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Showing 1–24 of 2,042 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Smoking Behavior Clear all
Terminated Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers

NCT03830892
View directory record Official record
Conditions
Electronic Cigarettes
Interventions
E-cigarette Lab Session 15 watts, 10 mg nicotine, E-cigarette Lab Session 15 watts, 30 mg nicotine, E-cigarette Lab Session 30 watts, 10 mg nicotine, E-cigarette Lab Session 30 watts, 30 mg nicotine, Own Brand Session - E-cigarette, Own Brand Session - E-cigarette/Cigarette
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
21 Years to 55 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 3, 2021 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Understanding the Effect of Flavor on Hookah Smoking Experience

NCT03589599
View directory record Official record
Conditions
Waterpipe Smoking
Interventions
Flavored tobacco, Non-flavored tobacco
Other
Lead sponsor
Florida International University
Other
Eligibility
18 Years to 30 Years
Enrollment
144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 2, 2020 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 1Phase 2 Interventional

A Preliminary Study of Sustained-Release Bupropion for Smoking Cessation in Bipolar Affective Disorder

NCT00593099
View directory record Official record
Conditions
Bipolar Disorder
Interventions
Bupropion, Placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 65 Years
Enrollment
5 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2006
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jun 9, 2026, 11:46 PM EDT
Recruiting Phase 4 Interventional

Smoking Cessation Program in the Construction Sector

NCT06098144
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking
Interventions
Nicorette, Tobacco Quit-line, Brief Behavioral Counseling, Intensive Behavioral Counseling
Drug · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Sep 2, 2025 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Harnessing the Power of Technology: MOMBA for Postpartum Smoking

NCT02237898
View directory record Official record
Conditions
Smoking Cessation
Interventions
MoMba Live Long app & Sensordrone™ carbon-monoxide sensor, Office contingency management, Sensordrone™ carbon-monoxide sensor, MoMba Live Long Smartphone application
Behavioral · Device
Lead sponsor
Yale University
Other
Eligibility
18 Years to 50 Years · Female only
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated May 20, 2020 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of E-Cigarette Nicotine Content in Smokers (Nicotine Flux Study)

NCT04332926
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Tobacco product administration and assessment, own brand cigarettes, Tobacco product administration and assessment, ECIG 30 Watts, 0 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 8 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 15 mg/ml nicotine, Tobacco product administration and assessment, ECIG 30 Watts, 30 mg/ml nicotine
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Feb 12, 2025 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Results available

Integrated Treatment for Smoking Cessation & Anxiety in People With HIV

NCT01393301
View directory record Official record
Conditions
Nicotine Dependence, Symptoms of Anxiety, HIV
Interventions
Integrated cognitive-behavioral therapy for smoking cessation and anxiety, Control
Behavioral
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
72 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2015
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 2, 2023 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Gradual vs. Abrupt Cessation Treatment for Smoking

NCT00297492
View directory record Official record
Conditions
Smoking Cessation
Interventions
Reduction Phone Counseling, Abrupt Phone Counseling, Minimal Abrupt Phone Counseling, Pre-Quit Nicotine Lozenges, Post-Quit Nicotine Lozenges
Behavioral · Drug
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
750 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2008
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Sep 19, 2013 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional

Smokers' Quitline for Asian Language Speakers

NCT01248832
View directory record Official record
Conditions
Smoking Cessation
Interventions
Telephone Counseling, Self-Help Materials
Behavioral
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years to 75 Years
Enrollment
2,277 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 12, 2020 · Synced Jun 9, 2026, 11:46 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Understanding Vape Marketing Study

NCT07129265
View directory record Official record
Conditions
E-cigarette, Vaping, Tobacco, Nicotine, Adolescent Behavior, Video Information, Digital Education Interventions
Interventions
Working group, Focus group
Other
Lead sponsor
Boston Children's Hospital
Other
Eligibility
13 Years and older
Enrollment
46 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2027
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Aug 18, 2025 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 2 Interventional Results available

Varenicline and Smoking Cessation in Schizophrenia

NCT01111149
View directory record Official record
Conditions
Schizophrenia, Smoking Cessation
Interventions
Sugar Pill, Varenicline, Bupropion HCl
Other · Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 75 Years
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2012
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Jul 16, 2014 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoke-free Home Intervention in Permanent Supportive Housing

