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ClinicalTrials.gov public records Last synced Nov 11, 2026, 12:55 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 2,335 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Smoking, Tobacco Clear all

Conditions: Nicotine Use Disorder, Nicotine Dependence
Interventions: Active rTMS with MagVenture MagPro double blind rTMS system, Sham rTMS; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 5 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: HIV, Smoking
Interventions: Counseling, Smoking Cessation drugs, Bronchoscopy, Blood Draw, Questionnaires; Behavioral · Other · Procedure
Lead sponsor: Boston Medical Center; Other
Eligibility: 18 Years to 75 Years
Enrollment: 53 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2023
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking, Tobacco Use
Interventions: Laboratory task modeling smoking lapse behavior; Behavioral
Lead sponsor: Penn State University; Other
Eligibility: 21 Years to 65 Years
Enrollment: 150 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: University Park, Pennsylvania

Conditions: Smoking Cessation
Interventions: Libre del Cigarrillo Smartphone App, Libre del Cigarrillo Printed Booklets, SmokefreeTXT en Español; Behavioral
Lead sponsor: H. Lee Moffitt Cancer Center and Research Institute; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Tampa, Florida

Conditions: Tobacco Use Disorder
Interventions: varenicline, Adaptation of Motivational Interviewing; Drug · Behavioral
Lead sponsor: VA Boston Healthcare System; Federal
Eligibility: 18 Years to 65 Years
Healthy volunteers: Healthy volunteers not accepted
U.S. locations: 1
States / cities: Brockton, Massachusetts

Conditions: Nicotine Dependence
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 13 Years to 17 Years
Enrollment: 25 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Pulmonary Disease, Chronic Obstructive
Interventions: Non-Interventional; Other
Lead sponsor: GlaxoSmithKline; Industry
Eligibility: 30 Years to 87 Years
Enrollment: 1,574 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2009
U.S. locations: 40
States / cities: Adamsville, Alabama • Foothill Ranch, California • Huntington Beach, California + 37 more

Conditions: Smoking Cessation
Interventions: Not listed
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 50 Years
Enrollment: 119 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2000 – 2012
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cancer
Interventions: Smoking Cessation Intervention, Carbon Monoxide Measurement, Internet-Based Intervention, Survey Administration, Tai Chi; Behavioral · Procedure · Other
Lead sponsor: Ohio State University Comprehensive Cancer Center; Other
Eligibility: 21 Years and older
Enrollment: 68 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Cigarette Smoking Behavior, E-Cigarette Use
Interventions: E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms, Cessation counseling; Other · Drug · Behavioral
Lead sponsor: Thomas Jefferson University; Other
Eligibility: 21 Years and older
Enrollment: 44 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Nicotine Dependence
Interventions: Transcranial Direct Current Stimulation, sham, Nicotine patch, Placebo patch, Varenicline Pill, Placebo pill, Motivational Interviewing; Device · Drug · Behavioral
Lead sponsor: National Institute on Drug Abuse (NIDA); NIH
Eligibility: 18 Years to 65 Years
Enrollment: 112 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2020
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Cigarette Smoking-Related Carcinoma
Interventions: Smartphone app-based Intervention (Actify! A app), Smartphone app-based Intervention (Actify! B app), Health Promotion and Education, Survey Administration; Behavioral · Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 1,812 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Tobacco Dependence
Interventions: Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor, Placebo ECIG with Tobacco Flavor, Placebo ECIG with Strawberry Vanilla Flavor; Other
Lead sponsor: Milton S. Hershey Medical Center; Other
Eligibility: 21 Years to 60 Years
Enrollment: 19 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2024
U.S. locations: 1
States / cities: Hershey, Pennsylvania

