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ClinicalTrials.gov public records Last synced Oct 20, 2026, 7:25 PM EDT

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Showing 97–120 of 181 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoke Exposure Clear all
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers

NCT01262170
View directory record Official record
Conditions
Smoking, Tobacco Use Disorder
Interventions
CigRx Lozenge, Tobacco Lozenge
Dietary Supplement · Other
Lead sponsor
Rock Creek Pharmaceuticals, Inc.
Industry
Eligibility
23 Years to 72 Years
Enrollment
109 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 30, 2015 · Synced Oct 20, 2026, 7:25 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol

NCT04661683
View directory record Official record
Conditions
Hookah Smoking, Secondhand Aerosol, Vascular Stiffness, Vaping
Interventions
Combustible Hookah Smoke, Electronic Hookah Aerosol, Clean Room Air
Other
Lead sponsor
University of California, Los Angeles
Other
Eligibility
21 Years to 49 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers Results available

Woodsmoke Particulate + Prednisone

NCT03861390
View directory record Official record
Conditions
Airway Inflammation
Interventions
60 mg Prednisone, Placebo
Drug
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 45 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 25, 2024 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional

Counseling to Reduce Children's SHS Exposure: A Trial With Maternal Smokers

NCT02117947
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Behavioral Counseling, Self-help control
Behavioral
Lead sponsor
Temple University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2011
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Feb 15, 2017 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Study of a Smartphone-Based Switch Program

NCT06544772
View directory record Official record
Conditions
Smoking Cessation
Interventions
Pivot cigarette smoking cessation program
Device
Lead sponsor
Pivot Health Technologies Inc.
Industry
Eligibility
21 Years to 65 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
San Carlos, California
Source: ClinicalTrials.gov public record
Updated Oct 2, 2025 · Synced Oct 20, 2026, 7:25 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

NCT06295757
View directory record Official record
Conditions
Tobacco Use, Cigarette Smoking, Nicotine Dependence
Interventions
Cigarettes
Other
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
21 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 13, 2026 · Synced Oct 20, 2026, 7:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Vaping and Smoking Withdrawal Project

NCT05772845
View directory record Official record
Conditions
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Interventions
Acute (24-hour) abstinence, Ad libitum smoking/vaping
Behavioral
Lead sponsor
State University of New York at Buffalo
Other
Eligibility
21 Years to 50 Years
Enrollment
370 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Mar 9, 2026 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Phase 2 Interventional

Clinical Study of Smoke-Break Liquid Cigarettes

NCT00715871
View directory record Official record
Conditions
Smoking
Interventions
Nicotine, Smoke-Break nicotine delivery device
Drug · Device
Lead sponsor
Smoke-Break, Inc.
Industry
Eligibility
18 Years to 70 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
1
States / cities
West Allis, Wisconsin
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Oct 20, 2026, 7:25 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Measuring Environmental Tobacco and Cannabis: Pollutants and Exposures

NCT06030674
View directory record Official record
Conditions
Healthy
Interventions
Secondhand cannabis emissions/smoke exposure
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 50 Years
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jun 16, 2026 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Sustaining Smoking Cessation in Smokers With Kids With Asthma

NCT00862368
View directory record Official record
Conditions
Asthma, Smoking Cessation
Interventions
PAM, PAM-Enhanced/Asthma Counseling Phone Calls, Follow-Up Phone Calls - Child Wellness Topic
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years and older
Enrollment
573 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
5
States / cities
Fall River, Massachusetts • Pawtucket, Rhode Island • Providence, Rhode Island + 1 more
Source: ClinicalTrials.gov public record
Updated Apr 25, 2012 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional

Pediatric Emergency Department Decision Support System to Reduce Secondhand Smoke

NCT02489708
View directory record Official record
Conditions
Asthma, Smoking Cessation
Interventions
Cessation Counseling
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
1 Day and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Dec 9, 2021 · Synced Oct 20, 2026, 7:25 PM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

VergeRx for Smokers Not Ready to Quit

NCT07693660
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
VergeRx, SmokefreeTXT, NRT Lozenge (Combination), Extended NRT Patch (16 weeks), Standard NRT Patch (8 weeks)
Behavioral · Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
592 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2027 – 2032
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

MassCONECT (Massachusetts Community Networks to Eliminate Cancer Disparities Through Education) 4 Kids: Promoting Smoke-free Homes

