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ClinicalTrials.gov public records Last synced Oct 22, 2026, 7:20 AM EDT

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Showing 409–432 of 2,080 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Not yet recruiting Phase 4 Interventional

Varenicline for Smoking Cessation in Pancreatitis

NCT07874841
View directory record Official record
Conditions
Pancreatitis, Chronic Pancreatitis, Acute Pancreatitis (AP), Recurrent Acute Pancreatitis
Interventions
Varenicline (VAR)
Drug
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Rochester, Minnesota
Source: ClinicalTrials.gov public record
Updated Oct 19, 2026 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Treating Chinese Smokers With Interactive Expert System

NCT00713895
View directory record Official record
Conditions
Smoking Cessation
Interventions
Expert System, Standard Self-Help
Behavioral
Lead sponsor
University of California, San Francisco
Other
Eligibility
18 Years and older
Enrollment
363 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2001 – 2005
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 11, 2018 · Synced Oct 22, 2026, 7:20 AM EDT
Completed No phase listed Observational

Electronic Cigarette Use During Pregnancy

NCT03480373
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Not listed
Lead sponsor
UConn Health
Other
Eligibility
16 Years to 45 Years · Female only
Enrollment
182 participants
Timeline
2018 – 2023
U.S. locations
6
States / cities
Denver, Colorado • Farmington, Connecticut • Hartford, Connecticut + 2 more
Source: ClinicalTrials.gov public record
Updated Sep 21, 2023 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Not applicable Interventional

Not Quite Ready to Quit

NCT01866722
View directory record Official record
Conditions
Smoking Cessation
Interventions
Usual care, Reduction, 5Rs
Behavioral
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
560 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Oct 22, 2026, 7:20 AM EDT
Terminated Not applicable Interventional Accepts healthy volunteers

"Quit Smoking on Your Own" Brief Online Study

NCT02103829
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Brief Intervention #1, Brief Intervention #2, Brief Intervention #3
Behavioral
Lead sponsor
i4Health
Other
Eligibility
18 Years and older
Enrollment
345 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2016
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 29, 2016 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Testing the Efficacy of A Scalable, Telephone-Delivered, Guided Imagery Tobacco Cessation Intervention

NCT05277831
View directory record Official record
Conditions
Smoking Cessation, Smoking, Smoking Reduction, Smoking, Cigarette, Smoking (Tobacco) Addiction, Smoking Habit
Interventions
Guided Imagery Intervention, Standard Behavioral Control
Other
Lead sponsor
University of Arizona
Other
Eligibility
18 Years and older
Enrollment
1,209 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
1
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Oct 16, 2026 · Synced Oct 22, 2026, 7:20 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Cigarette Harm Reduction With Electronic Cigarette Use

NCT03473483
View directory record Official record
Conditions
Nicotine Dependence, Tobacco Toxicity, Nicotine Dependence, Cigarettes, Cardiovascular Risk Factor, Nicotine Withdrawal
Interventions
SREC
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years to 70 Years
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Dec 9, 2022 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

NCT01796951
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Aspirin 325 mg daily, Celecoxib 200 mg BID
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
35 Years to 90 Years · Male only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 22, 2026, 7:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Maternal Smoking During Pregnancy and Female Fetal Testosterone Levels

NCT02610751
View directory record Official record
Conditions
Smoking
Interventions
Not listed
Lead sponsor
TriHealth Inc.
Other
Eligibility
18 Years and older · Female only
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2019
U.S. locations
2
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Aug 28, 2019 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 4 Interventional

Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)

NCT00000437
View directory record Official record
Conditions
Alcoholism, Smoking
Interventions
Naltrexone Tablet and Nicotine Patch, Naltrexone Tablet and Placebo Patch, Placebo Tablet and Nicotine Patch, Placebo Tablet and Placebo Patch
Drug
Lead sponsor
The Scripps Research Institute
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
1997 – 2005
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Apr 20, 2017 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Not applicable Interventional Results available

An Intervention to Reduce Second Hand Smoke Exposure Among Pediatric Emergency Patients

NCT02531594
View directory record Official record
Conditions
Smoking Cessation
Interventions
SBIRT, HHC
Behavioral
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Other
Eligibility
Not listed
Enrollment
770 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2022
U.S. locations
1
States / cities
Cincinnati, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 15, 2023 · Synced Oct 22, 2026, 7:20 AM EDT
Not listed Phase 2Phase 3 Interventional Accepts healthy volunteers

Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation

NCT00419731
View directory record Official record
Conditions
Tobacco Use Disorder
Interventions
Bupropion, Bupropion + Naltrexone
Drug
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2010
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 3, 2009 · Synced Oct 22, 2026, 7:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers Results available

Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers

NCT05279053
View directory record Official record
Conditions
Sex, Cigarette Smoking
Interventions
Abstinence and Smoking
Behavioral
Lead sponsor
University of California, Los Angeles
Other
Eligibility
18 Years to 45 Years
Enrollment
58 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Mar 20, 2026 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Positive Psychotherapy for Smoking Cessation Enhanced With Text Messaging: A Randomized Controlled Trial

