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ClinicalTrials.gov public records Last synced Nov 3, 2026, 2:40 AM EST

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Showing 97–120 of 797 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoker Clear all
Completed Not applicable Interventional Accepts healthy volunteers Results available

Varenicline-Aided Cigarette Reduction in Smokers Not Ready to Quit

NCT01308736
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Varenicline, Placebo pill
Drug
Lead sponsor
Rutgers, The State University of New Jersey
Other
Eligibility
18 Years to 64 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2014
U.S. locations
1
States / cities
New Brunswick, New Jersey
Source: ClinicalTrials.gov public record
Updated Jul 17, 2017 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Testing Financial Incentive Interventions in Dyadic-Smoker Couples

NCT04832360
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Financial Incentives
Behavioral
Lead sponsor
University of Georgia
Other
Eligibility
18 Years and older
Enrollment
190 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Athens, Georgia
Source: ClinicalTrials.gov public record
Updated Jan 24, 2025 · Synced Nov 3, 2026, 2:40 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Digitally Enhanced Smoking Cessation for High Risk Smokers

NCT04691297
View directory record Official record
Conditions
Smoking, Smoking Cessation, Lung Cancer Screening, Smoking, Tobacco, Smoking Behaviors
Interventions
Escape, Standard Care
Other
Lead sponsor
Dana-Farber Cancer Institute
Other
Eligibility
55 Years to 77 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
2
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 19, 2025 · Synced Nov 3, 2026, 2:40 AM EST
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Physical Activity in Promoting Smoking Cessation in African Americans

NCT01915810
View directory record Official record
Conditions
Current Smoker, Healthy Subject
Interventions
Exercise Intervention, Laboratory Biomarker Analysis, Nicotine Patch, Questionnaire Administration, Tobacco Cessation Counseling
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
21 Years to 65 Years
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2027
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 16, 2026 · Synced Nov 3, 2026, 2:40 AM EST
Not listed Phase 3 Interventional Accepts healthy volunteers

Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers

NCT01892813
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Use
Interventions
Nicotine replacement therapy - Transdermal nicotine patch, Nicotine replacement therapy - Nicotine gum, Nicotine replacement therapy - Nicotine lozenge, Bupropion, Varenicline, Combination pharmacotherapy - Transdermal nicotine patch + nicotine gum, Combination pharmacotherapy - Transdermal nicotine patch + nicotine lozenge, Combination pharmacotherapy - Transdermal nicotine patch + bupropion, Tobacco quitline referral, Tailored behavioral intervention, Alcohol use risk reduction, Behavioral activation for depressive symptoms, Behavioral management of postcessation weight gain
Drug · Behavioral
Lead sponsor
Mark Vander Weg
Other
Eligibility
18 Years to 99 Years
Enrollment
411 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2018
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Jul 11, 2017 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 1 Interventional

Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers

NCT01034020
View directory record Official record
Conditions
Substance Related Disorder, Nicotine Dependence
Interventions
Nicotine
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2009
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 2, 2017 · Synced Nov 3, 2026, 2:40 AM EST
Terminated No phase listed Observational Accepts healthy volunteers

Incorporation of Genetic Expression of Airway Epithelium With CT Screening for Lung Cancer

NCT01982149
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease, COPD
Interventions
Group 1, Group 2, Group 3
Genetic
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2020 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum

NCT02323438
View directory record Official record
Conditions
Smoking
Interventions
Usual Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2, Leading U.S. Nicotine Gum
Other
Lead sponsor
R.J. Reynolds Vapor Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
153 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2015
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jun 1, 2018 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers

Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2

NCT00135746
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
nicotine transdermal system
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 50 Years
Enrollment
128 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2007
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Potential Effects of Electronic Nicotine Delivery System Flavor Regulations on African American Menthol Smokers

NCT05023096
View directory record Official record
Conditions
Electronic Nicotine Delivery System Flavors
Interventions
Tobacco product administration and assessment
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
71 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Apr 22, 2026 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 1 Interventional Accepts healthy volunteers

Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine

NCT01092650
View directory record Official record
Conditions
Tobacco Toxicant Exposure
Interventions
Deuterated phenanthrene
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 27, 2014 · Synced Nov 3, 2026, 2:40 AM EST
Recruiting Not applicable Interventional

Testing the mHealth App Intervention for Nondaily Smokers "SiS4"

NCT06678243
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smiling instead of Smoking, QuitGuide
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
1,600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2028
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Biomarkers of Exposure and Biomarkers of Potential Harm in Adult Smokers Who Completely Switch to E-vapor Products

