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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Smokeless Tobacco Use Clear all
Completed Not applicable Interventional

Tobacco Cessation Via Doctors of Chiropractic

NCT00386945
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Brief counseling (Ask, Advise, Arrange)
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
201 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 25, 2011 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190101: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products

NCT03993769
View directory record Official record
Conditions
Tobacco Use
Interventions
A19010-F, B19010-F
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
64 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
6
States / cities
Rogers, Arkansas • Lexington, Kentucky • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

NCT00218270
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Tobacco free snuff
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
138 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

An Internet-Based Smokeless Tobacco Cessation Program for Teens

NCT00680615
View directory record Official record
Conditions
Smokeless Tobacco Use
Interventions
Tailored, enhanced condition, Usual Care
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
14 Years to 25 Years
Enrollment
1,716 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 4, 2012 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 1Phase 2 Interventional

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

NCT00218244
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Lower Nicotine Smokeless Tobacco Product, Behavioral Counseling
Other
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
56 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2001 – 2004
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD190103: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products

NCT03993795
View directory record Official record
Conditions
Tobacco Use
Interventions
A19010-W, B19010-F
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
63 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019
U.S. locations
6
States / cities
Rogers, Arkansas • Lexington, Kentucky • Springfield, Missouri + 3 more
Source: ClinicalTrials.gov public record
Updated Oct 24, 2019 · Synced Sep 29, 2026, 4:25 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Metabolism of Deuterated NNN in Smokeless Tobacco Users

NCT02414477
View directory record Official record
Conditions
Tobacco Toxicant Exposure
Interventions
Deuterated NNN
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
21 Years to 70 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Novel Determinants and Measures of Smokeless Tobacco Use: Study 2

NCT01067599
View directory record Official record
Conditions
Tobacco Use Disorder, Nicotine Dependence
Interventions
Low nicotine, Medium nicotine, High nicotine
Other
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
278 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
2
States / cities
Minneapolis, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Feb 25, 2018 · Synced Sep 29, 2026, 4:25 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Treating Smokeless Tobacco Use in Rural Veterans

NCT02994082
View directory record Official record
Conditions
Smokeless Tobacco, Nicotine Dependence
Interventions
Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management, Alcohol use risk reduction, Nicotine replacement therapy - transdermal nicotine patch, Nicotine replacement therapy - nicotine lozenge, Nicotine replacement therapy - nicotine gum, Bupropion sustained release, Varenicline, Combination nicotine replacement therapy, Combination nicotine replacement therapy + bupropion, Tobacco quit line, Educational materials
Behavioral · Drug
Lead sponsor
Mark Vander Weg
Federal
Eligibility
18 Years to 99 Years
Enrollment
123 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2020
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 23, 2019 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Controlled Study of the Ability of a Smokefree Tobacco Product to Increase the Quit Rate Among Cigarette Smokers

NCT00843622
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Low-nitrosamine smokefree tobacco product for oral use, Non-tobacco, non-nicotine placebo product
Drug · Other
Lead sponsor
Swedish Match AB
Industry
Eligibility
25 Years to 65 Years
Enrollment
250 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2010
U.S. locations
4
States / cities
Daytona Beach, Florida • Evansville, Indiana • Portland, Oregon + 1 more
Source: ClinicalTrials.gov public record
Updated Jun 16, 2014 · Synced Sep 29, 2026, 4:25 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Development of Biomarkers of Effect From Chronic Tobacco Usage

NCT01923402
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Not listed
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
35 Years to 60 Years · Male only
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
High Point, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 18, 2016 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

NCT00939029
View directory record Official record
Conditions
Smokeless Tobacco Use
Interventions
nicotine replacement therapy (nicotine patches), placebo NRT
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 55 Years
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2013
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated May 18, 2014 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]

NCT05030194
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
Interventions
Electronic Cigarette, Oral Nicotine Pouch
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years to 55 Years
Enrollment
15 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Oct 25, 2023 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Nicotine Lozenge to Reduce Smokeless Tobacco Use

NCT00218283
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotine Lozenge, Behavioral Counseling
Drug · Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
100 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2007
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 9, 2017 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation

NCT01341938
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
Commit® nicotine lozenges (4 mg) & self-help materials, Commit® nicotine lozenges (4 mg) & phone counseling & self-help materials, Phone counseling & self-help materials
Drug · Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
1,067 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 2 Interventional

Tobacco Quitlines:Adjunct to Dental Office Tobacco Intervention

NCT00384254
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
5 A, 3 A
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,177 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Jackson, Mississippi
Source: ClinicalTrials.gov public record
Updated Oct 25, 2011 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers Results available

Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction

NCT01018394
View directory record Official record
Conditions
Tobacco Dependence
Interventions
nicotine lozenges, tobacco-free snuff
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2012
U.S. locations
2
States / cities
Rochester, Minnesota • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Sep 12, 2013 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products

NCT01964807
View directory record Official record
Conditions
Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Interventions
Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine, Electronic Cigarette with no nicotine, Moist snuff, Sham Smoking, Secondhand cigarette smoke (SHS), Conditioned, filtered air, Sham Moist Snuff
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years to 50 Years
Enrollment
81 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2021
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 26, 2021 · Synced Sep 29, 2026, 4:25 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Influence of Authorized Smokeless Tobacco Product Modified Risk Claims II: Laboratory Assessment of Sensory and Subjective Effects

NCT07107139
View directory record Official record
Conditions
Smokeless Tobacco
Interventions
Copenhagen group, Snus group
Other
Lead sponsor
Roswell Park Cancer Institute
Other
Eligibility
21 Years and older
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated May 21, 2026 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Pilot Study to Evaluate the Efficacy and Safety of Ariva® Silver Wintergreen in Healthy Smokers

NCT01337817
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Ariva Silver Wintergreen, Ariva Wintergreen
Other
Lead sponsor
Star Scientific, Inc
Industry
Eligibility
23 Years to 72 Years
Enrollment
37 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Martinsburg, West Virginia
Source: ClinicalTrials.gov public record
Updated Oct 23, 2014 · Synced Sep 29, 2026, 4:25 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers

NCT01692353
View directory record Official record
Conditions
Cardiovascular Disease, Cigarette Smoking
Interventions
Subject's usual brand (UB) tobacco product
Other
Lead sponsor
R.J. Reynolds Tobacco Company
Industry
Eligibility
26 Years to 49 Years · Male only
Enrollment
168 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Feb 16, 2016 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

A Text-based Reduction Intervention for Smokeless Tobacco Cessation

NCT04315506
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
#EnufSnuff.TXT Intervention, Enough Snuff Intervention
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
532 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jul 16, 2024 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Bupropion SR for Treating Smokeless Tobacco Use

NCT00414180
View directory record Official record
Conditions
Smokeless Tobacco
Interventions
Bupropion SR
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
225 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2005
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Mar 13, 2011 · Synced Sep 29, 2026, 4:25 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Text-based Reduction Intervention for Smokeless Tobacco Cessation- Pilot Study

NCT06637358
View directory record Official record
Conditions
Smokeless Tobacco Cessation
Interventions
Extended Scheduled Gradual Reduction (SGR), Quit Coach
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older
Enrollment
69 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Sep 29, 2026, 4:25 AM EDT