- Conditions
- Arthroplasty, Replacement, Knee, Sleep Initiation and Maintenance Disorders
- Interventions
- Melatonin 5 mg, Placebo (Vitamin C)
- Dietary Supplement
- Lead sponsor
- Hospital for Special Surgery, New York
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 176 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2022
- U.S. locations
- 1
- States / cities
- New York, New York
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- Conditions
- Sleep Quality Post-TKA, Postoperative Knee Function, Quality of Life After Primary TKA
- Interventions
- Doxepin 6 mg, Ramelteon 8 mg, Placebo Tablets
- Drug
- Lead sponsor
- University of Washington
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 129 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2028
- U.S. locations
- 1
- States / cities
- Seattle, Washington