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ClinicalTrials.gov public records Last synced Oct 22, 2026, 2:19 PM EDT

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Showing 481–504 of 2,080 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Terminated Phase 1 Interventional

Novel Treatments to Enhance Smoking Cessation Before Cancer Surgery: Effects on Smoking and Surgical Outcomes

NCT01479998
View directory record Official record
Conditions
Smoking Cessation
Interventions
standard care, standard care plus contingency management
Other
Lead sponsor
Yale University
Other
Eligibility
18 Years to 85 Years
Enrollment
8 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
2
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 9, 2020 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers Results available

Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence

NCT00304707
View directory record Official record
Conditions
Smoking Cessation, Alcohol-Related Disorders
Interventions
Bupropion, placebo
Drug
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 70 Years
Enrollment
143 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Bedford, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 15, 2017 · Synced Oct 22, 2026, 2:19 PM EDT
Completed No phase listed Observational Accepts healthy volunteers

e-Cigarette - DNA Adducts

NCT03284632
View directory record Official record
Conditions
Smoking, Cigarette Smoking, Electronic Cigarettes
Interventions
Not listed
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years and older
Enrollment
217 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Nov 9, 2022 · Synced Oct 22, 2026, 2:19 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

NCT05493254
View directory record Official record
Conditions
Smoking Cessation
Interventions
Smoking cessation e-visit, Treatment As Usual
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
672 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2026
U.S. locations
1
States / cities
Charleston, South Carolina
Source: ClinicalTrials.gov public record
Updated Mar 5, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

E-cigarette Switching Older Adults

NCT06534905
View directory record Official record
Conditions
Tobacco Use, Opioid Use Disorder, Tobacco-Related Disorders
Interventions
E-cigarette, Control/Standard Advice
Other · Behavioral
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
50 Years and older
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jul 10, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Not yet recruiting Not applicable Interventional

Quit-Smoking Study for Native Hawaiians

NCT07075575
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking Cessation
Interventions
Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT)
Drug · Behavioral
Lead sponsor
University of Hawaii
Other
Eligibility
18 Years to 80 Years
Enrollment
75 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Honolulu, Hawaii
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana

NCT00743145
View directory record Official record
Conditions
Marijuana Smoking
Interventions
Inactive Marijuana (0% THC), Active Marijuana (5.5% THC), Active Marijuana (6.2% THC), Naltrexone, Placebo naltrexone
Drug
Lead sponsor
New York State Psychiatric Institute
Other
Eligibility
21 Years to 45 Years
Enrollment
23 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2009
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Sep 14, 2018 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional

Enhanced Smoking Cessation Intervention for Smokers Exposed to the World Trade Center (WTC) Disaster

NCT02538601
View directory record Official record
Conditions
Cigarette Smoking, Post Traumatic Stress Disorder, Signs and Symptoms, Respiratory
Interventions
CBT-A, CBT-S
Behavioral
Lead sponsor
Stony Brook University
Other
Eligibility
18 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2014
U.S. locations
1
States / cities
Stony Brook, New York
Source: ClinicalTrials.gov public record
Updated Sep 2, 2015 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Ventilation and Pulmonary Endothelium Toxicities of E-cigarettes: A Randomized Crossover Pilot Study

NCT02783768
View directory record Official record
Conditions
Pulmonary Disease, Chronic Obstructive, E-cigarettes
Interventions
E-cigarette, Sham, Hyperpolarized 3-Helium, Gadolinium
Device · Other · Drug
Lead sponsor
Columbia University
Other
Eligibility
21 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Oct 22, 2020 · Synced Oct 22, 2026, 2:19 PM EDT
Recruiting Phase 4 Interventional

The Options 2 Study

NCT06595459
View directory record Official record
Conditions
Smoker, Smoking Cessation
Interventions
Nicotine Pouches, Mini Nicotine lozenges
Drug
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
21 Years and older
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jun 22, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders

NCT06554873
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, NJOY e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 6, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Results available

Acceptance and Commitment Therapy for Tobacco Cessation Among Psychiatric Partial Hospital Patients

NCT03911960
View directory record Official record
Conditions
Tobacco Smoking, Psychiatric Disorder, Psychiatric Hospitalization
Interventions
Acceptance and Commitment Therapy, Enhanced Usual Care
Behavioral
Lead sponsor
The Miriam Hospital
Other
Eligibility
18 Years and older
Enrollment
17 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Sep 25, 2020 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

An EPIC Based BPA to Enhance Quit Line Referral and Use

NCT03229356
View directory record Official record
Conditions
Smoking Cessation
Interventions
Best Practices Advisory (BPA), BPA + Enhanced Education
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
18 Years and older
Enrollment
22 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2019
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Nov 18, 2023 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Early Phase 1 Interventional

