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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:26 PM EDT

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Showing 529–552 of 2,331 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Clear all
Completed Phase 2 Interventional Results available

Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk

NCT00861146
View directory record Official record
Conditions
Tobacco Use Cessation, Alcohol-related Disorders
Interventions
behavioral counseling plus contingency management
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
151 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2013
U.S. locations
2
States / cities
Newington, Connecticut • West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Apr 3, 2020 · Synced Oct 20, 2026, 11:26 PM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

Remote Incentives for Smoking Cessation Among AN Pregnant Women

NCT05019170
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Smartphone-based Financial Incentives, Best Practices
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older · Female only
Enrollment
5 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
2
States / cities
Anchorage, Alaska • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Dec 1, 2023 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

CSD170304: Study to Assess Nicotine Uptake in Smokers From Electronic and Combustible Cigarettes

NCT03294356
View directory record Official record
Conditions
Smoking
Interventions
FT210771, FT210751, 6T30134157764, G41A7C071, M011161212, FT21002
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 60 Years
Enrollment
210 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
5
States / cities
Tempe, Arizona • Lexington, Kentucky • St Louis, Missouri + 2 more
Source: ClinicalTrials.gov public record
Updated Nov 14, 2017 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Dianicline Treatment as an Aid to Smoking Cessation in Cigarette Smokers (AMERIDIAN)

NCT00387946
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation
Interventions
SSR591813L (dianicline)
Drug
Lead sponsor
Sanofi
Industry
Eligibility
18 Years and older
Enrollment
630 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
1
States / cities
Bridgewater, New Jersey
Source: ClinicalTrials.gov public record
Updated Feb 17, 2012 · Synced Oct 20, 2026, 11:26 PM EDT
Not listed No phase listed Observational Accepts healthy volunteers

The Impact of Smoking on Outcomes and Complications in Total Joint Arthroplasty: A Prospective Crossover Study

NCT04592302
View directory record Official record
Conditions
Smoking, Total Joint Arthroplasty
Interventions
Blood Draw
Diagnostic Test
Lead sponsor
Rothman Institute Orthopaedics
Other
Eligibility
18 Years to 99 Years
Enrollment
1,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluation of Organisational Changes to Promote Smoking Cessation

NCT00529256
View directory record Official record
Conditions
Adult Smokers
Interventions
Feeback group
Behavioral
Lead sponsor
Great Lakes Research Into Practice Network
Network
Eligibility
18 Years to 85 Years
Enrollment
87 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
East Lansing, Michigan
Source: ClinicalTrials.gov public record
Updated Sep 14, 2007 · Synced Oct 20, 2026, 11:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

NCT06260683
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Nicotine Replacement, Questionnaire Administration, Vaping
Drug · Other · Device
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability

NCT06105424
View directory record Official record
Conditions
Tobacco Use, Smoking, Smoking, Tobacco
Interventions
Lung Permeability Assessment
Procedure
Lead sponsor
RAI Services Company
Industry
Eligibility
30 Years to 50 Years
Enrollment
21 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Oct 27, 2023 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Results available

Impact of Varenicline on Blood-Oxygen-Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI) Activation on Smokers

NCT00934024
View directory record Official record
Conditions
Nicotine Dependence
Interventions
varenicline
Drug
Lead sponsor
Medical University of South Carolina
Other
Eligibility
21 Years to 60 Years
Enrollment
21 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Dec 10, 2018 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Understanding the Impact of Cartridge-Based Electronic Cigarettes and Generated Aerosols on Cardiopulmonary Health

NCT05199480
View directory record Official record
Conditions
E-Cig Use
Interventions
Tobacco flavored liquid type 1, Tobacco flavored liquid type 2
Drug
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years and older
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jul 1, 2025 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 1 Interventional Results available

New Approaches to Smoking Cessation in Heavy Drinkers

NCT02151591
View directory record Official record
Conditions
Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
Interventions
Varenicline
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 75 Years
Enrollment
26 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Feb 24, 2020 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 1 Interventional

Tobacco Cessation in Postmenopausal Women (Part II) - 2

NCT00061074
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Nicotrol
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
40 Years to 79 Years · Female only
Enrollment
1 participant
Healthy volunteers
Healthy volunteers not accepted
Timeline
1993 – 2000
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 2, 2015 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 3 Interventional

Quitlink : A Leveraging Solution to Tobacco Counseling

NCT00112268
View directory record Official record
Conditions
Smoking
Interventions
QuitLink (office support system for quit line referral)
Behavioral
Lead sponsor
Virginia Ambulatory Care Outcomes Research Network
Other
Eligibility
18 Years and older
Enrollment
3,200 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Oct 27, 2006 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Results available

