not listed
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years to 55 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2010
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 31, 2010 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Optimizing Sleep Health in Nurses

NCT05965609
View directory record Official record
Conditions
Circadian Rhythm Sleep-Wake Disorders, Shift Work Type, Sleep Initiation and Maintenance Disorders
Interventions
CBTI, MRTI
Behavioral
Lead sponsor
Oregon State University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Corvallis, Oregon
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Phase 1 Interventional

Sleep Enhancement Training Study for Experienced Shiftworkers

NCT00786357
View directory record Official record
Conditions
Shift-Work Sleep Disorder
Interventions
NIOSH shiftwork booklet, Sleep Enhancement Training System
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
40 Years and older
Enrollment
32 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2010
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 23, 2010 · Synced Oct 19, 2026, 6:37 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Effect of Night Float Call on Sleep and Activity Patterns Among Anesthesia Residents

NCT05043038
View directory record Official record
Conditions
Sleep Disorder, Shift Work, Fatigue, Sleep Disturbance
Interventions
Not listed
Lead sponsor
Stanford University
Other
Eligibility
Not listed
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Dec 18, 2024 · Synced Oct 19, 2026, 6:37 PM EDT
Recruiting Not applicable Interventional

Role of Sleep Reactivity in Shift Work Disorder

NCT05424406
View directory record Official record
Conditions
Shift-work Disorder
Interventions
Active phototherapy, Control phototherapy, Cognitive Behavioral Therapy (CBT), Sleep education control
Behavioral
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 19, 2026, 6:37 PM EDT
Recruiting Not applicable Interventional

A Pilot of a Personalized Circadian mHealth to Improve Sleep in Night Shift Workers

NCT06809335
View directory record Official record
Conditions
Shift Work Sleep Disorder
Interventions
Personalized circadian mHealth
Other
Lead sponsor
Henry Ford Health System
Other
Eligibility
18 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Novi, Michigan
Source: ClinicalTrials.gov public record
Updated Mar 2, 2026 · Synced Oct 19, 2026, 6:37 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Sleep and Circadian Treatments for Shift Workers

NCT03813654
View directory record Official record
Conditions
Shift-Work Sleep Disorder, Shift-Work Related Sleep Disturbance
Interventions
8-h Afternoon-Evening Sleep, 8-h Free Sleep
Behavioral
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
50 Years to 65 Years
Enrollment
33 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance

NCT07494084
View directory record Official record
Conditions
Shift Work Schedule, Circadian Rhythm, Insulin Resistance, Circadian Misalignment
Interventions
Metyrapone And Hydrocortisone, Dextrose, insulin
Drug
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 45 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Sep 18, 2026 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Probiotics in Occupational Shift Workers

NCT02951689
View directory record Official record
Conditions
Shift-Work Related Sleep Disturbance, Healthy
Interventions
Probiotic, Placebo
Dietary Supplement
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
22 Years to 55 Years · Female only
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2018
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 19, 2018 · Synced Oct 19, 2026, 6:37 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Circulating and Tissue-specific Lipids on Vascular Function and Insulin Sensitivity in Chronic Night Shift Workers

NCT06550115
View directory record Official record
Conditions
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity, Blood Pressure
Interventions
Time-restricted eating, Control eating
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2029
U.S. locations
1
States / cities
Fort Collins, Colorado
Source: ClinicalTrials.gov public record
Updated Dec 17, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Circadian Rhythm Disruption Effects on Smoke Inhalation

NCT04955431
View directory record Official record
Conditions
Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
Interventions
Sleep Restriction, Normal Sleep
Behavioral
Lead sponsor
University of Montana
Other
Eligibility
18 Years to 44 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Real-Time Caffeine Optimization During Total Sleep Deprivation

NCT04399083
View directory record Official record
Conditions
Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
Interventions
Caffeine
Dietary Supplement
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 39 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Sep 17, 2021 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Tech4Rest Trial With Team Truck Drivers

NCT03108599
View directory record Official record
Conditions
Sleep, Sleep Disturbance, Sleep Disorder, Shift Work, Health Knowledge, Attitudes, Practice, Health Behavior, Fatigue, Vibration; Exposure
Interventions
Enhanced Cab, Fit4Sleep
Other · Behavioral
Lead sponsor
Oregon Health and Science University
Other
Eligibility
21 Years and older
Enrollment
49 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jul 25, 2024 · Synced Oct 19, 2026, 6:37 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Pilot Study of Cognitive Behavioral Therapy - Insomnia (CBT-I) Among Professional Firefighters

NCT05087121
View directory record Official record
Conditions
Insomnia, Shift-Work Related Sleep Disturbance
Interventions
Cognitive Behavioral Therapy for Insomnia for Firefighters (CBT-I-F), Fitbit Inspire HR Wrist Worn Device (NCT04176926)
Behavioral · Device
Lead sponsor
Pacific University
Other
Eligibility
18 Years and older
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Forest Grove, Oregon
Source: ClinicalTrials.gov public record
Updated Dec 1, 2022 · Synced Oct 19, 2026, 6:37 PM EDT