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ClinicalTrials.gov public records Last synced Nov 10, 2026, 10:52 AM EST

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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smokeless Tobacco Use Clear all

Conditions: Tobacco Use
Interventions: Test Product A, Test Product B, Test Product C, Test Product D, Test Product E, Reference Product F: Subjects' OBMST; Other
Lead sponsor: Altria Client Services LLC; Industry
Eligibility: 22 Years to 65 Years
Enrollment: 64 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2024
U.S. locations: 2
States / cities: Bentonville, Arkansas • Springfield, Missouri

Conditions: Tobacco Use Disorder
Interventions: Web + Phone, Web Only, Phone Only, Usual Care; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 1,683 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2012
U.S. locations: 2
States / cities: San Diego, California • Eugene, Oregon

Conditions: Cigarette Smoking
Interventions: Tobacco-Heating Cigarette, Snus (Smokeless Tobacco), Tobacco-Burning Cigarette; Other
Lead sponsor: R.J. Reynolds Tobacco Company; Industry
Eligibility: 28 Years to 55 Years
Enrollment: 163 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 5
States / cities: Daytona Beach, Florida • Boise, Idaho • Portland, Oregon + 2 more

Conditions: Smoking
Interventions: Brief tobacco counseling; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 2,637 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2006 – 2009
U.S. locations: 3
States / cities: Jackson, Mississippi • New York, New York • Eugene, Oregon

Conditions: Smokeless Tobacco Use, Tobacco Dependence
Interventions: Not listed
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 359 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 3
States / cities: Minneapolis, Minnesota • Eugene, Oregon • Morgantown, West Virginia

Conditions: Smokeless Tobacco, Tobacco Use Cessation
Interventions: Phone counseling and written materials; Behavioral
Lead sponsor: HealthPartners Institute; Other
Eligibility: 18 Years and older
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2006
U.S. locations: 1
States / cities: Bloomington, Minnesota

Conditions: Tobacco Use Cessation
Interventions: 5 A, 3 A; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 2,177 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Jackson, Mississippi

Conditions: Smokeless Tobacco Use
Interventions: nicotine replacement therapy (nicotine patches), placebo NRT; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years to 55 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Smokeless Tobacco Cessation
Interventions: #EnufSnuff.TXT- First Responder, Enough Snuff Intervention; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Tobacco Use Disorder
Interventions: smoking cessation intervention, questionnaire administration, quality-of-life assessment, laboratory biomarker analysis, ecigarettes; Behavioral · Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years and older
Enrollment: 72 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 2011
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Tobacco Use Cessation
Interventions: Brief counseling (Ask, Advise, Arrange); Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2008
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Tobacco Use Cessation
Interventions: Multimedia Support Intervention; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 18 Years and older · Female only
Enrollment: 1,100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2018
U.S. locations: 1
States / cities: Eugene, Oregon

Conditions: Smoking, Smoking, Cigarette, Smoking, Tobacco, Betel Chewer's Mucosa, Tobacco Use, Tobacco Smoking, Alcohol Drinking, Smokeless Tobacco Hyperkeratosis
Interventions: mHealth; Diagnostic Test
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 5,122 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2031
U.S. locations: 1
States / cities: New York, New York

Conditions: Nicotine Dependence
Interventions: varenicline, placebo; Drug
Lead sponsor: Mayo Clinic; Other
Eligibility: 18 Years and older
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Rochester, Minnesota

Conditions: Smoking, Smoking Cessation
Interventions: Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet, Relapse Prevention Intervention; Behavioral
Lead sponsor: University of Tennessee; Other
Eligibility: 18 Years and older
Enrollment: 23,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2011 – 2017
U.S. locations: 2
States / cities: Memphis, Tennessee • Lackland Air Force Base, Texas

Conditions: Tobacco Use Disorder
Interventions: Lower Nicotine Smokeless Tobacco Product, Behavioral Counseling; Other
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2001 – 2004
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Cigarette Smoking
Interventions: Low-nitrosamine smokefree tobacco product for oral use, Non-tobacco, non-nicotine placebo product; Drug · Other
Lead sponsor: Swedish Match AB; Industry
Eligibility: 25 Years to 65 Years
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 4
States / cities: Daytona Beach, Florida • Evansville, Indiana • Portland, Oregon + 1 more

Conditions: Tobacco Use
Interventions: A19010-F, B19010-F; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 64 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 6
States / cities: Rogers, Arkansas • Lexington, Kentucky • Springfield, Missouri + 3 more

Conditions: Smokeless Tobacco Cessation
Interventions: Scheduled Gradual Reduction (SGR), Text Messages; Behavioral
Lead sponsor: Duke University; Other
Eligibility: 18 Years and older
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions: Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff; Other
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years to 50 Years
Enrollment: 81 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2013 – 2021
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Tobacco Use
Interventions: A19010-W, B19010-F; Other
Lead sponsor: RAI Services Company; Industry
Eligibility: 21 Years to 60 Years
Enrollment: 63 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 6
States / cities: Rogers, Arkansas • Lexington, Kentucky • Springfield, Missouri + 3 more

Conditions: Smokeless Tobacco Cessation
Interventions: All Nations Snuff Out Smokeless, Healthy Living; Behavioral
Lead sponsor: Lehigh University; Other
Eligibility: 18 Years and older
Enrollment: 384 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Bethlehem, Pennsylvania

Conditions: Smokeless Tobacco
Interventions: Herbal Snuff (Smokeless Tobacco); Drug
Lead sponsor: Masonic Cancer Center, University of Minnesota; Other
Eligibility: 18 Years to 65 Years
Enrollment: 55 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Tobacco Use Disorder, Nicotine Dependence
Interventions: Low nicotine, Medium nicotine, High nicotine; Other
Lead sponsor: University of Minnesota; Other
Eligibility: 18 Years and older
Enrollment: 278 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2012 – 2016
U.S. locations: 2
States / cities: Minneapolis, Minnesota • Eugene, Oregon

Search by objective public record fields.

Nicotine Pharmacokinetics and Subjective Effects of Oral Nicotine Products Relative to Smokeless Tobacco in Adult Users

Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users

Switching From Usual Brand Cigarettes to a Tobacco-heating Cigarette or Snus

Tobacco Cessation Via Public Health Dental Clinics

Novel Determinants and Measures of Smokeless Tobacco Use: Study 1

Telephone Counseling for Snuff Users

Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention

Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

Smokeless Tobacco Cessation Intervention for Firefighters

Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers

Tobacco Cessation Via Doctors of Chiropractic

A Multi-Media Approach to Partner Support in Smokeless Tobacco Cessation (UCare-ChewFree)

The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

Varenicline for the Treatment of Smokeless Tobacco

Preventing Relapse Following Involuntary Smoking Abstinence

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

Controlled Study of the Ability of a Smokefree Tobacco Product to Increase the Quit Rate Among Cigarette Smokers

CSD190101: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products

Addressing Tobacco Use Disparities Through an Innovative Mobile Phone Intervention

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

CSD190103: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products

Testing ANSOS for Efficacy in Multi-Tribal Urban Communities

Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure

Novel Determinants and Measures of Smokeless Tobacco Use: Study 2