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ClinicalTrials.gov public records Last synced Oct 22, 2026, 5:26 AM EDT

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Showing 385–408 of 2,080 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Completed Phase 2 Interventional

Very Low-Nicotine Cigarettes in Smokers With SUD

NCT01989507
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Nicotine, behavioral counseling for smoking cessation
Drug · Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years to 75 Years
Enrollment
250 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2021
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 28, 2021 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Effects of Smoking Environments on Craving and Smoking (CameraCue2.0)

NCT02551692
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Nicotine Patch, Varenicline, Placebo Nicotine Patch, Placebo Capsule
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 60 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 22, 2026, 5:26 AM EDT
Terminated Phase 1 Interventional Accepts healthy volunteers

Hookah Smoking, Carbon Monoxide, and Coronary Endothelial Function

NCT03166787
View directory record Official record
Conditions
Smoking, Endothelial Dysfunction
Interventions
Charcoal hookah, E-coal hookah, Cigarette, Carbon Monoxide inhalation, Room Air inhalation, vitamin C, tadalafil
Other · Drug
Lead sponsor
Cedars-Sinai Medical Center
Other
Eligibility
21 Years to 49 Years
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2020
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 9, 2021 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional

Development of a Tailored Smoking Cessation Program for Individuals With HIV Infection in Washington, D.C.

NCT04594109
View directory record Official record
Conditions
Tobacco Smoking
Interventions
Tailored behavioral counseling, Standard of Care
Behavioral
Lead sponsor
Colorado State University
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
Washington D.C., District of Columbia
Source: ClinicalTrials.gov public record
Updated Apr 19, 2023 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 3 Interventional

Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking

NCT00503230
View directory record Official record
Conditions
Tobacco Dependence, HIV Infections
Interventions
Standard Care Intervention (SCI), Culturally Tailored Intervention (CTI)
Behavioral
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2011
U.S. locations
8
States / cities
Lowell, Massachusetts • New Bedford, Massachusetts • Roxbury, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated May 3, 2013 · Synced Oct 22, 2026, 5:26 AM EDT
Completed No phase listed Observational

Organochlorine Exposure in Relation to Timing of Natural Menopause

NCT00353171
View directory record Official record
Conditions
Menopause
Interventions
Not listed
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
NIH
Eligibility
Not listed
Enrollment
514 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2019
U.S. locations
1
States / cities
Research Triangle Park, North Carolina
Source: ClinicalTrials.gov public record
Updated Jun 17, 2019 · Synced Oct 22, 2026, 5:26 AM EDT
Not yet recruiting Not applicable Interventional

Contingency Management to Promote Smoking Cessation: A Pilot Randomized Clinical Trial

NCT07685899
View directory record Official record
Conditions
Smoking Cessation
Interventions
Health Rewards, Control
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Jul 6, 2026 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

NCT01928719
View directory record Official record
Conditions
Tobacco Dependence
Interventions
Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
18 Years to 65 Years
Enrollment
280 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
2
States / cities
Washington D.C., District of Columbia • Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Oct 22, 2026, 5:26 AM EDT
Not yet recruiting Not applicable Interventional Accepts healthy volunteers

A Behavioral Application for Improving Smoking Cessation Among Smokers

NCT07493252
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Smartphone app-based Intervention (Actify! A app), Smartphone app-based Intervention (Actify! B app), Health Promotion and Education, Survey Administration
Behavioral · Other
Lead sponsor
Fred Hutchinson Cancer Center
Other
Eligibility
18 Years and older
Enrollment
1,812 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2029
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Aug 12, 2026 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 2 Interventional Results available

Meclizine as a Potential Smoking Cessation Treatment

NCT01443858
View directory record Official record
Conditions
Smoking Cessation
Interventions
Meclizine, Nicotine Patch, Placebo
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
146 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 1, 2014 · Synced Oct 22, 2026, 5:26 AM EDT
Recruiting Early Phase 1 Interventional Accepts healthy volunteers

Sex Differences in the Vascular Effects of E-cigarette Use

NCT06159608
View directory record Official record
Conditions
E-cigarette Use
Interventions
Local heating + L-NAME (NG-nitro-L-arginine methyl ester; nitric oxide synthase inhibitor), Chronic estrogen exposure
Drug · Other
Lead sponsor
Anna Stanhewicz, PhD
Other
Eligibility
18 Years to 24 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
Iowa City, Iowa
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 22, 2026, 5:26 AM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Effects of E-cigarette Use on Health

NCT06610838
View directory record Official record
Conditions
Electronic Cigarette Use
Interventions
Health Assessments
Other
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
600 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Dec 24, 2025 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Yoga for Smoking Cessation Feasibility Study

