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Showing 1–24 of 50 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Smokeless Tobacco Use Clear all
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

NCT07694492
View directory record Official record
Conditions
Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
Interventions
QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
Behavioral · Drug
Lead sponsor
University of Virginia
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Charlottesville, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 9, 2026 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Multi-Media Approach to Partner Support in Smokeless Tobacco Cessation (UCare-ChewFree)

NCT01885221
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Multimedia Support Intervention
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
1,100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2018
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 20, 2018 · Synced Sep 14, 2026, 1:33 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Human Laboratory Study of Smokeless Tobacco Products

NCT01100216
View directory record Official record
Conditions
Smokeless Tobacco
Interventions
Nicotine Lozenge, Stonewall Dissolvable Tobacco Pieces, Camel Snus Frost, Skoal Wintergreen
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 60 Years · Male only
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 9, 2014 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Switching From Usual Brand Cigarettes to a Tobacco-heating Cigarette or Snus

NCT02061917
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Tobacco-Heating Cigarette, Snus (Smokeless Tobacco), Tobacco-Burning Cigarette
Other
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
28 Years to 55 Years
Enrollment
163 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2009
U.S. locations
5
States / cities
Daytona Beach, Florida • Boise, Idaho • Portland, Oregon + 2 more
Source: ClinicalTrials.gov public record
Updated Feb 16, 2016 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate the Efficacy of Ariva® Silver Wintergreen, a Smoking Aversive Lozenge

NCT01336816
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva Silver Wintergreen, Placebo Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
43 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

A Pilot Study Evaluating Nicotine Lozenges and Self Help

NCT00888459
View directory record Official record
Conditions
Smokeless Tobacco Use
Interventions
nicotine replacement therapy, placebo NRT
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older · Male only
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
2
States / cities
Rochester, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 22, 2023 · Synced Sep 14, 2026, 1:33 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Metabolism of Deuterated NNN in Smokeless Tobacco Users

NCT02414477
View directory record Official record
Conditions
Tobacco Toxicant Exposure
Interventions
Deuterated NNN
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of FDA Authorized Smokeless Tobacco Claims Among US Adults Who Smoke Cigarettes

NCT06927700
View directory record Official record
Conditions
Tobacco Product Beliefs and Use
Interventions
Modified Risk Claim Type - None, Product Brand - General Snus, Product Brand - Copenhagen, Modified Risk Claim Type - Multiple Diseases, Modified Risk Claim Type - Lung Cancer
Behavioral
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
21 Years and older
Enrollment
1,257 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 3, 2026 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional

Tobacco Cessation Via Doctors of Chiropractic

NCT00386945
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Brief counseling (Ask, Advise, Arrange)
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 25, 2011 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190103: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products

NCT03993795
View directory record Official record
Conditions
Tobacco Use
Interventions
A19010-W, B19010-F
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
6
States / cities
Rogers, Arkansas • Lexington, Kentucky • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 2 Interventional

Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention

NCT00384254
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
5 A, 3 A
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 25, 2011 · Synced Sep 14, 2026, 1:33 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study

NCT06535867
View directory record Official record
Conditions
Smoking, Smoking, Cigarette, Smoking, Tobacco, Betel Chewer's Mucosa, Tobacco Use, Tobacco Smoking, Alcohol Drinking, Smokeless Tobacco Hyperkeratosis
Interventions
mHealth
Diagnostic Test
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
18 Years and older
Enrollment
5,122 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2031
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

NCT01337830
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva® Silver Wintergreen, Silver Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
111 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Novel Determinants and Measures of Smokeless Tobacco Use: Study 2

NCT01067599
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Low nicotine, Medium nicotine, High nicotine
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
2
States / cities
Minneapolis, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

NCT00218270
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Tobacco free snuff
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 14, 2026, 1:33 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Preventing Relapse Following Involuntary Smoking Abstinence

NCT01374724
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Tobacco Use Ban, Tailored Pamphlet, Informational Pamphlet, Relapse Prevention Intervention
Behavioral
Lead sponsor
University of Tennessee
Other
Eligibility
18 Years and older
Enrollment
23,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2017
U.S. locations
2
States / cities
Memphis, Tennessee • Lackland Air Force Base, Texas
Source: ClinicalTrials.gov public record
Updated Oct 31, 2016 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

NCT00939029
View directory record Official record
Conditions
Smokeless Tobacco Use
Interventions
nicotine replacement therapy (nicotine patches), placebo NRT
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2014 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Text-based Reduction Intervention for Smokeless Tobacco Cessation- Pilot Study

NCT06637358
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
Extended Scheduled Gradual Reduction (SGR), Quit Coach
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Varenicline for the Treatment of Smokeless Tobacco

NCT00813917
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varenicline, placebo
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2011
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 15, 2012 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use

NCT00218296
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Usual Care Group, Reduction Group
Drug · Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 70 Years
Enrollment
332 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 15, 2017 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Phase 1Phase 2 Interventional

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

NCT00218244
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Lower Nicotine Smokeless Tobacco Product, Behavioral Counseling
Other
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smokeless Tobacco Cessation Intervention for Firefighters

NCT05111041
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
#EnufSnuff.TXT- First Responder, Enough Snuff Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Sep 14, 2026, 1:33 AM EDT
Active, not recruiting Phase 1 Interventional Accepts healthy volunteers

Nornicotine in Smokeless Tobacco as a Precursor for Carcinogen Exposure

NCT03998735
View directory record Official record
Conditions
Smokeless Tobacco
Interventions
Herbal Snuff (Smokeless Tobacco)
Drug
Lead sponsor
Masonic Cancer Center, University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 25, 2025 · Synced Sep 14, 2026, 1:33 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Text-based Reduction Intervention for Smokeless Tobacco Cessation

NCT04315506
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
#EnufSnuff.TXT Intervention, Enough Snuff Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
532 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Sep 14, 2026, 1:33 AM EDT