Conditions: Vaping, Nicotine Dependence
Interventions: Double Blind Varenicline, Double Blind Placebo, QuitVaping, This Is Quitting; Drug · Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 16 Years to 25 Years
Enrollment: 261 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Smoking
Interventions: Very low nicotine content cigarettes, Normal nicotine content cigarettes; Drug
Lead sponsor: Saul Shiffman; Other
Eligibility: 18 Years and older
Enrollment: 312 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2017
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Tobacco Use Disorder
Interventions: Nicotine polacrilex, Bupropion; Drug
Lead sponsor: University of California, San Francisco; Other
Eligibility: 50 Years and older
Enrollment: 403 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2001 – 2009
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Pharmacokinetics, Bioavailability, Smoking Cessation
Interventions: Varenicline Tartrate Controlled Release; Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 55 Years
Enrollment: 24 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2008
U.S. locations: 2
States / cities: East Grand Forks, Minnesota • Fargo, North Dakota

Conditions: Cigarette Smoker, Current Every Day Smoker
Interventions: Medical Device, Questionnaire Administration, Tobacco Smoking; Device · Other · Behavioral
Lead sponsor: Roswell Park Cancer Institute; Other
Eligibility: 18 Years to 69 Years
Enrollment: 8 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Buffalo, New York

Conditions: Smoking
Interventions: Broccoli sprout homogenate, Alfalfa sprout homogenate; Dietary Supplement
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 40 Years
Enrollment: 51 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2010 – 2013
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Smoking, Cigarette, Smoking Cessation
Interventions: Smoking Cessation iPad Decision Aid Tool; Behavioral
Lead sponsor: University of Florida; Other
Eligibility: 18 Years to 100 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019
U.S. locations: 1
States / cities: Gainesville, Florida

Conditions: Smoking Cessation
Interventions: placebo, varenicline (CP-526,555); Drug
Lead sponsor: Pfizer; Industry
Eligibility: 18 Years to 75 Years
Enrollment: 128 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2010
U.S. locations: 9
States / cities: Aurora, Colorado • Farmington, Connecticut • New Haven, Connecticut + 6 more

Conditions: Smoking &Amp; Tobacco Cessation
Interventions: Experimental Smoking Cessation Program, Control Smoking Cessation Program; Other
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 1,647 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: Seattle, Washington

Conditions: Vaping
Interventions: Acted-Out Narrative Ads, Non-Acted-Out Narrative Testimonial Ads, Neutral Control Videos; Behavioral
Lead sponsor: UNC Lineberger Comprehensive Cancer Center; Other
Eligibility: 13 Years to 20 Years
Enrollment: 1,910 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Fairfield, Connecticut • Chapel Hill, North Carolina

Conditions: Nicotine Dependence
Interventions: mSMART; Device
Lead sponsor: Duke University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2018
U.S. locations: 1
States / cities: Durham, North Carolina

Search by objective public record fields.

Accelerated rTMS for the Reduction of Nicotine Craving

Impact of Smoking and Its Cessation on Systemic and Airway Immune Activation

Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior

Libre Del Cigarrillo: Development of an mHealth Smoking Cessation App to Extend Reach of a Validated Smoking Cessation Intervention for Spanish-speaking Smokers

Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal

Effects of Smoking Cues on Tobacco Craving Responses and the Reinforcing Efficacy of Cigarettes in Adolescent Smokers

Prevalence of Chronic Airway Obstruction in Subjects With a History of Cigarette Smoking in a Primary Care Setting

Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence

Online Tai Chi Intervention to Promote Smoking Cessation Among Cancer Survivors

Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.

Nicotine Withdrawal Symptoms and Smoking Relapse

A Behavioral Application for Improving Smoking Cessation Among Smokers

Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes

Varenicline for Nicotine Vaping Cessation in Adolescents

Very-Low Nicotine Cigarettes and Non-Daily Smokers

Maintaining Nonsmoking: Older Smokers - 1

An Investigation Of The Effects Of Food On The Absorption Of A Varenicline Controlled Release Formulation

Effects of Filter Ventilation on Sensory Response, Smoking Topography, and Inhalation in Current Every Day Cigarette Smokers

Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers

Feasibility of a Decision Aid for E-Cigarettes in Primary Care

Smoking Cessation Study for Patients With Schizophrenia or Schizoaffective Disorder

An Innovative Conversational Agent (Quitbot) for Smoking Cessation

Evaluating Narrative Vaping Prevention Video Ads for Adolescents and Young Adults

Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence