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ClinicalTrials.gov public records Last synced Oct 26, 2026, 9:47 PM EDT

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Showing 1105–1128 of 2,080 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Smoking Behavior Clear all
Not listed Phase 2Phase 3 Interventional

Brief Counseling to Reduce Injuries Among Emergency Department Patients Who Report Alcohol and Substance Use

NCT00547963
View directory record Official record
Conditions
Alcohol Drinking, Marijuana Smoking
Interventions
brief counseling
Behavioral
Lead sponsor
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NIH
Eligibility
18 Years and older
Enrollment
554 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2008
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 8, 2008 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Results available

Increasing Contingency Management Success in Smoking Cessation

NCT00273793
View directory record Official record
Conditions
Smoking
Interventions
Contingency Management
Behavioral
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
328 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2010
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jun 21, 2012 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Graphic Messages to Prevent E-Cigarette Use Among Black and Latino Adolescents

NCT04899999
View directory record Official record
Conditions
Vaping
Interventions
Financial reward graphic message, Health reward graphic message, Self-efficacy graphic message, Social norms graphic message
Behavioral
Lead sponsor
University of Rochester
Other
Eligibility
12 Years to 17 Years
Enrollment
362 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021
U.S. locations
1
States / cities
Rochester, New York
Source: ClinicalTrials.gov public record
Updated Aug 1, 2025 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Results available

'Questions About Quitting' Smoking Cessation Trial

NCT00992264
View directory record Official record
Conditions
Smoking
Interventions
Message Tone, Navigation, Proactive Outreach, Testimonials
Behavioral
Lead sponsor
Kaiser Permanente
Other
Eligibility
18 Years and older
Enrollment
1,865 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2013
U.S. locations
1
States / cities
Seattle, Washington
Source: ClinicalTrials.gov public record
Updated Oct 13, 2017 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional

Evaluation of an "Opt-Out" Inpatient Smoking Cessation Service on Smoking Behavior Study #1

NCT04827914
View directory record Official record
Conditions
Smoking Cessation
Interventions
Enhanced Care, Basic Care
Behavioral
Lead sponsor
Medical University of South Carolina
Other
Eligibility
18 Years and older
Enrollment
1,122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
6
States / cities
Charleston, South Carolina • Chester, South Carolina • Florence, South Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Early Phase 1 Interventional Accepts healthy volunteers Results available

Translating Extinction Research to Improve Pharmacotherapy for Tobacco Dependence

NCT02202499
View directory record Official record
Conditions
Smoking Cessation, Tobacco Dependence
Interventions
Varenicline, Counseling and Support Materials, Laboratory Assessments
Drug · Other
Lead sponsor
H. Lee Moffitt Cancer Center and Research Institute
Other
Eligibility
18 Years and older
Enrollment
86 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2019
U.S. locations
1
States / cities
Tampa, Florida
Source: ClinicalTrials.gov public record
Updated Nov 27, 2020 · Synced Oct 26, 2026, 9:47 PM EDT
Active, not recruiting Not applicable Interventional Accepts healthy volunteers

Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment

NCT03519451
View directory record Official record
Conditions
Depression, Tobacco Use Disorder, Current Every Day Smoker
Interventions
Internet-Based Intervention, Questionnaire Administration
Other
Lead sponsor
M.D. Anderson Cancer Center
Other
Eligibility
18 Years to 65 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2026
U.S. locations
1
States / cities
Houston, Texas
Source: ClinicalTrials.gov public record
Updated Oct 6, 2026 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Culturally Enhancing a Motivational Interviewing Intervention For Latinx Adolescents

NCT03947177
View directory record Official record
Conditions
Underage Alcohol Use, Smoking, Non-Tobacco Products
Interventions
GMIT+
Behavioral
Lead sponsor
Virginia Commonwealth University
Other
Eligibility
10 Years to 16 Years
Enrollment
59 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Richmond, Virginia
Source: ClinicalTrials.gov public record
Updated Jun 30, 2022 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Pictorial Warning Labels & Memory for Relative & Absolute Cigarette Health-risk Information Over Time in Adult Smokers

NCT03499340
View directory record Official record
Conditions
Smoking Cessation, Smoking, Cigarette
Interventions
text-only PWL, low arousal graphic PWL, high arousal graphic PWL, absolute risk, relative risk
Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
19 Years to 64 Years
Enrollment
3,213 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 17, 2018 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 3 Interventional Results available

Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

NCT01406223
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Bupropion, Nicotine patches, Placebo varenicline, Placebo bupropion, Placebo patch
Drug · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 50 Years
Enrollment
282 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2014
U.S. locations
2
States / cities
Durham, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Nov 14, 2017 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 2 Interventional Accepts healthy volunteers Results available

Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia

NCT01213524
View directory record Official record
Conditions
Tobacco Use Disorder, Schizophrenia
Interventions
sensorimotor replacement, 42 mg transdermal nicotine replacement, Placebo transdermal nicotine, usual brand smoking
Behavioral · Drug · Other
Lead sponsor
Brown University
Other
Eligibility
18 Years to 99 Years
Enrollment
75 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2005 – 2011
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Oct 19, 2020 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 3 Interventional Results available

Concurrent Bupropion / Varenicline for Smoking Cessation

NCT01303861
View directory record Official record
Conditions
Nicotine Dependence
Interventions
Varenicline, Bupropion, Nicotine patches, Nicotine Inhaler
Drug
Lead sponsor
Duke University
Other
Eligibility
18 Years to 65 Years
Enrollment
702 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2011 – 2013
U.S. locations
4
States / cities
Charlotte, North Carolina • Durham, North Carolina • Raleigh, North Carolina + 1 more
Source: ClinicalTrials.gov public record
Updated Aug 6, 2014 · Synced Oct 26, 2026, 9:47 PM EDT
Terminated Phase 3 Interventional Accepts healthy volunteers

Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With NRT

NCT06088862
View directory record Official record
Conditions
Smoking Cessation, Harm Reduction
Interventions
Nicoderm, Nicorette 4Mg Chewing Gum, Nicorette Lozenge Product, BIDI e-cigarette, on!
Drug · Other
Lead sponsor
Rose Research Center, LLC
Industry
Eligibility
22 Years to 65 Years
Enrollment
4 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
2
States / cities
Charlotte, North Carolina • Raleigh, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 30, 2025 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Results available

An Intervention to Promote Smoking Cessation Among Adults With Food Insecurity

NCT05259852
View directory record Official record
Conditions
Smoking Cessation, Food Insecurity
Interventions
Food Assistance and Cessation Resources Navigation Plus Economic Assistance, Food Assistance and Cessation Resources Navigation
Behavioral
Lead sponsor
Case Western Reserve University
Other
Eligibility
21 Years and older
Enrollment
55 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2023
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 5, 2024 · Synced Oct 26, 2026, 9:47 PM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

NCT06260683
View directory record Official record
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Nicotine Replacement, Questionnaire Administration, Vaping
Drug · Other · Device
Lead sponsor
Ohio State University Comprehensive Cancer Center
Other
Eligibility
21 Years and older
Enrollment
1,500 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2028
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Apr 6, 2026 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Solution And A Varenicline Patch Applied To The Skin

NCT00774605
View directory record Official record
Conditions
Smoking Cessation
Interventions
Varenicline free base solution, Varenicline free base patch
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 55 Years · Male only
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008
U.S. locations
1
States / cities
New Haven, Connecticut
Source: ClinicalTrials.gov public record
Updated Jan 26, 2009 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Inspired: Smartphone Videogame-Based Smoking Cessation Intervention

NCT03929003
View directory record Official record
Conditions
Smoking Cessation
Interventions
Inspired
Behavioral
Lead sponsor
Rowan University
Other
Eligibility
18 Years to 65 Years
Enrollment
48 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Glassboro, New Jersey
Source: ClinicalTrials.gov public record
Updated Mar 10, 2020 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional

Enhancing Tobacco Abstinence Following Hospitalization

NCT00222703
View directory record Official record
Conditions
Hospitalized Smokers, Chronic Diseases, Tobacco Use Disorder
Interventions
Smoking relapse prevention
Behavioral
Lead sponsor
University of Pittsburgh
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2005
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Sep 22, 2005 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 4 Interventional Results available

Randomized Study Comparing the Efficacy and Safety of Varenicline Tartrate to Placebo in Smoking Cessation When Subjects Are Allowed to Set Their Own Quit Date

NCT00691483
View directory record Official record
Conditions
Smoking Cessation
Interventions
placebo, varenicline
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 75 Years
Enrollment
659 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
12
States / cities
Litchfield Park, Arizona • Los Angeles, California • Santa Ana, California + 9 more
Source: ClinicalTrials.gov public record
Updated Nov 20, 2015 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Evaluating New Nicotine Standards for Cigarettes - Project 3

NCT03194256
View directory record Official record
Conditions
Smoking, Cigarette, Electronic Cigarettes
Interventions
Spectrum Research Cigarettes
Behavioral
Lead sponsor
Brown University
Other
Eligibility
15 Years to 20 Years
Enrollment
80 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2022
U.S. locations
1
States / cities
Providence, Rhode Island
Source: ClinicalTrials.gov public record
Updated Dec 18, 2023 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 2 Interventional Results available

Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms

NCT01199380
View directory record Official record
Conditions
Cigarette Smoking
Interventions
Standard Treatment, Behavioral Activation Treatment for Smoking, Transdermal Nicotine Patch
Behavioral · Drug
Lead sponsor
University of Maryland, College Park
Other
Eligibility
18 Years to 65 Years
Enrollment
184 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2016
U.S. locations
1
States / cities
College Park, Maryland
Source: ClinicalTrials.gov public record
Updated May 18, 2022 · Synced Oct 26, 2026, 9:47 PM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

Effects of Nicotine in Tobacco Smokers

NCT03651869
View directory record Official record
Conditions
Smoking, Tobacco, Smoking (Tobacco) Addiction
Interventions
Cigarette 1, Cigarette 2, Patch 1, Patch 2
Drug
Lead sponsor
University of Southern California
Other
Eligibility
21 Years and older
Enrollment
221 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2023
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Jul 13, 2023 · Synced Oct 26, 2026, 9:47 PM EDT
Recruiting No phase listed Observational Accepts healthy volunteers

Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRP

NCT06552741
View directory record Official record
Conditions
Substance Use Disorder, Alcohol Use Disorder
Interventions
Not listed
Lead sponsor
National Institute on Drug Abuse (NIDA)
NIH
Eligibility
18 Years to 99 Years
Enrollment
10,000 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2047
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Aug 24, 2026 · Synced Oct 26, 2026, 9:47 PM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

A Study to Develop a Strategy to Increase Lung Cancer Screening in Women Who May Be at Risk for Lung Cancer

NCT04848961
View directory record Official record
Conditions
Smoking
Interventions
LungTalk
Behavioral
Lead sponsor
Memorial Sloan Kettering Cancer Center
Other
Eligibility
50 Years to 80 Years · Female only
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2027
U.S. locations
7
States / cities
Basking Ridge, New Jersey • Middletown, New Jersey • Montvale, New Jersey + 4 more
Source: ClinicalTrials.gov public record
Updated May 6, 2026 · Synced Oct 26, 2026, 9:47 PM EDT