NCT04855357
View directory record Official record
Conditions
Smoking Cessation, Second Hand Tobacco Smoke
Interventions
Resident counselling, Staff Training
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
452 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated May 28, 2026 · Synced Jun 9, 2026, 11:46 PM EDT
Withdrawn Not applicable Interventional

Developing and Pilot Testing a Remote Smoking Cessation Digital Therapeutic for Individuals With Serious Mental Illness

NCT05031416
View directory record Official record
Conditions
Smoking Cessation
Interventions
LTQ
Combination Product
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 3, 2025 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Smoking Cessation in Rural Hospitals

NCT01063972
View directory record Official record
Conditions
Smoking Cessation
Interventions
Centralized disease management (CDM), Counseling (C)
Behavioral
Lead sponsor
Edward Ellerbeck, MD, MPH
Other
Eligibility
18 Years and older
Enrollment
606 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2015
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 7, 2019 · Synced Jun 9, 2026, 11:46 PM EDT
Not listed Phase 3 Interventional

Implementing Tobacco Control in Dental Practice

NCT00297700
View directory record Official record
Conditions
Smoking
Interventions
Active referral
Behavioral
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years and older
Enrollment
2,800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Jan 10, 2017 · Synced Jun 9, 2026, 11:46 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

Research Study on the Effects of Smoking on Arteries

NCT00948454
View directory record Official record
Conditions
Smoking
Interventions
Not listed
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
105 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 26, 2009 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Mindfulness Training for Smokers Online Feasibility Study

NCT02164656
View directory record Official record
Conditions
Cigarette Smoking, Mindfulness
Interventions
mindfulness for smokers
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
18 Years and older
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2013
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 11, 2015 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Effectiveness of Pedialink CEASE Module

NCT01087177
View directory record Official record
Conditions
Tobacco Use
Interventions
Exposure to practice that has been trained in Pedialink CEASE
Other
Lead sponsor
Massachusetts General Hospital
Other
Eligibility
18 Years and older
Enrollment
647 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2010 – 2011
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 21, 2012 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

The Study of AZD8529 for Smoking Cessation in Female Smokers

NCT02401022
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
AZD8529
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 75 Years · Female only
Enrollment
214 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
9
States / cities
Encino, California • La Jolla, California • Los Alamitos, California + 6 more
Source: ClinicalTrials.gov public record
Updated Nov 28, 2017 · Synced Jun 9, 2026, 11:46 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment

NCT03519451
View directory record Official record
Conditions
Depression, Tobacco Use Disorder, Current Every Day Smoker
Interventions
Internet-Based Intervention, Questionnaire Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Jun 9, 2026, 11:46 PM EDT
Recruiting Not applicable Interventional

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

NCT07202039
View directory record Official record
Conditions
Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
Interventions
Brief individual counseling sessions
Behavioral
Lead sponsor
Prisma Health-Upstate
Other
Eligibility
21 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Greenville, South Carolina
Source: ClinicalTrials.gov public record
Updated May 11, 2026 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

NCT01633567
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Culturally Targeted Cessation Program, Non-Targeted Cessation Program
Behavioral
Lead sponsor
University of Illinois at Chicago
Other
Eligibility
18 Years to 65 Years
Enrollment
400 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2016
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 3, 2017 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Not applicable Interventional

Increasing Cessation Motivation and Treatment Engagement Among Smokers in Pain

NCT03996902
View directory record Official record
Conditions
Chronic Pain, Smoking, Smoking Cessation
Interventions
Tailored intervention, Ask-Advise-Refer
Behavioral
Lead sponsor
Syracuse University
Other
Eligibility
18 Years and older
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
1
States / cities
Syracuse, New York
Source: ClinicalTrials.gov public record
Updated Jun 24, 2019 · Synced Jun 9, 2026, 11:46 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders

NCT01456936
View directory record Official record
Conditions
Smoking Cessation
Interventions
Placebo, varenicline tartrate, bupropion hydrochloride, Nicotine Replacement Therapy Patch
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
8,144 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2015
U.S. locations
77
States / cities
Mobile, Alabama • Phoenix, Arizona • Encino, California + 61 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2016 · Synced Jun 9, 2026, 11:46 PM EDT