NCT02997657
View directory record Official record
Conditions
Smoking Cessation
Interventions
Positive Psychotherapy, Standard smoking cessation counseling
Behavioral
Lead sponsor
Brown University
Other
Eligibility
18 Years and older
Enrollment
271 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2016 – 2021
U.S. locations
2
States / cities
Boston, Massachusetts • Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Mar 1, 2023 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers

NCT01702519
View directory record Official record
Conditions
Smoking
Interventions
nicotine
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
19 Years to 55 Years
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012
U.S. locations
1
States / cities
Lincoln, Nebraska
Source: ClinicalTrials.gov public record
Updated Mar 20, 2015 · Synced Oct 22, 2026, 7:20 AM EDT
Terminated Phase 2 Interventional Accepts healthy volunteers Results available

Mechanisms of Lorcaserin for Smoking Cessation

NCT04396834
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation
Interventions
Lorcaserin Oral Tablet, Placebo oral tablet
Drug
Lead sponsor
The Mind Research Network
Other
Eligibility
18 Years to 65 Years
Enrollment
3 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 20, 2023 · Synced Oct 22, 2026, 7:20 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Electronic Health Record-Enabled Evidence-Based Smoking Cessation Quality Improvement Implementation Program

NCT04107857
View directory record Official record
Conditions
Smoking Cessation
Interventions
ELEVATE enhancement to electronic health record (EHR) to improve cessation counseling offer, ELEVATE enhancement to electronic health record (EHR) to improve smoking cessation medication offer, Data Driven Feedback reports
Behavioral
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years and older
Enrollment
1,000,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2024
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 20, 2024 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

The Lung Screening, Tobacco and Health Project

NCT03200236
View directory record Official record
Conditions
Smoking, Tobacco, Tobacco-Related Carcinoma, Tobacco Use, Lung Cancer Screening
Interventions
Intensive Telephone Counseling (8 sessions) with nicotine replacement, Usual Care: Telephone counseling (3 sessions) with nicotine replacement
Behavioral
Lead sponsor
Georgetown University
Other
Eligibility
50 Years to 80 Years
Enrollment
1,114 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2022
U.S. locations
7
States / cities
Washington D.C., District of Columbia • Miami, Florida • Moline, Illinois + 4 more
Source: ClinicalTrials.gov public record
Updated Nov 2, 2023 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 4 Interventional Results available

Combination Nicotine Replacement for Alcoholic Smokers

NCT00064844
View directory record Official record
Conditions
Smoking, Alcoholism
Interventions
Cognitive Behavior Therapy for alcohol and smoking cessation, Nicoderm CQ nicotine patch, Placebo gum, Nicotine gum - Nicorette®
Behavioral · Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years and older
Enrollment
96 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2006
U.S. locations
1
States / cities
Newington, Connecticut
Source: ClinicalTrials.gov public record
Updated Aug 13, 2021 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Smoking on Opioid Receptor Binding: A PET Study

NCT00618631
View directory record Official record
Conditions
Substance-related Discorder
Interventions
Nicotine, Carfentanil
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
21 Years to 50 Years
Enrollment
26 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2015
U.S. locations
2
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Apr 5, 2018 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 2 Interventional Results available

Proactive Outreach for Smoking Treatment

NCT04988477
View directory record Official record
Conditions
Smoking, Tobacco, Mental Illness
Interventions
Study 3: Chronic care management, Study 2: Pilot trial
Behavioral
Lead sponsor
Sandra Japuntich
Other
Eligibility
18 Years and older
Enrollment
94 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Dec 8, 2025 · Synced Oct 22, 2026, 7:20 AM EDT
Active, not recruiting Phase 4 Interventional

Smoking Cessation Program in the Construction Sector

NCT06098144
View directory record Official record
Conditions
Smoking Cessation, Tobacco Use Cessation, Tobacco Smoking
Interventions
Nicorette, Tobacco Quit-line, Brief Behavioral Counseling, Intensive Behavioral Counseling
Drug · Behavioral
Lead sponsor
University of Miami
Other
Eligibility
18 Years and older
Enrollment
608 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2024 – 2027
U.S. locations
1
States / cities
Miami, Florida
Source: ClinicalTrials.gov public record
Updated Aug 21, 2026 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Neuroimaging Studies of Smoking and Treatment

NCT03085602
View directory record Official record
Conditions
Smoking Cessation
Interventions
Cognitive behavioral therapy, Health education
Behavioral
Lead sponsor
University of Kansas Medical Center
Other
Eligibility
18 Years to 55 Years
Enrollment
92 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Apr 16, 2019 · Synced Oct 22, 2026, 7:20 AM EDT
Completed Phase 3 Interventional Results available

Providing Free Nicotine Patches to Quitline Smokers

NCT01736085
View directory record Official record
Conditions
Smoking Cessation
Interventions
Telephone counseling, Voucher, Nicotine patches
Behavioral · Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
3,706 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Feb 19, 2020 · Synced Oct 22, 2026, 7:20 AM EDT