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ClinicalTrials.gov public records Last synced Nov 15, 2026, 7:18 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 913–936 of 2,615 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Sleep-Wake Disorders Clear all

Conditions: Restless Legs Syndrome, Ekbom Syndrome, Willis-Ekbom Disease
Interventions: Rotigotine; Drug
Lead sponsor: John Winkelman, MD, PhD; Other
Eligibility: 18 Years to 75 Years
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2015
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Insomnia, Fibromyalgia
Interventions: CBT; Behavioral
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 18 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2021
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Insomnia, Psychosis
Interventions: Cognitive Behavioral Therapy-Insomnia, Health and Wellness; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 80 Years
Enrollment: 152 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Baltimore, Maryland • Philadelphia, Pennsylvania

Conditions: Menopause, Insomnia
Interventions: Eszopiclone, Placebo; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 40 Years and older · Female only
Enrollment: 67 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Insomnia
Interventions: Solriamfetol 75 MG, Cognitive Behavioral Therapy for Insomnia (CBT-I), Monitoring, Placebo; Drug · Behavioral · Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 25 Years to 60 Years
Enrollment: 115 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Opioid Use Disorder, Pregnancy Related
Interventions: Empowering Pregnant Women and People Receiving Medications for Opioid Use Disorder; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Insomnia, Nicotine Dependence
Interventions: Eszopiclone, Bupropion; Drug
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 4 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2008
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Chronic Respiratory Conditions, Obstructive Sleep Apnea (OSA)
Interventions: F&P Mask; Device
Lead sponsor: Fisher and Paykel Healthcare; Industry
Eligibility: 22 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Columbia, South Carolina

Conditions: Migraine Disorders, Sleep Disorder
Interventions: Fremanezumab Prefilled Syringe [Ajovy]; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 22 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Insomnia, Secondary, Sleep Disturbance, Sleep, Sleep Initiation and Maintenance Disorders
Interventions: Dreem 3 System vs WatchPAT One, Usability Questionnaire; Device · Other
Lead sponsor: Dreem; Industry
Eligibility: 22 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022
U.S. locations: 1
States / cities: Encinitas, California

Conditions: Delirium, Sleep Disturbance
Interventions: Nighttime Vital Sign EHR Alert, No EHR alert; Behavioral · Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: Not listed
Enrollment: 1,436 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Spinal Cord Injury, Sleep-disordered Breathing, Spinal Cord Disease, Multiple Sclerosis
Interventions: Best practices PAP + patient Education +ongoing Support and Training, Sleep Education; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 73 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2020
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Hypersomnia, Narcolepsy, Nervous System Disease, Sleep Disorder
Interventions: Not listed
Lead sponsor: National Institute of Neurological Disorders and Stroke (NINDS); NIH
Eligibility: 5 Years and older
Enrollment: 83 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1996 – 2011
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Obstructive Sleep Apnea
Interventions: Device: Trial nasal mask (F&P); Device
Lead sponsor: Fisher and Paykel Healthcare; Industry
Eligibility: 22 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Obstructive Sleep Apnea, Down Syndrome
Interventions: Sleep study; Other
Lead sponsor: Oregon Health and Science University; Other
Eligibility: 2 Years to 17 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Portland, Oregon

Conditions: Insomnia
Interventions: ONLINE ONLY, STEPPED CARE; Behavioral
Lead sponsor: Stanford University; Other
Eligibility: 50 Years and older
Enrollment: 388 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2023
U.S. locations: 1
States / cities: Palo Alto, California

Conditions: Insomnia, Insomnia (Moderate)
Interventions: ASV therapy; Device
Lead sponsor: ResMed; Industry
Eligibility: 18 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Detroit, Michigan

Conditions: Obstructive Sleep Apnea
Interventions: Propofol, Dexmedetomidine; Drug
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years to 75 Years
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Obesity, Adolescent
Interventions: Breakfast; Behavioral
Lead sponsor: University of Texas at Austin; Other
Eligibility: 13 Years to 21 Years
Enrollment: 103 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Insomnia
Interventions: Cognitive Behavioral Therapy for insomnia (CBTi-CB-TM), Sleep Hygiene Education (SHE-TM); Behavioral
Lead sponsor: University of Michigan; Other
Eligibility: 21 Years and older
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Mood Disorders, Sleep Disorders, Migraine
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 7 Years to 120 Years
Enrollment: 1,944 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2004
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Mild Obstructive Sleep Apnea, Snoring
Interventions: Mouth Tape; Device
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 75 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2030
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Post Traumatic Stress Disorder, Sleep Disturbance
Interventions: Auricular Acupuncture; Device
Lead sponsor: United States Naval Medical Center, San Diego; Federal
Eligibility: 18 Years to 50 Years · Male only
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2014
U.S. locations: 1
States / cities: San Diego, California

Conditions: Obstructive Sleep Apnea, Alzheimer's Disease
Interventions: Continuous positive airway pressure device; Other
Lead sponsor: NYU Langone Health; Other
Eligibility: 30 Years to 75 Years
Enrollment: 38 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2019
U.S. locations: 2
States / cities: New York, New York

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Switching From Oral Dopamine Agonists to Rotigotine

Web-based CBT for Insomnia Patients With Fibromyalgia

CBT-I to Improve Functional Outcomes in Veterans With Psychosis

The Treatment of Insomnia in Symptomatic Peri- and Postmenopausal Women

Solriamfetol and CBT-I in Patients With Insomnia Disorder

Open Trial of Technology-Enhanced Behavioral Intervention for Buprenorphine Retention in Pregnant and Postpartum People

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban

Evaluation of F&P Mask, US, 2026

Fremanezumab, Migraine and Sleep

Robustness and Usability of the Dreem 3 System for at Home Sleep Monitoring in an Insomnia Population.

De-escalating Vital Sign Checks

Treatment of Sleep-disordered Breathing in Patients With SCI

Sleep Disorders of Patients With Diseases of the Nervous System

The Evaluation of a New Nasal Mask for the Treatment of Obstructive Sleep Apnea

Validation of Sleep Questionnaires in the Down Syndrome Population

The RESTING Insomnia Study: Randomized Controlled Study on Effectiveness of Stepped-Care Sleep Therapy

ASV Therapy for Insomnia

Sedation in Patients at Risk for Upper Airway Collapse

Increased Protein at Breakfast for Weight Management in Overweight Adolescents

Targeting Insomnia to Improve Outcomes in Adults With Problematic Cannabis Use

Family Study of Affective and Anxiety Spectrum Disorders

Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea.

Acupuncture for Sleep Disturbances in OEF/OIF Veterans With Post Traumatic Stress Disorder

Brain Sleep Clearance of Amyloid-Beta Peptides