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ClinicalTrials.gov public records Last synced Nov 7, 2026, 10:01 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 313–336 of 797 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoker Clear all

Conditions: Tobacco Use Disorder, Smoking
Interventions: Ariva® Silver Wintergreen, Silver Wintergreen; Other
Lead sponsor: Star Scientific, Inc; Industry
Eligibility: 23 Years to 72 Years
Enrollment: 111 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010
U.S. locations: 1
States / cities: Martinsburg, West Virginia

Conditions: Smoking Cessation
Interventions: Stepped-Care, Control; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 18 Years and older
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2009
U.S. locations: 1
States / cities: Walnut Creek, California

Conditions: Smoking, HIV Infections
Interventions: Varenicline tartrate, Nicotine Replacement Therapy, Biological Control, Motivational Interview; Drug · Other · Behavioral
Lead sponsor: Philip Diaz; Other
Eligibility: 18 Years and older
Enrollment: 294 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2013
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Nicotine Use Disorder
Interventions: Practice Quit Attempt; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 45 Years
Enrollment: 82 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2023
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence, Schizophrenia
Interventions: NRT, Bupropion SR 150mg bid, Relapse Prevention-Oriented Cognitive Behavioral Therapy; Drug · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 17 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2007
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Tobacco Use Disorder, Homelessness
Interventions: Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling, Nicotine rescue method, Bupropion; Drug · Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 70 Years
Enrollment: 133 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Nicotine Dependence
Interventions: Nicotine form, E-cigarette experimental flavor; Drug · Other
Lead sponsor: Yale University; Other
Eligibility: 21 Years and older
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2022
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Lung Cancer, Precancerous Condition, Tobacco Use Disorder
Interventions: calcitriol, laboratory biomarker analysis, pharmacological study; Drug · Other
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 40 Years to 79 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2018
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Lung Cancer, Non-small Cell Lung Cancer, Bronchioloalveolar Cancer
Interventions: Gefitinib; Drug
Lead sponsor: Memorial Sloan Kettering Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 65 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2010
U.S. locations: 1
States / cities: New York, New York

Conditions: Current Smoker, Never Smoker, Tobacco Use Disorder, Former Smoker, E-cig User
Interventions: Bronchoscopy, Electronic Cigarette, Laboratory Biomarker Analysis, Questionnaire Administration; Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years to 45 Years
Enrollment: 142 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2015 – 2021
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Asthma
Interventions: fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics; Drug
Lead sponsor: Gelb, Arthur F., M.D.; Individual
Eligibility: 10 Years to 80 Years
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: Lakewood, California

Conditions: Respiratory Diseases
Interventions: Not listed
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 75 Years
Enrollment: 30 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2013
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cigarette Smoking, Current Smoker
Interventions: Educational Intervention, Questionnaire Administration, Smoking Cessation Intervention; Other · Behavioral
Lead sponsor: M.D. Anderson Cancer Center; Other
Eligibility: 18 Years to 35 Years
Enrollment: 579 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018 – 2021
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Tobacco Use Disorder, HIV
Interventions: PSFW+, AHA, Nicotine polacrilex; Behavioral · Drug
Lead sponsor: Montefiore Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 512 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2020
U.S. locations: 2
States / cities: Baltimore, Maryland • The Bronx, New York

Conditions: HIV Infections, Smoking Cessation
Interventions: Standard Care, Motivational Enhancement; Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 70 Years
Enrollment: 444 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 1999 – 2004
U.S. locations: 5
States / cities: Fall River, Massachusetts • New Bedford, Massachusetts • Pawtucket, Rhode Island + 1 more

Conditions: Current Smoker, Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma, Laryngeal Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Oral Cavity Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma
Interventions: Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement, Quality-of-Life Assessment, Questionnaire Administration, Varenicline; Drug · Other
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 9 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 2
States / cities: Winston-Salem, North Carolina • Charleston, South Carolina

Conditions: Smoking, Anxiety Disorders
Interventions: Nicotine Patch, Smoking Termination and Anxiety Reduction Treatment, Education-Supportive Psychotherapy; Drug · Behavioral
Lead sponsor: University of Houston; Other
Eligibility: 18 Years to 65 Years
Enrollment: 74 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2016
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Schizophrenia
Interventions: ABT-126, Placebo; Drug
Lead sponsor: AbbVie (prior sponsor, Abbott); Industry
Eligibility: 20 Years to 55 Years
Enrollment: 157 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 20
States / cities: Chino, California • Garden Grove, California • National City, California + 17 more

Conditions: Electronic Cigarettes
Interventions: Own Brand Cigarette, ECIG 15 mg nicotine, sweetened, ECIG 15 mg nicotine, unsweet, ECIG 0 mg nicotine, sweetened, ECIG 0 mg nicotine, unsweet; Other
Lead sponsor: Virginia Commonwealth University; Other
Eligibility: 21 Years to 55 Years
Enrollment: 22 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2021
U.S. locations: 1
States / cities: Richmond, Virginia

Conditions: Smoking Cessation
Interventions: High intensity disease management, Low intensity disease management, Comparison group, Bupropion; Behavioral · Drug
Lead sponsor: University of Kansas Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 750 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009 – 2010
U.S. locations: 1
States / cities: Kansas City, Kansas

Conditions: Alcohol Drinking, Cigarette Smoking Toxicity
Interventions: Reduced nicotine cigarettes; Drug
Lead sponsor: Battelle Memorial Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 47 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2017 – 2021
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Nicotine Dependence
Interventions: Tolcapone, Placebo; Drug
Lead sponsor: University of Pennsylvania; Other
Eligibility: 18 Years to 55 Years
Enrollment: 19 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Tobacco Use Disorder
Interventions: Self-determination Intervention for Tobacco Dependence; Behavioral
Lead sponsor: University of Rochester; Other
Eligibility: 18 Years and older
Enrollment: 837 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2004 – 2008
U.S. locations: 1
States / cities: Rochester, New York

Conditions: Smoking
Interventions: active nicotine gum, Standard behavioral therapy; Drug · Behavioral
Lead sponsor: Brian Primack; Other
Eligibility: 18 Years and older
Enrollment: 505 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Search by objective public record fields.

Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers

Interventions for Smoking Among Persons in Recovery

Smoking Cessation Using Motivational Therapy and Varenicline

Neural Basis of Eating Behavior in Abstinent Smokers

Extended Duration Nicotine Replacement Therapy and Bupropion in Smokers With Schizophrenia

Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers

The Interaction of Flavor With Nicotine Form in Adult Smokers

Calcitriol in Preventing Lung Cancer in Smokers and Former Smokers at High Risk of Lung Cancer

Phase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor Gene

Effects of Electronic Cigarette Use on the Lungs

Mechanism(s) of Airflow Limitation During Exacerbation of Asthma

Bronchoscopy Assisted Sampling of Cells and Fluid From the Lower Respiratory Tract of Human Subjects

Quit4Health Intervention in Supporting Smoking Cessation and Preventing Smoking Initiation in Young Adults

RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers

Motivation and Patch Treatment for HIV-positive Smokers

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

Smoking Termination / Anxiety Reduction Treatment (ST/ART)

A Phase 2 Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia

The Effect of Electronic Cigarette Liquid Characteristics in Smokers.

Disease Management for Smoking Cessation

Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder

Pilot Study of Tolcapone in Smokers

Smokers' Health Project: Self-Determination and Maintaining Tobacco Abstinence

Cessation in Non-Daily Smokers