NCT04800211
View directory record Official record
Conditions
Tobacco Use
Interventions
Experimental: Test Product 1, Experimental: Test Product 2
Other
Lead sponsor
Altria Client Services LLC
Industry
Eligibility
30 Years to 65 Years
Enrollment
450 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
10
States / cities
Burbank, California • Wichita, Kansas • Lexington, Kentucky + 7 more
Source: ClinicalTrials.gov public record
Updated Mar 12, 2025 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 4 Interventional

Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch)

NCT00004551
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
nicotine replacement patch, mood management
Drug · Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1999 – 2003
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Sep 29, 2010 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 1 Interventional

Smoking Cessation for Depression and Anxiety Treatment

NCT02002858
View directory record Official record
Conditions
Smoking, Anxiety Disorders, Depression Disorders
Interventions
Nicotine Patch, Depression and Anxiety Smoking Cessation Treatment, Educational-Support Psychotherapy
Drug · Behavioral
Lead sponsor
University of Houston
Other
Eligibility
18 Years to 65 Years
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jul 7, 2017 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Results available

Quit For Life (QFL): Smoking Cessation Among Chinese Smokers Living With HIV

NCT05020899
View directory record Official record
Conditions
Smoking Cessation, HIV Infections
Interventions
Sessions with a trained counselor, Cell phone messages, Offered nicotine replacement therapy, Self-help guide for quitting smoking
Behavioral · Other
Lead sponsor
Boston Medical Center
Other
Eligibility
18 Years and older
Enrollment
109 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Dec 12, 2024 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 1 Interventional Accepts healthy volunteers

A Phase I Study to Evaluate the Pharmacokinetics of Multiple Doses of Varenicline in Healthy Adolescent Smokers

NCT00463918
View directory record Official record
Conditions
Smoking Cessation
Interventions
varenicline
Drug
Lead sponsor
Pfizer
Industry
Eligibility
12 Years to 16 Years
Enrollment
73 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007
U.S. locations
15
States / cities
Anniston, Alabama • Phoenix, Arizona • Hot Springs, Arkansas + 10 more
Source: ClinicalTrials.gov public record
Updated Nov 19, 2008 · Synced Nov 3, 2026, 2:40 AM EST
Withdrawn No phase listed Observational Accepts healthy volunteers

Monitoring and Outcome Measures in Asthmatics and Smokers During Pregnancy

NCT00425880
View directory record Official record
Conditions
Asthma, Tobacco Use
Interventions
Not listed
Lead sponsor
University of Kentucky
Other
Eligibility
18 Years to 35 Years · Female only
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2010
U.S. locations
1
States / cities
Lexington, Kentucky
Source: ClinicalTrials.gov public record
Updated Aug 9, 2013 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 2 Interventional Results available

Targeted Interventions for Weight-Concerned Smokers

NCT00105482
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Naltrexone, Transdermal nicotine replacement, Behavioral counseling
Drug · Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 5, 2013 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Airway and Pulmonary Vascular Endothelial Function in Healthy Smokers: Effect of Inhaled Glucocorticosteroid Treatment

NCT02141633
View directory record Official record
Conditions
Smoking
Interventions
echocardiogram plus albuterol, airway blood flow plus albuterol, Fluticasone propionate, placebo
Procedure · Drug
Lead sponsor
University of Miami
Other
Eligibility
25 Years to 75 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Dec 16, 2016 · Synced Nov 3, 2026, 2:40 AM EST
Recruiting Not applicable Interventional Accepts healthy volunteers

Impact of Cigarette and E-cigarette Menthol Regulation on Current Smokers of Menthol Cigarettes

NCT05896033
View directory record Official record
Conditions
Smoking Prevention and Control
Interventions
Non-Menthol Cigarettes, Tobacco Flavored E-cigarettes, Menthol Cigarettes, Menthol Flavored E-cigarettes
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years and older
Enrollment
240 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2027
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Jul 21, 2026 · Synced Nov 3, 2026, 2:40 AM EST
Completed Phase 3 Interventional Results available

Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking

NCT00282984
View directory record Official record
Conditions
Smoking Cessation
Interventions
placebo, Varenicline
Drug
Lead sponsor
Pfizer
Industry
Eligibility
35 Years to 75 Years
Enrollment
714 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2008
U.S. locations
3
States / cities
Hartford, Connecticut • Boston, Massachusetts • Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Apr 5, 2017 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Results available

Trial on the Effectiveness of Mindfulness Training for Smokers

NCT01093599
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Quit Line plus MTS, Quit Line Only
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
196 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 20, 2015 · Synced Nov 3, 2026, 2:40 AM EST
Completed Not applicable Interventional Accepts healthy volunteers Results available

Comparative Acceptability of Tobacco and Menthol Flavored E-cigarettes

NCT04996940
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
E-cigarette product
Device
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
21 Years and older
Enrollment
52 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Kansas City, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 13, 2023 · Synced Nov 3, 2026, 2:40 AM EST