The Effect of Nicotine Delivery Rate on Reinforcement

NCT03134339
View directory record Official record
Conditions
Nicotine
Interventions
Nicotine saline 0.00mcg/kg/s, Nicotine 0.24 mcg/kg/s, Nicotine 0.048 mcg/kg/s, Nicotine 0.024 mcg/kg/s
Drug
Lead sponsor
Yale University
Other
Eligibility
18 Years to 30 Years
Enrollment
18 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2017 – 2018
U.S. locations
1
States / cities
West Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Oct 22, 2018 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Short-Term Cardiovascular Effects of E-Cigarettes: Influence of Device Power

NCT03839745
View directory record Official record
Conditions
Cardiovascular Risk Factor, Nicotine Dependence
Interventions
Electronic Cigarette
Other
Lead sponsor
University of California, San Francisco
Other
Eligibility
21 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
2
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Jul 1, 2024 · Synced Oct 22, 2026, 2:19 PM EDT
Withdrawn Not applicable Interventional

Incentives for Participation Versus Outcomes

NCT01826331
View directory record Official record
Conditions
Smoking
Interventions
Incentives for Participation, Incentives for Cessation
Behavioral
Lead sponsor
University of Rhode Island
Other
Eligibility
18 Years and older
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2019
U.S. locations
1
States / cities
Kingston, Rhode Island
Source: ClinicalTrials.gov public record
Updated Apr 17, 2025 · Synced Oct 22, 2026, 2:19 PM EDT
Not listed Not applicable Interventional

Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence

NCT02635919
View directory record Official record
Conditions
Nicotine Dependence
Interventions
mSMART
Device
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2018
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Apr 3, 2018 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Coping Skills Treatment for Smoking Cessation

NCT01061528
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Transdermal Nicotine
Drug
Lead sponsor
Butler Hospital
Other
Eligibility
18 Years to 65 Years
Enrollment
116 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2013
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 16, 2018 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Young Adults' Responses to Anti-smoking Messages

NCT01954407
View directory record Official record
Conditions
Smoking
Interventions
Smoking-Related Messages
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 25 Years
Enrollment
2,200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jun 15, 2017 · Synced Oct 22, 2026, 2:19 PM EDT
Not yet recruiting Phase 4 Interventional

Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette Use

NCT07786896
View directory record Official record
Conditions
E Cigarette Use, Cessation, Tobacco, Cessation, Nicotine
Interventions
Nicotine Replacement Therapies, Brief Behavioral Counseling
Drug · Behavioral
Lead sponsor
West Virginia University
Other
Eligibility
21 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
2
States / cities
Greenville, North Carolina • Morgantown, West Virginia
Source: ClinicalTrials.gov public record
Updated Aug 26, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Completed No phase listed Observational

Gene-Environment Interactions in Rheumatoid Arthritis Autoimmunity Disease Severity

NCT00594451
View directory record Official record
Conditions
Rheumatoid Arthritis
Interventions
Not listed
Lead sponsor
University of Nebraska
Other
Eligibility
19 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2013
U.S. locations
1
States / cities
Omaha, Nebraska
Source: ClinicalTrials.gov public record
Updated Sep 1, 2023 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Mindfulness Training for Smoking Cessation

NCT05440903
View directory record Official record
Conditions
Smoking Cessation
Interventions
Headspace, TEDTalk
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2020 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 7, 2023 · Synced Oct 22, 2026, 2:19 PM EDT
Enrolling by invitation No phase listed Observational Accepts healthy volunteers

Using Smartwatches to Monitor Smoking in Real-life Situations

NCT07067151
View directory record Official record
Conditions
Smoking
Interventions
Not listed
Lead sponsor
National Institute on Minority Health and Health Disparities (NIMHD)
NIH
Eligibility
21 Years to 120 Years
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2028
U.S. locations
1
States / cities
Kansas City, Kansas
Source: ClinicalTrials.gov public record
Updated Oct 22, 2026 · Synced Oct 22, 2026, 2:19 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers

Low Dose Aspirin Inhibition of COX-2 Derived PGE2 in Male Smokers

NCT01796951
View directory record Official record
Conditions
Tobacco Use Disorder, Smoking
Interventions
Aspirin 325 mg daily, Celecoxib 200 mg BID
Drug
Lead sponsor
Vanderbilt University
Other
Eligibility
35 Years to 90 Years · Male only
Enrollment
6 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2016
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Apr 4, 2017 · Synced Oct 22, 2026, 2:19 PM EDT