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ClinicalTrials.gov public records Last synced Oct 19, 2026, 11:23 AM EDT

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Showing 25–48 of 2,331 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Clear all
Completed Not applicable Interventional Accepts healthy volunteers

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

NCT05271578
View directory record Official record
Conditions
Vascular Reactivity, Serum Biomarkers
Interventions
Standardized Electronic Research Cigarette, Nicotine Research Cigarette
Device
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 45 Years
Enrollment
55 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Dec 16, 2025 · Synced Oct 19, 2026, 11:23 AM EDT
Terminated Not applicable Interventional Results available

Engaging Working Memory and Distress Tolerance to Aid Smoking Cessation

NCT03565497
View directory record Official record
Conditions
Smoking Cessation
Interventions
Wellness Education Control Condition, Mindfulness Training, Mindfulness Training Plus IE
Behavioral
Lead sponsor
Boston University Charles River Campus
Other
Eligibility
18 Years to 65 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 17, 2023 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

Smoking Cessation for Cervical Cancer Survivors

NCT02157610
View directory record Official record
Conditions
Cervical Cancer, Tobacco Use, Smoking Cessation
Interventions
Self-Help Materials, Nicotine Patch, REDCap, Saliva Test, Telephone Counseling Sessions, Nicotine lozenge
Behavioral · Drug · Procedure
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older · Female only
Enrollment
202 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2021
U.S. locations
3
States / cities
Tampa, Florida • Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Jul 20, 2023 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Emergency Department Telephone Quitline

NCT00394420
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Telephone Quitline
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Jan 20, 2010 · Synced Oct 19, 2026, 11:23 AM EDT
Enrolling by invitation Not applicable Interventional

A Patient-Oriented Research Mentoring Program in Tobacco Dependence and Implementation Science Research

NCT05852860
View directory record Official record
Conditions
HIV, Smoking, Tobacco Use, Nicotine Dependence
Interventions
Clinician Nudge, Patient Nudge
Other
Lead sponsor
Abramson Cancer Center at Penn Medicine
Other
Eligibility
Not listed
Enrollment
500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2027
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Aug 14, 2026 · Synced Oct 19, 2026, 11:23 AM EDT
Not listed Not applicable Interventional Accepts healthy volunteers

Testing a Self-affirmation Intervention for Use in a Mobile Application

NCT03405220
View directory record Official record
Conditions
Smoking, Smoking Cessation, Smoking, Tobacco
Interventions
Self affirmation, 10 items, written examples, Self affirmation, 10 items, no examples, Self affirmation, 10 items, imagined examples, Self affirmation, 5 items, written examples, Self affirmation, 5 items, no examples, Self affirmation, 5 items, imagined examples, Self affirmation, 3 items, written examples, Self affirmation, 3 items, no examples, Self affirmation, 3 items, imagined examples
Behavioral
Lead sponsor
Kent State University
Other
Eligibility
21 Years to 65 Years
Enrollment
900 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Kent, Ohio
Source: ClinicalTrials.gov public record
Updated May 21, 2018 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Results available

TeleQuit Smoking Cessation Program

NCT00123682
View directory record Official record
Conditions
Smoking
Interventions
Proactive outreach to counseling, Reactive outreach to counseling, Intensive counseling, Self-help
Procedure
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
Not listed
Enrollment
3,120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2009
U.S. locations
3
States / cities
Palo Alto, California • Sepulveda, California • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 17, 2015 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Phase 3 Interventional

A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation

NCT00143286
View directory record Official record
Conditions
Smoking Cessation
Interventions
varenicline (CP-526,555)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
2,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
6
States / cities
Santa Ana, California • West Palm Beach, Florida • Lexington, Kentucky + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2007 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Phase 2 Interventional

TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)

NCT00413205
View directory record Official record
Conditions
Emphysema
Interventions
Placebo, RAR Gamma
Drug
Lead sponsor
Hoffmann-La Roche
Industry
Eligibility
44 Years and older
Enrollment
491 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2010
U.S. locations
12
States / cities
Birmingham, Alabama • Los Angeles, California • San Diego, California + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2016 · Synced Oct 19, 2026, 11:23 AM EDT
Withdrawn Phase 2 Interventional

Relapse Prevention Study in Newly Abstinent Smokers

NCT00793468
View directory record Official record
Conditions
Substance Dependence
Interventions
GSK598809, Nicotine Replacement Transdermal Patch, Placebo
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
18 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008
U.S. locations
10
States / cities
DeLand, Florida • Pembroke Pines, Florida • Stockbridge, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Feb 15, 2016 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Prevention Through Social Connections Among Adolescents - ASPIRE