NCT01537874
View directory record Official record
Conditions
Tobacco Smoking Behavior
Interventions
Motivational Interview, Usual best practices
Behavioral
Lead sponsor
Harvard School of Public Health (HSPH)
Other
Eligibility
17 Years and older
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
3
States / cities
Boston, Massachusetts • Lawrence, Massachusetts • Worcester, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 20, 2014 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Effects of Wood Smoke Particles on Influenza-induced Nasal Inflammation in Normal Volunteers

NCT02183753
View directory record Official record
Conditions
Response of Viral Infection to Woodsmoke
Interventions
wood smoke, clean air
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 40 Years
Enrollment
39 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 11, 2015 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Impact of Graphic Cigarette Warnings

NCT02247908
View directory record Official record
Conditions
Smoking
Interventions
Surgeon General's Warning, Graphic Warning
Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years and older
Enrollment
2,149 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
2
States / cities
Oakland, California • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 14, 2016 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Results available

Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products

NCT06179290
View directory record Official record
Conditions
Tobacco Use
Interventions
Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), Smoking Abstinence (menthol), Smoking Abstinence (non-menthol)
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
921 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
8
States / cities
Bentonville, Arkansas • Rogers, Arkansas • Overland Park, Kansas + 5 more
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

PROS Brief Smoking Cessation Counseling in Pediatric Practice to Reduce Secondhand Smoke Exposure of Young Children

NCT00135213
View directory record Official record
Conditions
Health Care Quality, Access, and Evaluation, Smoking Cessation
Interventions
training in smoking cessation
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
18 Years and older
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Jan 3, 2008 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Results available

Promoting Risk Reduction Among Young Adults With Asthma During Wildfire Smoke Events (TRAK)

NCT04724733
View directory record Official record
Conditions
Asthma
Interventions
Smoke Sense, Smoke Sense Plus
Behavioral
Lead sponsor
Washington State University
Other
Eligibility
18 Years to 26 Years
Enrollment
67 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020
U.S. locations
1
States / cities
Spokane, Washington
Source: ClinicalTrials.gov public record
Updated Apr 28, 2023 · Synced Oct 20, 2026, 7:25 PM EDT
Withdrawn No phase listed Observational

Hydroxycobalamin and Rural Emergency Medical Services Cyanide Exposure Patients: A Cost Analysis

NCT01656616
View directory record Official record
Conditions
Cyanide Poisoning
Interventions
Cyanide antidote administration
Drug
Lead sponsor
MaineHealth
Other
Eligibility
Not listed
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012
U.S. locations
1
States / cities
Portland, Maine
Source: ClinicalTrials.gov public record
Updated May 18, 2017 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Results available

Improving Tobacco Treatment Rates for Cancer Patients Who Smoke

NCT04738643
View directory record Official record
Conditions
Cancer, Tobacco Use, Smoking, Nicotine Dependence
Interventions
Tobacco Use Treatment Service and Varenicline Management
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
Not listed
Enrollment
685 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
2
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 8, 2025 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional

Clinical Effort Against Secondhand Smoke (CEASE) Program or Standard Care in Helping Parents Stop Smoking

NCT00664261
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
smoking cessation intervention, cancer prevention, counseling intervention, educational intervention, laboratory biomarker analysis, questionnaire administration, survey administration, study of high risk factors
Behavioral · Other · Procedure
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
Not listed
Enrollment
3,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2013
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 18, 2013 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers

Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

NCT00307203
View directory record Official record
Conditions
Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders
Interventions
bupropion SR, Cognitive Behavioral Group Therapy, nicotine replacement therapy
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
51 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1998 – 2004
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jan 11, 2017 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Circadian Rhythm Disruption Effects on Smoke Inhalation

NCT04955431
View directory record Official record
Conditions
Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
Interventions
Sleep Restriction, Normal Sleep
Behavioral
Lead sponsor
University of Montana
Other
Eligibility
18 Years to 44 Years · Male only
Enrollment
10 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Missoula, Montana
Source: ClinicalTrials.gov public record
Updated May 30, 2025 · Synced Oct 20, 2026, 7:25 PM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Incentive Programs for Female Substance Abusers Who Smoke - 3

NCT00064922
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Behavior Therapy
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
15 Years to 99 Years · Female only
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2006
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 20, 2026, 7:25 PM EDT