Innovative Digital Therapeutic for Smoking Cessation

NCT03694327
View directory record Official record
Conditions
Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence, Tobacco Dependence, Tobacco Use Disorder, Substance Use Disorder, Tobacco Smoking
Interventions
CT-101-M, QuitGuide
Device
Lead sponsor
My Digital Study
Industry
Eligibility
18 Years to 65 Years
Enrollment
158 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jun 6, 2022 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 4 Interventional Results available

Identifying Treatments to Motivate Smokers to Quit

NCT01122238
View directory record Official record
Conditions
Smoking, Smoking Cessation, Motivation, Nicotine Dependence
Interventions
Nicotine Patch, Nicotine Gum, Motivational Interviewing, Smoking Reduction, No Intervention, Nicotine Patch + Nicotine Gum
Drug · Behavioral · Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years to 99 Years
Enrollment
517 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 16, 2015 · Synced Oct 20, 2026, 11:26 PM EDT
Recruiting Phase 1 Interventional Accepts healthy volunteers

Oral Cannabidiol for Tobacco Cessation

NCT05445804
View directory record Official record
Conditions
Tobacco Use, Tobacco Smoking, Tobacco Dependence, Tobacco Use Disorder, Tobacco Use Cessation
Interventions
300 mg Cannabidiol, 600 mg Cannabidiol, Placebo
Drug
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years to 65 Years
Enrollment
50 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2027
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 7, 2026 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Harnessing the Power of Technology: MOMBA for Postpartum Smoking

NCT02237898
View directory record Official record
Conditions
Smoking Cessation
Interventions
MoMba Live Long app & Sensordrone™ carbon-monoxide sensor, Office contingency management, Sensordrone™ carbon-monoxide sensor, MoMba Live Long Smartphone application
Behavioral · Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 21, 2020 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Ultrasound and Motivational Enhancement for Prenatal Smoking Cessation

NCT00013793
View directory record Official record
Conditions
Pregnancy, Smoking
Interventions
Motivational enhancement and ultrasound
Behavioral
Lead sponsor
National Center for Research Resources (NCRR)
NIH
Eligibility
16 Years and older · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jun 24, 2005 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Impact of Vaping Prevention Advertisements

NCT04836455
View directory record Official record
Conditions
Vaping
Interventions
The FDA's The REal Cost vaping prevention ads - Health harms theme, The FDA's The Real Cost vaping prevention ads - Addiction theme, Neutral vaping ads
Behavioral
Lead sponsor
UNC Lineberger Comprehensive Cancer Center
Other
Eligibility
13 Years to 17 Years
Enrollment
1,565 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 24, 2024 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Project Q Pilot: Smoking Cessation for Light Smokers

NCT03416621
View directory record Official record
Conditions
Tobacco Use Cessation
Interventions
Cognitive behavioral cessation counseling, Counseling and placebo drug intervention, Counseling and active drug intervention
Behavioral · Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
31 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2020
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 29, 2021 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Results available

Ecological Momentary Intervention of Implementation Intentions Delivered by Text Message to Reduce Cigarette Smoking

NCT04967885
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Ecological Momentary Implementation Intentions Intervention (EMI-II)
Behavioral
Lead sponsor
Trustees of Dartmouth College
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021
U.S. locations
1
States / cities
Lebanon, New Hampshire
Source: ClinicalTrials.gov public record
Updated Apr 24, 2023 · Synced Oct 20, 2026, 11:26 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System

NCT07879638
View directory record Official record
Conditions
Smoking, Tobacco
Interventions
FT25614, FT25615, FT25616
Other
Lead sponsor
RAI Services Company
Industry
Eligibility
21 Years to 65 Years
Enrollment
480 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
4
States / cities
Atlanta, Georgia • Chicago, Illinois • Iselin, New Jersey + 1 more
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional

Functional Assessment Screening Tablets - Patient Reported Measures

NCT01080183
View directory record Official record
Conditions
Smoking
Interventions
Patient feedback form
Other
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 15, 2016 · Synced Oct 20, 2026, 11:26 PM EDT
Completed Not applicable Interventional Results available

Study of Mood Effects of Varenicline (Chantix) in Depressed Outpatient Smokers

NCT00525837
View directory record Official record
Conditions
Depressive Disorder, Smoking
Interventions
fixed dose varenicline, varenicline
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Nov 28, 2018 · Synced Oct 20, 2026, 11:26 PM EDT