NCT02703597
View directory record Official record
Conditions
Tobacco Use Behavior
Interventions
Surveys, ASPIRE, GSA-ASPIRE-Network
Behavioral
Lead sponsor
University of Florida
Other
Eligibility
11 Years to 18 Years
Enrollment
393 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2022
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Oct 23, 2024 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional

BABY STEPS II: SMS Scheduled Gradual Reduction Text Messages to Help Pregnant Smokers Quit

NCT01995097
View directory record Official record
Conditions
Smoking, Pregnancy
Interventions
Scheduled Gradual Reduction Text Messages, Support Text Messages
Behavioral
Lead sponsor
Duke University
Other
Eligibility
18 Years and older · Female only
Enrollment
331 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 8, 2019 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

NCT05294497
View directory record Official record
Conditions
Smoking, Tobacco Use, Tobacco Smoking
Interventions
Product A, Product B, Product C, Product D, Product N, Product E
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
2
States / cities
Lexington, Kentucky • Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Jun 29, 2022 · Synced Oct 19, 2026, 11:23 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Integrative-omics of the Disordered COPD Small Airway Epithelium

NCT02183818
View directory record Official record
Conditions
Smoking, COPD
Interventions
Not listed
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
18 Years to 100 Years
Enrollment
42 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2020
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated May 28, 2021 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional

An Intervention to Promote Use of Smoking Cessation Resources Among Adults Using Community Food Pantries

NCT05273450
View directory record Official record
Conditions
Smoking Cessation, Food Insecurity
Interventions
Quitline Information with Reinforcement
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
21 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Mar 12, 2024 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

An Online Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults

NCT06129123
View directory record Official record
Conditions
E-cigarette Use
Interventions
Live Free From E-cigarettes
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years to 24 Years
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jun 1, 2026 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Curbing Tobacco Use in Suburban and Rural Schools

NCT00513097
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Smoking Prevention Program, Focus Group, Survey
Behavioral
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
14 Years to 16 Years
Enrollment
1,289 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2017
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Nov 6, 2017 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing Different Theories of Smoking Cessation: An Intervention Study

NCT01209897
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking cessation booklet
Behavioral
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years and older
Enrollment
1,826 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2012
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated May 14, 2024 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effects of e-Cigarettes on Perceptions and Behavior - Remote Substudy # 1

NCT05958979
View directory record Official record
Conditions
Electronic Cigarette Use, Cigarette Smoking, Cigarette Use, Electronic, Vaping
Interventions
Control Marketing Strategies, Experimental Marketing Strategies
Other
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
601 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 25, 2023 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study

NCT00736255
View directory record Official record
Conditions
Attention Deficit Hyperactivity Disorder, Nicotine Dependence
Interventions
Transdermal Nicotine Patch, Lis-dexamphetamine (Vyvanse), Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 30, 2018 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia

NCT00218218
View directory record Official record
Conditions
Schizophrenia and Disorders With Psychotic Features, Tobacco Use Disorder, Schizophrenia
Interventions
Transdermal Nicotine Patch, 21 mg transdermal nicotine, placebo patch
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 80 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2002 – 2005
U.S. locations
2
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Jan 12, 2017 · Synced Oct 19, 2026, 11:23 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Effects of Electronic Cigarettes on Lung Biology

NCT02188511
View directory record Official record
Conditions
Lung Disease, Lung Disorder
Interventions
Group A, Group B, Group C, Group D, Group E
Other
Lead sponsor
Weill Medical College of Cornell University
Other
Eligibility
21 Years to 85 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jul 24, 2020 · Synced Oct 19, 2026, 11:23 AM EDT
Recruiting Phase 4 Interventional

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

NCT04604509
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Bupropion Hydrochloride Controlled-release, Nicotine Replacement, Questionnaire Administration, Tobacco Cessation Counseling, Varenicline
Drug · Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
2,010 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2028
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 7, 2026 · Synced Oct 19, 2026, 11:23 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

A Virtual Reality Game to Prevent E-cigarette and Cannabis Vaping

NCT07413432
View directory record Official record
Conditions
Cannabis, Vaping, Emotion Regulation
Interventions
Virtual reality videogame intervention for vaping prevention
Behavioral
Lead sponsor
Yale University
Other
Eligibility
11 Years to 15 Years
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 19, 2026, 11:23 AM EDT