NCT01030068
View directory record Official record
Conditions
Smoking Cessation
Interventions
Yoga, Wellness, Smoking cessation therapy
Behavioral · Other
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years to 65 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 7, 2011 · Synced Oct 22, 2026, 5:26 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation

NCT02004171
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
electronic cigarette, nicotine inhaler
Other · Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
18 Years to 60 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2015
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 19, 2016 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 3 Interventional

A 52-Week Placebo-Controlled Study Evaluating the Safety of Varenicline

NCT00143299
View directory record Official record
Conditions
Smoking Cessation
Interventions
varenicline (CP-526,555)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
375 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2005
U.S. locations
8
States / cities
Denver, Colorado • Milford, Massachusetts • Albuquerque, New Mexico + 5 more
Source: ClinicalTrials.gov public record
Updated Jun 4, 2007 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Tobacco Cessation Via Public Health Dental Clinics

NCT00683839
View directory record Official record
Conditions
Smoking
Interventions
Brief tobacco counseling
Behavioral
Lead sponsor
Oregon Research Institute
Other
Eligibility
18 Years and older
Enrollment
2,637 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2009
U.S. locations
3
States / cities
Jackson, Mississippi • New York, New York • Eugene, Oregon
Source: ClinicalTrials.gov public record
Updated Oct 26, 2011 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional Results available

Tobacco Intervention in Primary Care Treatment Opportunities for Providers

NCT02096029
View directory record Official record
Conditions
Smoking, Smoking Cessation
Interventions
Nicotine Replacement Therapy (NRT) Sampling, Ask, Advise, Refer (physician brief advice)
Other · Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
1,278 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2018
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2019 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Support Person Intervention to Promote a Smoking Helpline Among Under Resourced Smokers

NCT03096145
View directory record Official record
Conditions
Tobacco Cessation
Interventions
Telephone counseling 1 session, Mobile texting, Health incentive
Behavioral
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
60 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 11, 2019 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 1Phase 2 Interventional Results available

Message Framing for Telephone Quitline Callers

NCT00589277
View directory record Official record
Conditions
Smoking, Nicotine Dependence
Interventions
Gain-Framed counseling & Gain-framed materials, Standard care counseling + standard materials
Behavioral
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
2,032 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
1
States / cities
Buffalo, New York
Source: ClinicalTrials.gov public record
Updated Aug 26, 2021 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Efficacy and Cost of State Quitline Policies

NCT00366977
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation, Cost-effectiveness
Interventions
Multi-session telephone counseling, NRT patches
Behavioral · Drug
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
4,614 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2000 – 2005
U.S. locations
3
States / cities
Portland, Oregon • Seattle, Washington
Source: ClinicalTrials.gov public record
Updated May 2, 2011 · Synced Oct 22, 2026, 5:26 AM EDT
Withdrawn Early Phase 1 Interventional Accepts healthy volunteers

Health Literacy and Smoking Cessation in Low-SES Diverse Smokers - Project HALT II

NCT02942212
View directory record Official record
Conditions
Smoking Cessation
Interventions
Questionnaire, In-Depth Interviews, Breath Test, Nicotine Patches, Advice plus Phone Counseling, Advice plus Counseling Sessions, Self Assessment Questionnaires
Behavioral · Other · Drug
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
25 Years to 65 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2018
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated May 1, 2019 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Not applicable Interventional Results available

Internet-Administered Smoking Cessation Treatment for Overweight and Obese Smokers

NCT01259466
View directory record Official record
Conditions
Smoking Cessation, Overweight, Obesity
Interventions
Nicotine patch
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 65 Years
Enrollment
54 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Sep 28, 2015 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 2 Interventional Results available

Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)

NCT02796651
View directory record Official record
Conditions
Chronic Obstructive Pulmonary Disease - COPD
Interventions
Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Placebo for formoterol fumarate, Formoterol fumarate (12 μg), Formoterol fumarate (40 μg)
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
40 Years to 130 Years
Enrollment
132 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016
U.S. locations
20
States / cities
Glendale, Arizona • Phoenix, Arizona • Tempe, Arizona + 17 more
Source: ClinicalTrials.gov public record
Updated Feb 7, 2018 · Synced Oct 22, 2026, 5:26 AM EDT
Completed Phase 1Phase 2 Interventional Accepts healthy volunteers

Evaluating the Acute Effects of Electronic Nicotine Delivery Devices Marketed to Smokers.

NCT00932295
View directory record Official record
Conditions
Smoking
Interventions
OB, Sham smoking, CROWN SEVEN, NJOY
Other
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
18 Years to 55 Years
Enrollment
32 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Dec 13, 2016 · Synced Oct 22, 2026, 5:26 AM EDT